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Statistical design, monitoring, and analysis of clinical trials, Shih, Weichung Joe (rutgers University School Of Public Health, Piscataway, New Jersey, Usa) Aisner, Joseph (rutgers University Robert Wood Johnson Me


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Автор: Shih, Weichung Joe (rutgers University School Of Public Health, Piscataway, New Jersey, Usa) Aisner, Joseph (rutgers University Robert Wood Johnson Me
Название:  Statistical design, monitoring, and analysis of clinical trials
ISBN: 9780367772444
Издательство: Taylor&Francis
Классификация:



ISBN-10: 0367772442
Обложка/Формат: Hardcover
Страницы: 380
Вес: 0.91 кг.
Дата издания: 26.10.2021
Серия: Chapman & hall/crc biostatistics series
Язык: English
Издание: 2 ed
Иллюстрации: 13 tables, black and white; 25 line drawings, black and white; 25 illustrations, black and white
Размер: 23.39 x 15.60 x 2.39 cm
Читательская аудитория: Tertiary education (us: college)
Подзаголовок: Principles and methods
Рейтинг:
Поставляется из: Европейский союз
Описание: This book concentrates on the biostatistics component of clinical trials. This new, second edition is updated throughout and includes three new chapters. This text reflects the academic research, commercial development, and public health aspects of clinical trials.


      Старое издание

Statistical Analysis with Missing Data, Third Edit ion

Автор: Little
Название: Statistical Analysis with Missing Data, Third Edit ion
ISBN: 0470526793 ISBN-13(EAN): 9780470526798
Издательство: Wiley
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Цена: 12664.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Reflecting new application topics, Statistical Analysis with Missing Data offers a thoroughly up-to-date, reorganized survey of current methodology for handling missing data problems. The third edition reviews historical approaches to the subject and describe rigorous yet simple methods for multivariate analysis with missing values.

Statistical Monitoring of Clinical Trials

Автор: Michael A. Proschan; K. K. Gordon Lan; Janet Turk
Название: Statistical Monitoring of Clinical Trials
ISBN: 1441921346 ISBN-13(EAN): 9781441921345
Издательство: Springer
Рейтинг:
Цена: 19564.00 р.
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Описание: All three of this work`s authors are experts in adaptive methodology for clinical trials. Here, they offer an accessible, incremental approach to understanding Brownian motion as related to clinical trials that will develop insight into not only monitoring, but many other statistical issues germane to clinical trials.

Design and Analysis of Clinical Trials for Predictive Medicine

Автор: Matsui Shigeyuki
Название: Design and Analysis of Clinical Trials for Predictive Medicine
ISBN: 1466558156 ISBN-13(EAN): 9781466558151
Издательство: Taylor&Francis
Рейтинг:
Цена: 17609.00 р.
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Описание:

Design and Analysis of Clinical Trials for Predictive Medicine provides statistical guidance on conducting clinical trials for predictive medicine. It covers statistical topics relevant to the main clinical research phases for developing molecular diagnostics and therapeutics--from identifying molecular biomarkers using DNA microarrays to confirming their clinical utility in randomized clinical trials.

The foundation of modern clinical trials was laid many years before modern developments in biotechnology and genomics. Drug development in many diseases is now shifting to molecularly targeted treatment. Confronted with such a major break in the evolution toward personalized or predictive medicine, the methodologies for design and analysis of clinical trials is now evolving.

This book is one of the first attempts to contribute to this evolution by laying a foundation for the use of appropriate statistical designs and methods in future clinical trials for predictive medicine. It is a useful resource for clinical biostatisticians, researchers focusing on predictive medicine, clinical investigators, translational scientists, and graduate biostatistics students.

Design and Analysis of Clinical Trials with Time-to-Event Endpoints

Название: Design and Analysis of Clinical Trials with Time-to-Event Endpoints
ISBN: 1138372668 ISBN-13(EAN): 9781138372665
Издательство: Taylor&Francis
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Цена: 9492.00 р.
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Описание:

Using time-to-event analysis methodology requires careful definition of the event, censored observation, provision of adequate follow-up, number of events, and independence or noninformativeness of the censoring mechanisms relative to the event. Design and Analysis of Clinical Trials with Time-to-Event Endpoints provides a thorough presentation of the design, monitoring, analysis, and interpretation of clinical trials in which time-to-event is of critical interest.

After reviewing time-to-event endpoint methodology, clinical trial issues, and the design and monitoring of clinical trials, the book focuses on inferential analysis methods, including parametric, semiparametric, categorical, and Bayesian methods; an alternative to the Cox model for small samples; and estimation and testing for change in hazard. It then presents descriptive and graphical methods useful in the analysis of time-to-event endpoints. The next several chapters explore a variety of clinical trials, from analgesic, antibiotic, and antiviral trials to cardiovascular and cancer prevention, prostate cancer, astrocytoma brain tumor, and chronic myelogonous leukemia trials. The book then covers areas of drug development, medical practice, and safety assessment. It concludes with the design and analysis of clinical trials of animals required by the FDA for new drug applications.

Drawing on the expert contributors' experiences working in biomedical research and clinical drug development, this comprehensive resource covers an array of time-to-event methods and explores an assortment of real-world applications.

