Inter-Organellar Ca2+ Signaling In Health And Disease - Part A,362, Galluzzi, Lorenzo

Автор: Sajal Chakraborti; Naranjan S Dhalla
Название: Regulation of Ca2+-ATPases,V-ATPases and F-ATPases
ISBN: 3319796771 ISBN-13(EAN): 9783319796772
Издательство: Springer
Рейтинг:
Цена: 27950.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: The biological membranes of cellular organization enfold an important group of membrane proteins called the ATPases, which are not only versatile in maintaining chemical gradient and electrical potential across the membrane but also bring metabolites necessary for cell metabolism and drive out toxins, waste products and solutes that otherwise can curb cell functions. ATPases are distributed virtually in all live forms starting from unicellular to multicellular and also in viruses. There are different types of ATPases, which differ in function and structure and in the type of ions they transport. The three main types of the ion pump ATPase family are: (i) P-type ATPases that transport different ions across membranes and Ca2+ATPases belongs to this catagory (ii) F-type ATPase in mitochondria, chloroplasts and bacterial plasma membranes produce ATP using the proton gradient; and (iii) V-type ATPase catalyzes ATP hydrolysis to transport solutes and maintains acidic pH in organelles like lysosomes. Genetic defects in either of the ATPases cause several diseases and a number of researches have demonstrated the involvement of the members of ATPases in the cell pathology and diseases, thereby penetrating exciting new areas of our understanding. In this book, the authors summarize recent knowledge about the molecular mechanisms associated with Ca2+-ATPase, V-ATPase and F-ATPase in intracellular and extracellular Ca2+ transport, mitochondrial ATP synthase, vesicular H+ transport, and lysosomal pH regulation. This book thereby bridges the gap between fundamental research and biomedical and pharmaceutical applications. The book provides an informative resource to improve ATPase research and modern therapeutic approaches toward different life threatening diseases that are associated with dysregulation of the ATPases.

Автор: James D. Johnson, Michael J. Bround, Tobias Albrecht
Название: Ca2+-dependent Signal Transduction
ISBN: 161504664X ISBN-13(EAN): 9781615046645
Издательство: Mare Nostrum (Eurospan)
Рейтинг:
Цена: 9286.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Provides a review of the general principles of Ca2+ signal transduction and examples of some of the major Ca2+-dependent cellular processes. This volume also reviews the main sources of Ca2+ and the molecular effectors of Ca2+ signals, and provides some examples from the literature that illustrate how Ca2+ signalling works.

Автор: Sajal Chakraborti; Naranjan S Dhalla
Название: Regulation of Ca2+-ATPases,V-ATPases and F-ATPases
ISBN: 3319247786 ISBN-13(EAN): 9783319247786
Издательство: Springer
Рейтинг:
Цена: 34937.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: The three main types of the ion pump ATPase family are: (i) P-type ATPases that transport different ions across membranes and Ca2+ATPases belongs to this catagory (ii) F-type ATPase in mitochondria, chloroplasts and bacterial plasma membranes produce ATP using the proton gradient;