Описание: Antimicrobial resistance (AMR) is a global public health threat that needs immediate attention and action from the scientific community. Important topics include, microbial pathogenesis, AMR traits and major mechanisms underlying drug-resistance and the emerging strategies and technologies for combating AMR.
Автор: Bueno Juan Название: Preclinical Evaluation of Antimicrobial Nanodrugs ISBN: 3030438570 ISBN-13(EAN): 9783030438579 Издательство: Springer Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Translational medicine addresses the gap between research and the clinical application of new discoveries. To efficiently deliver new drugs to care centers, a preclinical evaluation, both in vitro and in vivo, is required to ensure that the most active and least toxic compounds are selected as well as to predict clinical outcome. Antimicrobial nanomedicines have been shown to have higher specificity in their therapeutic targets and the ability to serve as adjuvants, increasing the effectiveness of pre-existing immune compounds. The design and development of new standardized protocols for evaluating antimicrobial nanomedicines is needed for both the industry and clinical laboratory. These protocols must aim to evaluate laboratory activity and present models of pharmacokinetic-pharmacodynamic and toxicokinetic behavior that predict absorption and distribution. Likewise, these protocols must follow a theranostics approach, be able to detect promising formulations, diagnose the infectious disease, and determine the correct treatment to implement a personalized therapeutic behavior. Given the possibilities that nanotechnology offers, not updating to new screening platforms is inadequate as it prevents the correct application of discoveries, increasing the effect of the valley of death between innovations and their use.
This book is structured to discuss the fundamentals taken into account for the design of robust, reproducible and automatable evaluation platforms. These vital platforms should enable the discovery of new medicines with which to face antimicrobial resistance (RAM), one of the great problems of our time.
Автор: Alexander A. Vinks; Hartmut Derendorf; Johan W. Mo Название: Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics ISBN: 1493950819 ISBN-13(EAN): 9781493950812 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Over the past decade, significant progress has been made in the theory and applications of pharmacodynamics of antimicrobial agents. On the basis of pharmacokinetic-pharmacodynamic modeling concepts it has become possible to describe and predict the time course of antimicrobial effects under normal and pathophysiological conditions. The study of pharmacokinetic-pharmacodynamic relationships can be of considerable value in understanding drug action, defining optimal dosing regimens, and in making predictions under new or changing pre-clinical and clinical circumstances. Not surprisingly, pharmacokinetic-pharmacodynamic modeling concepts are increasingly applied in both basic and clinical research as well as in drug development. The book will be designed as a reference on the application of pharmacokinetic-pharmacodynamic principles for the optimization of antimicrobial therapy, namely pharmacotherapy, and infectious diseases. The reader will be introduced to various aspects of the fundamentals of antimicrobial pharmacodynamics, the integration of pharmacokinetics with pharmacodynamics for all major classes of antibiotics, and the translation of in vitro and animal model data to basic research and clinical situations in humans.
Автор: David A. Phoenix, Название: Novel Antimicrobial Agents and Strategies ISBN: 3527336389 ISBN-13(EAN): 9783527336388 Издательство: Wiley Рейтинг: Цена: 25336.00 р. Наличие на складе: Поставка под заказ.
Описание: A complete survey of current and future antimicrobial drugs and therapies, from small-molecule antibiotics to antimicrobial peptides and their engineered mimetics, from enzymes to nucleic acid therapeutics, and from metallic nanoparticles to photo- and sonosensitizers.