Cancer Clinical Trials: Current and Controversial Issues in Design and Analysis

Автор: Stephen L. George, Xiaofei Wang, Herbert Pang
Название: Cancer Clinical Trials: Current and Controversial Issues in Design and Analysis
ISBN: 0367261170 ISBN-13(EAN): 9780367261177
Издательство: Taylor&Francis
Рейтинг:
Цена: 7501.00 р.
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Описание: This book provides statisticians with an understanding of the critical challenges currently encountered in oncology trials. The book covers state-of-the-art approaches to the design and analysis of cancer clinical trials, such as adaptive designs, biomarker-based trials, and dynamic treatment regimes.

Design and Analysis of Quality of Life Studies in Clinical Trials, Second Edition

Автор: Fairclough
Название: Design and Analysis of Quality of Life Studies in Clinical Trials, Second Edition
ISBN: 1420061178 ISBN-13(EAN): 9781420061178
Издательство: Taylor&Francis
Рейтинг:
Цена: 22202.00 р.
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Описание: Presents a range of solutions to analytic issues. This title reflects developments in methodology with coverage of mixture models and a dataset example. It implements examples using SAS and R code and incorporates a number of examples from real QoL clinical trials to illustrate design and analysis methods.

Design and Analysis of Clinical Trials with Time-to-Event Endpoints

Название: Design and Analysis of Clinical Trials with Time-to-Event Endpoints
ISBN: 1420066390 ISBN-13(EAN): 9781420066395
Издательство: Taylor&Francis
Рейтинг:
Цена: 22202.00 р.
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Описание: Provides a presentation of the design, monitoring, analysis, and interpretation of clinical trials in which time-to-event is of critical interest. This book discusses the design and monitoring of Phase II and III clinical trials with time-to-event endpoints.

Dynamic Prediction in Clinical Survival Analysis

Автор: Van Houwelingen
Название: Dynamic Prediction in Clinical Survival Analysis
ISBN: 1439835330 ISBN-13(EAN): 9781439835333
Издательство: Taylor&Francis
Рейтинг:
Цена: 24499.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание:

There is a huge amount of literature on statistical models for the prediction of survival after diagnosis of a wide range of diseases like cancer, cardiovascular disease, and chronic kidney disease. Current practice is to use prediction models based on the Cox proportional hazards model and to present those as static models for remaining lifetime after diagnosis or treatment. In contrast, Dynamic Prediction in Clinical Survival Analysis focuses on dynamic models for the remaining lifetime at later points in time, for instance using landmark models.

Designed to be useful to applied statisticians and clinical epidemiologists, each chapter in the book has a practical focus on the issues of working with real life data. Chapters conclude with additional material either on the interpretation of the models, alternative models, or theoretical background. The book consists of four parts:

  • Part I deals with prognostic models for survival data using (clinical) information available at baseline, based on the Cox model
  • Part II is about prognostic models for survival data using (clinical) information available at baseline, when the proportional hazards assumption of the Cox model is violated
  • Part III is dedicated to the use of time-dependent information in dynamic prediction
  • Part IV explores dynamic prediction models for survival data using genomic data

Dynamic Prediction in Clinical Survival Analysis summarizes cutting-edge research on the dynamic use of predictive models with traditional and new approaches. Aimed at applied statisticians who actively analyze clinical data in collaboration with clinicians, the analyses of the different data sets throughout the book demonstrate how predictive models can be obtained from proper data sets.

Statistical Methods for Survival Data Analysis, 4th Edition

Автор: Lee
Название: Statistical Methods for Survival Data Analysis, 4th Edition
ISBN: 1118095022 ISBN-13(EAN): 9781118095027
Издательство: Wiley
Рейтинг:
Цена: 18050.00 р.
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Описание: Upgraded to reflect the latest research and software applications on the topic, this new edition continues to provide a comprehensive introduction to the statistical methods for analyzing survival data.

Clinical Data Analysis on a Pocket Calculator: Understanding the Scientific Methods of Statistical Reasoning and Hypothesis Testing

Автор: Cleophas Ton J., Zwinderman Aeilko H.
Название: Clinical Data Analysis on a Pocket Calculator: Understanding the Scientific Methods of Statistical Reasoning and Hypothesis Testing
ISBN: 3319800744 ISBN-13(EAN): 9783319800745
Издательство: Springer
Рейтинг:
Цена: 11878.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: In medical and health care the scientific method is little used, and statistical software programs are experienced as black box programs producing lots of p-values, but little answers to scientific questions. The pocket calculator analyses appears to be, particularly, appreciated, because they enable medical and health professionals and students for the first time to understand the scientific methods of statistical reasoning and hypothesis testing. So much so, that it can start something like a new dimension in their professional world. In addition, a number of statistical methods like power calculations and required sample size calculations can be performed more easily on a pocket calculator, than using a software program. Also, there are some specific advantages of the pocket calculator method. You better understand what you are doing. The pocket calculator works faster, because far less steps have to be taken, averages can be used. The current nonmathematical book is complementary to the nonmathematical "SPSS for Starters and 2nd Levelers" (Springer Heidelberg Germany 2015, from the same authors), and can very well be used as its daily companion.


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