Crispr-/cas9 based genome editing for treating genetic disorders and diseases, Gerrard, Brian A. (western Institute For Social Research, California, Usa) Shinefield, Jacqueline
Описание: One of the world's leading experts on genetics unravels one of the most important breakthroughs in modern science and medicine. If our genes are, to a great extent, our destiny, then what would happen if mankind could engineer and alter the very essence of our DNA coding? Millions might be spared the devastating effects of hereditary disease or the challenges of disability, whether it was the pain of sickle-cell anemia to the ravages of Huntington's disease. But this power to "play God" also raises major ethical questions and poses threats for potential misuse. For decades, these questions have lived exclusively in the realm of science fiction, but as Kevin Davies powerfully reveals in his new book, this is all about to change. Engrossing and page-turning, Editing Humanity takes readers inside the fascinating world of a new gene editing technology called CRISPR, a high-powered genetic toolkit that enables scientists to not only engineer but to edit the DNA of any organism down to the individual building blocks of the genetic code. Davies introduces readers to arguably the most profound scientific breakthrough of our time. He tracks the scientists on the front lines of its research to the patients whose powerful stories bring the narrative movingly to human scale. Though the birth of the "CRISPR babies" in China made international news, there is much more to the story of CRISPR than headlines seemingly ripped from science fiction. In Editing Humanity, Davies sheds light on the implications that this new technology can have on our everyday lives and in the lives of generations to come.
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Автор: Bernadette Mercieca-Spiteri, Jess.E. Thompson, Ronika Power, Rowan McLaughlin, Simon Stoddart Название: Temple People: Bioarchaeology, Resilience and Culture in Prehistoric Malta ISBN: 191334407X ISBN-13(EAN): 9781913344078 Издательство: Marston Book Services Рейтинг: Цена: 12870.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The ERC-funded FRAGSUS Project (Fragility and sustainability in small island environments: adaptation, culture change and collapse in prehistory, 2013–18) led by Caroline Malone has focused on the unique Temple Culture of Neolithic Malta and its antecedents. This third volume builds on the achievements of Mortuary customs in prehistoric Malta, published by the McDonald Institute in 2009. It seeks to answer many questions posed, but left unanswered, of the more than 200,000 fragments of mainly commingled human remains from the Xaghra Brochtorff Circle on Gozo. The focus is on the interpretation of a substantial, representative subsample of the assemblage, exploring dentition, disease, diet and lifestyle, together with detailed understanding of chronology and the affinity of the ancient population associated with the ‘Temple Culture’ of prehistoric Malta. The first studies of genetic profiling of this population, as well as the results of intra-site GIS and visualization, taphonomy, health and mobility, offer important insights into this complex mortuary site and its ritual. These data and the original assemblage are conserved in the National Museum of Archaeology in Valletta as a resource for future study.
Название: Crispr/cas9 system: applications and technology ISBN: 1536164267 ISBN-13(EAN): 9781536164268 Издательство: Nova Science Рейтинг: Цена: 13462.00 р. Наличие на складе: Невозможна поставка.
Описание: This compilation focuses on the CRISPR/Cas9 system, a genome editing tool that has been hailed as the most profound molecular biology discovery in the past decade. By employing the natural process of bacterial immunity towards bacteriophages, the tool allows researchers to precisely excise and edit parts of the genetic sequence to modify them. The authors summarize the molecular pathogenesis of hepatocellular carcinoma, available treatments/drugs and their limitations, the landscape of CRISPR targeting hepatocellular carcinoma, limitations and potential targets in future. The closing review summarises the use of CRISPR/Cas9 gene editing in ophthalmology and focuses on the advancement of gene editing in the cornea. The majority of corneal dystrophies are the result an autosomal dominant inheritance pattern within the TGFBI gene, which presents an ideal model suited for a CRISPR/Cas9 knock out methodology.
Автор: Bhattacharya Anjanabha, Parkhi Vilas, Char Bharat Название: CRISPR/Cas Genome Editing: Strategies And Potential For Crop Improvement ISBN: 3030420248 ISBN-13(EAN): 9783030420246 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Introduction to genome editing techniques: Implication in modern agriculture.- Application of bioinformatics tools in CRISPR/Cas.- CRISPR and food security: Application in cereal crops.- Improvement of floriculture crops using CRISPR/Cas and genome editing techniques.- Engineering crop plant resistance against abiotic stresses: CRISPR/Cas application and challenges.- Vegetable crop improvement using CRISPR/Cas.- Use of CRISPR/Cas in climate smart/resilient agriculture.- Intellectual Property Landscape on CRISPR/Cas.
Автор: Halford Nigel G. Название: Crop Biotechnology: Genetic Modification and Genome Editing ISBN: 1786347822 ISBN-13(EAN): 9781786347824 Издательство: World Scientific Publishing Рейтинг: Цена: 10483.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Plant molecular biology came to the fore in the early 1980s and there has been tremendous growth in the subject since then. The study of plant genes and genomes, coupled with the development of techniques for the incorporation of novel or modified genes into plants, eventually led to the commercialisation of genetically modified (GM) crops in the mid-1990s. This was seen as the start of a biotechnological revolution in plant breeding. However, plant biotechnology became one of the hottest debates of the age and, in Europe at least, has been mired in controversy and over-regulation. Nevertheless, recent years have seen further technological innovation in the development of a range of techniques that enable scientists to make specific changes to target genes.Through a detailed history and development of the science and techniques that underpin crop biotechnology, this title is concise, comprehensive and readable. As well as new sections on genome editing, this edition includes expanded sections on current GM crops and future developments in plant biotechnology, and updated sections on techniques, legislation and the GM crop debate.The previous edition of this book, titled Genetically Modified Crops, 2nd Edition, was published in November 2011.
Автор: Greely, Henry T. Название: Crispr People ISBN: 0262044439 ISBN-13(EAN): 9780262044431 Издательство: MIT Press Рейтинг: Цена: 4732.00 р. Наличие на складе: Нет в наличии.
Описание: "Beginning with the amazing tale of the Chinese "CRISPR Babies," Greely tells the complex story of human germline editing, covering the science, ethics, law, and politics"--
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