Therapeutic Enzymes: Function and Clinical Implications, Nikolaos Labrou
Автор: Nikolaos Labrou Название: Therapeutic Enzymes: Function and Clinical Implications ISBN: 9811377081 ISBN-13(EAN): 9789811377082 Издательство: Springer Рейтинг: Цена: 21661.00 р. Наличие на складе: Поставка под заказ.
Описание: Therapeutic enzymes exhibit fascinating features and opportunities, and represent a significant and promising subcategory of modern biopharmaceuticals for the treatment of several severe diseases. Research and drug developments efforts and the advancements in biotechnology over the past twenty years have greatly assisted the introduction of efficient and safe enzyme-based therapies for a range of both rare and common disorders. The introduction and regulatory approval of twenty different recombinant enzymes has enabled effective enzyme-replacement therapy. This volume aims to overview these therapeutic enzymes, focusing in particular on more recently approved enzymes produced by recombinant DNA technology. This volume is composed of four sections. Section 1 provides an overview of the production process and biochemical characterization of therapeutic enzymes, while Section 2 focuses upon the engineering strategies and delivery methods of therapeutic enzymes. Section 3 highlights the clinical applications of approved therapeutic enzymes, including aspects on their structure, indications and mechanisms of action. Together with information on these mechanisms, safety and immunogenicity issues and various adverse events of the recombinant enzymes used for therapy are discussed. Section 4, provides discussion on the prospective and future developments of new therapeutic enzymes. This book is aimed at academics, researchers and students undertaking advanced undergraduate/postgraduate programs in the biopharmaceutical/biotechnology area who wish to gain a comprehensive understanding of enzyme-based therapeutic molecules.
Описание: In this book, the major paradigm-shifting discoveries made in the past century on key cellular nanomachines are described in great detail: their complex yet precise and elegant design and function, as well as the diseases linked to their dysfunction and the therapeutic approaches to overcome them.
Автор: Jawahar L. Mehta; Pankaj Mathur; Naranjan S. Dhall Название: Biochemical Basis and Therapeutic Implications of Angiogenesis ISBN: 3319870084 ISBN-13(EAN): 9783319870083 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Поставка под заказ.
Описание: This book covers the latest developments in the therapeutic implications of angiogenesis, ranging from angiogenesis in the brain, angiogenesis in cancer, angiogenesis’ role in atherosclerosis and heart disease as well as metabolic disorders and peripheral vascular disease. The book is comprehensive in its coverage of angiogenesis in a diverse set of diseases and examines the role of cellular and subcellular structures during the development of angiogenesis. Well-organized and thorough, this is an ideal book for researchers and biomedical engineers working in the field of therapeutic implications of angiogenesis. This book also: Covers the basics of the physiology of angiogenesis, including VEGF pathways in angiogenesis, integr ins in angiogenesis, angiogenesis and exercise physiology, and more Details the role of angiogenesis in atherosclerosis and heart disease, including vascular endothelial growth factor and atherosclerotic plaque progression as well as angiogenesis and heart failure Illustrates in detail brain angiogenesis after stroke and the relationship between angiogenesis and Alzheimer's disease
Описание: In this book, the major paradigm-shifting discoveries made in the past century on key cellular nanomachines are described in great detail: their complex yet precise and elegant design and function, as well as the diseases linked to their dysfunction and the therapeutic approaches to overcome them.
Описание: LIST OF PARTICIPANTS 11 THERMOPHILIC HYDROLYTIC ENZYMES (PROTEINASES, AMYLASES) 17 Thermal Stability of Homologous Neutral Metalloendopeptidases in Thermo- philic and Mesophilic Bacteria: Structural Considerations M. YUTAN I 91 THERMOPHILIC DEHYDROGENASES 105 Thermophilic Glyceraldehyde-3-P Dehydrogenase R.
Автор: Rossen Donev Название: Ion channels as therapeutic targets,103 ISBN: 0128047941 ISBN-13(EAN): 9780128047941 Издательство: Elsevier Science Рейтинг: Цена: 21222.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
"Ion Channels as Therapeutic Targets" is the latest volume in the popular "Advances in Protein Chemistry and Structural Biology" series, an essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins, with each thematically organized volume guest edited by leading experts in a broad range of protein-related topics. Provides cutting-edge developments in protein chemistry and structural biologyDiscusses the use of ion channels as therapeutic targetsChapters are written by authorities in their fieldTargeted to a wide audience of researchers, specialists, and students
Автор: Vsevolod V. Gurevich Название: Arrestins - Pharmacology and Therapeutic Potential ISBN: 3662522993 ISBN-13(EAN): 9783662522998 Издательство: Springer Рейтинг: Цена: 43100.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume in Springer`s authoritative series on experimental pharmacology covers the molecular mechanisms and therapeutic implications of arrestin-mediated signaling, including the potential of re-engineered signaling proteins in the field of gene therapy.
Автор: Vladimir Voynov; Justin A. Caravella Название: Therapeutic Proteins ISBN: 1493959492 ISBN-13(EAN): 9781493959495 Издательство: Springer Рейтинг: Цена: 20263.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Emphasizing the newest developments in the field, this volume presents detailed methods with added emphasis on therapeutic protein discovery. It features key tips and valuable implementation advice to ensure successful results.
Автор: Linda O. Narhi Название: Biophysics for Therapeutic Protein Development ISBN: 1489992464 ISBN-13(EAN): 9781489992468 Издательство: Springer Рейтинг: Цена: 20896.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book assesses techniques used in therapeutic development across the product lifecycle from early discovery through expression and purification, large scale production, formulation development, lot-to-lot comparability studies, commercial support and more.
Описание: This book offers an overview of our current understanding of host defense peptides and their potential for clinical applications as well as some of the obstacles to this.
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