This book describes models of the neuron and multilayer neural structures, with a particular focus on mathematical models. It also discusses electronic circuits used as models of the neuron and the synapse, and analyses the relations between the circuits and mathematical models in detail.
The first part describes the biological foundations and provides a comprehensive overview of the artificial neural networks. The second part then presents mathematical foundations, reviewing elementary topics, as well as lesser-known problems such as topological conjugacy of dynamical systems and the shadowing property. The final two parts describe the models of the neuron, and the mathematical analysis of the properties of artificial multilayer neural networks.
Combining biological, mathematical and electronic approaches, this multidisciplinary book it useful for the mathematicians interested in artificial neural networks and models of the neuron, for computer scientists interested in formal foundations of artificial neural networks, and for the biologists interested in mathematical and electronic models of neural structures and processes.
Автор: Wulfram Gerstner Название: Spiking Neuron Models ISBN: 0521890799 ISBN-13(EAN): 9780521890793 Издательство: Cambridge Academ Рейтинг: Цена: 10454.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Aimed at courses in computational neuroscience, theoretical biology, biophysics, or neural networks, this 2002 text will suit students of physics, mathematics, or computer science, as well as biologists who are interested in mathematical modelling. A large number of worked examples are embedded in the profusely-illustrated text.
Автор: Kuehn Название: Human iPSC-derived Disease Models for Drug Discovery ISBN: 3031423488 ISBN-13(EAN): 9783031423482 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Поставка под заказ.
Описание: Since their development a decade ago, human induced pluripotent stem cells (iPSC) have revolutionized the study of human disease, given rise to regenerative medicine technologies, and provided exceptional opportunities for pharmacologic research. These cells provide an essentially unlimited supply of cell types that are difficult to obtain from patients, such as neurons or cardiomyocytes, or are difficult to maintain in primary cell culture. iPSC can be obtained from patients afflicted with a particular disease but, in combination with recently developed gene editing techniques, can also be modified to generate disease models. Moreover, the new techniques of 3 Dimensional printing and materials science facilitate the generation of organoids that can mirror organs under disease conditions. These properties make iPSC powerful tools to study how diseases develop and how they may be treated. In addition, iPSC can also be used to treat conditions in which the target cell population has been lost and such regenerative approaches hold great promise for currently untreatable diseases, including cardiac failure or photoreceptor degenerations.
Описание: Animal models and tests have become increasingly important for biomedical research, enabling a better understanding of pathogenic pathways involved in various human disorders. Over the last decades, zebrafish (Danio rerio) have become a very popular model organism in biomedical research. Recently, this fish has entered the waters of neuroscience and biological psychiatry, quickly becoming an indispensable model species in this field. With a high genetic homology to humans ( 75% based on coding regions), it is not surprising that humans and fish are very similar physiologically (and behaviorally). Therefore, it should not come as a surprise that zebrafish can be an excellent model of human neuropsychiatric disorders. While some classical psychiatrists may not too easily be persuaded by this generalization, the current book "The rights and wrongs of zebrafish: principles of behavioral phenotyping and CNS disease modeling" explains, in a domain-by-domain manner, how exactly zebrafish models can be used to target a wide range of human brain disorders and aberrant phenotypes. The contributors to this book are leading international scholars whose work spearheads innovative zebrafish neuroscience research around the world. Written by top experts in the field, this book makes for a useful, balanced and up-to-date reading that outlines the use of zebrafish to study the pathological mechanisms underlying neuropsychiatric disorders.
Chapter 9. Sleep phenotypes in zebrafish. David J. Echevarria and Kanza M. Khan
Chapter 10. Zebrafish neurobehavioral assays for drug addiction research. Henning Schneider
Chapter 11. Zebrafish behavioral models of ageing. Alistair J. Brock, Ari Sudwarts, Matthew O. Parker and Caroline H. Brennan
Chapter 12. Integrating morphological and behavioral phenotypes in developing zebrafish. Guozhu Zhang, Lisa Truong, Robert L. Tanguay and David M. Reif
Chapter 13. Neuroimaging phenotypes in zebrafish. Jeremy F.P. Ullmann and Andrew L. Janke
Chapter 14. Illustrated zebrafish neurobehavioral glossary. Allan V. Kalueff and the Zebrafish Neuroscience Research Consortium (ZNRC)
Автор: Armstrong Название: Neurophysiology of Neuroendocrine Neurons ISBN: 1118606817 ISBN-13(EAN): 9781118606810 Издательство: Wiley Рейтинг: Цена: 14248.00 р. Наличие на складе: Поставка под заказ.
Автор: Todd D Gould Название: Mood and Anxiety Related Phenotypes in Mice ISBN: 149396237X ISBN-13(EAN): 9781493962372 Издательство: Springer Рейтинг: Цена: 20263.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book offers a comprehensive resource for the behavioral approaches that are valuable for the characterization of mood and anxiety disorder-related behaviors in mice and the techniques that are utilized in the development of effective medications.
