Viral Replication Enzymes and Their Inhibitors Part A, 49, 

Название: Viral proteases and their inhibitors
ISBN: 0128097124 ISBN-13(EAN): 9780128097120
Издательство: Elsevier Science
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Описание: Viral Proteases and Their Inhibitors provides a thorough examination of viral proteases from their molecular components, to therapeutic applications. As information on three dimensional structures and biological functions of these viral proteases become known, unexpected protein folds and unique mechanisms of proteolysis are realized. This book investigates how this facilitates the design and development of potent antiviral agents used against life-threatening viruses. Users will find descriptions of each virus that detail the structure and function of viral proteases, discuss the design and development of inhibitors, and analyze the structure-activity relationships of inhibitors. This book is ideal biochemists, virologists and those working on antiviral agents.

Автор: R. Bercoff
Название: The Molecular Basis of Viral Replication
ISBN: 1468453521 ISBN-13(EAN): 9781468453522
Издательство: Springer
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Описание: the discovery of the "splicing" of the gene transcripts, the list would include the whole molecular genetics of the lambda bacteriophage, the notions of "promotor," "repressor," and "integration," the discovery of the reverse flow of genetic information, the very existence of oncogenes, the S`-terminal "cap" struc- ture of eukaryotic mRNAs, ...

Автор: Craig E. Cameron; Matthias Gotte; Kevin Raney
Название: Viral Genome Replication
ISBN: 1489984682 ISBN-13(EAN): 9781489984685
Издательство: Springer
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Цена: 32651.00 р.
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Описание: This book provides the first comprehensive review of viral genome replication strategies, emphasizing not only pathways and regulation but also the structure-function, mechanism, and inhibition of proteins and enzymes required for this process.

Автор: Supuran Claudiu T., Capasso Clemente
Название: Zinc Enzyme Inhibitors: Enzymes from Microorganisms
ISBN: 3319834444 ISBN-13(EAN): 9783319834443
Издательство: Springer
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Описание: An Elusive Task: A Clinically Useful Inhibitor of Metallo-β-Lactamases.- Inhibitors of Histidinol Dehydrogenase.- Botulinum Neurotoxin, Tetanus Toxin, and Anthrax Lethal Factor Countermeasures.- Inhibition and Activity Regulation of Bacterial Collagenases.- Fungal Carbonic Anhydrases and Their Inhibition.- Protozoan Carbonic Anhydrases.- Bacterial Carbonic Anhydrases.

Автор: Laura Kaguni
Название: DNA Replication Across Taxa,39
ISBN: 0128047356 ISBN-13(EAN): 9780128047354
Издательство: Elsevier Science
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Описание:

DNA Replication Across Taxa, the latest volume in The Enzymes series summarizes the most important discoveries associated with DNA replication.

Автор: Alan Kolber
Название: Mechanism and Regulation of DNA Replication
ISBN: 1468421263 ISBN-13(EAN): 9781468421262
Издательство: Springer
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Автор: Hisao Masai; Marco Foiani
Название: DNA Replication
ISBN: 981134972X ISBN-13(EAN): 9789811349720
Издательство: Springer
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Описание: This book reviews the latest trends and future directions of DNA replication research. The contents reflect upon the principles that have been established through the genetic and enzymatic studies of bacterial, viral, and cellular replication during the past decades. The book begins with a historical overview of the studies on eukaryotic DNA replication by Professor Thomas Kelly, a pioneer of the field. The following chapters include genome-wide studies of replication origins and initiation factor binding, as well as the timing of DNA replications, mechanisms of initiation, DNA chain elongation and termination of DNA replication, the structural basis of functions of protein complexes responsible for execution of DNA replication, cell cycle-dependent regulation of DNA replication, the nature of replication stress and cells’ strategy to deal with the stress, and finally how all these phenomena are interconnected to genome instability and development of various diseases. By reviewing the existing concepts ranging from the old principles to the newest ideas, the book gives readers an opportunity to learn how the classical replication principles are now being modified and new concepts are being generated to explain how genome DNA replication is achieved with such high adaptability and plasticity. With the development of new methods including cryoelectron microscopy analyses of huge protein complexes, single molecular analyses of initiation and elongation of DNA replication, and total reconstitution of eukaryotic DNA replication with purified factors, the field is enjoying one of its most exciting moments, and this highly timely book conveys that excitement to all interested readers.

Название: Initiation of dna replication in eukaryotes
ISBN: 3319246941 ISBN-13(EAN): 9783319246949
Издательство: Springer
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Описание: ГЇВїВЅ Every time a cell divides, a copy of its genomic DNA has to be faithfully copied to generate new genomic DNA for the daughter cells. The Initiation of DNA Replication in Eukaryotes will focus on how DNA replication is initiated in eukaryotic cells.

Автор: Ulrich Huebscher
Название: Proteins Involved in DNA Replication
ISBN: 1468487329 ISBN-13(EAN): 9781468487329
Издательство: Springer
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Автор: A. De Recondo
Название: New Approaches in Eukaryotic DNA Replication
ISBN: 1468443992 ISBN-13(EAN): 9781468443998
Издательство: Springer
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Описание: DNA replication in eukaryotes is an important field, particular- ly because of its direct impact on the study of cancer.