Cholesterol Modulation of Protein Function, Avia Rosenhouse-Dantsker; Anna N. Bukiya
Автор: Rosenhouse-Dantsker Avia, Bukiya Anna N. Название: Direct Mechanisms in Cholesterol Modulation of Protein Function ISBN: 3030142647 ISBN-13(EAN): 9783030142643 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In this book, renowned scientists describe how cholesterol interacts with various proteins. Recent progress made in the high-resolution visualization of cholesterol-protein interactions using crystallography and cryogenic electron microscopy has substantially advanced the knowledge of critical features. These features enable specific recognition of the cholesterol molecule by proteins, a process that was built on earlier studies using binding assays, computational modeling and site-directed mutagenesis. Direct Mechanisms in Cholesterol Modulation of Protein Function offers comprehensive insights into the current understanding of cholesterol-driven modulation of protein function via direct sensing. Its nine chapters are organized into two distinct parts. In the first part, the chapters introduce the reader to the general characteristics of cholesterol binding sites in proteins. This part starts with a tour into common cholesterol recognition motifs, followed by an overview of the major classes of steroid-binding proteins. It then continues with two chapters that present a comprehensive analysis of molecular and structural characteristics of cholesterol binding sites in transmembrane and soluble protein domains. In the second part of the book, examples of cholesterol binding sites and consequences of specific cholesterol recognition for protein function are presented for G protein-coupled receptors, ion channels and cholesterol-transporting proteins. The book is valuable for undergraduate and graduate students in biochemistry and nutrition, as well as basic science and medical researchers with a keen interest in the biophysical properties of cholesterol and physiological consequences of cholesterol presence in biological systems.
Описание: Non-vesicular intracellular cholesterol transport is an important mechanism for maintaining membrane cholesterol homeostasis. Recent reports of studies directed at soluble cholesterol transport proteins indicate that aberrant expression of the START proteins may contribute to disease states associated with disorders in cholesterol homeostasis.
Автор: Kathleen Sakamoto; Eric Rubin Название: Modulation of Protein Stability in Cancer Therapy ISBN: 1441924019 ISBN-13(EAN): 9781441924018 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This comprehensive monograph on the role of protein modulation in cancer therapeutics focuses on targeting molecules that regulate protein stability in a variety of tumors. Topics covered include ubiquitin ligases, deubiquitinating enzymes, and the proteasome.
Автор: Martin Ashley Название: Science of Cholesterol: Volume II ISBN: 1632423952 ISBN-13(EAN): 9781632423955 Издательство: Неизвестно Цена: 24783.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: T.Y. Chang; Dale A. Freeman Название: Intracellular Cholesterol Trafficking ISBN: 1461373263 ISBN-13(EAN): 9781461373261 Издательство: Springer Рейтинг: Цена: 15672.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: INTRODUCTION AND RATIONALE FOR INTRACELLULAR CHOLESTEROL TRAFFICKING This volume is an elaboration of an earlier small meeting held in St. Louis, Missouri. That meeting was generously funded by grants from Bristol-Myers Squibb, Merck and Company and Parke-Davis, however, the total funding available limited the size of the meeting.
Автор: Robert Bittman Название: Cholesterol ISBN: 0306454785 ISBN-13(EAN): 9780306454783 Издательство: Springer Рейтинг: Цена: 36570.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Experts investigate the biochemical and biomedical aspects of cholesterol, addressing its metabolism in normal and disease states. They discuss a broad range of topics, including key steps in the cholesterol biosynthetic pathway, and the role of cholesterol in cancer, atherosclerosis, and diseases of the nervous system.
Автор: Martin Ashley Название: Science of Cholesterol: Volume I ISBN: 1632423944 ISBN-13(EAN): 9781632423948 Издательство: Неизвестно Цена: 24783.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: J. Robin Harris Название: Cholesterol Binding and Cholesterol Transport Proteins: ISBN: 9048186218 ISBN-13(EAN): 9789048186211 Издательство: Springer Рейтинг: Цена: 36570.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Knowledge of cholesterol and its interaction with protein molecules is of fundamental importance. This books examines the structural and functional aspects of the families of cholesterol-binding and cholesterol transport proteins.
Автор: A. Stewart Truswell Название: Cholesterol and Beyond ISBN: 9400799772 ISBN-13(EAN): 9789400799776 Издательство: Springer Рейтинг: Цена: 10480.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This is a remarkable, concise history of research on diet and heart disease, which traces the rise and fall of coronary heart disease as the major cause of death in the first world, followed by the rise of this cause of death in the developing world.
Автор: J. Robin Harris Название: Cholesterol Binding and Cholesterol Transport Proteins: ISBN: 9400731744 ISBN-13(EAN): 9789400731745 Издательство: Springer Рейтинг: Цена: 36570.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Knowledge of cholesterol and its interaction with protein molecules is of fundamental importance. This books examines the structural and functional aspects of the families of cholesterol-binding and cholesterol transport proteins.
Автор: Robert Bittman Название: Cholesterol ISBN: 1461377072 ISBN-13(EAN): 9781461377078 Издательство: Springer Рейтинг: Цена: 36570.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Experts investigate the biochemical and biomedical aspects of cholesterol, addressing its metabolism in normal and disease states. They discuss a broad range of topics, including key steps in the cholesterol biosynthetic pathway, and the role of cholesterol in cancer, atherosclerosis, and diseases of the nervous system.
Автор: Leland L. Smith Название: Cholesterol Autoxidation ISBN: 1475796935 ISBN-13(EAN): 9781475796933 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Most components of the biosphere are continuously ex posed to oxygen from the atmosphere. Accordingly, the inex orable deterioration of all organic compounds by the slow attack of oxygen must occur. Despite this eventuality, a definitive treatment of oxygen-dependent decomposition of any single important natural product has not heretofore been made. The instant monograph attempts to provide a complete description of the autoxidation of one such impor tantnatural product, cholesterol, as the matter is currently understood. The autoxidation of cholesterol in Nature has been a matter of interest to others since the close of the nine teenth century and to me for the past three decades. In this monograph I present aspects of what I have learned about cholesterol autoxidation during that interval. Be cause of the diffuse ann troublesoae nature of the subject I have selected to cite references to the literature rather fully, so that all items discussed may be properly evaluated by the interested reader. Though such extensive citation of references makes for labored reading, I hope the text will serve as a definitive treatment of the subject from which other studies may be engendered without extensive recourse to the older material. An .attempt has been made to include much related in formation so that a detailed awareness of the interrelation ships between cholesterol autoxidation and other aspects of chemistry, metabolism, and toxicology may be had. I risk teaching more on the subject than any reader care to learn.
ООО "Логосфера " Тел:+7(495) 980-12-10 www.logobook.ru
