Автор: Matlin, Lisa M. Название: Only Ones Who Know, The ISBN: 0593599985 ISBN-13(EAN): 9780593599983 Издательство: Random House (USA) Рейтинг: Цена: 2759.00 р. Наличие на складе: Нет в наличии.
Автор: Matlin, Lisa M. Название: Stranger Upstairs, The ISBN: 0593599977 ISBN-13(EAN): 9780593599976 Издательство: Random House (USA) Рейтинг: Цена: 1655.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Matlin, Marlee Название: I`ll scream later ISBN: 1439171513 ISBN-13(EAN): 9781439171516 Издательство: Simon & Schuster Рейтинг: Цена: 2619.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Matlin, Lisa M Название: The Stranger Upstairs ISBN: 0593599950 ISBN-13(EAN): 9780593599952 Издательство: Random House (USA) Рейтинг: Цена: 2575.00 р. Наличие на складе: Нет в наличии.
Автор: Matlin, Marlee ; Cooney, Doug Название: Leading Ladies ISBN: 1481492276 ISBN-13(EAN): 9781481492270 Издательство: Simon & Schuster Рейтинг: Цена: 1608.00 р. Наличие на складе: Нет в наличии.
Описание: A close look at Gьnter Blobel's transformative contributions to molecular cell biology. The difficulty of reconciling chemical mechanisms with the functions of whole living systems has plagued biologists since the development of cell theory in the nineteenth century. As Karl S. Matlin argues in Crossing the Boundaries of Life, it is no coincidence that this longstanding knot of scientific inquiry was loosened most meaningfully by the work of a cell biologist, the Nobel laureate Gьnter Blobel. In 1975, using an experimental setup that did not contain any cells at all, Blobel was able to target newly made proteins to cell membrane vesicles, enabling him to theorize how proteins in the cell distribute spatially, an idea he called the signal hypothesis. Over the next twenty years, Blobel and other scientists were able to dissect this mechanism into its precise molecular details. For elaborating his signal concept into a process he termed membrane topogenesis--the idea that each protein in the cell is synthesized with an "address" that directs the protein to its correct destination within the cell--Blobel was awarded the Nobel Prize in Physiology or Medicine in 1999. Matlin argues that Blobel's investigative strategy and its subsequent application addressed a fundamental unresolved dilemma that had bedeviled biology from its very beginning--the relationship between structure and function--allowing biology to achieve mechanistic molecular explanations of biological phenomena. Crossing the Boundaries of Life thus uses Blobel's research and life story to shed light on the importance of cell biology for twentieth-century science, illustrating how it propelled the development of adjacent disciplines like biochemistry and molecular biology.
Описание: A close look at Gьnter Blobel's transformative contributions to molecular cell biology. The difficulty of reconciling chemical mechanisms with the functions of whole living systems has plagued biologists since the development of cell theory in the nineteenth century. As Karl S. Matlin argues in Crossing the Boundaries of Life, it is no coincidence that this longstanding knot of scientific inquiry was loosened most meaningfully by the work of a cell biologist, the Nobel laureate Gьnter Blobel. In 1975, using an experimental setup that did not contain any cells at all, Blobel was able to target newly made proteins to cell membrane vesicles, enabling him to theorize how proteins in the cell distribute spatially, an idea he called the signal hypothesis. Over the next twenty years, Blobel and other scientists were able to dissect this mechanism into its precise molecular details. For elaborating his signal concept into a process he termed membrane topogenesis--the idea that each protein in the cell is synthesized with an "address" that directs the protein to its correct destination within the cell--Blobel was awarded the Nobel Prize in Physiology or Medicine in 1999. Matlin argues that Blobel's investigative strategy and its subsequent application addressed a fundamental unresolved dilemma that had bedeviled biology from its very beginning--the relationship between structure and function--allowing biology to achieve mechanistic molecular explanations of biological phenomena. Crossing the Boundaries of Life thus uses Blobel's research and life story to shed light on the importance of cell biology for twentieth-century science, illustrating how it propelled the development of adjacent disciplines like biochemistry and molecular biology.
Автор: Matlin J. S. Название: Truth To Power ISBN: 0244195277 ISBN-13(EAN): 9780244195274 Издательство: Неизвестно Рейтинг: Цена: 3502.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A hasty departure from his previous newspaper, journalist David Driscoll arrives in the Midwest city of St Luke to start a new job at the town's foremost newspaper. He wastes no time in looking up his old playground protector, Mike Doyle, now a popular politician and leader of the city council. Doyle has power, glamour, and gets exactly what he wants. They see mutual benefits in each other and as they rekindle their acquaintance, it gets personal. What follows is a cat and mouse game set across the political and criminal backdrop of Prohibition America as each man tries to best the other.
ООО "Логосфера " Тел:+7(495) 980-12-10 www.logobook.ru
