Описание: This thesis describes the inception, design, and implementation of stereoselective desymmetrization reactions in the total synthesis of the natural products pactamycin and paspaline. In the case of pactamycin, the author develops a novel asymmetric Mannich reaction and symmetry-breaking reduction strategy to enable facile construction of the complex core architecture in fifteen steps using commercially available materials – the shortest synthesis to date. He subsequently demonstrates the flexibility of this approach in SAR investigations by highlighting the preparation of twenty-five unique pactamycin structural congeners. For paspaline, the author develops a biocatalytic desymmetrization strategy that allows the highly controlled synthesis of core stereochemistry and provides a platform for the development of new conceptual disconnections in the synthesis of 'steroid-like' natural products. This thesis offers a valuable resource for students embarking on a PhD in total synthesis.
Автор: Qayyum Husain; Mohammad Fahad Ullah Название: Biocatalysis ISBN: 3030250229 ISBN-13(EAN): 9783030250225 Издательство: Springer Рейтинг: Цена: 16070.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book introduces readers to industrially important enzymes and discusses in detail their structures and functions, as well as their manifold applications. Due to their selective biocatalytic capabilities, enzymes are used in a broad range of industries and processes. The book highlights selected enzymes and their applications in agriculture, food processing and discoloration, as well as their role in biomedicine. In turn, it discusses biochemical engineering strategies such as enzyme immobilization, metabolic engineering, and cross-linkage of enzyme aggregates, and critically weighs their pros and cons.Offering a wealth of information, and stimulating further research by presenting new concepts on enzymatic catalytic functions in basic and applied contexts, the book represents a valuable asset for researchers from academia and industry who are engaged in biochemical engineering, microbiology and biotechnology.
Автор: Alle Bruggink Название: Synthesis of ?-Lactam Antibiotics ISBN: 9401038511 ISBN-13(EAN): 9789401038515 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Process technology studies including new reactor concepts, possible short-cut routes and improved down-stream-processing methods complete a broad view on the scope and limitations of the presently developed industrial processes including an intriguing insight into future process possibilities.
Описание: This book investigates the use of palladium modified by bulky ligands as catalysts for new chemical transformations that rapidly assemble several classes of complex heterocyles. It documents the development of new chemical reactions involving carbon–carbon (C?C) and carbon–halogen (C?X) bond formation in the context of alkene difunctionalization and dearomatization reactions. Due to the ubiquity of heterocycles in bioactive natural products and life-improving pharmaceutical treatments, a long-term goal for synthetic organic chemists has been to develop novel and creative heterocycle syntheses that illicit a high degree of product diversity and are characterized by mild reaction conditions and limited waste production. A considerable fraction of leading pharmaceutical drugs contain at least one heterocycle within their chemical structure, and their prevalence in these technologies is strong evidence that the fundamental curiosities of organic chemistry lead to real-world solutions for the health and wellness of the global population.
Автор: Tamotsu Takahashi; K. Kanno; C. Kendall; M. Kotora Название: Metallocenes in Regio- and Stereoselective Synthesis ISBN: 364205689X ISBN-13(EAN): 9783642056895 Издательство: Springer Рейтинг: Цена: 52967.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Metallocene is a well known sandwich complex with two cyclopentadienyl ligands such as ferrocene. Reactions discussed here are (i) natural product synthesis, (ii) catalytic asymmetric synthesis, (iii) cyclization reactions, (iv)catalytic reactions, (iv) polymerization reactions and (v) carbon-carbon bond cleavage reactions.
Автор: Baugh, Lisa S. Название: Stereoselective Polymerization with Single-Site Catalysts ISBN: 0367577607 ISBN-13(EAN): 9780367577605 Издательство: Taylor&Francis Рейтинг: Цена: 7348.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Due to the ubiquity of heterocycles in bioactive natural products and life-improving pharmaceutical treatments, a long-term goal for synthetic organic chemists has been to develop novel and creative heterocycle syntheses that illicit a high degree of product diversity and are characterized by mild reaction conditions and limited waste production.
Автор: D.A. Abramowicz Название: Biocatalysis ISBN: 9401091269 ISBN-13(EAN): 9789401091268 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In addition to his own work, Liebig was training the world`s next generation of chemists in his laboratory in Giessen. This cadre of chemists were very impressed by the master teacher so that is it only natural that Liebig`s views should dominate with this next generation of chemists.
Автор: Eduardo Torres; Marcela Ayala Название: Biocatalysis Based on Heme Peroxidases ISBN: 3642445888 ISBN-13(EAN): 9783642445880 Издательство: Springer Рейтинг: Цена: 30606.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book presents recent advances on evolution, structure-function relation and catalytic mechanism as well as applied aspects such as bioreactor and protein engineering. It will help in the design of enhanced biocatalysts and biocatalytic processes.
Автор: Gonzalo,Gonzalo De Название: Biocatalysis In Asymmetric Synthesis ISBN: 0443190577 ISBN-13(EAN): 9780443190575 Издательство: Elsevier Science Рейтинг: Цена: 22570.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
ООО "Логосфера " Тел:+7(495) 980-12-10 www.logobook.ru
