Описание: This book provides with a comprehensive overview of the role of drug transporters in drug disposition and efficacy/toxicity, as well as drug-drug interactions and recent advances in the field.
Автор: Michel F. Eichelbaum; Bernard Testa; Andrew Somogy Название: Stereochemical Aspects of Drug Action and Disposition ISBN: 3642625754 ISBN-13(EAN): 9783642625756 Издательство: Springer Рейтинг: Цена: 12577.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Tse Francis Название: Preclinical Drug Disposition ISBN: 0824785002 ISBN-13(EAN): 9780824785000 Издательство: Taylor&Francis Рейтинг: Цена: 33686.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: For researchers and students in pharmacology and related fields, explains the standard techniques for investigating the absorption, distribution, metabolism, and excretion of test compounds using laboratory animals. Describes types of experiments, study design, animal preparation and maintenance, do
Автор: Igarashi Название: Nanomedicines And Nanoproducts ISBN: 1498706622 ISBN-13(EAN): 9781498706629 Издательство: Taylor&Francis Рейтинг: Цена: 29093.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Nanomedicines and Nanoproducts: Applications, Disposition, and Toxicology in the Human Body provides a detailed overview of the disposition of nanoproducts within the body, with a special focus on the respiratory and olfactory routes of nanoproduct administration, buccal exposure and the ingestion of nanoproducts, the integumentary system (formed by the skin, hair, nails, and associated glands), the ocular route, the systemic route, and toxicology as it relates to the nanoscale world.
Offering an interdisciplinary, big-picture view of the current and future state of nanotechnology, this book:
Identifies key points for the entry of nanoproducts, nanomedicines, and other nanoscale structures into the body
Reviews the bodily administration and subsequent disposition of nanoproducts via various exposure routes
Describes the intravenous route of administration for the therapeutic management of ocular disease
Discusses practical nanoproduct and nanomedicine applications, disposition, and toxicology
Summarizes various toxicological principles and the testing of nanoproducts
Nanomedicines and Nanoproducts: Applications, Disposition, and Toxicology in the Human Body addresses the scope of practical nanoparticle applications in academic research as well as industrial investigation, where "practical" is defined as advantageous in all aspects of nanoproduct disposition, efficacy, and toxicology. The book's goal is to introduce potentially beneficial applications and exciting topics regarding nanoproducts to a variety of professional and general readers.
Автор: Laszlo Prokai; Katalin Prokai-Tatrai Название: Peptide Transport and Delivery into the Central Nervous System ISBN: 3034894201 ISBN-13(EAN): 9783034894203 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The general characteristics of neuropeptides are discussed as a background for the understanding of their role in regulation of physiological systems. The extent of those systems that are crucially affected by neuropeptides is vast and the complexity of their interactions makes the clinical focus on a specific neu- ropeptide unsatisfactory. The clinical potential of neuropeptides affecting eating disorders, eNS behavioral disorders and the neuroregenerative and neuroprotective action of neuropeptides is discussed. It is probable that suc- cessful neuropeptide therapeutics will depend upon the application of trans- lational and combinational research using various ingenious combinations and antagonists, neuropeptide receptor ago- of neuropeptides, their agonists nists and antagonists, improved methods of delivery and the development of peptides targeted to the genetic profile of individual patients. References 1 DeWied D (1969) Effects of peptide hormones on behavior. In: WF Ganong, L Martini (eds): Frontiers in Neuroendocrinology. Oxford University Press, New York, 97-140 2 Sandman CA, Schally AV, Kastin AJ, Miller L H (1972) A neuroendocrine influence on attention and memory. J Comp Physiol Psychol80: 54-58 3 Kastin AJ, Olson RD, SchaUy A V, Coy DH (1979) CNS effects of peripherally adminis- tered brain peptides. Life Sci 25: 401-414 4 Strand FL, Saint-Come C, Lee TS, Lee SJ, Kume JA, Zuccarelli LA (1993) An ACTH/MSH 4-10 analog BIM 22015 has neurotrophic and myotrophic attributes during peripheral nerve regeneration. Peptides 14: 287-296 5 Strand FL (1999) Neuropeptides: Regulators ofPhysiologjcal Processes.
