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Human iPSC-derived Disease Models for Drug Discovery, Kuehn


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Автор: Kuehn
Название:  Human iPSC-derived Disease Models for Drug Discovery
ISBN: 9783031423482
Издательство: Springer
Классификация:



ISBN-10: 3031423488
Обложка/Формат: Hardback
Страницы: 332
Вес: 0.00 кг.
Дата издания: 08.12.2023
Серия: Handbook of experimental pharmacology
Язык: English
Издание: 1st ed. 2023
Иллюстрации: 30 illustrations, color; 70 illustrations, black and white; viii, 332 p. 100 illus., 30 illus. in color.
Размер: 235 x 155
Основная тема: Biomedicine
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: Since their development a decade ago, human induced pluripotent stem cells (iPSC) have revolutionized the study of human disease, given rise to regenerative medicine technologies, and provided exceptional opportunities for pharmacologic research. These cells provide an essentially unlimited supply of cell types that are difficult to obtain from patients, such as neurons or cardiomyocytes, or are difficult to maintain in primary cell culture. iPSC can be obtained from patients afflicted with a particular disease but, in combination with recently developed gene editing techniques, can also be modified to generate disease models. Moreover, the new techniques of 3 Dimensional printing and materials science facilitate the generation of organoids that can mirror organs under disease conditions. These properties make iPSC powerful tools to study how diseases develop and how they may be treated. In addition, iPSC can also be used to treat conditions in which the target cell population has been lost and such regenerative approaches hold great promise for currently untreatable diseases, including cardiac failure or photoreceptor degenerations.
Дополнительное описание: Part 1 General considerations.- Human iPS for clinical applications and cellular products.- 3D-printed iPS disease models.- Part 2 CNS iPSC and organoids.- iPS-derived neurons and brain organoids from patients (brain).- iPS-derived RGCs (eye).- iPS-derive



Phenotyping of human ipsc-derived neurons

Название: Phenotyping of human ipsc-derived neurons
ISBN: 0128222778 ISBN-13(EAN): 9780128222775
Издательство: Elsevier Science
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Цена: 19370.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Love is in the heir in this royally good rom com debut releasing in Spring 2023 - perfect for anyone who likes relatable heroines (with great hair), hot and aloof book boyfriends (with great hats), near misses, almost kisses and a corgi or two.

Perinatal Tissue-Derived Stem Cells

Автор: Babak Arjmand
Название: Perinatal Tissue-Derived Stem Cells
ISBN: 3319464086 ISBN-13(EAN): 9783319464084
Издательство: Springer
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Цена: 19564.00 р.
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Описание: This book covers several aspects of perinatal tissue-derived stem cells, from theoretical concepts to clinical applications. Topics include functions and different sources, immunomodulatory properties, translational point of view, GMP facility design and manufacturing for clinical translation, therapeutic potentials, and finally ethical considerations. The text provides a brief review of each type of perinatal stem cells and then focuses on their multi- or pluripotent properties, regenerative capacity, and future therapeutic potential in regenerative medicine. Additionally, the book discusses GMP compliance in stem cell facilities and the manufacture of stem cells for clinical translation. The chapters are authored by world-renowned experts in the perinatal stem cell field. Perinatal Tissue-Derived Stem Cells: Alternative Sources of Fetal Stem Cells, part of Springer's Stem Cell Biology and Regenerative Medicine series, is essential reading for basic and clinical scientists, clinicians, and pharmaceutical experts working or conducting research in the fields of stem cell biology, molecular aspects of stem cell research, tissue engineering, regenerative medicine, and cellular therapy.

