Combination Drug Delivery Approach as an Effective Therapy for Various Diseases, Kesharwani Prashant
Автор: Neutel Название: Combination Therapy in Hypertension ISBN: 1908517255 ISBN-13(EAN): 9781908517258 Издательство: Springer Рейтинг: Цена: 6008.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book addresses combined therapies for managing and treating hypertension, discusses benefits of monotherapy and combination therapy, examines risk of adverse effects, compliance and cost of the available therapies. Reviews relevant outcome studies.
Автор: Maciej Banach Название: Combination Therapy In Dyslipidemia ISBN: 3319367218 ISBN-13(EAN): 9783319367217 Издательство: Springer Рейтинг: Цена: 12577.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Comprising contributions from leading lipidologists from around the world, this book presents the latest and most comprehensive knowledge on the different options for combination therapy of dyslipidemia and includes discussion of future therapies that are currently in late stages of clinical evaluation.
Assurance of Sterility for Sensitive Combination Products and Materials: New Paradigms for the Next Generation of Medical Devices and Pharmaceuticals discusses the medical device industry and existing challenges regarding the exciting new world of sensitive combination products (SCPs) and their terminal sterilization. This book reassesses the current assumptions to assure the patient's best interests are met in the development of increasingly rigorous sterilization methods used to counteract MRSA and other 'super-bugs'. In addition, the book discusses the special challenges faced with implantable medical devices, sterilization requirements and further methods needed for material selection and the design process.
This book is unique in taking a holistic, end-to-end approach to sterilization, with a particular focus on materials selection and product design.
Introduces sterilization principles at the material selection and design stages
Addresses the industry need for new sterilization processes for new medical devices and biomaterials
Provides guidance to select the appropriate sterilization technique for newly developed sensitive combination products
Examines forward thinking tactics for matching new developments in material compatibility with possible regulatory and QSR strategies
Описание: In this thesis, Bernhard Schmidt describes his research into two fields in the chemical sciences: supramolecular and macromolecular chemistry. Schmidt first investigates cyclodextrins (CDs), which are well known for the formation of supramolecular host/guest complexes with hydrophobic molecules in aqueous solution.
Описание: While the safety assessment ("biocompatibility") of medical devices has been focused on issues of local tissue tolerance (irritation, sensitization, cytotoxicity) and selected quantal effects (genotoxicity and acute lethality) since first being regulated in the late 1950s, this has changed as devices assumed a much more important role in healthcare and became more complex in both composition and in their design and operation. Add to this that devices now frequently serve as delivery systems for drugs, and that drugs may be combined with devices to improve device performance, and the problems of ensuring patient safety with devices has become significantly more complex. A part of this, requirements for ensuring safety (once based on use of previously acceptable materials - largely polymers and metals) have come to requiring determining which chemical entities are potentially released from a device into patients (and how much is released).
Then an appropriate and relevant (yet also conservative) risk assessment must be performed for each identified chemical structure. The challenges inherent in meeting the current requirements are multifold, and this text seeks to identify, understand, and solve all of them. * Identify and verify the most appropriate available data.
* As in most cases such data is for a different route of exposure, transform it for use in assessing exposure by the route of interest. * As the duration (and rate) of exposure to moieties released from a device are most frequently different (longer) than what available data speaks to, transformation across tissue is required. * As innate and adaptive immune responses are a central part of device/patient interaction, assessing potential risks on this basis are required.
* Incorporating assessments for special populations such as neonates. * Use of (Q)SAR (Quantitative Structure Activity Relationships) modeling in assessments. * Performance and presentation of integrative assessments covering all potential biologic risks.
Appendices will contain summarized available biocompatibility data for commonly used device materials (polymers and metals) and safety assessments on the frequently seen moieties in extractions from devices.
