Overcoming Resistance to EGFR Inhibitors in EGFR Mutant NSCLC presents updated information on how EGFR mutant lung cancers evolve to evade EGFR inhibitors, clinical strategies that identify these mechanisms, and how to implement newer therapeutic strategies to combat resistance and improve patient survival. As resistance to EGFR inhibitors is often through re-activation of MEK/ERK and PI3K pathways, or through loss of cell death responses, there is much overlap with resistance to targeted therapies in other paradigms, such as BRAF inhibitors in BRAF mutant melanoma, and HER2 inhibitors in HER2 amplified breast cancer.
This book is a valuable resource for cancer researchers, clinicians, graduate students and other members of the biomedical field who are interested in promising treatments for lung cancer.
Автор: Bonavida, Benjamin Название: Improving The Therapeutic Ratio In Head And Neck Cancer,6 ISBN: 012817868X ISBN-13(EAN): 9780128178683 Издательство: Elsevier Science Рейтинг: Цена: 22738.00 р. Наличие на складе: Поставка под заказ.
Описание: Hydropedology is a microcosm for what is happening in Soil Science. This title brings together pedology (soil characteristics) with hydrology (movement of water) to understand and achieve the goals associated with modern soil science. It includes case studies that demonstrate the need for hydropedology in various practical applications.
Therapeutic Strategies to Overcome ALK Resistance in Cancer, Volume 16 presents current strategies to improve and prolong clinical benefit in ALK driven cancers. Most patients with ALK-driven cancer are sensitive to tyrosine kinase inhibitor (TKI) therapy, but resistance invariably develops. This book discusses topics such as structure and function of ALK, ALK rearranged lung cancer, resistance mechanisms to ALK TKI tumors, and novel therapeutic strategies to enhance crizotinib anti-tumor efficacy in ALCL. Additionally, it encompasses information on drug combinations to enhance ALK TKI anti-tumor efficacy in neuroblastoma and future perspectives in the field.
This book is a valuable resource for cancer researchers, clinicians and several members of biomedical field who need to understand more about how to fight ALK resistance in cancer treatment.
Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies, Volume Eleven summarizes the molecular mechanisms of drug resistance in colorectal cancer, along with the most up-to-date therapeutic strategies available. The book discusses reasons why colorectal tumors become refractory during the progression of the disease, but also explains how drug resistance occurs during chemotherapy. In addition, users will find the current therapeutic strategies used by clinicians in their practice in treating colorectal cancer. The combination of conventional anticancer drugs with chemotherapy-sensitizing agents plays a pivotal role in improving the outcome of colorectal cancer patients, in particular those with drug-resistant cancer cells.
From a clinical point-of-view, the content of this book provides clinicians with updated therapeutic strategies for a better choice of drugs for drug-resistant colorectal cancer patients. It will be a valuable source for cancer researchers, oncologists and several members of biomedical field who are dedicated to better treat patients with colorectal cancer.
Novel Therapies in Head and Neck Cancer: Beyond the Horizon, Volume Twelve provides a high-level synthesis of the latest treatments and outcomes relating to head and neck cancer. Chemotherapy and immunotherapy for those cancer types are rapidly evolving, and an updated source based on the expertise of internationally renowned researchers is necessary. This book discusses the outcome of recent trials using chemotherapy, novel approaches for HPV+ SCCA, cases in which immunotherapy is more likely to be successful, and precision medicine based on target therapies. Additionally, new approaches for rare diseases in head and neck and novel drug delivery platforms are presented.
This book will be a very useful source so that students, scientists and clinicians who can be facile with the data, build on what is known, and continue to offer cutting-edge, validated therapies to all patients.
Targeting Cell Survival Pathways to Enhance Response to Chemotherapy encompasses recently developed molecular targeting agents and approaches that suppress cell survival signaling. Cell survival signaling attenuates the effectiveness of conventional chemotherapy and numerous mechanisms have been described, and continue to be described, which contribute to cell survival in the face of chemotherapy treatment.
Key pathways leading to chemoresistance emanate from growth factor receptors, PI3K, STAT3, anti-apoptotic Bcl-2 family members, autophagy, and the DNA damage response pathway. New advances have underscored the potential of targeting each of these cell survival mechanisms to improve responsiveness to chemotherapy. This book reviews these recent advances and provides a foundational background and hints of new opportunities for basic, translational, and clinical investigators focused on improving therapeutic responses to chemotherapy.
Автор: Jewett, Anahid Название: Nk Cells In Cancer Immunotherapy: Successes And Challenges ISBN: 012822620X ISBN-13(EAN): 9780128226209 Издательство: Elsevier Science Рейтинг: Цена: 23075.00 р. Наличие на складе: Поставка под заказ.
