Автор: Kufer Название: Effector-Triggered Immunity ISBN: 1071624482 ISBN-13(EAN): 9781071624487 Издательство: Springer Рейтинг: Цена: 21661.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume presents a collection of protocols to study effector-triggered immunity (ETI) in both plants and animals from eminent groups in the field. The chapters in this book cover topics such as genetic manipulation of plant and animal pathogens, host cells, and the analysis of key host responses; and techniques used for the analysis of inflammasome activation, cell death pathways, and mitochondria damage in response to pathogens. All of these topics cover a broad spectrum of immunological, biochemical, cell biological, and structural biology approaches to examine ETI. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, Effector-Triggered Immunity: Methods and Protocols is a valuable resource for both expert and novice researchers who are interested in learning more about the important and developing field of ETI.
Автор: Klas K?rre; Marco Colonna Название: Specificity, Function, and Development of NK Cells ISBN: 3642468616 ISBN-13(EAN): 9783642468612 Издательство: Springer Рейтинг: Цена: 18284.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The discovery of NK receptors specific for MHC class I molecules, and the study of the role of co-stimulatory and adhesion molecules have led to an understanding of how NK cells recognize tumor and virally infected cells that have lost expression of MHC class I molecules or have altered distribution of normal cell surface molecules.
Автор: Domenico Ribatti Название: The Mast Cell ISBN: 3030241890 ISBN-13(EAN): 9783030241896 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Поставка под заказ.
Описание: Mast cells (MC) are phylogenetically old cells which are distributed throughout the human organism. MC are found in almost all of the major organs and tissues of the body, particularly in association with connective tissue structures such as blood vessels, lymphatic vessels and nerves, and in proximity to surfaces that interface the external environment, such as those of the respiratory and gastrointestinal system and the skin. This selective accumulation at tissue sites where foreign material attempts to invade the host suggests that MC are among the first cells to initiate defensive mechanisms. MC have long been recognized as key cells of type I hypersensitivity reactions. Several lines of evidence, however, indicate that they not only express critical effector functions in classic IgE-associated allergic disorders, but also play important roles in host defense against parasites, bacteria and perhaps even viruses. Indeed, it is now clear that MC can contribute to host defense in the context of either acquired or innate immune responses through the release of a myriad of pro-inflammatory and immunoregulatory molecules and the expression of a wide spectrum of surface receptors for cytokines and chemokines. Moreover, there is growing evidence that MC exert distinct non-immunological functions, playing a relevant role in tissue homeostasis, remodeling and fibrosis as well as in the processes of tissue angiogenesis.
Автор: Ribatti Domenico Название: The Mast Cell: A Multifunctional Effector Cell ISBN: 3030241920 ISBN-13(EAN): 9783030241926 Издательство: Springer Цена: 13974.00 р. Наличие на складе: Поставка под заказ.
Описание: Mast cells (MC) are phylogenetically old cells which are distributed throughout the human organism.
Название: Cytokine effector functions in tissues ISBN: 0128042141 ISBN-13(EAN): 9780128042144 Издательство: Elsevier Science Рейтинг: Цена: 18696.00 р. Наличие на складе: Поставка под заказ.
Описание:
Cytokine Effector Functions in Tissues discusses the cytokines networks in the context of the specific-tissue environment. It is an up-to-date collection of articles that addresses the specific issue of how the cytokines are able to condition tissue specific homeostasis. The book helps the reader understand how cytokines network inside the tissues and highlights whether tissue-protection or exacerbation will be finally controlled. It describes the cytokines detected and regulated in different tissues, such as the brain, lungs, spleen, liver, pancreas and intestine, also addressing the issue of timing in specific cell types.
Categorizes the cytokines based primarily on tissue and target cells
Emphasizes different roles and outcomes observed during innate and adaptive response
Represents a rapid guide to cytokines in health and disease in tissue and organ context
Presents a different view on how known mediators may work if analyzed in a different perspective, determining the final outcome on tissue-specific target cells
Автор: Eckhard R. Podack Название: Cytotoxic Effector Mechanisms ISBN: 364273913X ISBN-13(EAN): 9783642739132 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Concentrates on the salient H&E histopathology of each entity discussed with brief descriptors of the clinical features, differential diagnosis, and relevant literature references for each entity. The book features a bulleted format with H&E illustrations to match histopathologic criteria. Helpful ancillary tests, in particular, appropriate immunohistochemical panels are also summarised.