Автор: Michael S. Ritsner Название: Handbook of Schizophrenia Spectrum Disorders, Volume II ISBN: 9401781311 ISBN-13(EAN): 9789401781312 Издательство: Springer Рейтинг: Цена: 26120.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The Handbook of Schizophrenia Spectrum Disorders, Volume II illustrates new developments in conceptual models, research methodology, genetics and genomics, brain imaging and neurochemical studies in schizophrenia spectrum disorders.
Описание: Recent advances in understanding the role of protein dysmetabolism in neurodegeneration was the theme of the Fondation IPSEN meeting addressing Genotype-Proteotype-Phenotype relationships.
Автор: Strack Stefan, Usachev Yuriy M. Название: Techniques to Investigate Mitochondrial Function in Neurons ISBN: 1493983296 ISBN-13(EAN): 9781493983292 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Neuromethods Preface... Preface... Table of Contents... Contributing Authors...
1. Three-Dimensional Reconstruction of Neuronal Mitochondria by Electron Tomography Guy Perkins 2. Measuring Mitochondrial Shape with ImageJ Ronald A. Merrill, Kyle H. Flippo, and Stefan Strack 3. Live Imaging Mitochondrial Transport in Neurons Meredith M. Course, Chung-Han Hsieh, Pei-I Tsai, Jennifer A. Codding-Bui, Atossa Shaltouki, and Xinnan Wang 4. Techniques to Investigate Bioenergetics of Mitochondria William I. Sivitz 5. Respirometry in Neurons Liang Zhang and Eugenia Trushina 6. Measuring ATP in Axons with FRET Lauren Y. Shields, Bryce A. Mendelsohn, and Ken Nakamura 7. Characterizing Metabolic States using Fluorescence Lifetime Imaging Microscopy (FLIM) of NAD(P)H Thomas S. Blacker and Michael R. Duchen 8. Techniques for Simultaneous Mitochondrial and Cytosolic Ca2+ Imaging in Neurons Jacob E. Rysted, Zhihong Lin, and Yuriy M. Usachev 9. Live Imaging of Mitochondrial ROS Production and Dynamic Redox Balance in Neurons Karolina Can, Sebastian Kьgler, and Michael Mьller 10. Monitoring of Permeability Transition Pore Openings in Isolated Individual Brain Mitochondria Nickolay Brustovetsky and Tatiana Brustovetsky 11. Examination of Mitochondrial Ion Conductance by Patch Clamp in Intact Neurons and Mitochondrial Membrane Preparations Elizabeth A. Jonas and Nelli Mnatsakanyan 12. Monitoring of Permeability Transition Pore Openings in Mitochondria of Cultured Neurons Tatiana Brustovetsky and Nickolay Brustovetsky 13. Protocols for Assessing Mitophagy in Neuronal Cell Lines and Primary Neurons Ruben K. Dagda and Monica Rice 14. Examining Mitochondrial Function at Synapses In Situ Gregory T. Macleod and Maxim V. Ivannikov 15. Proteomic Analysis of Neuronal Mitochondria Kelly L. Stauch and Howard S. Fox 16. Measuring Mitochondrial Pyruvate Oxidation Lawrence R. Gray, Alix A.J. Rouault, Lalita Oonthonpan, Adam J. Rauckhorst, Julien A. Sebag, and Eric B. Taylor
Описание: The visual system of insects has attracted histologists for a long time. We have detailed histological studies of the visual systems of Diptera, Hymenoptera and Odonata dating from the last century: Leydig's (1864) study on optical ganglia of insects, Ciaccio's (1876) on the fine structure of the first ganglion in the mosquitos and Hickson's (1885) giving for the first time an exact description of the three optical ganglia of Musca. From 1896 several papers appeared using neuro- histological methods, mainly Golgi techniques and methylene blue staining. In 1896 Kenyon published his work on the bee-brain and in 1897 described the relationships of neurons in the optic ganglia with a modified Golgi method. Another work, by Jonescu (1909), should be mentioned: "Vergleichende Unter- suchungen am Gehirn der Honigbiene." In the same year Cajal's findings on the optic ganglia of the fly were published; then in 1915 Cajal and Sanchez wrote a definitive monograph on the neural elements and their connections in the same animal that remained the main reference in this field for decades. In both works Golgi techniques were used. Since then there have been only a few new publications on the subject: (Gribakin, 1967; Perrelet and Baumann, 1969 a, b; Perrelet, 1970; Varela and Porter, 1969; Skrzipek and Skrzipek, 1971, 1973; Grundler, 1972: Snyder, Menzel and Laughlin, 1973). They deal mainly with the receptors of the retina.
Описание: Introduction.- Part I: Preliminaries.- Foundations of artificial neural networks.- Part II: Mathematical foundations.- General foundations.- Foundations of dynamical systems theory.- Part III: Mathematical models of the neuron.- Models of the whole neuron.- Models of parts of the neuron.- Part IV: Mathematical models of the perceptron.- General model of the perceptron.- Linear perceptrons.- Weakly nonlinear perceptrons.- Nonlinear perceptrons.- Concluding remarks and comments.
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