Sigma Receptors: Their Role in Disease and as Therapeutic Targets, Sylvia B. Smith; Tsung-Ping Su

Автор: Sylvia B. Smith; Tsung-Ping Su
Название: Sigma Receptors: Their Role in Disease and as Therapeutic Targets
ISBN: 3319501720 ISBN-13(EAN): 9783319501727
Издательство: Springer
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Цена: 23757.00 р.
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Описание: Originally confused with opioid receptors and then orphan receptors with no biological function, Sigma Receptors are now recognized as relevant to many degenerative diseases with remarkable potential as therapeutic targets.

Автор: Hopkins
Название: Novel Therapeutic Approaches to the Treatment of Parkinson`s Disease
ISBN: 3319399241 ISBN-13(EAN): 9783319399249
Издательство: Springer
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Цена: 32142.00 р.
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Описание: Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

Автор: Iqbal S. Grewal
Название: Therapeutic Targets of the TNF Superfamily
ISBN: 1441927999 ISBN-13(EAN): 9781441927996
Издательство: Springer
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Цена: 26120.00 р.
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Описание: For two decades, TNF superfamily has been the most investigated area of basic medical research. This book offers a state-of-the-art account of that research, including the role of TNF superfamily members to fight cancer and autoimmune disease.

Автор: Richard M. Epand
Название: Host Defense Peptides and Their Potential as Therapeutic Agents
ISBN: 3319329472 ISBN-13(EAN): 9783319329475
Издательство: Springer
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Цена: 22203.00 р.
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Описание: This book offers an overview of our current understanding of host defense peptides and their potential for clinical applications as well as some of the obstacles to this.

Автор: Han Asard; Alajos B?rczi; Roland J. Caubergs
Название: Plasma Membrane Redox Systems and their role in Biological Stress and Disease
ISBN: 0792354672 ISBN-13(EAN): 9780792354673
Издательство: Springer
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Цена: 32004.00 р.
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Описание: Provides a treatment of the involvement of plasma membrane redox reactions in the origin and development of biological stress and disease. This book contains chapters which cover the role of plasma membrane redox systems in cell defence, growth control, antioxidative defence reactions, development of tumour cells, and entry of toxins and viruses.

Автор: Felix J. Kim; Gavril W. Pasternak
Название: Sigma Proteins: Evolution of the Concept of Sigma Receptors
ISBN: 3319658514 ISBN-13(EAN): 9783319658513
Издательство: Springer
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Цена: 39130.00 р.
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Описание: Two sigma receptor subtypes have been proposed, sigma1 and 2. Largely based on traditional pharmacologic approaches, the Sigma1 protein has been associated with a broad range of signaling systems, including G-protein coupled receptors, NMDA receptors, and ion channels.

Автор: Kloc Malgorzata
Название: The Golgi Apparatus and Centriole: Functions, Interactions and Role in Disease
ISBN: 3030231720 ISBN-13(EAN): 9783030231729
Издательство: Springer
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Цена: 34937.00 р.
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Описание: This volume takes a closer look how the cell organelles Golgi apparatus (also known as the Golgi complex or Golgi body), and centriole are structurally and functionally intertwined.Initially, it was believed that the role of Golgi complex is limited to the packaging and preparation for secretion of various cellular proteins, while the centriole participates in cell division and cilia formation. However, since their discovery nearly 200 years ago, it became clear that these two organelles are interacting, and that their functions are much more complex and far reaching than previously thought. Recent findings indicate that the Golgi–Centriole relationship may be important for directional protein transport, cell polarization and cell cycle progression. Current studies indicate that Golgi and centriole also participate in development and act as cellular and immunological sensors, and that their abnormalities lead to cell and developmental abnormalities, Alzheimer, cancer, various lipid disorders and neurological and immunological diseases in humans. This volume combines the latest information on the structure, molecular composition, and roles of Golgi and centriole in various cellular functions and diseases. The better understanding of the Golgi–centriole interactions may lead to the development of novel therapies for the treatment of various diseases, including cancer.

Автор: Deric L. Wheeler; Yosef Yarden
Название: Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease
ISBN: 1493920529 ISBN-13(EAN): 9781493920525
Издательство: Springer
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Цена: 22203.00 р.
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Описание: Receptor Tyrosine Kinase: Structure, Functions and Role in Human Disease, for the first time, systematically covers the shared structural and functional features of the RTK family.

Автор: Silvia Dossena; Markus Paulmichl
Название: The Role of Pendrin in Health and Disease
ISBN: 3319827804 ISBN-13(EAN): 9783319827803
Издательство: Springer
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Цена: 20962.00 р.
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Описание: This book reviews the current state of knowledge on the genetics, molecular biology and physiology of pendrin, with a particular focus on pendrin dysfunction and the consequences for human health.

Автор: Rossen Donev
Название: Ion channels as therapeutic targets,103
ISBN: 0128047941 ISBN-13(EAN): 9780128047941
Издательство: Elsevier Science
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Цена: 21222.00 р.
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Описание:

"Ion Channels as Therapeutic Targets" is the latest volume in the popular "Advances in Protein Chemistry and Structural Biology" series, an essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins, with each thematically organized volume guest edited by leading experts in a broad range of protein-related topics.
Provides cutting-edge developments in protein chemistry and structural biologyDiscusses the use of ion channels as therapeutic targetsChapters are written by authorities in their fieldTargeted to a wide audience of researchers, specialists, and students

Автор: Kloc Malgorzata
Название: The Golgi Apparatus and Centriole: Functions, Interactions and Role in Disease
ISBN: 3030231755 ISBN-13(EAN): 9783030231750
Издательство: Springer
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Цена: 34937.00 р.
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Описание:

Volume Content

I. Golgi and Centriole Structure, Assembly and Regulation

1. Title: "The Evolution of Centriole Structure: Heterochrony, Neoteny, and Hypermorphosis"

Authors: Tomer Avidor-Reiss and Katerina Turner

2. Title: "The role of protein acetylation in centrosome biology"

Authors: Delowar Hossain and William Y. Tsang

3. Title: "Formins, Golgi and the centriole"

Author: John Copeland

4. Title: "Role of intracellular transport in the centriole-dependent formation of Golgi ribbon"

Authors: Alexander A. Mironov, Ivan D. Dimov, and Galina V. Beznoussenko

5. Title: "RhoA pathway and actin regulation of the Golgi/centriole complex"

Authors: Malgorzata Kloc, JarekWosik, Jacek Z Kubiak, Rafik Mark Ghobrial

6. Title: "Multiple roles of Rab GTPases at the Golgi"

Authors: CinziaProgida

II. Golgi and Centriole Positioning, Interactions and Dynamics

7. Title: "Positioning of the Centrosome and Golgi Complex"

Author: Amos Orlofsky