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Evaluation of enzyme inhibitors in drug discovery - a guide for medicinal chemists and pharmacologists, second edition, Copeland, Ra


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Автор: Copeland, Ra
Название:  Evaluation of enzyme inhibitors in drug discovery - a guide for medicinal chemists and pharmacologists, second edition
ISBN: 9781118488133
Издательство: Wiley
Классификация:

ISBN-10: 111848813X
Обложка/Формат: Hardback
Страницы: 576
Вес: 1.11 кг.
Дата издания: 05.03.2013
Язык: English
Издание: 2 ed
Размер: 165 x 242 x 34
Читательская аудитория: Professional & vocational
Подзаголовок: A guide for medicinal chemists and pharmacologists
Ссылка на Издательство: Link
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Поставляется из: Англии


Zinc Enzyme Inhibitors: Enzymes from Microorganisms

Автор: Supuran Claudiu T., Capasso Clemente
Название: Zinc Enzyme Inhibitors: Enzymes from Microorganisms
ISBN: 3319834444 ISBN-13(EAN): 9783319834443
Издательство: Springer
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Цена: 32142.00 р.
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Описание: An Elusive Task: A Clinically Useful Inhibitor of Metallo-β-Lactamases.- Inhibitors of Histidinol Dehydrogenase.- Botulinum Neurotoxin, Tetanus Toxin, and Anthrax Lethal Factor Countermeasures.- Inhibition and Activity Regulation of Bacterial Collagenases.- Fungal Carbonic Anhydrases and Their Inhibition.- Protozoan Carbonic Anhydrases.- Bacterial Carbonic Anhydrases.

The Design of Covalent-Based Inhibitors

Автор: Ward Richard A., Grimster Neil
Название: The Design of Covalent-Based Inhibitors
ISBN: 0128216891 ISBN-13(EAN): 9780128216897
Издательство: Elsevier Science
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Цена: 23244.00 р.
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Описание:

Annual Report on Medicinal Chemistry series, highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

Pharmacology for Chemists: Drug Discovery in Context

Название: Pharmacology for Chemists: Drug Discovery in Context
ISBN: 1782621423 ISBN-13(EAN): 9781782621423
Издательство: Royal Society of Chemistry
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Цена: 18372.00 р.
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Описание: This textbook explains the key issues in pharmacology to chemists interested in or planning to work in drug discovery.

Zinc Enzyme Inhibitors

Автор: Claudiu T. Supuran; Clemente Capasso
Название: Zinc Enzyme Inhibitors
ISBN: 3319461117 ISBN-13(EAN): 9783319461113
Издательство: Springer
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Цена: 30745.00 р.
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Описание: Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

Farnesyltransferase Inhibitors in Cancer Therapy

Автор: Sa?d M. Sebti; Andrew D. Hamilton
Название: Farnesyltransferase Inhibitors in Cancer Therapy
ISBN: 1468496069 ISBN-13(EAN): 9781468496062
Издательство: Springer
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Цена: 20962.00 р.
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mTOR Pathway and mTOR Inhibitors in Cancer Therapy

Автор: Vitaly A. Polunovsky; Peter J. Houghton
Название: mTOR Pathway and mTOR Inhibitors in Cancer Therapy
ISBN: 1617796948 ISBN-13(EAN): 9781617796944
Издательство: Springer
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Цена: 28732.00 р.
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Описание: The target of rapamycin (TOR) was rst identi ed in Saccharomyces cerevisiae and subsequently in mammals (mTOR) as a conserved atypical serine/threonine kinase. Rapamycin was isolated as a product of the soil bacteria Streptomyces hygroscopicus, identi ed in a soil sample taken from the island of Rapa Nui (Easter Island).

PARP Inhibitors for Cancer Therapy

Автор: Nicola J. Curtin; Ricky A. Sharma
Название: PARP Inhibitors for Cancer Therapy
ISBN: 3319141503 ISBN-13(EAN): 9783319141503
Издательство: Springer
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Цена: 23757.00 р.
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Описание: PARP Inhibitors for Cancer Therapy provides a comprehensive overview of the role of PARP in cancer therapy. PARP plays a pivotal role in DNA repair and may contribute to the therapeutic resistance to DNA damaging agents used to treat cancer.

