Model-Assisted Bayesian Designs for Dose Finding and Optimization, Yuan, Ying
Автор: Cheung, Ying Kuen Название: Dose Finding by the Continual Reassessment Method ISBN: 1420091514 ISBN-13(EAN): 9781420091519 Издательство: Taylor&Francis Рейтинг: Цена: 24499.00 р. Наличие на складе: Поставка под заказ.
Автор: Wolfgang von der Linden; Volker Dose; Rainer Fisch Название: Maximum Entropy and Bayesian Methods Garching, Germany 1998 ISBN: 9401059829 ISBN-13(EAN): 9789401059824 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of the 18th International Workshop on Maximum Entropy and Bayesian Methods of Statistical Analysis
Автор: Wolfgang von der Linden; Volker Dose; Rainer Fisch Название: Maximum Entropy and Bayesian Methods Garching, Germany 1998 ISBN: 0792357663 ISBN-13(EAN): 9780792357667 Издательство: Springer Рейтинг: Цена: 27245.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Taken from the 1998 MaxEnt conference, this work contains a range of applications of Bayesian probability theory and maximum entropy methods to problems of concern in such fields as physics, image processing, coding theory, machine learning, economics, data analysis and various other problems.
Автор: Takashi Daimon; Akihiro Hirakawa; Shigeyuki Matsui Название: An Introduction to Dose-Finding Methods in Early Phase Clinical Trials ISBN: 4431555846 ISBN-13(EAN): 9784431555841 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Included are rule-based and model-based designs, such as 3 + 3 designs, accelerated titration designs, toxicity probability interval designs, continual reassessment method and related designs, and escalation overdose control designs.
Автор: Naitee Ting Название: Dose Finding in Drug Development ISBN: 144192115X ISBN-13(EAN): 9781441921154 Издательство: Springer Рейтинг: Цена: 20896.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: If you have ever wondered when visiting the pharmacy how the dosage of your prescription is determined this book will answer your questions. It introduces the drug development process and explains the practical concerns in selecting doses for a new drug.
Описание: This handbook provides an overview of up-to-date statistical methods required for design, monitoring and analysis for dose finding clinical trials, focusing both on the clinical aspects as well as statistical considerations. This book will not cover statistical methods for Phase II non-dose finding studies or Phase III clinical trials.
Автор: Pazhayattil Ajay, Sayeed-Desta Naheed, Fredro-Kumbaradzi Emilija Название: Solid Oral Dose Process Validation, Volume Two: Lifecycle Approach Application ISBN: 3030274837 ISBN-13(EAN): 9783030274832 Издательство: Springer Рейтинг: Цена: 11878.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The textbook addresses the lifecycle concepts (Stage 1, 2, 3) of Process Validation. Regulatory bodies such as US FDA, EMEA, WHO, PIC/S have adopted the ICH lifecycle approach. Organizations have an opportunity to harmonize and align PV activities for all regulated markets. The concepts discussed provides a direction on how to approach solid dose manufacturing process validation for regulatory compliance. Solid Oral Dose Process Validation, Lifecycle Approach: Application, Volume Two and the companion Volume One, Solid Dose Process Validation, The Basics, also available as a set, provide directions and solutions for the pharmaceutical industry. The topics and chapters give a systematic understanding for the application of lifecycle concepts in solid dose pharmaceutical manufacturing. Since solid dose formulations encompass majority of the pharmaceutical preparations, it is essential information for pharmaceutical professionals who use the process validation lifecycle approach. This set is published as a comprehensive solution for solid dose process validation.
Автор: Tallarida, Ronald J. Название: Drug Synergism and Dose-Effect Data Analysis ISBN: 0367398346 ISBN-13(EAN): 9780367398347 Издательство: Taylor&Francis Рейтинг: Цена: 9798.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Not since this author's bestselling Manual of Pharmacologic Calculation-long out of print-has there been a reference available for drug data analysis, and even that work did not deal with drug combinations. Although pharmacologists and most other scientists know what synergism is, mainstream textbooks tend to neglect it as a quantitative topic. Few researchers are familiar with the quantitative methodology needed to differentiate synergistic responses from the simply additive responses expected from drug combinations or a single drug's interaction with endogenous chemicals.
In Drug Synergism and Dose-Effect Data Analysis, noted pharmacologist, mathematician, and author Ronald J. Tallarida finally brings these methods to light. Drawing on statistical theory and methods but keeping the special needs of the pharmacologist in mind, he begins his treatment with dose-response relations, the statistical analysis of the data, and the models that describe them. He also offers the only modern presentation of probit and logit analysis and provides detailed calculation methods not found in typical statistics books. Numerous examples accompany a presentation that clearly illustrates the calculations and experimental design considerations for modern drug analysis. You'll find the conceptual background, the algorithms, and new research developments. In short, Drug Synergism and Dose-Effect Data Analysis has everything you need to perform, with confidence, the quantitative analysis of dose response data.
Автор: Ronald J. Tallarida; Leonard S. Jacob Название: The Dose—Response Relation in Pharmacology ISBN: 1468462679 ISBN-13(EAN): 9781468462678 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Another line of investigation is concerned with the kinetic theories of drug-receptor interaction, the effort there being to provide a general theory that is applicable to wide classes of drugs. Second, many students fail to appreciate the differences in and the limitations of the various theories, beginning with the classical theory of A.
Автор: Pazhayattil Ajay Babu, Sayeed-Desta Naheed, Fredro-Kumbaradzi Emilija Название: Solid Oral Dose Process Validation: The Basics, Volume 1 ISBN: 3030024717 ISBN-13(EAN): 9783030024710 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Currently there are no process validation (PV) textbooks addressing the lifecycle concepts (Stage 1, 2, 3). Recent regulatory guidance's such as US FDA, EMEA, WHO, PIC/S have adopted the ICH lifecycle approach. The concepts are now harmonized across regulatory guidance's and organizations have an opportunity to align PV activities for all regulated markets. Therefore a need exists for consensus and direction on how to approach solid dose manufacturing process validation for regulatory compliance. Solid Dose Process Validation: The Basics, Volume One and companion Solid Dose Process Validation: Lifecycle Approach Application, Volume Two, also available as a set, provide directions and solutions for these unmet needs for the pharmaceutical industry. The topics and chapters give a systematic understanding for the application of lifecycle concepts in solid dose pharmaceutical manufacturing. All approaches meet the regulatory requirements enlisted in the guidance’s, which is the precursor to applying the concepts. This set is published as a comprehensive solution for solid dose process validation. Since solid dose formulations encompass majority of the pharmaceutical preparations, it is essential information for pharmaceutical professionals who use the process validation lifecycle approach.
Описание: Naltrexone is an opiate antagonist drug developed in the 1970s and approved by the FDA in 1984 as a safe and effective treatment for opiate and drug abuse. This book describes the history of naltrexone, including its potential therapeutic uses, its effects on the immune system, and its pharmacological properties.
Описание: Optimal dose individualization has become more important in improving clinical efficacy and safety. Therefore, the role of optimal dose finding in early clinical drug development so as to maximize successful clinical use is emphasized.
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