Автор: Fong Название: Antimicrobial Resistance in the 21st Century ISBN: 3319785370 ISBN-13(EAN): 9783319785370 Издательство: Springer Рейтинг: Цена: 25155.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Antimicrobial resistance is now a general problem. Many of us have elderly relatives who died from a drug-resistant infection, and some of us have suffered from a resistant urinary infection that likely came from intestinal bacteria following antibiotic consumption. Antimicrobial Resistance in the 21st Century provides a broad introduction to the subject in which the situation with problematic pathogens is detailed, the biology of resistance is described, and gaining approval for new antibiotics is discussed. Some topics are immediately practical, such as watching for resistant pathogen sub-populations in cultures taken from patients; other topics point to future research efforts that may lead to new antimicrobials and ways to stimulate the action of existing ones. Overall, Antimicrobial Resistance in the 21st Century provides an update for physicians, serves as a starting point for graduate students interested in solving the resistance problem, and may serve as a text for a course on resistance. Lay readers familiar with microbiology will gain an appreciation for a medical issue that promises to be one of the most important of our time. Ignatius Fong, Department of Medicine, University of Toronto Series Editor – Emerging Infectious Diseases of the 21st Century David Shlaes, Founder, Anti-Infectives Consulting Editor – Antimicrobial Agents and ChemotherapyKarl Drlica, The Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey
Автор: Pieter S. Hiemstra; Sebastian A. J. Zaat Название: Antimicrobial Peptides and Innate Immunity ISBN: 3034807678 ISBN-13(EAN): 9783034807678 Издательство: Springer Рейтинг: Цена: 22201.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book details the evolution of cysteine-containing antimicrobial peptides and their role in host defense in plants and micro-organisms. It also examines the role of antimicrobial peptides in disease and gives an outlook on new therapeutic options.
Автор: Molly Courtenay Название: Antimicrobial stewardship for nursing practice / ISBN: 178924269X ISBN-13(EAN): 9781789242690 Издательство: Marston Book Services Рейтинг: Цена: 4425.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: With antimicrobial resistance on the rise, appropriate stewardship is more important than ever. This textbook, the first written by nurses for nurses, provides a clear and concise approach to good practice.
Автор: by S Snigdha; Sabu Thomas; Название: Engineered Antimicrobial Surfaces ISBN: 9811546290 ISBN-13(EAN): 9789811546297 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume looks at the different aspects involved in controlling microbial growth and the techniques employed in obtaining sterile surfaces. It covers research on coatings, nano-materials, herbal materials, naturally occurring antimicrobials in designing antimicrobial surfaces. It discusses issues of antibiotic resistance, synthesis techniques, toxicity, and current and potential applications of antimicrobial surfaces, and this book will serve as a useful reference to a broad range of scientists, industrial practitioners, graduate and undergraduate students, and other professionals in the fields of polymer science and engineering, materials science, surface science, bioengineering and chemical engineering.
Автор: J. F. Snell; J. W. Corcoran; K. L. Arora; F. E. Ha Название: Mechanism of Action of Antimicrobial and Antitumor Agents ISBN: 3642463061 ISBN-13(EAN): 9783642463068 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume is the third in the series devoted to Antibiotics initiated by Springer Verlag in 1967.
Автор: Trevor J. Franklin; George Alan Snow Название: Biochemistry and Molecular Biology of Antimicrobial Drug Action ISBN: 1441935495 ISBN-13(EAN): 9781441935496 Издательство: Springer Рейтинг: Цена: 11753.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The subject is one of major interest in basic microbiology and infectious diseases and the book is a known classic.
Автор: Snigdha S., Thomas Sabu, Radhakrishnan E. K. Название: Engineered Antimicrobial Surfaces ISBN: 9811546320 ISBN-13(EAN): 9789811546327 Издательство: Springer Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Chapter 1: The Need for Engineering Antimicrobial Surfaces.- Chapter 2: A Thirst For Polymeric Antimicrobial Surfaces/Coatings For Diverse Applications.- Chapter 3: Potential Target Sites That Are Affected By Antimicrobial Surfaces.- Chapter 4: Carbon Nanotube-based Antimicrobial and Antifouling Surfaces.- Chapter 5: Engineered Phyllosilicate Clay Based Antimicrobial Surfaces.-Chapter 6: Modulating Surface Energy And Surface Roughness For Inhibiting Microbial Growth.- Chapter 7: Antimicrobial metal-based nanomaterials and their industrial and biomedical applications.
Автор: Donald L. Jungkind; Joel E. Mortensen; Henry S. Fr Название: Antimicrobial Resistance ISBN: 1475792050 ISBN-13(EAN): 9781475792058 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Development and Implications of Antimicrobial Resistance One of the most ominous trends in the field of antimicrobial chemotherapy over the past decade has been the increasing pace of development of antimicrobial resistance among microbial pathogens.
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