Автор: Alfred Wittinghofer Название: Ras Superfamily Small G Proteins: Biology and Mechanisms 2 ISBN: 3319077600 ISBN-13(EAN): 9783319077604 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This second of two volumes discusses subfamily proteins which function in molecular and vesicular transport mechanisms inside the cell. In this volume the focus lies on the Rab, Ran and Arf subfamily members. As in Volume 1, the book is written by international renowned scientists in the field of small G-proteins. In elaborate reviews, biochemistry, structure, function and G-protein - effector interactions are described. Together with Volume 1 this book provides an comprehensive state-of-the-art work on small G-proteins (GTPases). It is written for Graduates and Professors in Biochemistry and Cell Biology interested in the mechanism and function of small G-proteins but are extremely valuable for those who want to move into the field.
Автор: Frank Kozielski, FSB Название: Kinesins and Cancer ISBN: 9401797315 ISBN-13(EAN): 9789401797313 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This interdisciplinary volume collates research work on kinesins and cancer. Authors attempt to validate members of the kinesin superfamily as potential targets for drug development in cancer chemotherapy. The work begins by highlighting the importance of kinesins, summarising current knowledge and how they are shown to be crucial for mitosis. Chapters go on to explore how this family of proteins are emerging as a novel target for chemotherapeutic intervention and drug development. Readers will learn how kinesins travel along microtubules to fulfill their many roles in intracellular transport or cell division. Several compounds that inhibit two mitotic kinesins (called Eg5 and CENP-E) have entered Phase I and II clinical trials and are explored in these chapters. Additional mitotic kinesins are currently being validated as drug targets, raising the possibility that the repertoire of kinesin-based drug targets may expand in the future. The book is suitable as a reference standard for the field of kinesins and cancer. It will interest those in academia and pharmaceutical companies, and anyone with an interest in the medical relevance of these proteins, which cutting edge methodologies are now enabling us to understand in astonishing detail.
Название: The Kinesin Superfamily Handbook ISBN: 113858956X ISBN-13(EAN): 9781138589568 Издательство: Taylor&Francis Рейтинг: Цена: 22202.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book brings together current information on the families that make up the kinesin superfamily of molecular motors in one comprehensive text; an ideal reference for reseachers looking to make comparisons between different familiies, for specific information on a family, or simply for an overview of the kinesin superfamily.
Автор: Alfred Wittinghofer Название: Ras Superfamily Small G Proteins: Biology and Mechanisms 2 ISBN: 3319378082 ISBN-13(EAN): 9783319378084 Издательство: Springer Рейтинг: Цена: 18284.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This second of two volumes discusses subfamily proteins which function in molecular and vesicular transport mechanisms inside the cell. It is written for Graduates and Professors in Biochemistry and Cell Biology interested in the mechanism and function of small G-proteins but are extremely valuable for those who want to move into the field.
Автор: Ruggiero Florence Название: The Collagen Superfamily and Collagenopathies ISBN: 3030675912 ISBN-13(EAN): 9783030675912 Издательство: Springer Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book aims at providing insights into the collagen superfamily and the remarkable diversity of collagen function within the extracellular matrix.
Автор: Ruggiero Название: The Collagen Superfamily and Collagenopathies ISBN: 3030675947 ISBN-13(EAN): 9783030675943 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book aims at providing insights into the collagen superfamily and the remarkable diversity of collagen function within the extracellular matrix.
Автор: Suzuki Название: The Cadherin Superfamily ISBN: 4431567593 ISBN-13(EAN): 9784431567592 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Поставка под заказ.
Описание: This book presents an overview of the entire field of cadherin research and provides the current basic concept of cadherins. Cadherins have been widely accepted as key regulators of animal development and physiological functions, and it also has become clear that they play essential roles in various human diseases. With contributions by leading scientists, the book covers various aspects of the cadherin superfamily including the history of cadherin research, basic properties of classical cadherins as well as non-classical cadherins, cadherin-associated proteins, and the roles of cadherins in health and diseases. In addition, the book presents some contradictory results and important unanswered questions, and the authors propose their working hypotheses or future directions, to inspire future studies. This volume enables graduate students and young researchers to learn the basics and gain a comprehensive image of the cadherin superfamily, and experts in the field will easily find various topics of interest in relevant areas of study. Additionally, a list of cadherin-related diseases is included for quick reference to cadherins in human diseases.
Автор: Iain J. McEwan, PhD Название: The Nuclear Receptor Superfamily ISBN: 149398120X ISBN-13(EAN): 9781493981205 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The NuclearReceptor Superfamily, Second Edition will benefit those starting out in thenuclear receptor research field as well as to more established researchers whowish to apply different methods to a particular receptor or research problem.
Автор: Alfred Wittinghofer Название: Ras Superfamily Small G Proteins: Biology and Mechanisms 1 ISBN: 3709118050 ISBN-13(EAN): 9783709118054 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This first of two volumes provides a general overview of the genetics, structure, mechanism and regulation of the Ras superfamily proteins and describes in detail the signaling pathways and processes regulated by specific members of this family. The focus of this first volume is on the Rho and Ras subfamily of small G proteins. Renowned scientists provide insights into the biochemistry of the classical and non-classical small G-protein family members, their spatio-temporal regulation, their effectors and their roles in health and disease. Together with Volume 2, this book provides a comprehensive and state-of-the-art work on small G-proteins (GTPases). It is intended for graduates and professors in biochemistry and cell biology already working on small G-proteins (small GTPases), but also offers an extremely valuable resource for those readers who are new to the field.
Автор: Coluccio Lynne M. Название: Myosins: A Superfamily of Molecular Motors ISBN: 3030380610 ISBN-13(EAN): 9783030380618 Издательство: Springer Цена: 27950.00 р. Наличие на складе: Поставка под заказ.
Описание: This highly authoritative volume highlights the remarkable superfamily of molecular motors called myosins, which are involved in such diverse cellular functions as muscle contraction, intracellular transport, cell migration and cell division.
Автор: McEwan, PhD Название: The Nuclear Receptor Superfamily ISBN: 1493937227 ISBN-13(EAN): 9781493937226 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Thisvolume aims to describe acomplementary range of molecular, cell biological, and in vivo protocols used to investigatethe structure–function of nuclear receptors, together with experimentalapproaches that may lead to new drugs to selectively target nuclearreceptor-associated diseases. The NuclearReceptor Superfamily, Second Edition will benefit those starting out in thenuclear receptor research field as well as to more established researchers whowish to apply different methods to a particular receptor or research problem.Written in the highly successful Methods in Molecular Biology seriesformat, chapters include introductions to their respective topics, lists of thenecessary materials and reagents, step-by-step, readily reproducible laboratoryprotocols, and tips on troubleshooting and avoiding known pitfalls.Authoritativeand cutting-edge, The Nuclear ReceptorSuperfamily, Second Edition aims to ensure successful results in thefurther study of this vital field.
Автор: Isabelle Vernos Название: Kinesin Protocols ISBN: 1617371785 ISBN-13(EAN): 9781617371783 Издательство: Springer Рейтинг: Цена: 20263.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: By the end of the 1980s only two microtubule-dependent motors, the plus end-directed kinesin and the minus end-directed cytoplasmic dynein, had been identified.
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