Описание: This book summarizes the latest advances in pain research. All the chapters were contributed by speakers from Asian Pain Symposium (APS) on Acute and Chronic Pain, which was held in Taipei in 2017. Founded in Kyoto, Japan in 2000, the APS serves as a platform for scientists to present recent findings in pain research and discuss research orientation in this field. APS 2017 focused on novel strategies for pain treatment. Written by experts from various disciplines, from molecular to functional, and from basic to clinic studies, this book is composed of 18 review articles on the physiology and pathology of pain in these research fields. Specific topics include circuitry, neurotransmitter, physiology, behavior, neuropathology, pharmacology, and the treatments for neuropathic pain disorders. The book is a valuable resource for researchers and graduate students in pain medicine and neuroscience.
Автор: A. D. Grinnell Название: Calcium and Ion Channel Modulation ISBN: 146128273X ISBN-13(EAN): 9781461282730 Издательство: Springer Рейтинг: Цена: 12157.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: One result is an enormous increase in our understanding of how ion channels function in nerve and muscle cells and a widening perspective on the role of ion channels in non-neuronal cell physiology and development.
Автор: Ross G. Cameron; George Feuer Название: Apoptosis and Its Modulation by Drugs ISBN: 3642630251 ISBN-13(EAN): 9783642630255 Издательство: Springer Рейтинг: Цена: 52243.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: with contributions by numerous experts
Автор: James E Barrett Название: Pharmacological Mechanisms and the Modulation of Pain,75 ISBN: 0128038837 ISBN-13(EAN): 9780128038833 Издательство: Elsevier Science Рейтинг: Цена: 29812.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
"Pharmacological Mechanisms and the Modulation of Pain," the newest volume in the "Advances in Pharmacology" series, presents the pharmacological mechanisms and the modulation of pain. With a variety of chapters and the best authors in the field, this volume is an essential resource for pharmacologists, immunologists, and biochemists alike. Contains contributions from the best authors in the field of pharmacology that focus on the pharmacological mechanisms and modulation of painProvides an essential resource for pharmacologists, immunologists, and biochemists
Автор: Rosenhouse-Dantsker Avia, Bukiya Anna N. Название: Direct Mechanisms in Cholesterol Modulation of Protein Function ISBN: 3030142647 ISBN-13(EAN): 9783030142643 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In this book, renowned scientists describe how cholesterol interacts with various proteins. Recent progress made in the high-resolution visualization of cholesterol-protein interactions using crystallography and cryogenic electron microscopy has substantially advanced the knowledge of critical features. These features enable specific recognition of the cholesterol molecule by proteins, a process that was built on earlier studies using binding assays, computational modeling and site-directed mutagenesis. Direct Mechanisms in Cholesterol Modulation of Protein Function offers comprehensive insights into the current understanding of cholesterol-driven modulation of protein function via direct sensing. Its nine chapters are organized into two distinct parts. In the first part, the chapters introduce the reader to the general characteristics of cholesterol binding sites in proteins. This part starts with a tour into common cholesterol recognition motifs, followed by an overview of the major classes of steroid-binding proteins. It then continues with two chapters that present a comprehensive analysis of molecular and structural characteristics of cholesterol binding sites in transmembrane and soluble protein domains. In the second part of the book, examples of cholesterol binding sites and consequences of specific cholesterol recognition for protein function are presented for G protein-coupled receptors, ion channels and cholesterol-transporting proteins. The book is valuable for undergraduate and graduate students in biochemistry and nutrition, as well as basic science and medical researchers with a keen interest in the biophysical properties of cholesterol and physiological consequences of cholesterol presence in biological systems.
Автор: Watson, Ronald Ross Название: Neurological Modulation Of Sleep ISBN: 0128166584 ISBN-13(EAN): 9780128166581 Издательство: Elsevier Science Рейтинг: Цена: 26444.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: ITIL(R) 4 Managing Professional CoursewareITIL 4 Managing Professional (ITIL MP) consists of four modules and is the next level of ITIL 4 to be released after ITIL 4 Foundation. ITIL MP targets IT practitioners working within technology and digital teams across businesses. The Managing Professional (MP) stream provides practical and technical knowledge about how to run successful IT-enabled services, teams and workflows. The Managing Professional Transition module is designed to allow ITIL v3 candidates to easily transition to ITIL 4. They can get the ITIL 4 Managing Professional designation through one course and one exam. The material includes;¢ Updated glossaries with highlighted changes for `Create, Deliver & Support`, `Drive Stakeholder Value` and `Direct, Plan & Improve`¢ New diagram packs with annotations for `Create, Deliver & Support`, `Drive Stakeholder Value` and `Direct, Plan & Improve`¢ Updated syllabi with highlighted changes for `Create, Deliver & Support`, `Drive Stakeholder Value` and `Direct, Plan & Improve`¢ The `High Velocity IT` manuscript, syllabus, glossary and diagram pack remain unchanged¢ Practices Overviews and the product brochure remain unchanged¢ An up-to-date Quick Reference Guide with all the information you need¢ Updated Core Manuscripts, for `Create, Deliver & Support`, `Drive Stakeholder Value` and `Direct, Plan & Improve`¢ While the changes are quite large, they have been made for streamlining or refinement only¢ There have been no changes to the examinable content or the key concepts
Автор: Stephens Gary Название: Modulation of Presynaptic Calcium Channels ISBN: 9400763336 ISBN-13(EAN): 9789400763333 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book presents recent advances in knowledge of the regulation of presynaptic Ca2+ channels. These represent one of the most widely modulated proteins in the body, target of a range of effector pathways and drugs; this range will be fully represented here.
