Overcoming Resistance To Egfr Inhibitors In Egfr Mutant Nsclc,17, Faber, Anthony
Автор: Satya Prakash Gupta Название: Matrix Metalloproteinase Inhibitors ISBN: 3034807643 ISBN-13(EAN): 9783034807647 Издательство: Springer Рейтинг: Цена: 26120.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: MMPs are involved in numerous biological processes, fostering tissue degradation resulting in pathologies from osteoarthritis to tumor metastasis. This book focuses on the latest quantitative research into the endogenous inhibitors that disrupt MMP activity.
Автор: T. Kato; W. Kr?mer; K.-H. Kuck; D.M. Norris; H. Sc Название: Sterol Biosynthesis Inhibitors and Anti-Feeding Compounds ISBN: 3642697925 ISBN-13(EAN): 9783642697920 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Living organisms are separated from the outside world by their membranes, which perform important roles for maintaining their lives. Sterols are indispensable com- ponents in eukaryotic organisms for stabilizing membranes composed of phospho- lipid bilayers. Most prokaryotic organisms, on the other hand, do not contain sterols in their membranes, although recent studies indicated that the bacterium Methylo- coccus capsulatus produces sterols 1) and many strains of Mycoplasma, bacteria without cell walls, require sterols as an essential growth factor 2). Some bacterial species synthesize hopanoids which are hypothesized to function like st rols in eu- karyotic organisms 3). Significance of ergosterol in fungi has been recognized from the fact that the yeast Saccharomyces cerevisiae requires ergosterol for growth, when cultured in a strictly anaerobic condition "'. l: .lectron microscopic studies showed that membrane structures disappeared in the yeast grown anaerobically without a supplement of ergosterol 5.6), indicating the necessity of ergosterol for membrane biogenesis. Further confirmation of the significant role of ergosterol in the membranes was derived from the studies on polyene antibiotics. In the presence of polyenes such as nystatin, filipin and amphotericin B, fungal cells lose selective permeability of the membranes, since polyenes interact with ergosterol, such that the structure of the fungal membranes is disrupted 7).
Название: Viral proteases and their inhibitors ISBN: 0128097124 ISBN-13(EAN): 9780128097120 Издательство: Elsevier Science Рейтинг: Цена: 15831.00 р. Наличие на складе: Поставка под заказ.
Описание: Viral Proteases and Their Inhibitors provides a thorough examination of viral proteases from their molecular components, to therapeutic applications. As information on three dimensional structures and biological functions of these viral proteases become known, unexpected protein folds and unique mechanisms of proteolysis are realized. This book investigates how this facilitates the design and development of potent antiviral agents used against life-threatening viruses. Users will find descriptions of each virus that detail the structure and function of viral proteases, discuss the design and development of inhibitors, and analyze the structure-activity relationships of inhibitors. This book is ideal biochemists, virologists and those working on antiviral agents.
Автор: Bradley J. Till; Joanna Jankowicz-Cieslak; Owen A. Название: Low-Cost Methods for Molecular Characterization of Mutant Plants ISBN: 3319162586 ISBN-13(EAN): 9783319162584 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: With the appropriate validation of sample quality and longevity, they can provide sufficient DNA for a variety of molecular applications, such as marker studies and TILLING, at approximately one tenth of the cost per sample when compared to commercial kits.
Описание: Novel Sensitizing Agents for Therapeutic Anti-EGFR Antibodies presents a description of the sensitizers used to overcome resistance to anti-EGFR targeted antibody therapies in cancer, including novel engineered antibody drugs and other sensitizers. The book gives insights into the landscape of anti-EGFR based cancer treatments, the challenges of targeted therapy, and a glimpse into the future of antibody therapy. It offers pertinent science information on strategies used for the rational design and discovery of novel sensitizing agents, and in addition, translational studies involving pre-clinical and clinical design. This book is an indispensable resource for cancer researchers, medicinal chemists and other biomedical scientists. Finally, the book covers basic science strategies used in drug discovery and preclinical evaluation focused on EGFR blockage resistance, as well as clinical trial methodology, including clinical pharmacokinetics and imaging to address issues of efficacy evaluation of the new anticancer sensitizers for anti-EGFR drug resistance.
Описание: This book provides an outline of epigenetics as a whole, while also specifically examining a range of epigenetic players, including histone acetyl transferases (HATs) and histone deacetylases (HDACs). It chiefly focuses on the emerging targets of HDACs and their implications for various neurological disorders, while also discussing the drawbacks of current therapeutic strategies, the classification of HDAC inhibitors, and their promising effects in connection with specific neurological disorders. The book explores the potential use of these inhibitors as novel therapeutic agents, considers the current challenges involved in using them to tackle neurological complications, and offers a novel solution by designing isoform-selective inhibitors and employing combinatorial therapeutic strategies. Its final section, which explores future directions, elaborates on the possibility of enhancing HDAC inhibitors’ therapeutic efficacy against various neurological complications.
Автор: D. Vazquez Название: Inhibitors of Protein Biosynthesis ISBN: 3642813119 ISBN-13(EAN): 9783642813115 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Viral Replication Enzymes and their Inhibitors, Part B, Volume 50 in The Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics surrounding enzymes.
Автор: Pitman Michael Название: A Mutant Ape? The Origin of Man`s Descent ISBN: 1999966457 ISBN-13(EAN): 9781999966454 Издательство: Неизвестно Рейтинг: Цена: 6035.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This volume is the umbilical offshoot of its 'mother book', Science and the Soul. Both are truly original works. We begin by linking with the latter. Then, using facts from palaeoanthropology, biology (classical and molecular), information theory, design theory and philosophy, A Mutant Ape? assesses the two main interpretations of your human origin.
The simple difference between these interpretations is identified. So also are the differences between man and ape. Thence the book follows the course of palaeoanthropological history until the second world war and deals with each main character in the order of its scientific discovery. After the war things become, with more workers in the field, more complex. Finds worldwide are covered and various theories seeking to locate human emergence are described and criticised. These include an account of the recent impact of genetics before, at last, we both turn to Australia and return to Europe for the summing up.
Read thoroughly and by the end what will you think? The books Adam and Evolution and A Potted Grammar of Natural Dialectic may further help to clarify the issue.
Описание: Viral Replication Enzymes and their Inhibitors Part A, Volume 49, the latest release in the Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of related topics
Автор: H.-W. Denker Название: Implantation ISBN: 3540084797 ISBN-13(EAN): 9783540084792 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: On one hand, we have fairly well substantiated experimental and clinical evidence that the efficacy of these contraceptives lies with other factors as well, for example their influence on sperm migration and capacitation or their influence on the transportation of the unfertilized egg.
Автор: Paul R. Sanberg; Hitoo Nishino; Cesario V. Borlong Название: Mitochondrial Inhibitors and Neurodegenerative Disorders ISBN: 1468498215 ISBN-13(EAN): 9781468498219 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Believed to be the remnants of bacterial infection of eukaryotic cells eons ago, the mitochondrion evolved a symbiotic relationship in which it dutifully served as the efficient source of A TP for cell function.
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