Accurate sample size calculation ensures that clinical studies have adequate power to detect clinically meaningful effects. This results in the efficient use of resources and avoids exposing a disproportionate number of patients to experimental treatments caused by an overpowered study.
Sample Size Calculations for Clustered and Longitudinal Outcomes in Clinical Research explains how to determine sample size for studies with correlated outcomes, which are widely implemented in medical, epidemiological, and behavioral studies.
The book focuses on issues specific to the two types of correlated outcomes: longitudinal and clustered. For clustered studies, the authors provide sample size formulas that accommodate variable cluster sizes and within-cluster correlation. For longitudinal studies, they present sample size formulas to account for within-subject correlation among repeated measurements and various missing data patterns. For multiple levels of clustering, the level at which to perform randomization actually becomes a design parameter. The authors show how this can greatly impact trial administration, analysis, and sample size requirement.
Addressing the overarching theme of sample size determination for correlated outcomes, this book provides a useful resource for biostatisticians, clinical investigators, epidemiologists, and social scientists whose research involves trials with correlated outcomes. Each chapter is self-contained so readers can explore topics relevant to their research projects without having to refer to other chapters.
Автор: R.H. Farrell Название: Multivariate Calculation ISBN: 146138530X ISBN-13(EAN): 9781461385301 Издательство: Springer Рейтинг: Цена: 16769.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Material on manifolds and locally compact groups had not yet reached the pages of multivariate books of the time and also much material about multivariate computations existed only in the journal literature or in unpublished sets oflecture notes.
Автор: Drozdenko Myroslav Название: Premium Calculation Principles and Their Properties ISBN: 363920509X ISBN-13(EAN): 9783639205091 Издательство: Неизвестно Рейтинг: Цена: 11920.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This Special Issue presents proceedings of the International Conference on Behavioral Health and Traumatic Brain Injury convened in October 2008 that brought together over 100 international scientists, health care professionals, policy makers, US Military personnel, and family members, addressing the issues of mild traumatic brain injury and post traumatic stress disorder in the military.
Описание: This is an ideal textbook for the students of pharmacy, biotechnology and basic sciences. It is also a valuable reference for pharmacists working in industry and institutions.
Автор: Matthieu Lesnoff; Renaud Lancelot; Charles-Henri M Название: Calculation of Demographic Parameters in Tropical Livestock Herds ISBN: 9402403523 ISBN-13(EAN): 9789402403527 Издательство: Springer Рейтинг: Цена: 15672.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Having indicators to assess the effect of zootechnical, sanitary, economic or political intervention or the impact of environmental risks makes it possible to draw up strategies for improving domestic animal populations.
There exist literary histories of probability and scientific histories of probability, but it has generally been thought that the two did not meet. Campe begs to differ. Mathematical probability, he argues, took over the role of the old probability of poets, orators, and logicians, albeit in scientific terms. Indeed, mathematical probability would not even have been possible without the other probability, whose roots lay in classical antiquity.
The Game of Probability revisits the seventeenth and eighteenth-century "probabilistic revolution," providing a history of the relations between mathematical and rhetorical techniques, between the scientific and the aesthetic. This was a revolution that overthrew the "order of things," notably the way that science and art positioned themselves with respect to reality, and its participants included a wide variety of people from as many walks of life. Campe devotes chapters to them in turn. Focusing on the interpretation of games of chance as the model for probability and on the reinterpretation of aesthetic form as verisimilitude (a critical question for theoreticians of that new literary genre, the novel), the scope alone of Campe's book argues for probability's crucial role in the constitution of modernity.
Описание: This book explains how to determine sample size for studies with correlated outcomes, which are widely implemented in medical, epidemiological, and behavioral studies. For clustered studies, the authors provide sample size formulas that account for variable cluster sizes and within-cluster correlation. For longitudinal studies, they present samp
Автор: Chow, Shein-chung Shao, Jun Wang, Hansheng Lokhnygina, Yuliya Название: Sample size calculations in clinical research ISBN: 0367657767 ISBN-13(EAN): 9780367657765 Издательство: Taylor&Francis Рейтинг: Цена: 5970.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Like the well-regarded and bestselling second edition, Sample Size Calculations in Clinical Research, Third Edition, presents statistical procedures for performing sample size calculations during various phases of clinical research and development. This new edition contains updates and four new chapters written specifically for this v
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