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Regulators and Effectors of Small GTPases: Ras Family, Balch, W. E.

Regulators and Effectors of Small GTPases: Ras Family 9780121828127

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Автор: Balch, W. E.
Название: Regulators and Effectors of Small GTPases: Ras Family
ISBN: 9780121828127
Издательство: Elsevier Science
Классификация:

ISBN-10: 0121828123
Обложка/Формат: Hardback
Страницы: 824
Вес: 1.22 кг.
Дата издания: 07.06.2006
Язык: English
Размер: 235 x 167 x 34
Читательская аудитория: Professional & vocational
Ссылка на Издательство: Link
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Поставляется из: Европейский союз

Regulators and Effectors of Small GTPases: Rho Family

Автор: Balch, W. E.
Название: Regulators and Effectors of Small GTPases: Rho Family
ISBN: 0121828115 ISBN-13(EAN): 9780121828110
Издательство: Elsevier Science
Рейтинг:
Цена: 22738.00 р.
Наличие на складе: Поставка под заказ.

Bone Regulators and Osteoporosis Therapy

Автор: Stern Paula H.
Название: Bone Regulators and Osteoporosis Therapy
ISBN: 303057377X ISBN-13(EAN): 9783030573775
Издательство: Springer
Цена: 20962.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: This volume is designed to provide an understanding of current and potential therapies for osteoporosis. Several following chapters describe factors affecting bone including systemic hormones with significant effects on bone, and local mediators including growth factors, prostaglandins, cytokines and chemokines.

Integrins in Health and Disease

Автор: Gullberg
Название: Integrins in Health and Disease
ISBN: 3031237803 ISBN-13(EAN): 9783031237805
Издательство: Springer
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Цена: 23757.00 р.
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Описание: Integrins are heterodimeric cell surface receptors which anchor cells to different extracellular matrix proteins or act as cell-cell receptors. They play pivotal roles not only across a wide range of physiological processes including tissue morphogenesis, wound healing, and regulation of cell growth, but also in numerous pathological conditions such as autoimmunity, infectious disease, and carcinogenesis. This book aims to provide readers a summary of the most important integrins and their respective biological functions. Readers will learn about knockout- and animal models to study the functionality of key collagen-, laminin-, and nephronectin-binding integrins. Additionally, the role of integrins in pathological tissue remodeling in joints and in developing and diseased cardiac tissue are discussed. Reviews of the current knowledge of the role of integrins in tissue and tumor fibrosis, angiogenesis and tumor progression are an important part of this work. Finally, the book discusses integrins in the context of the immune system, how to target integrin-ligand interactions with antibodies, and the role of integrins as receptors for bacterial and viral cell invasion. Both experienced researchers and clinicians, as well as PhD students who wish to study the extracellular matrix and cell adhesion molecules will find “Integrins in Health and Disease - Key Effectors of Cell-Matrix and Cell-Cell Interactions” authoritative, easily accessible, and vastly informative. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.

Bone Morphogenetic Proteins: Systems Biology Regulators

Автор: Slobodan Vukicevic; Kuber T. Sampath
Название: Bone Morphogenetic Proteins: Systems Biology Regulators
ISBN: 3319837532 ISBN-13(EAN): 9783319837536
Издательство: Springer
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Цена: 27950.00 р.
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Описание: This book focuses on the salient features of the biology of Bone Morphogenetic Proteins and the advances in our understanding of their structure and function and of downstream signaling, as well as their governance in systems biology from bone and dentin to kidney, cancer, diabetes, iron homeostasis and angiogenesis, including rare musculoskeletal disorders. BMPs, also referred to as growth and differentiation factors, are members of the TGF-beta superfamily and are highly conserved from fruit flies to mammals and are responsible for the formation of practically every organ during embryo development and involved in adult tissue injury and repair. BMPs establish their extracellular gradient by interacting with their respective antagonists and regulate their function through SMAD-dependent down-stream signaling effector genes. This volume is aimed at scientists and professionals dealing with metabolic disorders, nutrition, systems biology diseases, rare musculoskeletal conditions, and disorders related to iron metabolism, including anemia of chronic disease, hereditary hemochromatosis and beta thalassemia.

