Design of Caspase Inhibitors as Potential Clinical Agents,
Автор: Sir John R. Vane; Jack H. Botting; R.M. Botting Название: Improved Non-Steroid Anti-Inflammatory Drugs: COX-2 Enzyme Inhibitors ISBN: 9401090319 ISBN-13(EAN): 9789401090315 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Thus the anti-inflammatory actions of non-steroid anti-inflammatory drugs (NSAIDs) may be due to the inhibition of COX-2, whereas the unwanted side-effects such as irritation of the stomach lining and toxic effects on the kidney are due to inhibition of the constitutive enzyme, COX-I.
Автор: Goran Claeson; Michael F. Scully; Vijay V. Kakkar; Название: The Design of Synthetic Inhibitors of Thrombin ISBN: 1489924205 ISBN-13(EAN): 9781489924209 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The symposium was organized in four sessions: (1) Structural features of the interaction of thrombin with substrates and inhibitors, (2) Synthetic inhibitors, (3) Hirudin and its analogues, and (4) Pharmacological and clinical considerations.
Автор: Goran Claeson; Michael F. Scully; Vijay V. Kakkar; Название: The Design of Synthetic Inhibitors of Thrombin ISBN: 030644593X ISBN-13(EAN): 9780306445934 Издательство: Springer Рейтинг: Цена: 32004.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The symposium was organized in four sessions: (1) Structural features of the interaction of thrombin with substrates and inhibitors, (2) Synthetic inhibitors, (3) Hirudin and its analogues, and (4) Pharmacological and clinical considerations.
Автор: Ward Richard A., Grimster Neil Название: The Design of Covalent-Based Inhibitors ISBN: 0128216891 ISBN-13(EAN): 9780128216897 Издательство: Elsevier Science Рейтинг: Цена: 23244.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Annual Report on Medicinal Chemistry series, highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.
Автор: G. Strube Название: ACE Inhibitors in Hypertension ISBN: 9401057370 ISBN-13(EAN): 9789401057370 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The treatment of hypertension has progressed in stages following the development of a succession of increasingly effective drugs, each allowing a greater proportion of patients to be treated with fewer and fewer side-effects.
Автор: Gerry A. Higgs; Brian Henderson Название: Novel Cytokine Inhibitors ISBN: 3034895720 ISBN-13(EAN): 9783034895729 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: It addresses different therapeutic intervention possibilities for new drugs, such as the cellular source of cytokines, specific receptors which induce cytokine synthesis, intracellular regulators of cytokine gene induction and expression, secretion and activation of cytokines, cytokine receptors and signalling pathways from these receptors.
Автор: Timothy D. Warner Название: Endothelin and Its Inhibitors ISBN: 3642632378 ISBN-13(EAN): 9783642632372 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: With contributions by numerous experts
Автор: Giancarlo Folco; Bengt Samuelsson; Robert C. Murph Название: Novel Inhibitors of Leukotrienes ISBN: 3034897367 ISBN-13(EAN): 9783034897365 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Many new antileukotriene drugs are now marketed as antiasthma drugs and represent the first new drugs in this field since the 1970s.
Автор: Patel, Harun Название: Third Generation EGFR Inhibitors ISBN: 0081026617 ISBN-13(EAN): 9780081026618 Издательство: Elsevier Science Рейтинг: Цена: 26107.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Third Generation EGFR Inhibitors: Overcoming EGFR Resistance and Toxicity Problems reviews current issues relating to the design of reversible and irreversible third generation EGFR inhibitors, highlighting the types of mutation responsible for resistance, and providing different chemical starting points for researchers to optimize and develop in designing the next generation of drugs. Beginning with an introduction to EGFR inhibitors and a review of inhibitors currently approved or in clinical trials, the book goes on to discuss current approaches in the development of both covalent irreversible and covalent reversible EGFR Inhibitors. In addition, mechanisms of resistance to third generation inhibitors, and discovery of fourth generation allosteric C797S inhibitors are explored before a discussion of potential future trends.
This comprehensive coverage of the design and development of improved analogues to overcome the problems of resistance and toxicity associated with third generation EGFR inhibitors makes Third Generation EGFR Inhibitors a crucial resource for medicinal chemists, drug developers, and researchers investigating cancer therapeutics.
Includes full synthetic schemes of all approved and in-trial third generation inhibitors
Highlights the emergence of fourth generation EGFR inhibitors and the possibilities of them overcoming constraints of third generation compounds
Provides a structural correlation of third and fourth generation EGFR inhibitors, reviewing both their design strategies and typical anticancer activity
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