Автор: Kassinos, Stavros Название: Inhaled Medicines ISBN: 0128149744 ISBN-13(EAN): 9780128149744 Издательство: Elsevier Science Рейтинг: Цена: 25265.00 р. Наличие на складе: Поставка под заказ.
Описание:
The inhaled route to deliver drugs to the lungs is widely accepted for treatment of lung diseases, and has been used recently for the systematic administration of drugs. The efficacy of local drug delivery to the lung depends on the amount and site of deposition within the lungs, as well as on post-deposition events. Therefore, quantifying regional deposition, dissolution, local clearance and absorption processes is important in assessing and optimising topical treatments as well as systemic delivery of drugs with limited lung bioavailability. Quantifying regional deposition in vivo via respiratory imaging remains challenging. Experimental, in vivo, assessment of deposition can be complimented by in vitro models often in combination with in silico methods, based in part on Computational Fluid Particle methods, and in part on hybrid 1D-3D methods. Similarly, it is difficult to directly quantify the clinical impact of kinetically competing processes of dissolution, clearance and permeation. Researches rely on a combination of ex vivo, in vitro and computational in silico methods. Yet, for in silico methods to be able to deliver their promise, they must be accepted into the drug development, regulation and approval cycle. Inhaled Medicines in the Age of in silico Population Studies responds to a need for well-designed protocols that will validate these emerging methods in order to generate the necessary consensus among the stakeholders involved. The book aims to show that the technological ingredients are in place, setting the stage for a future of inhaled drug development based in large part on in silico studies. Opportunities and challenges are addressed by a number of experts who tackle the drug delivery problem from different scientific angles. In this highly multidisciplinary field, where progress is occurring at the intersection of several fields of engineering and science, there is a clear need for a book that integrates knowledge and understanding and articulates a clear vision for the upcoming future.
Автор: Naitee Ting Название: Dose Finding in Drug Development ISBN: 144192115X ISBN-13(EAN): 9781441921154 Издательство: Springer Рейтинг: Цена: 20896.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: If you have ever wondered when visiting the pharmacy how the dosage of your prescription is determined this book will answer your questions. It introduces the drug development process and explains the practical concerns in selecting doses for a new drug.
Автор: Pazhayattil Ajay, Sayeed-Desta Naheed, Fredro-Kumbaradzi Emilija Название: Solid Oral Dose Process Validation, Volume Two: Lifecycle Approach Application ISBN: 3030274837 ISBN-13(EAN): 9783030274832 Издательство: Springer Рейтинг: Цена: 11878.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The textbook addresses the lifecycle concepts (Stage 1, 2, 3) of Process Validation. Regulatory bodies such as US FDA, EMEA, WHO, PIC/S have adopted the ICH lifecycle approach. Organizations have an opportunity to harmonize and align PV activities for all regulated markets. The concepts discussed provides a direction on how to approach solid dose manufacturing process validation for regulatory compliance. Solid Oral Dose Process Validation, Lifecycle Approach: Application, Volume Two and the companion Volume One, Solid Dose Process Validation, The Basics, also available as a set, provide directions and solutions for the pharmaceutical industry. The topics and chapters give a systematic understanding for the application of lifecycle concepts in solid dose pharmaceutical manufacturing. Since solid dose formulations encompass majority of the pharmaceutical preparations, it is essential information for pharmaceutical professionals who use the process validation lifecycle approach. This set is published as a comprehensive solution for solid dose process validation.
Описание: Optimal dose individualization has become more important in improving clinical efficacy and safety. Therefore, the role of optimal dose finding in early clinical drug development so as to maximize successful clinical use is emphasized.
Описание: Naltrexone is an opiate antagonist drug developed in the 1970s and approved by the FDA in 1984 as a safe and effective treatment for opiate and drug abuse. This book describes the history of naltrexone, including its potential therapeutic uses, its effects on the immune system, and its pharmacological properties.
Автор: Finlay, Warren Название: Finlay - MECHANICS INHALE PHARMCETCL AEROSOL, 2e ISBN: 0081027494 ISBN-13(EAN): 9780081027493 Издательство: Elsevier Science Рейтинг: Цена: 22065.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
The Mechanics of Inhaled Pharmaceutical Aerosols: An Introduction, Second Edition provides a concise, but thorough exposition of fundamental concepts in the field of pharmaceutical aerosols. This revised edition will allow researchers in the field to gain a thorough understanding of the field from first principles, allowing them to understand, design, develop and improve inhaled pharmaceutical aerosol devices and therapies. Chapters consider mechanics and deposition, specifically in the respiratory tract, while others discuss the mechanics associated with the three existing types of pharmaceutical inhalation devices. This text will be very useful for academics and for courses taught at both undergraduate and graduate levels.