Bone Morphogenetic Proteins: Systems Biology Regulators

Автор: Slobodan Vukicevic; Kuber Sampath
Название: Bone Morphogenetic Proteins: Systems Biology Regulators
ISBN: 3319475053 ISBN-13(EAN): 9783319475059
Издательство: Springer
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Цена: 25155.00 р.
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Rho Family GTPases

Автор: Edward J. Manser
Название: Rho Family GTPases
ISBN: 9048168732 ISBN-13(EAN): 9789048168736
Издательство: Springer
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Цена: 32004.00 р.
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Описание:

This volume provides a unique collection of detailed chapters from some of the leading research groups in the world, many of which have made key discoveries in the field. This allows for particularly insightful discussion of the current understanding of Rho function.

Work on signal transduction pathways involving Rho family GTPases started some ten years ago. There is now a realization that these highly conserved molecular switches not only serve to coordinate cytoskeletal organization but also impact on diverse aspects of cell biology such as membrane trafficking, transcriptional regulation and mitotic progression.

Humans contain more than 20 Rho type GTPases. This volume not only presents a detailed phylogenetic analysis of Rho proteins, but also discusses the possible origins of the human members. Such an analysis of human Rho GTPases has not previously been attempted.

The book includes an overview of how Rho GTPases become activated which is complemented by an extensive Chapter by Darerca Owen and Helen Mott who unravel the beautiful molecular details given to us by the many structural studies of Rho GTPases.

The key areas currently being investigated in relation to these ubiquitous proteins are described for both in vitro and in vivo systems. These are presented in a format that ensures the reader can approach the topic with minimal background knowledge, while ultimately bringing the subject to the level of an expert. Timely and highly authoritative, this volume illuminates newer findings, particularly as they relate to Rho proteins in vertebrate biology.

PAS Proteins: Regulators and Sensors of Development and Physiology

Автор: Stephen T. Crews
Название: PAS Proteins: Regulators and Sensors of Development and Physiology
ISBN: 1461351154 ISBN-13(EAN): 9781461351153
Издательство: Springer
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Цена: 13974.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание:

The subject of this volume is a comprehensive examination of the biochemistry and biology of all classes of known PAS proteins, with the intention that readers will find insight into their own work and ideas from study of the multitude of PAS protein functions. PAS proteins control numerous physiological and developmental events, and span phylogeny from bacteria to man. Bacterial and plant PAS proteins act as sensors of environmental stimuli, including light, oxygen, and energy status.

Not surprising, given these roles, there is intense investigation of the roles of bHLH-PAS proteins in issues of human health including: (1) cancer induction, (2) cancer growth and vascularity, (3) birth defects, including Down syndrome, (4) appetite control and obesity, (5) sleep rhythm disorders, and (6) mental health disorders such as social interactions and learning.

PAS proteins encompass many fields of biology, and scientists who work in these fields (circadian rhythms, oxygen regulation, toxin metabolism, bacterial sensors, and development) are an audience, particularly those who actively work on PAS proteins and researchers interested in transcriptional control, signal transduction, and evolution.

Bone Regulators and Osteoporosis Therapy

Автор: Stern Paula H.
Название: Bone Regulators and Osteoporosis Therapy
ISBN: 303057380X ISBN-13(EAN): 9783030573805
Издательство: Springer
Рейтинг:
Цена: 20962.00 р.
Наличие на складе: Поставка под заказ.

Описание: This volume is designed to provide an understanding of current and potential therapies for osteoporosis. Several following chapters describe factors affecting bone including systemic hormones with significant effects on bone, and local mediators including growth factors, prostaglandins, cytokines and chemokines.

