Описание: Oligonucleotides represent one of the most significant pharmaceutical breakthroughs in recent years, showing great promise as diagnostic and therapeutic agents for malignant tumors, cardiovascular disease, diabetes, viral infections, and many other degenerative disorders. The Handbook of Analysis of Oligonucleotides and Related Products is an essential reference manual on the practical application of modern and emerging analytical techniques for the analysis of this unique class of compounds. A strong collaboration among thirty leading analytical scientists from around the world, the book provides readers with a comprehensive overview of the most commonly used analytical techniques and their advantages and limitations in assuring the identity, purity, quality, and strength of an oligonucleotide intended for therapeutic use. Topics discussed include: Strategies for enzymatic or chemical degradation of chemically modified oligonucleotides toward mass spectrometric sequencing Purity analysis by chromatographic or electrophoretic methods, including RP-HPLC, AX-HPLC, HILIC, SEC, and CGE Characterization of sequence-related impurities in oligonucleotides by mass spectrometry and chromatography Structure elucidation by spectroscopic methods (IR, NMR, MS) as well as base composition and thermal melt analysis (Tm) Approaches for the accurate determination of molar extinction coefficient of oligonucleotides Accurate determination of assay values Assessment of the overall quality of oligonucleotides, including microbial analysis and determination of residual solvents and heavy metals Strategies for determining the chemical stability of oligonucleotides The use of hybridization techniques for supporting pharmacokinetics and drug metabolism studies in preclinical and clinical development Guidance for the presentation of relevant analytical information towards meeting current regulatory expectations for oligonucleotide therapeutics This resource provides a practical guide for applying state-of-the-art analytical techniques in research, development, and manufacturing settings.
Автор: Morris MB Название: Molecular Biotechnology with 107 colour diagrams ISBN: 8123929153 ISBN-13(EAN): 9788123929156 Издательство: CBS India Рейтинг: Цена: 14630.00 р. 20900.00-30% Наличие на складе: Есть (1 шт.) Описание: The book is a complete treatise on molecular biotechnology covering all important aspects with accuracy and up-to-date account. The book emphasizes on recombinant DNA technology, molecular research procedures, regulation of gene expression in proaryotes, and production of heterologous proteins in eukaryotic cells.
Molecular Dynamics Simulation of Nanocomposites using BIOVIA Materials Studio, Lammps and Gromacs presents the three major software packages used for molecular dyanmics simulation of nanocomposites. Materials Studio, Lammps and Gromacs are all used for performing nanocomposites simulations and analysis. The purpose of this book is to provide the readers with an in-depth view of molecular dynamics modeling of nanocomposites using Materials Studio, Lammps and Gromacs. The book explains in detail how to use each of these packages most effectively, using real-world examples to show when each should be used. The latter two of these are open-source codes, which can be used for modelling at no cost.
As well as offering an introduction to molecular dynamics simulation, and explaining how it is applied to nanocomposites, the book includes several case studies, to show how each of the software packages are used to predict various properties of nanocomposites, including metal-matrix, polymer-matrix and ceramic-matrix based nanocomposites. The properties explored include mechanical, thermal, optical and electrical properties. The concept of perl scripting is discussed in detail. The questions this book answers for readers include:
Which module to use?
How do I perform optimization?
Which ensemble to use?
How do I calculate mechanical, thermal, optical and electrical properties?
How do I perform scripting in Materials Studio, Lammps and Gromacs?
This is the first book that explores methodologies for using Materials Studio, Lammps and Gromacs in the same place. It will be beneficial for students, researchers and scientists working in the field of molecular dynamics simulation.
Detailed explanation of basic commands and modules of Materials Studio, Lammps and Gromacs
Shows how Materials Studio, Lammps and Gromacs predict mechanical, thermal, electrical and optical properties of nanocomposites
Uses case studies to show which software should be used to solve a variety of nanoscale modelling problems
Автор: Malik, Muhammad Imran Название: Molecular Characterization Of Polymers ISBN: 0128197684 ISBN-13(EAN): 9780128197684 Издательство: Elsevier Science Рейтинг: Цена: 32844.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Molecular Characterization of Polymers presents a range of advanced and cutting-edge methods for the characterization of polymers at the molecular level, guiding the reader through theory, fundamentals, instrumentation, and applications, and supporting the end goal of efficient material selection and improved material performance.
Each chapter focuses on a specific technique or family of techniques, including the different areas of chromatography, field flow fractionation, long chain branching, static and dynamic light scattering, mass spectrometry, NMR, X-Ray and neutron scattering, polymer dilute solution viscometry, microscopy, and vibrational spectroscopy. In each case, in-depth coverage explains how to successfully implement and utilize the technique.