1. Measurement of Transcellular Transport Rates and Intracellular Drug Sequestration in the Presence of an Extracellular Concentration Gradient
Kyoung Ah Min and Gus R. Rosania
2. Kinetic Design for Establishing Long Term Stationary Cytosol Concentrations during Drug Transport across P-gp Expressing Confluent Cell Monolayers to Facilitate Measuring Cytosol Concentration, Fitting Drug Molar Partition Coefficients into the Cytosolic Monolayer of the Plasma Membrane and Kinetically Identifying Drug Uptake Transporters
Joe Bentz
3. In Vitro Methodologies to Assess Potential for Transporter-Mediated Drug-Drug Interactions
Jibin Li, Qing Wang, and Ismael J. Hidalgo
4. Determination of Fraction Unbound and Unbound Partition Coefficient to Estimate Intracellular Free Drug Concentration
Sangwoo Ryu, Keith Riccardi, Samantha Jordan, Nathaniel Johnson, and Li Di
5. Quantitative Analysis of Intracellular Drug Concentrations in Hepatocytes
Chitra Saran, James J. Beaudoin, Nathan D. Pfeifer, and Kim L.R. Brouwer
6. Quantification of Intracellular Drug Aggregates and Precipitates
Phillip Rzeczycki and Gus R. Rosania
7. Quantitative Phenotypic Analysis of Drug Sequestering Macrophage Subpopulations
Mikhail D. Murashov
8. Using an Integrated QSAR Model to Check Whether Small-Molecule Xenobiotics Will Accumulate in Biomembranes, with Particular Reference to Fluorescent Imaging Probes
Richard W. Horobin and Juan C. Stockert
9. Diversity-Oriented Fluorescence Library Approach (DOFLA) for Discovery of Cell-Permeable Probes for Applications in Live Cell Imaging
Dongdong Su and Young-Tae Chang
Part II: Macromolecules, Biologics, and Nanoparticles
10. Overcoming Cellular and Systemic Barriers to Design the Next Wave of Peptide Therapeutics
Jerome Hochman, Tomi Sawyer, and Ruchia Duggal
11. Intracellular Targeting of Cyclotides for Therapeutic Applications
Nicole Lawrence and David J. Craik
12. Cellular Trafficking of Monoclonal and Bispecific Antibodies
John J. Rhoden and Christopher M. Wiethoff
13. Quantitative Drug Target Imaging Using Paired-Agent Principles
Kenneth M. Tichauer, Negar Sadeghipour, Yu "Winston" Wang, Summer L. Gibbs, Jonathan T.C. Liu, and Kimberley S. Samkoe
14. Quantitative Determination of Intracellular Bond Cleavage
Joshua A. Walker, Michelle R. Sorkin, and Christopher A. Alabi
15. Development and Application of a Single Cell-Level PK-PD Model for ADCs
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Автор: G.R. Wilkinson; M.D. Rawlins Название: Drug Metabolism and Disposition ISBN: 085200902X ISBN-13(EAN): 9780852009024 Издательство: Springer Рейтинг: Цена: 37594.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Larry G. Hansen Название: The ortho Side of PCBs ISBN: 1461372992 ISBN-13(EAN): 9781461372998 Издательство: Springer Рейтинг: Цена: 19591.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: PCBs have captured the attention of scientists, journalists and the public for three decades, but during most of that time attention was focused on a small number of the 209 possible chlorobiphenyls.
Описание: This book provides with a comprehensive overview of the role of drug transporters in drug disposition and efficacy/toxicity, as well as drug-drug interactions and recent advances in the field. Transporters are known determinants of drug disposition and efficacy/toxicity. In general, they are divided into solute carrier (SLC) and ATP binding cassette (ABC) families, and are located along cell membranes, where they mediate drug uptake into cells and export out of cells. Drug transporters are essential in maintaining cell homeostasis, and their gene mutations may cause or contribute to severe human genetic disorders, such as cystic fibrosis, neurological disease, retinal degeneration, anemia, and cholesterol and bile transport defects. Conversely, some diseases may also alter transporter functions and expressions, in turn aggravating disease process. Further, since over-expression of some ABC transporters is a potential contributor to multidrug-resistance (MDR), the book presents a number of strategies to overcome MDR, including ABC transporter inhibitors and applying epigenetic methods to modulate transporter expressions and functions. This book is useful for graduate students and professionals who are looking to refresh or expand their knowledge of this exciting field.
Описание: Harmonically modulated luminescence combines the advantages of highly sensitive luminescence metrology with an immediate dynamic access to carrier lifetime in semiconductors at a minimum of required a priori information.
Описание: Harmonically modulated luminescence combines the advantages of highly sensitive luminescence metrology with an immediate dynamic access to carrier lifetime in semiconductors at a minimum of required a priori information.
Название: Quantitative Biology ISBN: 0367864770 ISBN-13(EAN): 9780367864774 Издательство: Taylor&Francis Рейтинг: Цена: 8573.00 р. Наличие на складе: Поставка под заказ.
Описание: Providing an overview of quantitative biology, this book presents practical tools for the observation, modeling, design, and manipulation of biological systems from the molecular to cellular levels. The book offers an introduction to fundamental concepts and computational, mathematical, and experimental studies of molecular and cellular behavior
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