Because of the interdisciplinary nature of this book, it will also serve a wide audience that includes engineers and scientists involved with inhaled aerosol therapies.
Provides a concise, but thorough exposition of fundamental concepts in the field of pharmaceutical aerosols
Allows researchers in the field to gain an up-to-date, thorough understanding of the field from first principles
Introduces the pharmaceutical aerosols field to the many engineers and scientists entering the area
Автор: Schleimer, Robert P. Название: Inhaled Steroids in Asthma ISBN: 0824705858 ISBN-13(EAN): 9780824705855 Издательство: Taylor&Francis Рейтинг: Цена: 22202.00 р. Наличие на складе: Поставка под заказ.
Автор: H.P. Witschi; I.Y.R. Adamson; J.D. Brain Название: Toxicology of Inhaled Materials ISBN: 364269523X ISBN-13(EAN): 9783642695230 Издательство: Springer Рейтинг: Цена: 22203.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: With contributions by numerous experts
Автор: Tallarida, Ronald J. Название: Drug Synergism and Dose-Effect Data Analysis ISBN: 0367398346 ISBN-13(EAN): 9780367398347 Издательство: Taylor&Francis Рейтинг: Цена: 9798.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Not since this author's bestselling Manual of Pharmacologic Calculation-long out of print-has there been a reference available for drug data analysis, and even that work did not deal with drug combinations. Although pharmacologists and most other scientists know what synergism is, mainstream textbooks tend to neglect it as a quantitative topic. Few researchers are familiar with the quantitative methodology needed to differentiate synergistic responses from the simply additive responses expected from drug combinations or a single drug's interaction with endogenous chemicals.
In Drug Synergism and Dose-Effect Data Analysis, noted pharmacologist, mathematician, and author Ronald J. Tallarida finally brings these methods to light. Drawing on statistical theory and methods but keeping the special needs of the pharmacologist in mind, he begins his treatment with dose-response relations, the statistical analysis of the data, and the models that describe them. He also offers the only modern presentation of probit and logit analysis and provides detailed calculation methods not found in typical statistics books. Numerous examples accompany a presentation that clearly illustrates the calculations and experimental design considerations for modern drug analysis. You'll find the conceptual background, the algorithms, and new research developments. In short, Drug Synergism and Dose-Effect Data Analysis has everything you need to perform, with confidence, the quantitative analysis of dose response data.
Автор: Pazhayattil Ajay Babu, Sayeed-Desta Naheed, Fredro-Kumbaradzi Emilija Название: Solid Oral Dose Process Validation: The Basics, Volume 1 ISBN: 3030024717 ISBN-13(EAN): 9783030024710 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Currently there are no process validation (PV) textbooks addressing the lifecycle concepts (Stage 1, 2, 3). Recent regulatory guidance's such as US FDA, EMEA, WHO, PIC/S have adopted the ICH lifecycle approach. The concepts are now harmonized across regulatory guidance's and organizations have an opportunity to align PV activities for all regulated markets. Therefore a need exists for consensus and direction on how to approach solid dose manufacturing process validation for regulatory compliance. Solid Dose Process Validation: The Basics, Volume One and companion Solid Dose Process Validation: Lifecycle Approach Application, Volume Two, also available as a set, provide directions and solutions for these unmet needs for the pharmaceutical industry. The topics and chapters give a systematic understanding for the application of lifecycle concepts in solid dose pharmaceutical manufacturing. All approaches meet the regulatory requirements enlisted in the guidance’s, which is the precursor to applying the concepts. This set is published as a comprehensive solution for solid dose process validation. Since solid dose formulations encompass majority of the pharmaceutical preparations, it is essential information for pharmaceutical professionals who use the process validation lifecycle approach.
Автор: Ronald J. Tallarida; Leonard S. Jacob Название: The Dose—Response Relation in Pharmacology ISBN: 1468462679 ISBN-13(EAN): 9781468462678 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Another line of investigation is concerned with the kinetic theories of drug-receptor interaction, the effort there being to provide a general theory that is applicable to wide classes of drugs. Second, many students fail to appreciate the differences in and the limitations of the various theories, beginning with the classical theory of A.
Автор: Tallarida, Ronald J. Название: Drug Synergism and Dose-Effect Data Analysis ISBN: 1584880457 ISBN-13(EAN): 9781584880455 Издательство: Taylor&Francis Рейтинг: Цена: 27562.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
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