From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors, Volume 88, the latest release in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this updated edition include Targeting muscarinic M1 receptor in neurodegeneration, Photo‐switchable allosteric ligands, Computational approaches for the design of mGlu receptor allosteric modulators, Allosteric modulation of GLP‐1 receptor in metabolic disorders, Group II mGluR roles in the nervous system and their roles in addiction, RAMPs as allosteric modulators of Class B GPCRs, Structure‐based discovery and development of mGlu5 NAMs, and much more.
Описание: This book summarizes the latest advances in pain research. All the chapters were contributed by speakers from Asian Pain Symposium (APS) on Acute and Chronic Pain, which was held in Taipei in 2017. Founded in Kyoto, Japan in 2000, the APS serves as a platform for scientists to present recent findings in pain research and discuss research orientation in this field. APS 2017 focused on novel strategies for pain treatment. Written by experts from various disciplines, from molecular to functional, and from basic to clinic studies, this book is composed of 18 review articles on the physiology and pathology of pain in these research fields. Specific topics include circuitry, neurotransmitter, physiology, behavior, neuropathology, pharmacology, and the treatments for neuropathic pain disorders. The book is a valuable resource for researchers and graduate students in pain medicine and neuroscience.
Описание: The book deals with the neuronal circuits of the visual thalamocortical system, the brainstem and basal forebrain modulatory systems and their neurotransmitters acting upon these circuits, and the neuronal activities in the visual thalamocortical system as changed during shifts in behavioral states of vigilance from wake to sleep.
Автор: Stephens Gary, Mochida Sumiko Название: Modulation of Presynaptic Calcium Channels ISBN: 9401781095 ISBN-13(EAN): 9789401781091 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book will bring together leading international experts to discuss recent advances in basic scientific knowledge regarding the regulation of presynaptic Ca2+ channels. Importantly, Ca2+ channels represent one of the most widely modulated proteins in the body, being the target of a range of effector pathways and drugs; this range will be fully represented here. A number of therapeutic drugs target the Ca2+ channel complex, including the anti-epileptic gabapentinoid and analgesic ziconotide drugs and the pharmaceutical industry is searching for Ca2+ channel blocking drugs, particularly in the pain, epilepsy, ataxia and migraine areas. Such potential future therapies will be discussed here. Scientific disciplines will focus on electrophysiological studies, but will extend to neuroscience, genetics and biochemical areas. The work described will represent advances at the cutting edge of current neuroscience research and is timely and highly appropriate for the Springer book series.
Автор: C.H.M. Brunia; Herbert Heuer; Christoph Fromm; J.A Название: Generation and Modulation of Action Patterns ISBN: 3642714781 ISBN-13(EAN): 9783642714788 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: During the academic year 1984/85 a study group on "Per- ception and Action" was established at the Center for Inter- disciplinary Research of the University of Bielefeld. Among the various activities of this group was a series of symposia. This volume covers the proceedings of one of the sym- posia, held in October 1984 and entitled "Generation and Modulation of Action Patterns." Bringing together scientists from diverse disciplines in gen- eral is challenging, but also hazardous. Aware of the notori- ous communication problems, it was tried to keep the number of representatives of at least the major areas of Neurobiology and Psychology about equal and to elicit pre- sentations that combine experimental findings with theoret- ical statements on major issues in motor control. Despite the different' viewpoints, concepts, research strategies, and methods as they are reflected in the present volume, there was the general impression among the participants that such a multidisciplinary effort was profitable and one step on the way to the realization of common goals and com- mon conceptual grounds.
Автор: Kuei-Yuan Tseng; Marco Atzori Название: Monoaminergic Modulation of Cortical Excitability ISBN: 1441944281 ISBN-13(EAN): 9781441944283 Издательство: Springer Рейтинг: Цена: 30606.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book provides a comprehensive, integrated comparison of the complex modulatory action of dopamine, noradrenaline, and serotonin receptors in the cortex.