Adipose-derived stem cells

Автор: Gimble
Название: Adipose-derived stem cells
ISBN: 161737959X ISBN-13(EAN): 9781617379598
Издательство: Springer
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Цена: 23757.00 р.
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Описание: During the past decade, a wide range of scientific disciplines have adopted the use of adipose-derived stem/stromal cells (ASCs) as an important tool for research and discovery. In Adipose-Derived Stem Cells: Methods and Protocols, experts from the field, including members of the esteemed International Federation of Adipose Therapeutics and Science (IFATS), provide defined and established protocols in order to further codify the utilization of these powerful and accessible cells. With chapters organized around approaches spanning the discovery, pre-clinical, and clinical processes, much of the emphasis is placed on human ASC, while additional techniques involving small and large animal species are included. As a volume in the highly successful Methods in Molecular Biology™ series, the detailed contributions include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Adipose-Derived Stem Cells: Methods and Protocols serves as a vital reference text for experienced researchers as well as new students on the path to further exploring the incredible potential of ASCs.

Marine-Derived Biomaterials for Tissue Engineering Applications

Автор: Andy H. Choi; Besim Ben-Nissan
Название: Marine-Derived Biomaterials for Tissue Engineering Applications
ISBN: 9811388547 ISBN-13(EAN): 9789811388545
Издательство: Springer
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Цена: 15372.00 р.
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Описание:

This book presents the latest advances in marine structures and related biomaterials for applications in both soft- and hard-tissue engineering, as well as controlled drug delivery. It explores marine structures consisting of materials with a wide variety of characteristics that warrant their use as biomaterials. It also underlines the importance of exploiting natural marine resources for the sustainable development of novel biomaterials and discusses the resulting environmental and economic benefits.
The book is divided into three major sections: the first covers the clinical application of marine biomaterials for drug delivery in tissue engineering, while the other two examine the clinical significance of marine structures in soft- and hard-tissue engineering, respectively. Focusing on clinically oriented applications, it is a valuable resource for dentists, oral and maxillofacial surgeons, orthopedic surgeons, and students and researchers in the field of tissue engineering.
Stem Cell-Derived Models in Toxicology

Автор: Mike Clements; Liz Roquemore
Название: Stem Cell-Derived Models in Toxicology
ISBN: 1493966596 ISBN-13(EAN): 9781493966592
Издательство: Springer
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Цена: 19564.00 р.
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Описание: This detailed volume brings together a diverse collection of stem cell-derived model-based toxicity assays, from those routinely used to those deemed to have considerable potential. With a focus on differentiated tissues, the chapters explore numerous cardiotoxicity applications as well as coverage of neurotoxicity, hepatotoxicity, and more. Written for the Methods in Pharmacology and Toxicology series, the contents of this book aim to enable adoption of these protocols in laboratories that are interested in entering the field as well as to facilitate the transfer of best practices between laboratories that are already actively pursuing these technologies.

Authoritative and cutting-edge, Stem Cell-Derived Models in Toxicology serves as a vital resource for researchers aiming to improve risk assessment in drug discovery and design.
Human Pluripotent Stem Cell Derived Organoid Models,159

Автор: Spence, J.
Название: Human Pluripotent Stem Cell Derived Organoid Models,159
ISBN: 0128215313 ISBN-13(EAN): 9780128215319
Издательство: Elsevier Science
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Цена: 23075.00 р.
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Описание:

Organoids are complex three-dimensional in vitro organ-like model systems. Organoids can be derived from pluripotent stem cells or primary donor tissue and have been used to address fundamental questions about development, stem cell biology and organ regeneration. Human organoids have invigorated new exploration into the cellular makeup of human organs during development, in the adult and during disease. Efforts to improve complexity in organoid systems, and to make organoid systems more robust, reproducible and controlled have prompted continued refinement of methods used to generate and culture organoids. This volume will highlight recent and emerging advances that describe organoid differentiation protocols for many different organ systems, that implement organoids as tools to understand complexity and maturation, high content drug screening, disease modeling, and understanding development and evolution. Readers can expect to gain knowledge in the most recent differentiation protocols from experts in their respective areas.

