Organoid Technology for Disease Modelling and Personalized Treatment, Yahaya Badrul Hisham

Автор: Spence, J.
Название: Human Pluripotent Stem Cell Derived Organoid Models,159
ISBN: 0128215313 ISBN-13(EAN): 9780128215319
Издательство: Elsevier Science
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Описание:

Organoids are complex three-dimensional in vitro organ-like model systems. Organoids can be derived from pluripotent stem cells or primary donor tissue and have been used to address fundamental questions about development, stem cell biology and organ regeneration. Human organoids have invigorated new exploration into the cellular makeup of human organs during development, in the adult and during disease. Efforts to improve complexity in organoid systems, and to make organoid systems more robust, reproducible and controlled have prompted continued refinement of methods used to generate and culture organoids. This volume will highlight recent and emerging advances that describe organoid differentiation protocols for many different organ systems, that implement organoids as tools to understand complexity and maturation, high content drug screening, disease modeling, and understanding development and evolution. Readers can expect to gain knowledge in the most recent differentiation protocols from experts in their respective areas.

Автор: Davies, Jamie
Название: Organs and Organoids
ISBN: 0128126361 ISBN-13(EAN): 9780128126363
Издательство: Elsevier Science
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Organs and Mini-Organs combines contributions from leading practitioners who work under the editorial control of an acclaimed researcher who also served for eight years as Editor-in-Chief of the journal Organogenesis, the first journal on this topic. The book begins with an introduction, but then delves into chapters that present advice on how to make organoids for many systems. In addition, case studies that illustrate the uses of organioids are presented, along with discussions on future directions and specific problems that need to be solved.