Advances In Adrenergic Receptor Biology,67, Wang, Qin

Автор: Gerald Litwack
Название: Receptor Purification
ISBN: 1461267714 ISBN-13(EAN): 9781461267713
Издательство: Springer
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Автор: Gerald Litwack
Название: Receptor Purification
ISBN: 146126779X ISBN-13(EAN): 9781461267799
Издательство: Springer
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Автор: Hao Wu
Название: TNF Receptor Associated Factors (TRAFs)
ISBN: 1441924205 ISBN-13(EAN): 9781441924209
Издательство: Springer
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Описание:

This book is the only literature that is entirely devoted to TNF Receptor Associated Factors (TRAFs). Almost every aspect of TRAF signaling is covered. The book is intended for a wide audience, including researchers in the field of TRAF signaling and students and postdoctoral fellows learning cell biology and cell signal transduction. This exciting new volume is up-to-date on the most recent advances in TRAF signal transduction.

Автор: Fisher, Paul B.
Название: Receptor Tyrosine Kinases,147
ISBN: 0128201428 ISBN-13(EAN): 9780128201428
Издательство: Elsevier Science
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Описание:

Advances in Cancer Research, Volume 147, the latest release in this ongoing, well-regarded serial, provides invaluable information on the exciting and fast-moving field of cancer research in the area of Receptor Tyrosine Kinases (RTKs) in the context of major basic science and translational advances, its importance in the development of a large number of anti-cancer drugs over the decades, and a peek into postulated advances in the coming decades for a number of RTK. Chapters in this new release has been contributed by a group of International leading scientists with a rich history of original contributions to the field.

Автор: Zhixiang Wang
Название: ErbB Receptor Signaling
ISBN: 1493972189 ISBN-13(EAN): 9781493972180
Издательство: Springer
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Описание: This volume contains protocols specifically designed for studying cell signaling mediated by ErbB receptors, all applicable to the study of a broad range of ErbB receptor-mediated signaling from basic research to clinic applications, from cultured cells to various animal models and primary cancer cells from patients.

Автор: Deric L. Wheeler; Yosef Yarden
Название: Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease
ISBN: 1493920529 ISBN-13(EAN): 9781493920525
Издательство: Springer
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Описание: Receptor Tyrosine Kinase: Structure, Functions and Role in Human Disease, for the first time, systematically covers the shared structural and functional features of the RTK family.

Автор: Y.A. Vinnikov; N. Bobrov; S. Price
Название: Evolution of Receptor Cells
ISBN: 3642817270 ISBN-13(EAN): 9783642817274
Издательство: Springer
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Описание: A dinner party at his apartment is among the warmest of my memories, and nothing could please me more than to have the opportunity to introduce him in per- son to my colleagues in Western Europe, the Americas, Japan, and Australia.

Автор: McEwan, PhD
Название: The Nuclear Receptor Superfamily
ISBN: 1493937227 ISBN-13(EAN): 9781493937226
Издательство: Springer
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Цена: 19564.00 р.
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Описание: Thisvolume aims to describe acomplementary range of molecular, cell biological, and in vivo protocols used to investigatethe structure–function of nuclear receptors, together with experimentalapproaches that may lead to new drugs to selectively target nuclearreceptor-associated diseases. The NuclearReceptor Superfamily, Second Edition will benefit those starting out in thenuclear receptor research field as well as to more established researchers whowish to apply different methods to a particular receptor or research problem.Written in the highly successful Methods in Molecular Biology seriesformat, chapters include introductions to their respective topics, lists of thenecessary materials and reagents, step-by-step, readily reproducible laboratoryprotocols, and tips on troubleshooting and avoiding known pitfalls.Authoritativeand cutting-edge, The Nuclear ReceptorSuperfamily, Second Edition aims to ensure successful results in thefurther study of this vital field.

Автор: Lieberman Benjamin A.
Название: Steroid Receptor Methods / Protocols and Assays
ISBN: 0896037541 ISBN-13(EAN): 9780896037540
Издательство: Springer
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Описание: A distinguished team of principal investigators and their associates describe in step-by-step detail a cross-section of the latest research techniques available for studying the endocrine system. As a basis for sophisticated biochemical analysis of receptor properties, the contributors provide methods for the production and purification of a variety of receptors, including progesterone, glucocorticoid, and androgen. Other protocols allow the reader to experiment with DNA binding characteristics, hormone binding assays, and the use of combinatorial chemistry for drug discovery. A series of novel methods utilizing the latest advances in immunochemistry, yeast two-hybrid screening, and fluorescence are included for the detection and analysis of a variety of cellular proteins that influence steroid receptor effectiveness.