Автор: Kiselevsky Название: Atlas Effectors of Anti-Tumor Immunity ISBN: 9048177685 ISBN-13(EAN): 9789048177684 Издательство: Springer Рейтинг: Цена: 20896.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This illustrated Atlas is a unique scientific publication. It includes major issues of up-to-date information about immunophenotype, morphology and the function of the main effectors of anti-tumor immunity in a well presented format.
Автор: Yona Keisari Название: Tumor Ablation ISBN: 9400799322 ISBN-13(EAN): 9789400799325 Издательство: Springer Рейтинг: Цена: 22201.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book examines the principles of the various ablation modalities as well as how each method affects the tumor cells and their microenvironment. It also detials how these effects are responsible for the induction of specific anti-tumor immunity.
Описание: Many breakthroughs in biological research and translational healthcare advancements have been achieved by studying the response of biological systems to extreme environments. The spaceflight platform provides a unique environment where researchers can explore fundamental questions into cellular and molecular response mechanisms to unveil novel insight into human health and disease. Since the physical force of gravity has shaped the architecture of all biological systems on our planet, spaceflight provides the opportunity to see life in a new adaptational mode - in response to reduced gravity. This enables investigations into the effects of the microgravity environment and associated changes in mechanical forces on mammalian cells/tissues and microbial pathogens, to bring novel insight into disease mechanisms, which are not discernable using conventional experimental approaches. Research using spaceflight platforms represents a paradigm shift in how we observe life processes and is on the leading edge of research discoveries into cellular and molecular mechanisms of health and disease. By incorporating the views of leading authors, this book highlights landmark discoveries and advances in mammalian cellular and microbiology research in both true spaceflight and ground-based spaceflight analogue environments for scientists and students alike who are interested in the influence of physical forces on mammalian and microbial cells, how this impacts transition between normal homeostasis and disease, and basic mechanisms of adaptation to low gravity environments. To provide a thorough understanding of this research, this book covers a range of topics including: (i) description the physical forces interacting with cells in microgravity and microgravity analogue environments, (ii) how alterations in these cellular forces impact human physiology, specifically immune function, (iii) use of these environments to develop organotypic three-dimensional (3-D) tissue culture models as predictive human surrogates for organogenesis and disease research, and (iv) microbial pathogen responses to culture in these environments, focusing on infectious disease Collectively, this information reflects a critical step in preparation for long-duration human space exploration, advances our knowledge of basic biological processes and mechanisms important to understand normal function and disease, and may lead to new strategies for treatment and prevention.
Автор: Gilland, Joseph Название: Elemental Magic 2nd edition, Volume I ISBN: 0815348533 ISBN-13(EAN): 9780815348535 Издательство: Taylor&Francis Рейтинг: Цена: 5970.00 р. Наличие на складе: Нет в наличии.
Описание: 'Elemental Magic' is jam-packed with rich, original illustrations from the author himself which help explain and illuminate the technique, philosophy, and approach behind classical hand drawn animated effects and how to apply these skills to your digital projects.
Автор: Linqi Zhang; Sharon R. Lewin Название: HIV Vaccines and Cure ISBN: 9811344280 ISBN-13(EAN): 9789811344282 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book provides a comprehensive review of the major barriers to HIV cure and vaccine. It covers the fundamental virology and immunology leading to HIV transmission, protection from infection and long term HIV persistence on antiretroviral therapy. In addition, strategies being tested to eliminate persistent HIV and the rational design of vaccines to induce protective immunity are covered. This book also discusses the challenges related to the design of clinical trials for testing the safety and efficacy of these innovative approaches. This book will provide a systematic overview and also discuss controversial issues for researchers in virology and immunology, as well as practicing physicians, and scientists in the pharmaceutical industry.
Описание: A practical reference to managing side effects associated with FDA-approved cancer immunotherapy drugs. Part One contains chapter-based overviews of immune checkpoint inhibitors in the clinic. Part Two is structured by common and uncommon toxicities that affect major organ sites throughout the body.
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