Extracellular Sugar-Based Biopolymers Matrices, Ephraim Cohen; Hans Merzendorfer

Автор: Ruggiero
Название: The Collagen Superfamily and Collagenopathies
ISBN: 3030675947 ISBN-13(EAN): 9783030675943
Издательство: Springer
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Цена: 19564.00 р.
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Описание: This book aims at providing insights into the collagen superfamily and the remarkable diversity of collagen function within the extracellular matrix.

Автор: Federico Maurizio, Ridolfi Barbara
Название: Extracellular Vesicles in Diagnosis and Therapy
ISBN: 1071623400 ISBN-13(EAN): 9781071623404
Издательство: Springer
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Цена: 18167.00 р.
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Описание: This detailed book provides an exhaustive picture of current methods to detect, isolate, and analyze extracellular vesicles (EVs) from diverse sources, now seen as potential disease biomarkers as well as tools for the development of new therapies. Beginning with a section on detection and isolation of EVs, the volume continues with chapters covering different methods to isolate and quantify EVs from specialized tissues/organs and body fluids, methods devoted to analyzing EV components, as well as cutting-edge methods to engineer EVs. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Extracellular Vesicles in Diagnosis and Therapy serves as an ideal guide for researchers seeking to learn more about the complexities of cell-to-cell communication.

Автор: Robert Mecham
Название: The Extracellular Matrix: an Overview
ISBN: 364226719X ISBN-13(EAN): 9783642267192
Издательство: Springer
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Цена: 28732.00 р.
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Описание: Covering a wide spectrum of topics including collagen types and the role of the ECM in human disease and pathogenesis, this volume is a timely overview of the structure, regulation, and function of the major macromolecules that form the extracellular matrix.

Автор: Yo Kikuchi; Elena Y. Rykova
Название: Extracellular Nucleic Acids
ISBN: 3642264190 ISBN-13(EAN): 9783642264191
Издательство: Springer
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Цена: 26120.00 р.
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Описание: Following their emergence as key players in biology and the medical sciences, this book covers newly developing fields related to extracellular nucleic acids, including their basic biology, their ecology and their implications for medical science.

Автор: Ephraim Cohen; Hans Merzendorfer
Название: Extracellular Sugar-Based Biopolymers Matrices
ISBN: 3030129187 ISBN-13(EAN): 9783030129187
Издательство: Springer
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Цена: 27950.00 р.
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Описание: The extracellular matrix (ECM) is an acellular three-dimensional network composed of proteins, glycoproteins, proteoglycans and exopolysaccharides. It primarily serves as a structural component in the tissues and organs of plants and animals, or forms biofilms in which bacterial cells are embedded. ECMs are highly dynamic structures that undergo continuous remodeling, and disruptions are frequently the result of pathological processes associated with severe diseases such as arteriosclerosis, neurodegenerative illness or cancer. In turn, bacterial biofilms are a source of concern for human health, as they are associated with resistance to antibiotics. Although exopolysaccharides are crucial for ECM formation and function, they have received considerably little attention to date. The respective chapters of this book comprehensively address such issues, and provide reviews on the structural, biochemical, molecular and biophysical properties of exopolysaccharides. These components are abundantly produced by virtually all taxa including bacteria, algae, plants, fungi, invertebrates and vertebrates. They include long unbranched homopolymers (cellulose, chitin/chitosan), linear copolymers (alginate, agarose), peptoglycans such as murein, heteropolymers like a variety of glycosaminoglycans (hyaluronan, dermatan, keratin, heparin, Pel), and branched heteropolymers such as pectin and hemicellulose. A separate chapter is dedicated to modern industrial and biomedical applications of exopolysaccharides and polysaccharide-based biocomposites. Their unique chemical, physical and mechanical properties have attracted considerable interest, inspired basic and applied research, and have already been harnessed to form structural biocomposite hybrids for tailor-made applications in regenerative medicine, bioengineering and biosensor design. Given its scope, this book provides a substantial source of basic and applied information for a wide range of scientists, as well as valuable textbook for graduate and advanced undergraduate students.

Автор: Cohen
Название: Extracellular Composite Matrices in Arthropods
ISBN: 3319821695 ISBN-13(EAN): 9783319821696
Издательство: Springer
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Цена: 39130.00 р.
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Описание: Emphasis is placed on the elaborate cuticular matrices in insects and crustaceans, spider and insect silks, sialomes of phytophagous and blood-feeding arthropods as well as on secretions of male and female accessory glands. Focus is placed largely on insects, due to the extensive body of published research that in part is the result of available whole genome sequences of several model species (in particular Drosophila melanogaster) and accessible ESTs for other species. Such advances have facilitated fundamental insights into genomic, proteomic and molecular biology-based physiology. This new volume contains comprehensive contributions on extracellular composite matrices in arthropods. The building blocks of such matrices are formed in and secreted by single layered epithelial cells into exterior domains where their final assembly takes place. Additionally, the unique mechanical properties of natural biocomposites like chitin/chitosan, the crustacean mineralized exoskeleton, the pliant protein resilin or insect and spider silks, have inspired basic and applied research that yield sophistical biomimetics and structural biocomposite hybrids important for future industrial and biomedical use. In summary, this book provides an invaluable vast source of basic and applied information for a plethora of scientists as well as textbook for graduate and advanced undergraduate students.

