Role of mitochondria in human aging and diseas e: from genes to cell signaling( annals of the new york academy of sciences volume 1042), Berg, Jessica W. (assistant Professor Of Law And Bioethics, Assistant Professor Of Law And Bioethics, Case Western Reserve Unviersity, Schools Of Law
Описание: This volume in the Encyclopedia of Sustainability Science and Technology, Second Edition, describes the breadth of science and engineering knowledge critical to advancing sustainable built environments, from architecture and design, mechanical engineering, lighting, and materials to water and energy, public policy, and economics.
Автор: Orrenius Название: Mitochondrial Signaling in Health and Disease ISBN: 1439880026 ISBN-13(EAN): 9781439880029 Издательство: Taylor&Francis Рейтинг: Цена: 29093.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Mitochondria have traditionally been associated with metabolic functions; however recent research has uncovered a central role for these organelles in cell signaling, cell survival, and cell death. Mitochondrial dysfunction is a factor in a myriad of pathophysiological conditions, including age-related neurodegenerative disorders, cancer, metabolic syndrome, and cardiovascular disease. Mitochondrial Signaling in Health and Disease examines themes essential for the maintenance of the mitochondrial redox (reduction-oxidation) energy axis.
With contributions from an impressive cadre of internationally recognized scientists, the book discusses coordinated mitochondrial functions that regulate cell function by discrete signaling pathways. Topics discussed include:
Electron transport and energy production
Mitochondrial biogenesis and dynamics
Mitochondrial signaling
Apoptosis and autophagy
Pharmacology signaling
Epigenetic signaling: mitochondrial methylation and acetylation reactions
An essential resource for life and health scientists as well as pharmaceutical industry professionals, this volume highlights the importance of mitochondrial signaling and its role in establishing a harmonized communication between several cellular compartments. The information in this volume is critical to those developing mitochondrion-targeted therapies aimed at assuaging mitochondrial dysfunction or the specific factors contributing to its dysfunction.
Mitochondria are sometimes called the powerhouses of eukaryotic cells, because mitochondria are the site of ATP synthesis in the cell. ATP is the universal energy currency, it provides the power that runs all other life processes. Humans need oxygen to survive because of ATP synthesis in mitochondria. The sugars from our diet are converted to carbon dioxide in mitochondria in a process that requires oxygen. Just like a fire needs oxygen to burn, our mitochondria need oxygen to make ATP. From textbooks and popular literature one can easily get the impression that all mitochondria require oxygen. But that is not the case. There are many groups of organismsm known that make ATP in mitochondria without the help of oxygen. They have preserved biochemical relicts from the early evolution of eukaryotic cells, which took place during times in Earth history when there was hardly any oxygen avaiable, certainly not enough to breathe. How the anaerobic forms of mitochondria work, in which organisms they occur, and how the eukaryotic anaerobes that possess them fit into the larger picture of rising atmospheric oxygen during Earth history are the topic of this book.
Автор: Muntaser Ibrahim, Charles Rotimi Название: The Genetics of African Populations in Health and Disease ISBN: 1107072026 ISBN-13(EAN): 9781107072022 Издательство: Cambridge Academ Рейтинг: Цена: 12514.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Biomedical approaches increasingly work with human variation and this volume focuses on Africa, the most genetically diverse continent, and the birthplace of modern humans. It considers population structure and the genetic basis of common infectious and non-communicable diseases in historic and modern contexts, to shed light on human biology.
Описание: In this book, Clarisse de Souza and Carla Leitao discuss how the semiotic inspection method and communicability evaluation method, which are both qualitative methods, can also be used in scientific contexts to generate new knowledge about HCI. The discussion goes into deep considerations about scientific methodology, calling the reader`s attention to the essence of qualitative methods in research.
Автор: Justin C. St. John Название: Mitochondrial DNA, Mitochondria, Disease and Stem Cells ISBN: 1627038671 ISBN-13(EAN): 9781627038676 Издательство: Springer Рейтинг: Цена: 22201.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The reader is then introduced to how mtDNA is transmitted through the oocyte and how stem cells can be used to study mitochondrial biogenesis and mtDNA replication and transcription in undifferentiated pluripotent and differentiating cells and how mitochondria adapt during this process.
Автор: Korotkov, Sergey (leading Researcher, Russian Academy Of Sciences, Sechenov Institute Of Evolutionary Physiology And Biochemistry, St. Petersburg, Rus Название: Mitochondria as a key intracellular target of thallium toxicity ISBN: 0323955312 ISBN-13(EAN): 9780323955317 Издательство: Elsevier Science Рейтинг: Цена: 21391.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Let`s Learn About the Forest is an interactive oversized board book that encourages little ones to use their imaginations and power of discovery to find the different animals and items in the forest God created. As they do, they will also learn interesting facts about the different animals and their habitats.
Описание: Human Ageing: A Unique Experience explores the biology of human ageing focusing on the individual.
Автор: Rakesh Srivastava Название: Apoptosis, Cell Signaling, and Human Diseases ISBN: 1617377139 ISBN-13(EAN): 9781617377136 Издательство: Springer Рейтинг: Цена: 22201.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: These volumes present a concise synthesis of recent developments in the understanding of both cell survival and apoptotic pathways.
Автор: Rakesh Srivastava Название: Apoptosis, Cell Signaling, and Human Diseases ISBN: 1617378232 ISBN-13(EAN): 9781617378232 Издательство: Springer Рейтинг: Цена: 26120.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Apoptosis, Cell Signaling, and Human Diseases: Molecular Mechanisms, Volumes 1 and 2, present a concise synthesis of recent developments in the understanding of both cell survival and apoptotic pathways. Particular attention is given to apoptosis in human diseases, such as different forms of cancer.
Описание: Written specifically for architects, this is the first clear and concise explanation of Heidegger`s architectural thinking in the context of his work.
Автор: Jos? Mar?n-Garc?a Название: Mitochondria and Their Role in Cardiovascular Disease ISBN: 1489997660 ISBN-13(EAN): 9781489997661 Издательство: Springer Рейтинг: Цена: 23058.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Over the past two decades, due to dramatic advances in molecular and cell biology, biochemistry, and genetics, our view on mitochondria as a relatively static cellular powerhouse has changed radically. We now know that these organelles play a critical role in the normal and in the damaged heart. Written by Dr. Jos? Mar?n-Garc?a, Director of the Molecular Cardiology and Neuromuscular Institute, Mitochondria and Their Role in Cardiovascular Disease brings readers up- to-date on the many significant advances in the field of mitochondrial cardiovascular medicine. The book begins with a general introduction to mitochondria, followed by laboratory methods to study the structure and function of the organelle, regulation of replication and biogenesis, and the mechanisms and functional consequences of mitophagia and mitochondrial dynamics. Subsequent chapters deal with mitochondrial oxidative stress and the role that the organelle plays in cell signaling and cell death. Discussions will be undertaken on the biochemistry of mitochondrial cell signaling, including the nature of the proteins engaged in these processes, many of them only recently discovered. Later chapters examine the role of mitochondria and mitochondrial abnormalities in cardiovascular diseases, including their diagnosis, therapeutic options currently available, animal models of mitochondrial disease, and new frontiers in mitochondria cardiovascular medicine, including areas of research that are relatively new or developing, such as proteomics, next generation sequencing, and systems biology.
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