Автор: Ducry Название: Antibody-Drug Conjugates ISBN: 1627035400 ISBN-13(EAN): 9781627035408 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book presents detailed protocols for key antibody-drug conjugates techniques necessary for working in the field. It provides step-by-step methodologies that are readily reproducible and features expert tips and key implementation advice.
Автор: Van Delft Floris, Lambert John M. Название: Chemical Linkers in Antibody-Drug Conjugates (Adcs) ISBN: 1839162635 ISBN-13(EAN): 9781839162633 Издательство: Royal Society of Chemistry Рейтинг: Цена: 45923.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Chemical Linkers in Antibody-Drug Conjugates aims to shine a detailed light on the various key attributes of chemical linkers in ADCs, for drug-to-antibody ratio, for stability, for release mechanism of payload, for pharmacokinetics, for stability determination, and for efficacy and safety.
Автор: L. Nathan Tumey Название: Antibody-Drug Conjugates ISBN: 1493999281 ISBN-13(EAN): 9781493999286 Издательство: Springer Рейтинг: Цена: 16070.00 р. Наличие на складе: Поставка под заказ.
Описание:
This volume looks at key methodologies that are commonly used across antibody drug conjugates (ADCs) programs. The chapters in this book cover topics such as conjugations to endogenous cysteine residues; click chemistry conjugations; antibody conjugations via glycosyl remodeling; analysis of ADCs by native mass spectrometry; characterization of ADCs by capillary electrophoresis; LC/MS methods for studying lysosomal ADC catabolism; and determination of ADC concentration by ligand-binding assays. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Cutting-edge and practical, Antibody-Drug Conjugates: Methods and Protocols is a valuable resource that aims to lower the “activation barrier” when undertaking a new discipline, and provides a “toolbox” for the next generation of ADC scientists.
Автор: Ulf Grawunder; Stefan Barth Название: Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins ISBN: 3319468758 ISBN-13(EAN): 9783319468754 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This book describes the newest developments in antibody drug conjugates and immunotoxins, paving their way to clinical application. Lessons learned from the current state of the art are used to further improve our understanding of their mechanisms of action and off target activities.
The book introduces scientists to all of the prerequisites that must be properly addressed, including identification of the right target, specific traits of target binding antibodies, proper selection of the toxic payload, internalization induced by binding, and next generation conjugation and linker technologies. These knowledge-based, revolutionary new drug principles will form the cornerstone of the future standard of care and will lead to major advances in application, as well as improved quality of life and patient survival rates. This book will be of interest to biotech companies and researchers working in the fields of immunology, pharmacology, and oncology.
Автор: Ulf Grawunder; Stefan Barth Название: Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins ISBN: 3319836099 ISBN-13(EAN): 9783319836096 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book describes the newest developments in antibody drug conjugates and immunotoxins, paving their way to clinical application. Lessons learned from the current state of the art are used to further improve our understanding of their mechanisms of action and off target activities. The book introduces scientists to all of the prerequisites that must be properly addressed, including identification of the right target, specific traits of target binding antibodies, proper selection of the toxic payload, internalization induced by binding, and next generation conjugation and linker technologies. These knowledge-based, revolutionary new drug principles will form the cornerstone of the future standard of care and will lead to major advances in application, as well as improved quality of life and patient survival rates. This book will be of interest to biotech companies and researchers working in the fields of immunology, pharmacology, and oncology.
Автор: Gail Lewis Phillips Название: Antibody-Drug Conjugates and Immunotoxins ISBN: 1489997008 ISBN-13(EAN): 9781489997005 Издательство: Springer Рейтинг: Цена: 22201.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume collets leading research on antibody-drug conjugates and immunotoxins. It examines all aspects of ADCs and ITs from clinical development through to targeted therapeutic applications and the latest technologies.
Автор: Laurent Ducry Название: Antibody-Drug Conjugates ISBN: 1493960261 ISBN-13(EAN): 9781493960262 Издательство: Springer Рейтинг: Цена: 16769.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book presents detailed protocols for key antibody-drug conjugates techniques necessary for working in the field. It provides step-by-step methodologies that are readily reproducible and features expert tips and key implementation advice.