Автор: Lakshmi Kiran Chelluri
Название: Stem Cells and Extracellular Matrices
ISBN: 1615043764 ISBN-13(EAN): 9781615043767
Издательство: Mare Nostrum (Eurospan)
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Цена: 6237.00 р.
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Описание: Stem cells have great potential in regenerative medicine and tissue injury. Regulation of stem cell homeostasis in a 3D microenvironment is controlled by the niche components that influence stem cell fate, regulation, and function. It is therefore necessary to understand the mechanisms of cell-cell interaction, molecular cross talk between stem cells and their extracellular matrix environment.

Автор: Gullberg
Название: Integrins in Health and Disease
ISBN: 3031237803 ISBN-13(EAN): 9783031237805
Издательство: Springer
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Цена: 23757.00 р.
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Описание: Integrins are heterodimeric cell surface receptors which anchor cells to different extracellular matrix proteins or act as cell-cell receptors. They play pivotal roles not only across a wide range of physiological processes including tissue morphogenesis, wound healing, and regulation of cell growth, but also in numerous pathological conditions such as autoimmunity, infectious disease, and carcinogenesis. This book aims to provide readers a summary of the most important integrins and their respective biological functions. Readers will learn about knockout- and animal models to study the functionality of key collagen-, laminin-, and nephronectin-binding integrins. Additionally, the role of integrins in pathological tissue remodeling in joints and in developing and diseased cardiac tissue are discussed. Reviews of the current knowledge of the role of integrins in tissue and tumor fibrosis, angiogenesis and tumor progression are an important part of this work. Finally, the book discusses integrins in the context of the immune system, how to target integrin-ligand interactions with antibodies, and the role of integrins as receptors for bacterial and viral cell invasion. Both experienced researchers and clinicians, as well as PhD students who wish to study the extracellular matrix and cell adhesion molecules will find “Integrins in Health and Disease - Key Effectors of Cell-Matrix and Cell-Cell Interactions” authoritative, easily accessible, and vastly informative. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.

Автор: Kovalszky
Название: The Extracellular Matrix and the Tumor Microenvironment
ISBN: 3030997073 ISBN-13(EAN): 9783030997076
Издательство: Springer
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Цена: 25155.00 р.
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Описание: This book introduces the most important and best studied extracellular and pericellular molecules of the tumor microenvironment. It gives a comprehensive overview of their role in tumor development and cancer progression. Twelve chapters deal with the biochemical and biophysical background of extracellular matrix (ECM) changes in the tumor stroma compared to the physiological state. The reader learns about the major ECM components that are deregulated during cancer development and how they are associated with cancer progression associated with survival, inflammation process, among others. These are followed by recent data about the cooperative activity of extracellular matrix in tumor metabolism, promoting cancer progression. Two chapters focus specifically on the critical role of the ECM in tumor angiogenesis, linking this process to cellular infiltration and metastatic behavior of tumors. The final part describes how the ECM influences the success of immuno- and chemotherapy in cancer patients, its potential as biomarkers for diagnosis, prognosis, and therapeutic target, as well as the mechanism of resistance-associated changes in the ECM. This book is an interesting read for anyone who want to know more about ECM and cancer biology. Early career scientists can use it as an introduction to the field, offering an excellent tool for studying ECM. Advanced researchers and clinicians can gain a broader overview of the subject, considering the role of ECM for influencing every cancer hallmark as well as in the response of cancer treatments. The work serves to inspire future research and shows that the ECM should be considered as an important factor in the development of cancer therapeutics. The series "Biology of Extracellular Matrix" is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.

Автор: Harrison, Paul
Название: Extracellular Vesicles in Health and Disease
ISBN: 9814411981 ISBN-13(EAN): 9789814411981
Издательство: Taylor&Francis
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Цена: 23734.00 р.
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Автор: Jean-Paul Truchot
Название: Comparative Aspects of Extracellular Acid-Base Balance
ISBN: 364283132X ISBN-13(EAN): 9783642831324
Издательство: Springer
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Цена: 18284.00 р.
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Описание: However, in accord with differing designs and con- straints along animal evolution, varying effector organs and mechanisms are at work to maintain an appropriate acid-base state in the organism.

Автор: Elizabeth D. Hay
Название: Cell Biology of Extracellular Matrix
ISBN: 1461282268 ISBN-13(EAN): 9781461282266
Издательство: Springer
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Цена: 16979.00 р.
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Описание: At a recent meeting to discuss the domains of cell biology, I put forth a case for the extracellular matrix, even though my argument ran the risk of falling on deaf ears.