Dynamic Force Spectroscopy and Biomolecular Recognition, Bizzarri, Anna Rita
Автор: Randy Read; Alexandre G. Urzhumtsev; Vladimir Y. L Название: Advancing Methods for Biomolecular Crystallography ISBN: 9400762313 ISBN-13(EAN): 9789400762312 Издательство: Springer Рейтинг: Цена: 33401.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This work presents a snapshot of the state of the art of modern biomolecular crystallography, from crystallisation through structure determination and even interactive presentation on the web.
Автор: Randy Read; Alexandre G. Urzhumtsev; Vladimir Y. L Название: Advancing Methods for Biomolecular Crystallography ISBN: 9400763190 ISBN-13(EAN): 9789400763197 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This work presents a snapshot of the state of the art of modern biomolecular crystallography, from crystallisation through structure determination and even interactive presentation on the web.
Автор: Anna Rita Bizzarri, Salvatore Cannistraro Название: Dynamic Force Spectroscopy and Biomolecular Recognition ISBN: 1138374520 ISBN-13(EAN): 9781138374522 Издательство: Taylor&Francis Рейтинг: Цена: 9492.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Molecular recognition, also known as biorecognition, is the heart of all biological interactions. Originating from protein stretching experiments, dynamic force spectroscopy (DFS) allows for the extraction of detailed information on the unbinding process of biomolecular complexes. It is becoming progressively more important in biochemical studies and is finding wider applications in areas such as biophysics and polymer science. In six chapters, Dynamic Force Spectroscopy and Biomolecular Recognition covers the most recent ideas and advances in the field of DFS applied to biorecognition: Chapter 1: Reviews the basic and novel aspects of biorecognition and discusses the emerging capabilities of single-molecule techniques to disclose kinetic properties and molecular mechanisms usually hidden in bulk measurements Chapter 2: Describes the basic principle of atomic force microsocopy (AFM) and DFS, with particular attention to instrumental and theoretical aspects more strictly related to the study of biomolecules Chapter 3: Overviews the theoretical background in which experimental data taken in nonequilibrum measurements of biomolecular unbinding forces are extrapolated to equilibrium conditions Chapter 4: Reviews the most common and efficient strategies adopted in DFS experiments to immobilize the interacting biomolecules to the AFM tip and to the substrate Chapter 5: Presents and discusses the most representative aspects related to the analysis of DFS data and the challenges of integrating well-defined criteria to calibrate data in automatic routinary procedures Chapter 6: Overviews the most relevant DFS applications to study biorecognition processes, including the biotin/avidin pair, and selected results on various biological complexes, including antigen/antibody, proteins/DNA, and complexes involved in adhesion processes Chapter 7: Summarizes the main results obtained by DFS applied to study biorecognition processes with forthcoming theoretical and experimental advances Although DFS is a widespread, worldwide technique, no books focused on this subject have been available until now. Dynamic Force Spectroscopy and Biomolecular Recognition provides the state of the art of experimental data analysis and theoretical procedures, making it a useful tool for researchers applying DFS to study biorecognition processes.
Автор: Marek Prochazka Название: Surface-Enhanced Raman Spectroscopy ISBN: 3319239902 ISBN-13(EAN): 9783319239903 Издательство: Springer Рейтинг: Цена: 15672.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book gives an overview of recent developments in RS and SERS for sensing and biosensing considering also limitations, possibilities and prospects of this technique.
Описание: This lecture notes book presents how enhanced structural information of biomolecular ions can be obtained from interaction with photons of specific frequency - laser light.
Автор: Hagen, Wilfred Raymond Название: Biomolecular EPR Spectroscopy ISBN: 0367577402 ISBN-13(EAN): 9780367577407 Издательство: Taylor&Francis Рейтинг: Цена: 7348.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This lecture notes book presents how enhanced structural information of biomolecular ions can be obtained from interaction with photons of specific frequency - laser light.
Описание: This book gives an overview of recent developments in RS and SERS for sensing and biosensing considering also limitations, possibilities and prospects of this technique.