Автор: Nevoltris Название: Antibody Engineering ISBN: 1493986473 ISBN-13(EAN): 9781493986477 Издательство: Springer Рейтинг: Цена: 21661.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This detailed new edition provides complete and easy access to a variety of antibody engineering techniques. The volume explores topics such as the generation of native, synthetic, or immune antibody libraries, the selection of lead candidates via the different powerful and innovative display technologies, Fc engineering, as well as their production, characterization, and optimization of antibodies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and up-to-date, Antibody Engineering: Methods and Protocols, Third Edition presents the reader with an extensive toolbox to create the powerful molecules of tomorrow.
Описание: In the anti-breast cancer antibody field the availability of molecular engineering approaches to humanize murine antibodies has induced intense interest in the creation of less immunogenic antibody forms that are now available for clinical testing.
Background.- High-throughput Sequencing of the Paired Human Immunoglobulin Heavy and Light Chain Repertoire.- In-Depth Determination and Analysis of the Human Paired Heavy and Light Chain Antibody Repertoire.- Paired VH: VL Analysis of Naпve B Cell Repertoires and Comparison to Antigen-Experienced B Cell Repertoires in Healthy Human Donors.- Conclusions and Future Perspectives.- Appendices.
Автор: Gabriele Proetzel; Hilmar Ebersbach Название: Antibody Methods and Protocols ISBN: 1493959301 ISBN-13(EAN): 9781493959303 Издательство: Springer Рейтинг: Цена: 20263.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This Methods in Molecular Biology (TM) volume covers in vitro and in vivo generation of antibodies, as well as techniques for screening, analysis and modification of antibodies and antibody fragments. Offers materials lists, protocols and troubleshooting tips.
Название: Antibody Therapeutics ISBN: 0367200570 ISBN-13(EAN): 9780367200572 Издательство: Taylor&Francis Рейтинг: Цена: 24499.00 р. Наличие на складе: Поставка под заказ.
Описание: El paquete Courseware consiste de dos publicaciones , VeriSM - Fundamentos Courseware y Fundamentos guia de estudio.Este material de entrenamiento cubre el plan de estudios para la calificacion VeriSM fundamentos. El entrenamiento puede ser entregado durante dos dias. Este Courseware esta acreditado para preparar al estudiante para la certificacion VeriSM. VeriSM Fundamentos consiste de dos partes: VeriSM Essentials y VeriSM Plus, cada uno cubriendo un dia de entrenamiento.Los estudiantes que ya tienen un certificado en Gestion de Servicios (TI) pueden beneficiarse del conocimiento que ya tienen. Son el publico objetivo para el entrenamiento VeriSM Plus unicamente. Cuando aprueben el examen VeriSM Plus, recibiran el certificado de VeriSM fundamentos. Proveedores de entrenamiento que quieran ofrecer un dia de capacitacion sobre principios de gestion de servicios podrian decidir ofrecer unicamente el entrenamiento de VeriSM Essentials. Los estudiantes que aprueben el examen VeriSM Essentials, recibiran el certificado de VeriSM Essentials. Si posteriormente ellos aprueban el examen VeriSM plus, recibiran automaticamente el certificado VeriSM Fundamentos.El courseware cubre los siguientes temas:¢ La organizacion del servicio (Essentials)¢ Cultura del servicio (Essentials)¢ Personas y cultura organizacional (Essentials)¢ El modelo VeriSM (Ambas)¢ Practicas progresivas (Plus)¢ Tecnologias innovadoras (Plus)VeriSM es un enfoque holistico y orientado a la empresa, que le ayuda a comprender el creciente panorama de las mejores practicas y como integrarlas para ofrecer valor al consumidor.Esto es una evolucion en el pensamiento de la Gestion de Servicios y ofrece un enfoque actualizado, incluyendo las ultimas practicas y desarrollos tecnologicos, para ayudar a las organizaciones a transformar su negocio en la nueva realidad de la era digital.VeriSM es un enfoque de Gestion de Servicios que esta Dirigido por el valor, Evolutivo, Responsivo (Adaptado) e Integrado VeriSM es una marca registrada y propiedad del IFDC, la Fundacion Internacional de Habilidades Digitales
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