This practical resource is highly valuable to researchers and advanced students in polymer science, materials science, and engineering, and to those from other disciplines and industries who are unfamiliar with polymer characterization techniques.
Автор: Bo Mattiasson; Lei Ye Название: Molecularly Imprinted Polymers in Biotechnology ISBN: 3319371487 ISBN-13(EAN): 9783319371481 Издательство: Springer Рейтинг: Цена: 28732.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Controlled radical polymerization techniques for molecular imprinting.- From bulk polymers to nanoparticles.- Post-imprinting and in-cavity functionalization.- Characterization of MIPs (affinity, selectivity, site heterogeneity...).- Theoretical aspects and computer modelling.- MIPs in aqueous environments, by Bin Lu.- MIPs for binding macromolecules.- Solid phase extraction.- Sensors.- MIPs for catalysis and synthesis.- Wastewater treatment.- MIPs as tools for bioassays, biotransformation and drug delivery.
Описание: Chapter 1. Introduction.- Chapter 2. Synthetic Strategies for the Generation of Molecularly Imprinted Polymers.- Chapter 3. Special Control by Molecular Imprinting Materials-zero-order Sustained Release, Enantioselective MIPs and Self-regulated Drug Delivery Microdevices.- Chapter 4. Water Compatible Molecularly Imprinted Polymers.- Chapter 5. Stimuli Responsive Imprinted DDS.- Chapter 6. MIP as Drug Delivery Systems for Dermal Delivery.- Chapter 7. MIP as Drug Delivery Systems of Anticancer Agents.- Chapter 8. MIP as Dug Delivery Systems of Ophthalmic Drugs.- Chapter 9. MIP as Drug Delivery Systems for Special Application.- Chapter 10. Outlook.
Описание: Written in the perspective of an experimental chemist, this book puts together some fundamentals from chemistry, solid state physics and quantum chemistry, to help with understanding and predicting the electronic and optical properties of organic semiconductors, both polymers and small molecules. The text is intended to assist graduate students and researchers in the field of organic electronics to use theory to design more efficient materials for organic electronic devices such as organic solar cells, light emitting diodes and field effect transistors. After addressing some basic topics in solid state physics, a comprehensive introduction to molecular orbitals and band theory leads to a description of computational methods based on Hartree-Fock and density functional theory (DFT), for predicting geometry conformations, frontier levels and energy band structures. Topological defects and transport and optical properties are then addressed, and one of the most commonly used transparent conducting polymers, PEDOT:PSS, is described in some detail as a case study.
Описание: Reflecting the interdisciplinary nature of Quantum Efficiency in Complex Systems, this title is of interest to physicists, chemists, materials scientists, and device engineers in academia, scientific laboratories and modern industry.
Автор: Lundblad, Roger L. Название: Biochemistry and Molecular Biology Compendium ISBN: 0367389002 ISBN-13(EAN): 9780367389000 Издательство: Taylor&Francis Рейтинг: Цена: 8726.00 р. Наличие на складе: Поставка под заказ.
Описание: Collected here for the first time are Elaine J. Lawless`s key articles on the topics of reciprocal ethnography and women`s narrative which influenced not only folklore, but also the allied fields of anthropology, sociology, performance studies, and women`s and gender studies. Lawless`s methods and research continue to be critically relevant in today`s global struggle for gender equality.
Автор: Habasaki, Junko Название: Molecular Dynamics of Nanostructures and Nanoionics ISBN: 9814800775 ISBN-13(EAN): 9789814800778 Издательство: Taylor&Francis Рейтинг: Цена: 21284.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book discusses complex nanostructured systems exemplified by nanoporous silicates, spontaneously formed gels from silica-nanocolloidal solutions, and related systems and examines them using molecular dynamics simulations.
Автор: Varshney Название: Plant Genetics and Molecular Biology ISBN: 3319913123 ISBN-13(EAN): 9783319913124 Издательство: Springer Рейтинг: Цена: 48913.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book reviews the latest advances in multiple fields of plant biotechnology and the opportunities that plant genetics, genomics and molecular biology have offered for agriculture improvement. Advanced technologies can dramatically enhance our capacity in understanding the molecular basis of traits and utilizing the available resources for accelerated development of high yielding, nutritious, input-use efficient and climate-smart crop varieties. In this book, readers will discover the significant advances in plant genetics, structural and functional genomics, trait and gene discovery, transcriptomics, proteomics, metabolomics, epigenomics, nanotechnology and analytical & decision support tools in breeding. This book appeals to researchers, academics and other stakeholders of global agriculture.
Описание: From probe design to applications in clinical settings, this book provides a diverse set of instructive examples, guided by experts in the field who offer easy-to-follow experimentals.
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