Описание: Chemical industries, dairy units, oil and gas refineries, petro-chemical complexes and fertilizer manufacturing units are few of those areas which are incomplete without anti-corrosive treatment for concrete surface. Environmental effects, spillage and dust- emission are few of those processes which can corrode concrete. Protection of concrete surface of constructed elements from corrosive attack "arising through very harsh corrosive conditions" from all those (and many more) sources of corrosion becomes a moral duty of a Civil Engineer. This book is an effort in this direction to share the applied knowledge with the budding Engineers so that they are aware of such protective measures to be taken for the situations they are put into which I am sure, you must have found it to be of significant importance. One save of production stoppage with use of knowledge contained in this book would serve the very purpose of bringing it out.
Описание: Luckily, the parking lot only deleted footage every three months because of the relatively heavy flow of tourism that took place at Cramond Ghost Island during the summer months. The old man in charge of the parking lot security cameras asked us why we needed the footage. Ethan told him that I met someone there at noon on a Saturday in July and that the police needed to verify that this meeting took place on that date. The old man had to review footage of the four Saturdays in July. He grumbled as he escorted us to a small viewing room at the rear end of the parking lot. Ethan and I sat down next to the old man as he began his search. He
Автор: Ahmad, Sarfraz Название: Overcoming Drug Resistance In Gynecologic Cancers,20 ISBN: 012824299X ISBN-13(EAN): 9780128242995 Издательство: Elsevier Science Рейтинг: Цена: 23075.00 р. Наличие на складе: Поставка под заказ.
Описание: Digital Information Design (DID) is primarily a business information management (BIM) model. As with any model it is used to help you to describe problems and test potential solutions. DID is not like any other method or framework model; it is independent of any other existing model or framework and does not claim to manage the entirety of the design of business information services. DID identifies useful and widely used best practices that are designed specifically for use in any phase of business information service development from idea, conception, specification, design, test, handover, service management and operation, or managing architectural issues or hardware and software installation. Primarily, DID was developed to manage the quality of information, and how to put it to good use. The DID model has been designed for you to identify what you need and when you need it when designing business information services and as a broad guide, identifies key points in existing frameworks that are particularly useful. The model is wholly independent of all other frameworks (including BiSL and BiSL Next in which the basic design is rooted). You can choose and use whatever you wish, the model will help you to assess the validity of your choice(s) and identify strengths and weaknesses in your approach.The DID model focuses on the common languages to describe key elements of design (need and value, mission and capability), key business information perspectives (business, information/data, services and technology) and the high-level domains (governance, strategy, improvement and operation) that must be managed in order to effectively run any business.DID helps you to identify only what you need to ensure that business information design reflects what is needed by your enterprise. The model can be used entirely separately from the framework level guidance discussed and it can be used at any level in the organization. The essentials of DID are explained in two books: this book, Foundation and the Practitioner book that will be published later.
Автор: Supuran, Claudiu T. Название: Ph Interfering Agents As Chemosensitizers In Cancer Therapy,13 ISBN: 0128207019 ISBN-13(EAN): 9780128207017 Издательство: Elsevier Science Рейтинг: Цена: 23075.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
pH Interfering Agents as Chemosensitizers In Cancer Therapy, Volume Thirteen provides a detailed overview of the chemosensitizers for the treatment of cancer spanning from biochemical and structural features to pharmacology and drug-design, including technological applications. The book is structured with innovative outlines and a distinction between experimental and clinical results. The continuous discovery and assessment of the role played by old/new synthetic drugs, natural compounds and technological applications has led to the urgent need of classification in terms of biological activity, mechanism of action, clinical outcomes, cancer cell lines sensible to the treatment, and potentialities to better orient research in this field.
Moreover, all the aspects relevant for medicinal chemistry (drug design, structure-activity relationships, permeability data, cytotoxicity, appropriate statistical procedures, and molecular modeling studies) are strictly considered.
Описание: Chemical industries, dairy units, oil and gas refineries, petro-chemical complexes and fertilizer manufacturing units are few of those areas which are incomplete without anti-corrosive treatment for concrete surface. Environmental effects, spillage and dust- emission are few of those processes which can corrode concrete. Protection of concrete surface of constructed elements from corrosive attack "arising through very harsh corrosive conditions" from all those (and many more) sources of corrosion becomes a moral duty of a Civil Engineer. This book is an effort in this direction to share the applied knowledge with the budding Engineers so that they are aware of such protective measures to be taken for the situations they are put into which I am sure, you must have found it to be of significant importance. One save of production stoppage with use of knowledge contained in this book would serve the very purpose of bringing it out.
Описание: Discover new places with fully updated road atlases from Collins. Full colour map of Ireland at 9 miles to 1 inch (1:570,240), with clear, detailed road network and counties and new administrative areas shown in colour. This double-sided map covers the whole of Ireland, and is ideal for reference or route planning.
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