Автор: Ebling Francis J. P., Piggins Hugh D. Название: Neuroendocrine Clocks and Calendars ISBN: 303055645X ISBN-13(EAN): 9783030556457 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book explores how daily and seasonal rhythmicity is generated, how these rhythms are synchronised by our environment, and how they regulate the neuroendocrine systems that impact our physiology and behaviour. The constraints of surviving in a seasonal environment have shaped human evolution and migration, have shaped our societies and cultures, and continue to influence our everyday lives, health and wellbeing. Identifying the mechanisms whereby seasonal rhythmicity is generated and regulates the brain and body is not only important for understanding the natural world and relevant to animal production, it also offers many insights into the human condition. Each chapter is written by an international expert in the field of chronobiology. A historical perspective on how research into photoperiodism and rhythmicity progressed is initially provided, but the main focus of this book is on the remarkable studies in the last few decades that have unravelled the molecular and cellular machinery underpinning circadian and circannual timing. Topics covered include the role of melatonin in communicating seasonal information to the brain and pituitary gland, the neuroanatomical pathways in mammals, birds and fish by which changes in photoperiod reach the hypothalamus, the role of glial cells (tanycytes) and thyroid hormone in seasonal rhythmicity, neuroplasticity across seasons, effects of changing day length on mood, regulation of “clock“ gene expression, and the role of the suprachiasmatic nucleus. This book will appeal to all students and researchers who wish to learn about current and past research on daily and seasonal rhythmicity. This is the tenth volume in the International Neuroendocrine Federation (INF) Masterclass in Neuroendocrinology series (Volumes 1-7 published by Wiley) that aims to illustrate highest standards and encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology.
Автор: Joseph S. Takahashi; Fred W. Turek; Robert Y. Moor Название: Circadian Clocks ISBN: 1461354382 ISBN-13(EAN): 9781461354383 Издательство: Springer Рейтинг: Цена: 26122.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The Handbook of Behavioral Neurobiology series deals with the aspects of neurosciences that have the most direct and immediate bearing on behavior. It presents the most current research available in the specific areas of sensory modalities. This volume explores circadian rhythms.
Автор: Hideharu Numata; Barbara Helm Название: Annual, Lunar, and Tidal Clocks ISBN: 443155260X ISBN-13(EAN): 9784431552604 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: There is more to biological rhythms than circadian clocks. This book aims at promoting the exciting potential of a deeper understanding of circannual, circatidal, and circalunar clocks. It highlights new developments, summarizes existing knowledge, and integrates different perspectives with the tools and ideas of diverse fields of current biology. For predominantly pragmatic reasons, research in recent decades was mostly concerned with circadian clocks. Clocks on other timescales, however, have been largely neglected and therefore still appear "enigmatic". Thanks to the rapid development of methods in molecular biology as well as in ecology, we are now able to re-approach these clocks. Laboratories around the world are showing fresh interest and substantial progress is being made in many independent projects. The book's two sections address the moon-derived circatidal, circasemilunar, and lunar cycles on the one hand (10 chapters), and the sun-derived circannual cycles on the other (6 chapters). This work brings together authors with an expansive array of expertise and study systems, ranging from tidal cycles of marine invertebrates to annual cycles of birds and mammals, and from behavioral to genetic and epigenetic backgrounds. While great challenges remain to be mastered, the book aims at conveying the excitement of unraveling, broadly, the rhythms of life.
Автор: Vinod Kumar Название: Biological Timekeeping: Clocks, Rhythms and Behaviour ISBN: 8132238869 ISBN-13(EAN): 9788132238867 Издательство: Springer Рейтинг: Цена: 39130.00 р. Наличие на складе: Поставка под заказ.
Описание: This book is a concise, comprehensive and up-to-date account of fundamental concepts and potential applications of biological timekeeping mechanisms in animals and humans. It also discusses significant aspects of the organization and importance of timekeeping mechanisms in both groups. Divided into seven sections, it addresses important aspects including fundamental concepts; animal and human clocks; clock interactions; clocks and metabolism and immune functions; pineal, melatonin and timekeeping; and clocks, photoperiodism and seasonal behaviours. The book also focuses on biological clock applications in a 24x7 human society, particularly in connection with life-style associated disorders like obesity and diabetes. It is a valuable resource for advanced undergraduates, researchers and professionals engaged in the study of the science of biological timekeeping.
Автор: Ebling Francis J. P., Piggins Hugh D. Название: Neuroendocrine Clocks and Calendars ISBN: 3030556425 ISBN-13(EAN): 9783030556426 Издательство: Springer Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: People use science every single day in their jobs! From a smoothie maker creating a vortex to blend fruit and vegetables to firefighters extinguishing a blaze by breaking the fire triangle, the jobs and occupations at the heart of this super-creative non-fiction read will inspire all children to seek out the everyday science in the world around us.
Автор: Achim Kramer; Martha Merrow Название: Circadian Clocks ISBN: 3642448534 ISBN-13(EAN): 9783642448539 Издательство: Springer Рейтинг: Цена: 55901.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book provides the reader with a contemporary and comprehensive overview about the molecular, cellular and system-wide principles of circadian clock regulation. Emphasis is placed on the importance of circadian clocks for the timing of therapeutic interventions.
