Sample Sizes for Clinical Trials, Julious, Steven A.
Старое издание
Автор: Steven A. Julious Название: Estimating Samples Sizes in Clinical Trials ISBN: 1584887397 ISBN-13(EAN): 9781584887393 Издательство: Taylor&Francis Цена: 15310.00 р. Наличие на складе: Поставка под заказ. Описание: Featuring worked examples and problems based on real-world scenarios, this book takes readers through the process of calculating the sample size for various types of clinical trials. It covers the most common types of clinical trials across different phases. It discusses how assumptions made in a sample size calculation can impact the calculation.
Davidson's Assessment in Medicine is a collection of 1250 best-of-five multiple choice questions, arranged to correspond with the chapters of the Twenty-third Edition of Davidson's Principles and Practice. The questions follow the style used in many international undergraduate and early postgraduate exams. For each question the answers are accompanied by a short piece of remediation/ feedback with references back to the main textbook for further information.
This book is an excellent broad assessment text and forms a highly useful complement to the main textbook.
It will help students increase the efficiency with which they acquire the factual knowledge necessary for both passing examinations and good medical practice. Although written to accompany Davidson's Principles and Practice of Medicine, this book can be used alongside any clinical medicine textbook.
Автор: Lawrence M. Friedman; Curt D. Furberg; David L. De Название: Fundamentals of Clinical Trials ISBN: 3319307738 ISBN-13(EAN): 9783319307732 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Поставка под заказ.
Описание: This is the fifth edition of a very successful textbook on clinical trials methodology, written by recognized leaders who have long and extensive experience in all areas of clinical trials. The three authors of the first four editions have been joined by two others who add great expertise. A chapter on regulatory issues has been included and the chapter on data monitoring has been split into two and expanded. Many contemporary clinical trial examples have been added. There is much new material on adverse events, adherence, issues in analysis, electronic data, data sharing and international trials. This book is intended for the clinical researcher who is interested in designing a clinical trial and developing a protocol. It is also of value to researchers and practitioners who must critically evaluate the literature of published clinical trials and assess the merits of each trial and the implications for the care and treatment of patients. The authors use numerous examples of published clinical trials to illustrate the fundamentals. The text is organized sequentially from defining the question to trial closeout. One chapter is devoted to each of the critical areas to aid the clinical trial researcher. These areas include pre-specifying the scientific questions to be tested and appropriate outcome measures, determining the organizational structure, estimating an adequate sample size, specifying the randomization procedure, implementing the intervention and visit schedules for participant evaluation, establishing an interim data and safety monitoring plan, detailing the final analysis plan and reporting the trial results according to the pre-specified objectives. Although a basic introductory statistics course is helpful in maximizing the benefit of this book, a researcher or practitioner with limited statistical background would still find most if not all the chapters understandable and helpful. While the technical material has been kept to a minimum, the statistician may still find the principles and fundamentals presented in this text useful.
Автор: Schulz Kenneth Название: Essential Concepts in Clinical Research ISBN: 0702073946 ISBN-13(EAN): 9780702073946 Издательство: Elsevier Science Рейтинг: Цена: 6230.00 р. Наличие на складе: Поставка под заказ.
Описание:
This practical guide speaks to two audiences: those who read and those who conduct research. Clinicians are medical detectives by training. For each patient, they assemble clinical clues to establish causes of signs and symptoms. The task involves both clinical acumen and knowledge of medical research. This book helps guide clinicians through this detective work, by enabling them to make sense of research and to review medical literature critically. It will also be invaluable to researchers who conduct clinical research, particularly randomized controlled trials.
Building on previously published, peer-reviewed articles from The Lancet, this handbook is essential for busy clinicians and active researchers interested in research methods.
Written by leaders in the field of clinical research who have published extensively with authorship of hundreds of articles in medical journals.
The authorship includes one of the three authors of the CONSORT guidelines for the reporting of randomized controlled trials.
The book presents the essential concepts to a wide array of topics including randomized control trials, descriptive studies, cohort studies, case-control studies, bias, and screening tests.
The book utilises a readable and humorous prose style, lightening what can be a difficult area for clinical readers.
Derived from decades of teaching clinical research in seminar settings the book will empower clinicians to make sense of, and critically appraise, current medical research and will enable researchers to enrich the quality of their work.
For this Second Edition, the authors have revised and updated the original 16 chapters and added six new chapters. For busy clinicians and active researchers interested in research methods, this book provides helpful tools to derive satisfaction - indeed, fun - from clinical science.
Описание: This book provides an extensive overview of the principles and methods of sample size calculation and recalculation in clinical trials. Blinded sample size recalculation procedures for internal pilot study designs are considered, as well as methods for sample size reassessment in adaptive designs that use unblinded data from interim analyses.