Автор: Wani, Mohmmad Younus Название: Combination Therapy Against Multidrug Resistance ISBN: 0128205768 ISBN-13(EAN): 9780128205761 Издательство: Elsevier Science Рейтинг: Цена: 19875.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Combination Therapy against Multidrug Resistance explores the potential of combination therapy as an efficient strategy to combat multi-drug resistance. Multidrug resistance (MDR) occurs when microorganisms such as bacteria, fungi, viruses, and parasites are excessively exposed to antimicrobial drugs such as antibiotics, antifungals, or antivirals, and in response the microorganism undergoes mutations or develops different resistance mechanisms to combat the drug for its survival. MDR is becoming an increasingly serious problem in both developed and developing nations. Bacterial resistance to antibiotics has developed faster than the production of new antibiotics, making bacterial infections increasingly difficult to treat, and the same is true for a variety of other diseases. Combination therapy proves to be a promising strategy as it offers potential benefits such as a broad spectrum of efficacy, greater potency than the drugs used in monotherapy, improved safety and tolerability, and reduction in the number of resistant organisms. This book considers how combination therapy can be applied in multiple situations, including cancer, HIV, tuberculosis, fungal infections, and more. Combination Therapy Against Multidrug Resistance gathers the most relevant information on the prospects of combination therapy as a strategy to combat multridrug resistance and helping to motivate the industrial sector and government agencies to invest more in research and development of this strategy as a weapon to tackle the multidrug resistance problem. It will be useful to academics and researchers involved in the development of new antimicrobial or antiinfective agents and treatment strtategies to combat multidrug resistance. Clinicians and medical nurses working in the field of infection prevention and control (IPC) will also find the book relevant
Автор: Maciej Banach Название: Combination Therapy In Dyslipidemia ISBN: 3319204327 ISBN-13(EAN): 9783319204321 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Comprising contributions from leading lipidologists from around the world, this book presents the latest and most comprehensive knowledge on the different options for combination therapy of dyslipidemia and includes discussion of future therapies that are currently in late stages of clinical evaluation. Dyslipidemia is a leading cause of cardiovascular morbidity and mortality and most patients with this condition fail to achieve adequate control of their serum lipid levels with monotherapy. However, recent US and European guideline recommendations, based on randomized, controlled trials, fail to discuss combination therapy options for patients with dyslipidemia.Statins remain the mainstay of drug therapy for hyperlipidemia and chapters in this book specifically examine the role of add-on therapy with different agents modulating the different lipid fractions in the blood, e.g. bile acid sequestrants, fibric acid derivatives (fibrates), omega-3 fatty acids (fish oils), inhibitors of Niemann-Pick C1 like 1 (NPC1L1) protein, cholesteryl ester transfer protein (CETP), apolipoprotein B-100 and microsomal triglyceride transfer protein (MTP) and the emerging proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors. There is additional discussion of the role of non-drug therapy options such as nutraceuticals, functional foods and lipoprotein apheresis. The book also discusses the combination of antihypertensive drugs with lipid-lowering drugs in the management of cardiovascular risk in patents with dyslipidemia.
Автор: Erik De Clercq; Anne-Mieke Vandamme Название: Combination Therapy of AIDS ISBN: 3034896042 ISBN-13(EAN): 9783034896047 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: An extensive assessment of combination therapy of AIDS. Main focus is put on the Highly Active Antiretroviral Therapy (HAART) but other therapies like salvage therapy are also discussed. The chapters cover efficacy, treatment, causes of treatment failure, clinical care, guidelines, pharmacology.
Описание: In this thesis, Bernhard Schmidt describes his research into two fields in the chemical sciences: supramolecular and macromolecular chemistry. Schmidt first investigates cyclodextrins (CDs), which are well known for the formation of supramolecular host/guest complexes with hydrophobic molecules in aqueous solution.
Описание: 1. Introduction - History and Where We are Headed 2. Regulatory Guidance3. Sample Preparation and Biocompatibility Testing4. Testing for Leachables and Extractables5. Where the Data is - And What is It?6. Bridging Issues of Route7. Risk Assessments for Medical Devices8. (Q)SAR 9. Histopathology in Medical Device Studies10. Assessment of Nanomaterial Devices11. Integrated Safety Assessments for Devices12. Toxicity of Common Extractables and Leachables
Автор: E. Garaci; Allan L. Goldstein Название: Combination Therapies ISBN: 1461364728 ISBN-13(EAN): 9781461364726 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: These molecules, termed biological response modifiers (BRMs) , have been sequenced, synthesized and produced in large enough quantities to test in animals and humans resulting in the development of new approaches to the treatment of human disease, in particular, cancers and infectious diseases.
Описание: This book describes the growing clinical and healthcare relevance of nano-therapeutics in treating respiratory diseases. It further discusses the current trends in understanding the disease pathology using different in vitro and in vivo models, which are important towards the onsite clinical applications and development of new therapeutics.
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