Автор: Serena Germano
Название: Receptor Tyrosine Kinases
ISBN: 1493917889 ISBN-13(EAN): 9781493917884
Издательство: Springer
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Цена: 13974.00 р.
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Описание: Receptor Tyrosine Kinases: Methods and Protocols explores on the most widely studied of the protein classes, known for their central role in several cellular functions and in a variety of human pathologies. Beginning with a section on activation and signaling of Receptor Tyrosine Kinases (RTKs), the book continues with chapters on aberrant expression of RTKs, trafficking and negative regulation, as well as RTKs as pharmacological targets. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Receptor Tyrosine Kinases: Methods and Protocols contains an up-to-date overview of the most relevant and widely used methods employed in this field, providing detailed protocols that molecular and cellular biologists could easily adopt in their research programs on RTKs.

Автор: Serena Germano
Название: Receptor Tyrosine Kinases
ISBN: 1493954490 ISBN-13(EAN): 9781493954490
Издательство: Springer
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Описание:

Part I: RTKs Activation and Signalling

1. Analysis of Receptor Tyrosine Kinase (RTK) Phosphorylation by Immunoblotting

Martina McDermott and Norma O'Donovan

2. Analysis of Changes in Phosphorylation of Receptor Tyrosine Kinases: Antibody Arrays

Sweta Rani and Lorraine O'Driscoll

3. Analysis of Epidermal Growth Factor Receptor Dimerization by BS³ Crosslinking

Harmony F. Turk and Robert S. Chapkin

4. Single-Molecule Optical Methods Analyzing Receptor Tyrosine Kinase Activation in Living Cells

Inhee Chung and Ira Mellman

5. Evaluation of the Dimerization Profiles of HER Tyrosine Kinases by Time-Resolved Fцrster Resonance Energy Transfer (TR-FRET)

Evelyne Lopez-Crapez, Alexandre Ho-Pun-Cheung, Patrick Garnero, and Hervй Bazin

6. Applying the Proximity Ligation Assay (PLA) to Mouse Preimplantation Embryos for Identifying Protein-Protein Interactions In Situ

Ivan Bedzhov and Marc P. Stemmler

Part II: RTKs Aberrant Expression

7. Analysis of Receptor Tyrosine Kinase Gene Amplification on the Example of FGFR1

Diana Boehm, Anne von Mдssenhausen, and Sven Perner

8. Quantification of the Effects of Mutations on Receptor Tyrosine Kinase (RTK) Activation in Mammalian Cells

Lijuan He and Kalina Hristova

Part III: RTKs Trafficking and Negative Regulation

9. Cell Surface Biotinylation of Receptor Tyrosine Kinases to Investigate Intracellular Trafficking

Mathieu J.F. Crupi, Douglas S. Richardson, and Lois M. Mulligan

10. Studying N-Linked Glycosylation of Receptor Tyrosine Kinases

Harri M. Itkonen and Ian G. Mills

11. Identification of Receptor Protein Tyrosine Phosphatases (RPTPs) as Regulators of Receptor Tyrosine Kinases (RTKs) Using an RPTP siRNA-RTK Substrate Screen

Hojin Lee and Anton M. Bennett

12. Downregulation of Receptor Tyrosine Kinases Through Ubiquitination: Analysis by Immunodetection

Noriaki Shimokawa and Noriyuki Koibuchi

13. Regulation of Receptor Tyrosine Kinases by miRNA: Overexpression of miRNA Using Lentiviral Inducible Expression Vectors

XiangDong Le, Andrew T. Huang, Yunyun Chen, and Stephen Y. Lai

Part IV: RTKs as Pharmacological Targets

14. Human Tumor Xenografts in Mouse as a Model for Evaluating Therapeutic Efficacy of Monoclonal Antibodies or Antibody-Drug Conjugate Targeting Receptor Tyrosine Kinases

Liang Feng, Wei Wang, Hang-Ping Yao, Jianwei Zhou, Ruiwen Zhang, and Ming-Hai Wang

15. Receptor Tyrosine Kinase Targeting in Multicellular Spheroids

Susan Breslin and Lorraine O'Driscoll

16. Receptor Tyrosine Kinases and Drug Resistance: Development and Characterization of In Vitro Models of Resistance to RTK Inhibitors

Claire Corcoran and Lorraine O'Driscoll

Автор: Iain J. McEwan, PhD
Название: The Nuclear Receptor Superfamily
ISBN: 149398120X ISBN-13(EAN): 9781493981205
Издательство: Springer
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Цена: 13974.00 р.
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Описание: The NuclearReceptor Superfamily, Second Edition will benefit those starting out in thenuclear receptor research field as well as to more established researchers whowish to apply different methods to a particular receptor or research problem.