Автор: Kufer Название: Effector-Triggered Immunity ISBN: 1071624512 ISBN-13(EAN): 9781071624517 Издательство: Springer Рейтинг: Цена: 21661.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume presents a collection of protocols to study effector-triggered immunity (ETI) in both plants and animals from eminent groups in the field. The chapters in this book cover topics such as genetic manipulation of plant and animal pathogens, host cells, and the analysis of key host responses; and techniques used for the analysis of inflammasome activation, cell death pathways, and mitochondria damage in response to pathogens. All of these topics cover a broad spectrum of immunological, biochemical, cell biological, and structural biology approaches to examine ETI. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, Effector-Triggered Immunity: Methods and Protocols is a valuable resource for both expert and novice researchers who are interested in learning more about the important and developing field of ETI.
Автор: Klas K?rre; Marco Colonna Название: Specificity, Function, and Development of NK Cells ISBN: 3642468616 ISBN-13(EAN): 9783642468612 Издательство: Springer Рейтинг: Цена: 18284.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The discovery of NK receptors specific for MHC class I molecules, and the study of the role of co-stimulatory and adhesion molecules have led to an understanding of how NK cells recognize tumor and virally infected cells that have lost expression of MHC class I molecules or have altered distribution of normal cell surface molecules.
Название: Cytokine effector functions in tissues ISBN: 0128042141 ISBN-13(EAN): 9780128042144 Издательство: Elsevier Science Рейтинг: Цена: 18696.00 р. Наличие на складе: Поставка под заказ.
Описание:
Cytokine Effector Functions in Tissues discusses the cytokines networks in the context of the specific-tissue environment. It is an up-to-date collection of articles that addresses the specific issue of how the cytokines are able to condition tissue specific homeostasis. The book helps the reader understand how cytokines network inside the tissues and highlights whether tissue-protection or exacerbation will be finally controlled. It describes the cytokines detected and regulated in different tissues, such as the brain, lungs, spleen, liver, pancreas and intestine, also addressing the issue of timing in specific cell types.
Categorizes the cytokines based primarily on tissue and target cells
Emphasizes different roles and outcomes observed during innate and adaptive response
Represents a rapid guide to cytokines in health and disease in tissue and organ context
Presents a different view on how known mediators may work if analyzed in a different perspective, determining the final outcome on tissue-specific target cells
Автор: Ribatti Domenico Название: The Mast Cell: A Multifunctional Effector Cell ISBN: 3030241920 ISBN-13(EAN): 9783030241926 Издательство: Springer Цена: 13974.00 р. Наличие на складе: Поставка под заказ.
Описание: Mast cells (MC) are phylogenetically old cells which are distributed throughout the human organism.
Автор: Eckhard R. Podack Название: Cytotoxic Effector Mechanisms ISBN: 364273913X ISBN-13(EAN): 9783642739132 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Concentrates on the salient H&E histopathology of each entity discussed with brief descriptors of the clinical features, differential diagnosis, and relevant literature references for each entity. The book features a bulleted format with H&E illustrations to match histopathologic criteria. Helpful ancillary tests, in particular, appropriate immunohistochemical panels are also summarised.
Автор: Domenico Ribatti Название: The Mast Cell ISBN: 3030241890 ISBN-13(EAN): 9783030241896 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Поставка под заказ.
Описание: Mast cells (MC) are phylogenetically old cells which are distributed throughout the human organism. MC are found in almost all of the major organs and tissues of the body, particularly in association with connective tissue structures such as blood vessels, lymphatic vessels and nerves, and in proximity to surfaces that interface the external environment, such as those of the respiratory and gastrointestinal system and the skin. This selective accumulation at tissue sites where foreign material attempts to invade the host suggests that MC are among the first cells to initiate defensive mechanisms. MC have long been recognized as key cells of type I hypersensitivity reactions. Several lines of evidence, however, indicate that they not only express critical effector functions in classic IgE-associated allergic disorders, but also play important roles in host defense against parasites, bacteria and perhaps even viruses. Indeed, it is now clear that MC can contribute to host defense in the context of either acquired or innate immune responses through the release of a myriad of pro-inflammatory and immunoregulatory molecules and the expression of a wide spectrum of surface receptors for cytokines and chemokines. Moreover, there is growing evidence that MC exert distinct non-immunological functions, playing a relevant role in tissue homeostasis, remodeling and fibrosis as well as in the processes of tissue angiogenesis.