Alpha-Glucosidase Inhibitors

Автор: Ghani, Usman
Название: Alpha-Glucosidase Inhibitors
ISBN: 0081027796 ISBN-13(EAN): 9780081027790
Издательство: Elsevier Science
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Цена: 29476.00 р.
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Описание:

Alpha-glucosidase Inhibitors: Clinically Promising Candidates for Anti-diabetic Drug Discovery presents information that researchers can use to address a whole host of promising leads for the development of novel, oral, anti-diabetic drugs with improved efficacy and fewer side effects. Beginning with a discussion of the huge potential of α -glucosidase inhibitor leads and adaptations, and highlighting their importance within the field of anti-diabetic drug discovery, the book provides chemical structures, detailed background information and in vivo and in vitro biological activity data, and more economical adaptations of these structures.

Drawing on the author's expert research in the field, this book highlights promising leads for development and helps researchers select the most appropriate inhibitors for their own work. It is a useful tool not only for anti-diabetic drug development researchers, but also for those whose research may be enhanced by an understanding of α -glucosidase inhibitor chemistry and activity.

Parp Inhibitors for Cancer Therapy

Автор: Curtin Nicola J., Sharma Ricky A.
Название: Parp Inhibitors for Cancer Therapy
ISBN: 3319344897 ISBN-13(EAN): 9783319344898
Издательство: Springer
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Цена: 20962.00 р.
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Описание: PARP Inhibitors for Cancer Therapy provides a comprehensive overview of the role of PARP in cancer therapy. The volume covers the history of the discovery of PARP (poly ADP ribose polymerase) and its role in DNA repair. In addition, a description of discovery of the PARP family, and other DNA maintenance-associated PARPs will also be discussed. The volume also features a section on accessible chemistry behind the development of inhibitors. PARP inhibitors are a group of pharmacological inhibitors that are a particularly good target for cancer therapy. PARP plays a pivotal role in DNA repair and may contribute to the therapeutic resistance to DNA damaging agents used to treat cancer. Researchers have learned a tremendous amount about the biology of PARP and how tumour-specific defects in DNA repair can be exploited by PARPi. The “synthetic lethality” of PARPi is an exciting concept for cancer therapy and has led to a heightened activity in this area.

Design of Caspase Inhibitors as Potential Clinical Agents

Название: Design of Caspase Inhibitors as Potential Clinical Agents
ISBN: 0367386577 ISBN-13(EAN): 9780367386573
Издательство: Taylor&Francis
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Цена: 9798.00 р.
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Описание:

Presents the Therapeutic Potential for Caspase Inhibitors: Present and Future

Caspases represent one of the most specific protease families described to date. These extremely important enzymes are crucial to the destruction of aberrant cells - the body's self-protection mechanism for warding off the growth of abnormal cells, many of which can promote cancer. Design of Caspase Inhibitors as Potential Clinical Agents introduces cutting-edge evidence regarding caspases' role in pro-inflammatory responses. New research now shows that the inhibition of caspase function is a critical component for the treatment of many diseases, including:

  • Arthritic and neurological disorders
  • Lung disease
  • Hereditary fever syndromes
  • Inflammatory bowel and skin diseases
  • Sepsis
  • Liver fibrosis

Outlines Efforts to Develop Molecule Inhibitors for Caspase Activity Transformation

Under the editorial guidance of authoritative inflammatory disease, small molecule discovery, and apoptosis researchers, the book organizes the wide array of caspase literature into one convenient resource. It also summarizes the relative difficulty of transitioning a caspase small molecule inhibitor from the lab to the clinic and suggests approaches to circumvent this difficulty. Taking a novel, yet core approach to disease treatment, this seminal work sets the stage to combat a slew of debilitating diseases through groundbreaking drug development.

Proteinkinase Inhibitors

Автор: Laufer Stefan
Название: Proteinkinase Inhibitors
ISBN: 3030681823 ISBN-13(EAN): 9783030681821
Издательство: Springer
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Цена: 19564.00 р.
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Описание: Chapters written by experts from industry and academia cover the function, structure and topology of Proteinkinases, molecular modelling, disclose how to achieve high level of selectivity for kinase inhibitors, and exploit kinase inhibitors for cancer treatment.

Natural Products as Enzyme Inhibitors

Автор: Maheshwari
Название: Natural Products as Enzyme Inhibitors
ISBN: 9811909318 ISBN-13(EAN): 9789811909313
Издательство: Springer
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Цена: 20962.00 р.
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Описание: Chapters in this book cover topics such as plant-derived inhibitors of serine proteases, pancreatic lipase (PL) inhibitors from indigenous medicinal plants, amylase inhibitors and their applications in agriculture and food processing industries and advances in silico techniques used in the study of enzyme inhibitors.


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