Автор: Hinrich Rahmann Название: Gangliosides and Modulation of Neuronal Functions ISBN: 3642719341 ISBN-13(EAN): 9783642719349 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of the NATO Advanced Research Workshop on Gangliosides and Modulation of Neuronal Functions held at the University of Stuttgart-Hohenheim, Stuttgart, FRG, October 20-24, 1986
Автор: K. Kuba; H. Higashida; D.A. Brown; T. Yoshioka Название: Slow Synaptic Responses and Modulation ISBN: 4431669752 ISBN-13(EAN): 9784431669753 Издательство: Springer Рейтинг: Цена: 9083.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Information flow as nerve impulses in neuronal circuits is regulated at synapses. The synapse is therefore a key element for information processing in the brain. Much attention has been given to fast synaptic transmission, which predominantly regulates impulse-to-impulse transmission. Slow synaptic transmission and modu- lation, however, sometimes have been neglected in considering and attempting to understand brain function. Slow synaptic potentials and modulation occur with a considerable delay in response to the accumulation of synaptic and modulatory inputs. In these contexts, they are plastic in nature and play important roles in information processing in the brain. A symposium titled "Slow Synaptic Responses and Modulation" was held as the satellite symposium to the 75th Annual Meeting of the Physiological Society of Japan on March 30-31, 1998, in Kanazawa. The theme was selected not only for the reason mentioned above, but also because of the considerable involvement of many Japanese scholars in establishing the basic issues. Following the dawn of synaptic physiological research, as Sir John Eccles, Sir Bernard Katz, and Professor Stephen Kuffler carried out pioneer work, Professor Kyozou Koketsu and Professor Benjamin Libet, the students of Sir John Eccles, and their colleagues established the concept of slow synaptic responses and modulation by studying vertebrate sympathetic ganglia. Since then, the concept has been ex- panded with detailed investigations of both peripheral and central synapses at the levels of single ion channels, intracellular Ca"] dynamics, intracellular transduc- tion mechanisms, and genes.
Автор: Watson, Ronald Ross Название: Neurological Modulation Of Sleep ISBN: 0128166584 ISBN-13(EAN): 9780128166581 Издательство: Elsevier Science Рейтинг: Цена: 26444.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: ITIL(R) 4 Managing Professional CoursewareITIL 4 Managing Professional (ITIL MP) consists of four modules and is the next level of ITIL 4 to be released after ITIL 4 Foundation. ITIL MP targets IT practitioners working within technology and digital teams across businesses. The Managing Professional (MP) stream provides practical and technical knowledge about how to run successful IT-enabled services, teams and workflows. The Managing Professional Transition module is designed to allow ITIL v3 candidates to easily transition to ITIL 4. They can get the ITIL 4 Managing Professional designation through one course and one exam. The material includes;¢ Updated glossaries with highlighted changes for `Create, Deliver & Support`, `Drive Stakeholder Value` and `Direct, Plan & Improve`¢ New diagram packs with annotations for `Create, Deliver & Support`, `Drive Stakeholder Value` and `Direct, Plan & Improve`¢ Updated syllabi with highlighted changes for `Create, Deliver & Support`, `Drive Stakeholder Value` and `Direct, Plan & Improve`¢ The `High Velocity IT` manuscript, syllabus, glossary and diagram pack remain unchanged¢ Practices Overviews and the product brochure remain unchanged¢ An up-to-date Quick Reference Guide with all the information you need¢ Updated Core Manuscripts, for `Create, Deliver & Support`, `Drive Stakeholder Value` and `Direct, Plan & Improve`¢ While the changes are quite large, they have been made for streamlining or refinement only¢ There have been no changes to the examinable content or the key concepts
Автор: Ross G. Cameron; George Feuer Название: Apoptosis and Its Modulation by Drugs ISBN: 3642630251 ISBN-13(EAN): 9783642630255 Издательство: Springer Рейтинг: Цена: 52243.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: with contributions by numerous experts
Автор: Corrado L. Galli; Marina Marinovich; Alan M. Goldb Название: Modulation of Cellular Responses in Toxicity ISBN: 3642798748 ISBN-13(EAN): 9783642798740 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of the NATO Advanced Study Institute on the Modulation of Cellular Response in Toxicity, held in Ponte di Legno, Italy , January 24 - February 3, 1994.
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