Автор: Yona Keisari Название: Tumor Ablation ISBN: 9400799322 ISBN-13(EAN): 9789400799325 Издательство: Springer Рейтинг: Цена: 22201.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book examines the principles of the various ablation modalities as well as how each method affects the tumor cells and their microenvironment. It also detials how these effects are responsible for the induction of specific anti-tumor immunity.
Автор: Kiselevsky Название: Atlas Effectors of Anti-Tumor Immunity ISBN: 9048177685 ISBN-13(EAN): 9789048177684 Издательство: Springer Рейтинг: Цена: 20896.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This illustrated Atlas is a unique scientific publication. It includes major issues of up-to-date information about immunophenotype, morphology and the function of the main effectors of anti-tumor immunity in a well presented format.
Автор: Dariusz Leszczynski Название: Radiation Proteomics ISBN: 9400758952 ISBN-13(EAN): 9789400758957 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Methods of proteomics have been shown to be powerful tools in search of target proteins - proteins that respond in cells to an internal or an external stimulus. This book, by presenting the current status of the use of proteomics in radiation biology, will help to attract attention to the field of radiation proteomics.
Автор: Acharyya Название: The Systemic Effects of Advanced Cancer ISBN: 3031072723 ISBN-13(EAN): 9783031072727 Издательство: Springer Рейтинг: Цена: 11179.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This textbook discusses the systemic consequences of cancer, covering a range of topics from tumor-promoting systemic effects to the development of cachexia, as summarized in the introductory chapter 1. Part I of this textbook focuses on tumor-promoting systemic effects and begins with a chapter on how tumor-derived extracellular vesicles and particles lay the foundation for future metastases (Chapter 2). Chapter 3 discusses how metastatic cells that have colonized the bone impact the local bone microenvironment, neighboring muscles, and host physiology. Chapter 4 summarizes the available strategies for targeting metastatic cancer and emphasizes the need to incorporate a systemic view of the disease. Following this overview of the systemic effects of cancer progression, Part II of the textbook discusses cancer-induced cachexia, a debilitating systemic effect of advanced cancer. Chapters 5-7 examine the key signaling pathways (interleukin-6/GP130, NF-kB, and muscle proteolysis) that drive the development of cancer cachexia. Chapters 8 and 9 in Part III of this textbook explore how toxicities from anti-cancer therapy are associated with the onset of cachexia in cancer patients, and provide insight into potential approaches to simultaneously target both cancer and cachexia. Chapters 10 and 11 (Part IV) conclude this textbook by outlining promising approaches for the diagnosis and treatment of cachexia as well as strategies to prevent the development of cachexia through exercise. An understanding of the systemic effects of cancer is essential for the design of effective anti-cancer and anti-cachexia treatment strategies. As such, this textbook provides key information for both students and scientists engaged in cancer research and oncology.
Автор: Wu, C-ting Название: Homology Effects ISBN: 0120176467 ISBN-13(EAN): 9780120176465 Издательство: Elsevier Science Рейтинг: Цена: 19370.00 р. Наличие на складе: Поставка под заказ.
Автор: Balch, W. E. Название: Regulators and Effectors of Small GTPases: Ras Family ISBN: 0121828123 ISBN-13(EAN): 9780121828127 Издательство: Elsevier Science Рейтинг: Цена: 22738.00 р. Наличие на складе: Поставка под заказ.
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