Rho GTPases

Автор: Francisco Rivero
Название: Rho GTPases
ISBN: 1493993437 ISBN-13(EAN): 9781493993437
Издательство: Springer
Рейтинг:
Цена: 23757.00 р.
Наличие на складе: Поставка под заказ.

Описание: This detailed book expands upon the previous edition with a collection of methods for those performing experimental work on small GTPases of the Rho family. Split into four sections, the volume explores computational modeling and imaging procedures, biochemical methods related to post-translational modifications of Rho GTPases as well as some high throughput methods, functional assays that allow for monitoring the consequences of manipulating Rho GTPases in a variety of cell types and cell biology processes, and techniques specifically designed for studies in selected non-mammalian model organisms (zebrafish, social ameba, plants and algae). Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on trouble shooting and avoiding known pitfalls.

Authoritative and up-to-date, Rho GTPases: Methods and Protocols, Second Edition constitutes an invaluable tool for all those with an interest in this remarkable family of signaling proteins.

Rho GTPases

Автор: Rivero
Название: Rho GTPases
ISBN: 1493986112 ISBN-13(EAN): 9781493986118
Издательство: Springer
Рейтинг:
Цена: 23757.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание:

Part I: Computational Modeling and Imaging

1. Computational Modeling of the Dynamics of Spatiotemporal Rho GTPase Signaling: A Systematic Review

Shabnam Khatibi, Karina Islas Rios, and Lan K. Nguyen

2. Uncovering Bistability in the Rac1/RhoA Signaling Network through Integrating Computational Modeling and Experimentation

Alex von Kriegsheim and Lan K. Nguyen

3. Modeling Rho GTPase Dynamics Using Boolean Logic

Joseph H.R. Hetmanski, Jean-Marc Schwartz, and Patrick T. Caswell

4. EdgeProps: A Computational Platform for Correlative Analysis of Cell Dynamics and Near-Edge Protein Activity

Anastasia Zhurikhina, Timothy Qi, Klaus M. Hahn, Timothy C. Elston, and Denis Tsygankov

5. Applying Perturbation Expectation-Maximization to Protein Trajectories of Rho GTPases

Peter K. Koo and Simon G.J. Mochrie

6. Parallel High Resolution Imaging of Leukocyte Chemotaxis under Agarose with Rho Family GTPase Biosensors

George R.R. Bell, Dean E. Natwick, and Sean R. Collins

7. Characterization of Genetically-Encoded FRET Biosensors for Rho Family GTPases

Sara K. Donnelly, Veronika Miskolci, Alice M. Garrastegui, Dianne Cox, and Louis Hodgson

8. Screening for Rho GTPase Modulators in Actin-Dependent Processes Exemplified by Phagocytosis

Daniel Schlam, Sergio Grinstein, and Spencer A. Freeman

Part II: Biochemistry and High Throughput Methods

9. An In Vitro Kinase Assay to Assess Rac1 Phosphorylation by ERK

Daniel Brandwein, Junfeng Tong, Laiji Li, Barbara Ballermann, and Zhixiang Wang

10. Methods to Study Rho GTPases Using Bacterial Toxins

Gudula Schmidt

11. Assessment of S-Glutathionylated Rac1 in Cells Using Biotin-Labeled Glutathione

Hannah Edenbaum and Jingyan Han

12. High Throughput Assay for RhoGEFs Based on the Transcreener^(R) GDP Assay

Robert G. Lowery and Meera Kumar

13. Small Volume Flow Cytometry-Based Multiplex Analysis of the Activity of Small GTPases

Peter Simons, Virginie Bondu, Angela Wandinger-Ness, and Tione Buranda

Part III: Cell Types and Processes

14. Methods to Study the Roles of Rho GTPases in Platelet Function

Francisco Rivero and Simon Calaminus

15. Methods to Investigate the Role of Rho GTPases in Osteoclast Function

Anne Morel, Anne Blangy, and Virginie Vives

16. Methods to Study the Role of Cdc42, Rac1 and Rac2 in B Cell Cytoskeletal Respon

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