Автор: Patrizia Campolongo; Liana Fattore Название: Cannabinoid Modulation of Emotion, Memory, and Motivation ISBN: 1493922939 ISBN-13(EAN): 9781493922932 Издательство: Springer Рейтинг: Цена: 20896.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The endocannabinoid system consists of cannabinoid receptors, their endogenous lipid ligands (endocannabinoids) and the enzymatic machinery for their synthesis and degradation.
Автор: K. Kuba; H. Higashida; D.A. Brown; T. Yoshioka Название: Slow Synaptic Responses and Modulation ISBN: 4431669752 ISBN-13(EAN): 9784431669753 Издательство: Springer Рейтинг: Цена: 9083.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Information flow as nerve impulses in neuronal circuits is regulated at synapses. The synapse is therefore a key element for information processing in the brain. Much attention has been given to fast synaptic transmission, which predominantly regulates impulse-to-impulse transmission. Slow synaptic transmission and modu- lation, however, sometimes have been neglected in considering and attempting to understand brain function. Slow synaptic potentials and modulation occur with a considerable delay in response to the accumulation of synaptic and modulatory inputs. In these contexts, they are plastic in nature and play important roles in information processing in the brain. A symposium titled "Slow Synaptic Responses and Modulation" was held as the satellite symposium to the 75th Annual Meeting of the Physiological Society of Japan on March 30-31, 1998, in Kanazawa. The theme was selected not only for the reason mentioned above, but also because of the considerable involvement of many Japanese scholars in establishing the basic issues. Following the dawn of synaptic physiological research, as Sir John Eccles, Sir Bernard Katz, and Professor Stephen Kuffler carried out pioneer work, Professor Kyozou Koketsu and Professor Benjamin Libet, the students of Sir John Eccles, and their colleagues established the concept of slow synaptic responses and modulation by studying vertebrate sympathetic ganglia. Since then, the concept has been ex- panded with detailed investigations of both peripheral and central synapses at the levels of single ion channels, intracellular Ca"] dynamics, intracellular transduc- tion mechanisms, and genes.
Автор: Avia Rosenhouse-Dantsker; Anna N. Bukiya Название: Cholesterol Modulation of Protein Function ISBN: 3030042774 ISBN-13(EAN): 9783030042776 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In this book, renowned scientists describe the role of steroid chirality and modification of lipid membrane physical properties in the modulation of G protein-coupled receptors and ion channels. The application of commonly-used technical approaches such as mass spectrometry and nucleic magnetic resonance transfer spectroscopy for studies on cholesterol distribution and alteration of lipid bilayer characteristics is also discussed. This book offers comprehensive insights into the current understanding of cholesterol-driven modulation of protein function via mechanisms that extend beyond lipid-protein direct interactions. In the first part, the chapters introduce the reader to the use of the chemical derivatives of cholesterol as a valuable laboratory tool in the studies of cholesterol-driven modulation of protein function. In the second part, examples of cholesterol-induced changes in membrane physical characteristics are presented and discussed in light of their multifaceted contribution to the effect of cholesterol on protein function. The book will be of interest to undergraduate and graduate students as well as basic science and medical researchers with a keen interest in the biophysical properties of cholesterol and physiological consequences of cholesterol presence in biological systems.
Автор: Hinrich Rahmann Название: Gangliosides and Modulation of Neuronal Functions ISBN: 3642719341 ISBN-13(EAN): 9783642719349 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of the NATO Advanced Research Workshop on Gangliosides and Modulation of Neuronal Functions held at the University of Stuttgart-Hohenheim, Stuttgart, FRG, October 20-24, 1986
Автор: Watson, Ronald Ross Название: Modulation of Sleep by Obesity, Diabetes, Age, and Diet ISBN: 0128103078 ISBN-13(EAN): 9780128103074 Издательство: Elsevier Science Рейтинг: Цена: 23244.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Sleep disorder is a rampant problem in the US, with over 40 million Americans currently diagnosed according to the NIH. There is a clear association between sleep disorder and a wide range of other human disorders –performance deficiencies, psychiatric illnesses, heart disease, obesity and more – but in spite of this there is not yet a convenient overview on the market detailing the impact of obesity, age, diabetes and diet on sleep duration and attendant health outcomes. This volume focuses on the interaction between sleep and these factors, with special attention being paid to the potential for neurological modulation of sleep via diet. The volume aid readers in understanding the role each of these factors plays in sleep architecture and its regulation by circadian biology and neurology.
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