Computer Simulations of Aggregation of Proteins and Peptides, Li Mai Suan, Kloczkowski Andrzej, Cieplak Marek
Автор: Randall J. Mrsny, Ann Daugherty Название: Proteins and Peptides: Pharmacokinetic, Pharmacodynamic, and Metabolic Outcomes ISBN: 1420078062 ISBN-13(EAN): 9781420078060 Издательство: Taylor&Francis Рейтинг: Цена: 19293.00 р. 27562.00-30% Наличие на складе: Есть (1 шт.) Описание: Addressing the increased use of protein and peptide candidates as treatments for previously untreatable diseases, this comprehensive and progressive source provides the reader with a roadmap to an increased understanding of issues critical for successfully developing a protein or peptide therapeutic candidate. Proteins and Peptides is an invaluable source for drug discovery and development scientists in the biopharmaceutical industry who frequently navigate the maze of protein and peptide pharmacokinetics, pharmacodynamics, and metabolism.
Key features include:
issues related to delivery of protein and peptide therapeutics in elderly populations and pharmacogenomics
lessons learned on the major marketed areas of proteins and peptides, including interleukins, interferons, growth factors, and peptide hormones
innovations for protein and peptide delivery such as needle-less delivery
strategies for delivery of these molecules to locations such as the eye and brain
generic issues of proteins and peptides
Автор: Banisch, Sven Название: Markov chain aggregation for agent-based models ISBN: 3319248758 ISBN-13(EAN): 9783319248752 Издательство: Springer Рейтинг: Цена: 9781.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This self-contained text develops a Markov chain approach that makes the rigorous analysis of a class of microscopic models that specify the dynamics of complex systems at the individual level possible.
Описание: This volume fills the gap in protein review and protocal literature while summarizing recent achievements in the understanding of the relationships between protein misfoldings, aggregation, and development of protein deposition disorders. It is devoted to the general questions of conformational disorders and includes discussion of involvement of such common factors as molecular chaperones, oxidative damage, proteasome, glycosoaminoglycans, serum amyloid protein P and several others in the development of different disorders. Some experimental techniques applicable for the visualization of protein deposition in vivo and in vitro are also present.
This book reviews current research on the important processes involved in neurodegenerative diseases (e.g. Alzheimer's disease) and the peptides and proteins involved in the amyloidogenic processes. It covers the design and developments of anti-amyloid inhibitors, and gives readers a fundamental understanding of the underlying oligomerization and aggregation processes of these diseases from both computational and experimental points of view.
Описание: The interaction of globular proteins with silica nanoparticles is dominated by electrostatic interactions and can be controlled by pH and ionic strength, while the bridging of nanoparticles by adsorbed protein molecules leads to large-scale hybrid aggregates of protein with the nanoparticles.
Автор: Lawson Kay, Poguntke Thomas Название: How Political Parties Respond: Interest Aggregation Revisited ISBN: 0415664152 ISBN-13(EAN): 9780415664158 Издательство: Taylor&Francis Рейтинг: Цена: 7042.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book focuses specifically on the question of interest aggregation: do parties today perform that function? If so, how and if not, in what different ways do they seek to show themselves responsive to the electorate?
Автор: Catherine A. Macken; Alan S. Perelson Название: Branching Processes Applied to Cell Surface Aggregation Phenomena ISBN: 3540156569 ISBN-13(EAN): 9783540156567 Издательство: Springer Рейтинг: Цена: 11173.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Aggregation processes are studied within a number of different fields--c- loid chemistry, atmospheric physics, astrophysics, polymer science, and biology, to name only a few. Aggregation pro ces ses involve monomer units (e. g., biological cells, liquid or colloidal droplets, latex beads, molecules, or even stars) that join together to form polymers or aggregates. A quantitative theory of aggre- tion was first formulated in 1916 by Smoluchowski who proposed that the time e- lution of the aggregate size distribution is governed by the infinite system of differential equations: (1) K . . c. c. - c k = 1, 2, . . . k 1. J 1. J L i]j=k j=l where c is the concentration of k-mers, and aggregates are assumed to form by ir- k reversible condensation reactions i-mer ] j-mer -+ (i+j)-mer]. When the kernel K . . can be represented by A + B(i+j) + Cij, with A, B, and C constant; and the in- 1. J itial condition is chosen to correspond to a monodisperse solution (i. e., c (0) = 1 0, k > 1), then the Smoluchowski equation can be co' a constant; and ck(O) solved exactly (Trubnikov, 1971; Drake, 1972; Ernst, Hendriks, and Ziff, 1982; Dongen and Ernst, 1983; Spouge, 1983; Ziff, 1984). For arbitrary K, the solution ij is not known and in some ca ses may not even exist.
Автор: Bernadette Bouchon-Meunier Название: Aggregation and Fusion of Imperfect Information ISBN: 3662110733 ISBN-13(EAN): 9783662110737 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Haya Shajaiah; Ahmed Abdelhadi; Charles Clancy Название: Resource Allocation with Carrier Aggregation in Cellular Networks ISBN: 3319605399 ISBN-13(EAN): 9783319605395 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book introduces an efficient resource management approach for future spectrum sharing systems. The book focuses on providing an optimal resource allocation framework based on carrier aggregation to allocate multiple carriers` resources efficiently among mobile users.
Автор: William, Oliver D., Название: Reinsurance and the law of aggregation : ISBN: 0367502852 ISBN-13(EAN): 9780367502850 Издательство: Taylor&Francis Рейтинг: Цена: 27562.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Aggregation mechanisms are one of the core instruments for structuring reinsurance contracts. This book systematically examines each element of an aggregation mechanism, tracing the inconsistent usage of aggregation language in the markets and scrutinizing the tests developed by courts and arbitral tribunals.
Автор: Banisch Sven Название: Markov Chain Aggregation for Agent-Based Models ISBN: 3319796917 ISBN-13(EAN): 9783319796918 Издательство: Springer Рейтинг: Цена: 10480.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This self-contained text develops a Markov chain approach that makes the rigorous analysis of a class of microscopic models that specify the dynamics of complex systems at the individual level possible.
Автор: Youhong Tang; Ben Zhong Tang Название: Principles and Applications of Aggregation-Induced Emission ISBN: 3030075591 ISBN-13(EAN): 9783030075590 Издательство: Springer Рейтинг: Цена: 25155.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book explores the aggregation-induced emission (AIE) effect, which has opened new avenues for the development of advanced luminogenic materials in the aggregate or solid state. By enabling light emission in the practically useful solid state, AIE has the potential to significantly expand the technological applications of luminescent materials. This book addresses principles, methods, and applications of AIEs, offering a new platform for the investigation of light-emitting processes from luminogen aggregates. Applications of AIE include biomedical diagnostics, sensor materials, and optoelectronic devices, among others, and are described in detail within the book. The development of a new generation of AIEgens, a deep understanding of the AIE mechanism(s), and the exploration of advanced technological applications will enable this exciting field to develop further. Headed by the pioneering researcher who started the field, Professor Ben Zhong Tang, this book combines both principles and applications and brings together global researchers in the field to report the progress, current challenges, and potential breakthroughs that may be accomplished in the near future.Provides an authoritative account of the fundamentals, properties, and potential of AIE by the pioneer of this active, highly-researched field;Highlights technological applications of AIE spanning biomedicine, sensor materials, and optoelectronics, among others;Presents a comprehensive view on challenges in the further development of AIE and derived technologies.
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