Описание: This book provides an extensive overview of the principles and methods of sample size calculation and recalculation in clinical trials. Blinded sample size recalculation procedures for internal pilot study designs are considered, as well as methods for sample size reassessment in adaptive designs that use unblinded data from interim analyses.
Автор: Chow, Shein-chung Shao, Jun Wang, Hansheng Название: Sample size calculations in clinical research, third edition ISBN: 1138740985 ISBN-13(EAN): 9781138740983 Издательство: Taylor&Francis Рейтинг: Цена: 22202.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Like the well-regarded and bestselling second edition, Sample Size Calculations in Clinical Research, Third Edition, presents statistical procedures for performing sample size calculations during various phases of clinical research and development. This new edition contains updates and four new chapters written specifically for this version.
Описание: This volume helps medical researchers design clinical trials to improve survival, remission duration, or time to recurrence of disease. Written in a user-friendly step-by-step format, this work enables researchers, even those with no background in statistics, determine sample size and write statistical considerations for their protocols.
Accurate sample size calculation ensures that clinical studies have adequate power to detect clinically meaningful effects. This results in the efficient use of resources and avoids exposing a disproportionate number of patients to experimental treatments caused by an overpowered study.
Sample Size Calculations for Clustered and Longitudinal Outcomes in Clinical Research explains how to determine sample size for studies with correlated outcomes, which are widely implemented in medical, epidemiological, and behavioral studies.
The book focuses on issues specific to the two types of correlated outcomes: longitudinal and clustered. For clustered studies, the authors provide sample size formulas that accommodate variable cluster sizes and within-cluster correlation. For longitudinal studies, they present sample size formulas to account for within-subject correlation among repeated measurements and various missing data patterns. For multiple levels of clustering, the level at which to perform randomization actually becomes a design parameter. The authors show how this can greatly impact trial administration, analysis, and sample size requirement.
Addressing the overarching theme of sample size determination for correlated outcomes, this book provides a useful resource for biostatisticians, clinical investigators, epidemiologists, and social scientists whose research involves trials with correlated outcomes. Each chapter is self-contained so readers can explore topics relevant to their research projects without having to refer to other chapters.
Автор: Takashi Sozu; Tomoyuki Sugimoto; Toshimitsu Hamasa Название: Sample Size Determination in Clinical Trials with Multiple Endpoints ISBN: 3319220047 ISBN-13(EAN): 9783319220048 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
1.Introduction.- 2.Continuous Co-primary Endpoints.- 3.Binary Co-primary Endpoints.- 4.Convenient Sample Size Formula.- 5.Continuous Primary Endpoints.- 6. Further Developments.- A.Sample Size Calculation Using other Contrasts for Binary Endpoints.- B.Empirical Power for Sample Size Calculation for Binary Co-primary Endpoints.- C.Numerical Tables for Ck in the Convenient Sample Size Formula for the Three Co-primary Continuous Endpoints Cace.- D.Software Programs for Sample Size Calculation for Continuous Co-primary Endpoints.- References.
Автор: Pfeiffer Название: A Practical Guide To Managing Clini ISBN: 1138196509 ISBN-13(EAN): 9781138196506 Издательство: Taylor&Francis Рейтинг: Цена: 14545.00 р. Наличие на складе: Поставка под заказ.
Описание:
A Practical Guide to Managing Clinical Trials is a basic, comprehensive guide to conducting clinical trials. Designed for individuals working in research site operations, this user-friendly reference guides the reader through each step of the clinical trial process from site selection, to site set-up, subject recruitment, study visits, and to study close-out. Topics include staff roles/responsibilities/training, budget and contract review and management, subject study visits, data and document management, event reporting, research ethics, audits and inspections, consent processes, IRB, FDA regulations, and good clinical practices. Each chapter concludes with a review of key points and knowledge application.
Unique to this book is "A View from India," a chapter-by-chapter comparison of clinical trial practices in India versus the U.S. Throughout the book and in Chapter 10, readers will glimpse some of the challenges and opportunities in the emerging and growing market of Indian clinical trials.
Описание: This book provides statisticians with an understanding of the critical challenges currently encountered in oncology trials. The book covers state-of-the-art approaches to the design and analysis of cancer clinical trials, such as adaptive designs, biomarker-based trials, and dynamic treatment regimes.
Автор: Michael A. Proschan; K. K. Gordon Lan; Janet Turk Название: Statistical Monitoring of Clinical Trials ISBN: 1441921346 ISBN-13(EAN): 9781441921345 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: All three of this work`s authors are experts in adaptive methodology for clinical trials. Here, they offer an accessible, incremental approach to understanding Brownian motion as related to clinical trials that will develop insight into not only monitoring, but many other statistical issues germane to clinical trials.
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