Автор: Fern?ndez Название: Physics at the Biomolecular Interface ISBN: 3319308513 ISBN-13(EAN): 9783319308517 Издательство: Springer Рейтинг: Цена: 20896.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This bookfocuses primarily on the role of interfacial forces in understanding biologicalphenomena at the molecular scale. By providing a suitable statisticalmechanical apparatus to handle the biomolecular interface, the book becomesuniquely positioned to address core problems in molecular biophysics. Ithighlights the importance of interfacial tension in delineating a solution tothe protein folding problem, in unravelling the physico-chemical basis ofenzyme catalysis and protein associations, and in rationally designingmolecular targeted therapies. Thus grounded in fundamental science, the bookdevelops a powerful technological platform for drug discovery, while it is setto inspire scientists at any level in their careers determined to address themajor challenges in molecular biophysics.Theacknowledgment of how exquisitely the structure and dynamics of proteins and theiraqueous environment are related attests to the overdue recognition thatbiomolecular phenomena cannot be effectively understood without dealing withinterfacial behaviour. There is an urge to grasp how biologically relevantbehaviour is shaped by the structuring of biomolecular interfaces and howinterfacial tension affects the molecular events that take place in the cell.This book squarely addresses these needs from a physicist perspective.Thebook may serve as a monograph for practitioners and, alternatively, as anadvanced textbook. Fruitful reading requires a background in physical chemistryand some basics in biophysics. The selected problems at the end of the chaptersand the progression in conceptual difficulty make it a suitable textbook for agraduate level course or an elective course for seniors majoring in chemistry,physics, biomedical engineering or related disciplines.
Описание: This all-new Pathfinder (R) Guide covers two stunning island destinations in one unique volume - In Orkney, eight walks feature on the largest island, Mainland, with another six located on Hoy, Rousay and South Ronaldsay. In Shetland, seven routes explore Mainland, with seven more rambles on Bressay, Mousa, St Ninian`s Isle, Unst, West Burra and Y
Автор: Fernбndez Stigliano Ariel Название: Biomolecular Interfaces: Interactions, Functions and Drug Design ISBN: 3319368141 ISBN-13(EAN): 9783319368146 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
The Aqueous Interface of a Soluble Protein or the Birth of Epistructural Biology.- Electrostatic Exploration of Biomolecular Interfaces: The Chemical Function of Interfacial Water.- Semiempirical Solution to the Protein Folding Problem Through a Combination of Structural and Epistructural Approaches.- Packing Defects and Protein Hydration: Dynamics of the Aqueous Interface.- Proteins in the Order-Disorder Twilight: Unstable Interfaces Promote Protein Aggregation.- Evolution of Protein Structure Degradation and Lessons for the Drug Designer.- Chemical Functionality of the Aqueous Interface in Soluble Proteins.- The Biomolecular Interface as a Selectivity Filter for Drug-Based Targeted Therapy.- Wrapping-Based Re-Engineering of an Anticancer Drug to Make it Safer.- Biomolecular Interfaces Provide Universal Markers for Drug Specificity and Personalized Medicine.- Controlling Induced Folding Through Wrapping Drug Design.- Wrapping Drug Combinations for Therapeutic Editing of Side Effects: Systems Biology Meets Wrapping Technology.- Multi-Target Control of Drug Impact: A Therapeutic Imperative in Cancer Systems Biology.- Engineering Therapeutic Alignments between Immune Response and Molecularly Targeted Cancer Treatment.- High-Level Quantum Chemistry Empowers the Wrapping Technology for Drug Design.- Epilogue.- Appendix 1. Code for Dehydron Identification.- Appendix 2. Solutions of Problems.
Автор: Rashid Bashir; Mauro Ferrari; Steven T. Wereley Название: BioMEMS and Biomedical Nanotechnology ISBN: 1489977430 ISBN-13(EAN): 9781489977434 Издательство: Springer Рейтинг: Цена: 22201.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Part I. Micro and Nanoscale Biosensors and Materials: Biosensors and Biochips.- Cantilever Assays: A Universal Platform for Multi-plexed Label-Free Bioassays.- An On-chip Artificial Pore For Molecular Sensing.- Cell Based Chemical Sensing Technologies.- Fabrication issues of Biomedical Micro Devices.- Intelligent Polymeric Networks in Biomolecular Sensing.- Part II Processing and Integrated Systems: A Multi-Functional Micro Total Analysis System ( TAS) Platform for Transport and Sensing of Biological Fluids using Microchannel Parallel Electrodes.- Dielectrophoretic Traps for Cell Manipulation.- BioMEMS for Cellular Manipulation and Analysis.- Implantable Wireless Microsystems.- Microfluidic Tectonics: An integrated organic autonomous platform.- AC Electrokinetic Stirring and Focusing of Nanoparticles.- Part III. Micro-fluidics and Characterization: Particle Dynamics in a Dielectrophoretic Microdevice.- Microfluidics Simulations I.- Modeling Electroosmotic Flow in Nanochannels.- Nano-Particle Image Velocimetry: A Near-Wall Velocimetry Technique with Submicron Spatial Resolution.- Optical MEMS-Based Sensor Development with Applications to Microfluidics.- Vascular Cell Responses to Fluid Shear Stress.
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