Therapeutic Applications of Adenoviruses, Ng, Philip

Автор: Walter Doerfler; Petra B?hm
Название: The Molecular Repertoire of Adenoviruses I
ISBN: 364279498X ISBN-13(EAN): 9783642794988
Издательство: Springer
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Описание: For decades this virus system has served - and continues to do so - to pioneer investigations on the molecular biology, biochemistry and genetics of mammalian cell systems.

Автор: Ng, Philip
Название: Therapeutic Applications of Adenoviruses
ISBN: 0367658186 ISBN-13(EAN): 9780367658182
Издательство: Taylor&Francis
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Автор: Walter Doerfler; Petra B?hm
Название: The Molecular Repertoire of Adenoviruses III
ISBN: 3642795889 ISBN-13(EAN): 9783642795886
Издательство: Springer
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Описание: For decades this virus system has served--and continues to do so--to pioneer investigations on the molecular biology, biochemistry and genetics of mammalian cell systems.

Автор: W. Doerfler
Название: The Molecular Biology of Adenoviruses I
ISBN: 3642694624 ISBN-13(EAN): 9783642694622
Издательство: Springer
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Описание: A puzzling epidemiological problem was the driving force behind the discovery of human adenoviruses by Wallace Rowe and his colleagues 30 years ago. The potential of adenoviruses as research tools in the molecular and cellular biology of eukaryotic cells was recognized as early as the late 1950s and early 1960s by several investigators.

Автор: William S. M. Wold; Ann E. Tollefson
Название: Adenovirus Methods and Protocols
ISBN: 1617376698 ISBN-13(EAN): 9781617376696
Издательство: Springer
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Описание: This updated book is an essential resource for adenovirus (Ad) researchers beginning in the field, and an inspirational starting point for researchers looking to branch into new areas of Ad study. New chapters address innovative, exciting areas of emphasis in Ad research.

Автор: W. Doerfler
Название: The Molecular Biology of Adenoviruses 3
ISBN: 3642695515 ISBN-13(EAN): 9783642695513
Издательство: Springer
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Автор: Walter Doerfler; Petra B?hm
Название: The Molecular Repertoire of Adenoviruses II
ISBN: 3642795013 ISBN-13(EAN): 9783642795015
Издательство: Springer
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Описание: For decades this virus system has served--and continues to do so--to pioneer investigations on the molecular biology, biochemistry and genetics of mammalian cell systems.

Автор: Flint S Jane Et Al
Название: Human Adenoviruses: From Villains To Vectors
ISBN: 9813109793 ISBN-13(EAN): 9789813109797
Издательство: World Scientific Publishing
Цена: 19483.00 р.
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Описание: Human adenoviruses play a central role in human diseases and as vectors for vaccines and gene delivery. This monograph describes the underlying principles of adenovirus molecular and structural biology, pathogenesis, antiviral measures and vector development.

Автор: Harold S. Ginsberg
Название: The Adenoviruses
ISBN: 1468479377 ISBN-13(EAN): 9781468479379
Издательство: Springer
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Автор: W. Doerfler
Название: The Molecular Biology of Adenoviruses 2
ISBN: 3642464963 ISBN-13(EAN): 9783642464966
Издательство: Springer
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Описание: The data summarized in this chapter show that morphological transformation and oncogenesis by adenoviruses are brought about by the coordinated activity of regions E1A and E1B. Gene products of each of these subregions appear to fulfill distinct roles in oncogenic transformation, with the possible exception of the product(s) encoded by the O. 9-kb E1A mRNA. Also unclear is the func- tion of the 20-kd E1B protein, which has a small role, if any, in morphological transformation, but appears to be essential for the development of the oncogenic phenotype, as defined by the ability of transformed cells to grow in immuno- deficient nude mice. The differences in biological properties of oncogenic and nononcogenic adenoviruses must be attributed to differences in the primary structure of the respective E1A and E1B gene products, in particular of the product(s) of the 1. 0-kb E1A mRNA and of the 55-kd protein encoded by the 2. 2-kb EiB mRNA. The availability of cold-sensitive adenovirus mutants has enabled us to conclude that the transformed phenotype is maintained as a result of continuous expression of at least region E1A gene products, and is therefore not the result of a hit-and-run mechanism. Despite the progress in our understanding of adenovirus transformation and oncogenesis, virtually nothing is known about the precise mechanism by which the viral gene products bring about the neoplastic changes in cells. The only exception is the demonstration that Ad12 region E1A (1.