Автор: Amita Sehgal Название: Circadian Rhythms and Biological Clocks Part B,552 ISBN: 0128033800 ISBN-13(EAN): 9780128033807 Издательство: Elsevier Science Рейтинг: Цена: 23244.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Two new volumes of Methods in Enzymology continue the legacy of this premier serial with quality chapters authored by leaders in the field. Circadian Rhythms and Biological Clocks Part A and Part B is an exceptional resource for anybody interested in the general area of circadian rhythms. As key elements of timekeeping are conserved in organisms across the phylogenetic tree, and our understanding of circadian biology has benefited tremendously from work done in many species, the volume provides a wide range of assays for different biological systems. Protocols are provided to assess clock function, entrainment of the clock to stimuli such as light and food, and output rhythms of behavior and physiology. This volume also delves into the impact of circadian disruption on human health. Contributions are from leaders in the field who have made major discoveries using the methods presented here.
Автор: Leland N. Jr. Edmunds Название: Cellular and Molecular Bases of Biological Clocks ISBN: 1461283299 ISBN-13(EAN): 9781461283294 Издательство: Springer Рейтинг: Цена: 14673.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The six chapters of this work include a brief introduction to circadian (24-hour) rhythms, a survey of circadian organization at the cellular level, and a description of the important microorganisms that have served as experimental models for biochemical analysis.
Автор: Moskalev, Alexey Название: Epigenetics of Aging and Longevity ISBN: 0128110600 ISBN-13(EAN): 9780128110607 Издательство: Elsevier Science Рейтинг: Цена: 19875.00 р. Наличие на складе: Поставка под заказ.
Описание:
Epigenetics of Aging and Longevity provides an in-depth analysis of the epigenetic nature of aging and the role of epigenetic factors in mediating the link between early-life experiences and life-course health and aging. Chapters from leading international contributors explore the effect of adverse conditions in early-life that may result in disrupted epigenetic pathways, as well as the potential to correct these disrupted pathways via targeted therapeutic interventions. Intergenerational epigenetic inheritance, epigenetic drug discovery, and the role of epigenetic mechanisms in regulating specific age-associated illnesses--including cancer and cardiovascular, metabolic, and neurodegenerative diseases--are explored in detail.
This book will help researchers in genomic medicine, epigenetics, and biogerontology better understand the epigenetic determinants of aging and longevity, and ultimately aid in developing therapeutics to extend the human life-span and treat age-related disease.
Автор: Alexey Moskalev Название: Biomarkers of Human Aging ISBN: 3030249697 ISBN-13(EAN): 9783030249694 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book collects and reviews, for the first time, a wide range of advances in the area of human aging biomarkers. This accumulated data allows researchers to assess the rate of aging processes in various organs and systems, and to individually monitor the effectiveness of therapies intended to slow aging.In an introductory chapter, the editor defines biomarkers of aging as molecular, cellular and physiological parameters that demonstrate reproducible changes - quantitative or qualitative - with age. The introduction recounts a study which aimed to create a universal model of biological age, whose most predictive parameters were albumin and alkaline phosphatase (indication liver function), glucose (metabolic syndrome), erythrocytes (respiratory function) and urea (renal function).The book goes on to describe DNA methylation, known as the “epigenetic clock,” as currently the most comprehensive predictor of total mortality. It is also useful for predicting mortality from cancer and cardiovascular diseases, and for analyzing the effects of lifestyle factors including diet, exercise, and education. Individual contributions draw additional insight from research on genetics and epigenetic aging markers, and immunosenescence and inflammaging markers. A concluding chapter outlines the challenge of integrating of biological and clinical markers of aging.Biomarkers of Human Aging is written for professionals and practitioners engaged in the study of aging, and will be useful to both advanced students and researchers.
Автор: Arthur V. Everitt; Suresh I. S. Rattan; David G. C Название: Calorie Restriction, Aging and Longevity ISBN: 9400791151 ISBN-13(EAN): 9789400791152 Издательство: Springer Рейтинг: Цена: 28732.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Long-term reduction in calorie intake will delay the onset of age-related diseases such as heart disease, diabetes and cancer. This book provides the latest information on the beneficial effects of calorie restriction on health and life-span.
Автор: Yashin Anatoliy I., Stallard Eric, Land Kenneth C. Название: Biodemography of Aging: Determinants of Healthy Life Span and Longevity ISBN: 940241388X ISBN-13(EAN): 9789402413885 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume is a critical exposition of the data and analyses from a full decade of rigorous research into how age-related changes at the individual level, along with other factors, contribute to morbidity, disability and mortality risks at the broader population level. After summarizing the state of our knowledge in the field, individual chapters offer enlightening discussion on a range of key topics such as age trajectory analysis in select and general populations, incidence/age patterns of major chronic illnesses, and indices of cumulative deficits and their use in characterizing and understanding the detailed properties of individual aging. The book features comprehensive statistical analyses of unique longitudinal data sets including the unique resource of the Framingham Heart Study, with its more than 60 years of follow-up. Culminating in penetrating conclusions about the insights gained from the work involved, this book adds much to our understanding of the links between aging and human health.
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