Perinatal Tissue-Derived Stem Cells: Alternative Sources of Fetal Stem Cells

Автор: Arjmand Babak
Название: Perinatal Tissue-Derived Stem Cells: Alternative Sources of Fetal Stem Cells
ISBN: 3319835149 ISBN-13(EAN): 9783319835143
Издательство: Springer
Рейтинг:
Цена: 13974.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: This book covers several aspects of perinatal tissue-derived stem cells, from theoretical concepts to clinical applications. Topics include functions and different sources, immunomodulatory properties, translational point of view, GMP facility design and manufacturing for clinical translation, therapeutic potentials, and finally ethical considerations. The text provides a brief review of each type of perinatal stem cells and then focuses on their multi- or pluripotent properties, regenerative capacity, and future therapeutic potential in regenerative medicine. Additionally, the book discusses GMP compliance in stem cell facilities and the manufacture of stem cells for clinical translation. The chapters are authored by world-renowned experts in the perinatal stem cell field. Perinatal Tissue-Derived Stem Cells: Alternative Sources of Fetal Stem Cells, part of Springer’s Stem Cell Biology and Regenerative Medicine series, is essential reading for basic and clinical scientists, clinicians, and pharmaceutical experts working or conducting research in the fields of stem cell biology, molecular aspects of stem cell research, tissue engineering, regenerative medicine, and cellular therapy.

Adipose-Derived Stem Cells

Автор: Jeffrey M. Gimble; Bruce A. Bunnell
Название: Adipose-Derived Stem Cells
ISBN: 1493957813 ISBN-13(EAN): 9781493957811
Издательство: Springer
Рейтинг:
Цена: 20263.00 р.
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Описание: This comprehensive reference features experts from the field, including members of the International Federation of Adipose Therapeutics and Science (IFATS), who provide well defined protocols that further codify the applications of these powerful cells.

Mesenchymal Stem Cell Derived Exosomes

Автор: Yaoliang Tang
Название: Mesenchymal Stem Cell Derived Exosomes
ISBN: 012800164X ISBN-13(EAN): 9780128001646
Издательство: Elsevier Science
Рейтинг:
Цена: 12462.00 р.
Наличие на складе: Поставка под заказ.

Описание: Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas – cardiovascular research and stem cells. Mesenchymal Stem Cell Derived Exosomes provides insight into the biofunction and molecular mechanisms, practical tools for research, and a look toward the clinical applications of this exciting phenomenon which is emerging as an effective diagnostic. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived exosomes as a diagnostic and therapeutic tool.

Myeloid-derived suppressor cells and cancer

Автор: Escors, David Talmadge, James E. Breckpot, Karine Van Ginderachter, Jo A. Kochan, Grazyna
Название: Myeloid-derived suppressor cells and cancer
ISBN: 3319268198 ISBN-13(EAN): 9783319268194
Издательство: Springer
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Цена: 9141.00 р.
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Описание: The book starts with an introduction to and history of myeloid-derived suppressor cells (MDSCs), followed by a description of their differentiation, their role in the tumour microenvironment and their therapeutic targeting.

Engineering Biology For Microbial Biosynthesis Of Plant-Derived Bioactive Compounds

Автор: Wei,Yongjun
Название: Engineering Biology For Microbial Biosynthesis Of Plant-Derived Bioactive Compounds
ISBN: 0443155585 ISBN-13(EAN): 9780443155581
Издательство: Elsevier Science
Рейтинг:
Цена: 21222.00 р.
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Cell-Derived Matrices Part B,157

Автор: Caballero, David
Название: Cell-Derived Matrices Part B,157
ISBN: 0128201746 ISBN-13(EAN): 9780128201749
Издательство: Elsevier Science
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Цена: 23075.00 р.
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Описание:

Cell-Derived Matrices Part B, Volume 157 provides a detailed description and step-by-step methods surrounding the use of three-dimensional cell-derived matrices for tissue engineering applications. Chapters in this new release include Glaucomatous cell-derived matrices, Cardiac tissue explants decellularization, Decellularization of skin matrices for wound healing applications, Guiding axonal growth by aligned cell-derived matrices for spinal cord injury regeneration, Human Mesenchymal Stem Cell-Derived Matrices for Enhanced Osteoregeneration, Amniotic decellularized matrices, Three-Dimensional (3-D) Tissue Reconstruction without Scaffold, Tubular cell-derived matrices for TERM applications, and more.


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