Описание: This volume provides a comprehensive overview of recent advances in targeting glutamate signaling for the treatment of major psychiatric and neurological disorders. It draws on the latest findings in glutamate neurobiology and offers valuable insights into the application of translational principles in neuroscience drug discovery and development. In each chapter, glutamate as a neurotransmitter, its receptors and transporters, and their interplay with other neurotransmitters and neurotrophic factors, are discussed in the context of a specific, highly prevalent and disabling CNS disease. Most recent and detailed information is provided on Ischemic Stroke, Chronic Stress, Major Depressive Disorder, Bipolar Disorder, Autism Spectrum Disorders (ASD), Posttraumatic Stress Disorder (PTSD), Alzheimer’s Dementia, Schizophrenia, Impulsive Aggression, Substance Use Disorders (SUD), Amyotrophic Lateral Sclerosis (ALS), Chronic Pain, Multiple Sclerosis, Parkinson’s Disease, Attention Deficit Hyperactivity Disorder (ADHD), Migraine, Epilepsy and Anxiety disorders. Moreover, the book includes an extensive overview of glutamatergic treatments already available on the market, and those which are currently in pharmaceutical drug development pipelines. The primary beneficiaries will be neurology and psychiatry specialists and residents, neuroscientists, neuropharmacologists, pharmaceutical industry and clinical research organization professionals, academics, and clinicians working with psychiatric and neurological patients with comorbidities such as cardiologists, pulmonologists, and endocrinologists. This book will also appeal to psychiatry and neurology subspecialists and clinicians working in neuroscience labs seeking an easy-to-understand yet comprehensive overview of contemporary evidence-based clinical insights backed by basic science (preclinical) research evidence. Given its scope, the book is also a unique and indispensable resource for both preclinical and clinical neuroscientists, medical advisors, and clinical research specialists in the pharmaceutical industry. In addition, it will appeal to neuroscience and neuropsychopharmacology students and guide them through the complexities of glutamate involvement in the pathophysiology of the most common debilitating brain diseases with high unmet medical needs.
Описание: Offers a comprehensive overview of the role of neurosteroids and neuroactive steroids, such as pregnenolone and dehydroepiandrosterone, allopregnanolone, progesterone and others in the regulation of brain processes and neuropsychiatric disorders.
Описание: This book provides an up-to-date overview of the role of neurosteroids and neuroactive steroids in the regulation of brain processes and neuropsychiatric disorders. It addresses the neurosteroid function in brain development and plasticity, in both the normal and the pathological brain.
Автор: Manfred Gerlach; J?rgen Deckert; Kay Double; Eleni Название: Neuropsychiatric Disorders ISBN: 321199906X ISBN-13(EAN): 9783211999066 Издательство: Springer Рейтинг: Цена: 44582.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This multidisciplinary book includes current research papers and reviews in the areas of basic neuroscience, neural mechanisms underlying neurodegenerative disorders. It further includes new approaches for neuroprotective treatments, clinical, neurobiological and treatment aspects of psychiatric disorders.
Автор: Gene S. Fisch; Jonathan Flint Название: Transgenic and Knockout Models of Neuropsychiatric Disorders ISBN: 1617376078 ISBN-13(EAN): 9781617376078 Издательство: Springer Рейтинг: Цена: 34799.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In this up-to-date survey and critical assessment of transgenic and knockout models in neuropsychiatry and behavior, a panel of leading researchers comprehensively assesses how and whether the genetic abnormalities produced from these models manifest the neuropsychiatric disorders to which they correspond.
1. The Brain on Stress: The Good and the Bad Bruce S. McEwen
2. Regulation of Excitatory Synapses by Stress Hormones Marian Joлls, Harm Krugers, Henk Karst
3. Synaptic Stress, Changes in Glutamate Transmission and Circuitry, and Psychopatology Laura Musazzi, Giulia Treccani, Carla Perego, Nicoletta Nava, Jens R Nyengaard, Maurizio Popoli
4. Dual Regulation of Glutamatergic Transmission and Cognition by Stress in Prefrontal Cortex Zhen Yan
5. Role of Endocannabinoids in Regulating Glucocorticoid Effects on Memory for Emotionally Arousing Experiences Piray Atsak, Benno Roozendaal, Patrizia Campolongo
6. Endocannabinoid Signaling & Synaptic Plasticity During Stress J. Megan Gray, Haley A. Vecchiarelli, Matthew N. Hill
7. Stress Induced Metaplasticity at GABA Synapses Jaideep S. Bains
8. Stress Modulation of Synaptic Plasticity in the Hippocampus Menahem Segal, Nicola Maggio
9. Neural-Cognitive Effects of Stress in the Hippocampus Jeansok J. Kim, Blake A. Pellman, Eun Joo Kim
10. Evolutionary, Historical and Mechanistic Perspectives on How Stress Affects Memory and Hippocampal Synaptic Plasticity George E. Farmer, Collin R. Park, Laura A. Bullard, David M. Diamond
11. Acute Stress Disrupts Short- and Long-term Patterns of Synaptic Plasticity in Dorsal Hippocampus and Subiculum: Implications for Hippocampal Output and Behaviour John G. Howland, Don A. Davies
12. Synaptic Mechanisms and Cognitive Computations Underlying Stress Effects on Cognitive Function Gediminas Luksys, Carmen Sandi
13. Altered GABA Function in Major Depression Beverly French, Marianne L. Seney, Etienne Sibille
14. Pathology in Astroglia, Glutamate and GABA in Major Depressive Disorder: Evidence from Studies of Human Postmortem Tissue Grazyna Rajkowska
15. Evidence of Glutamatergic Dysfunction in the Pathophysiology of SchizophreniaJ.C. Hammond, D. Shan, J.H. Meador-Woodruff, R.E. McCullumsmith
16. Metabolic Stress and Neuropsychiatric Disorders Claudia A. Grillo, Lawrence P. Reagan
17. Using our Understanding of Stress Related Effects on Glutamate Neurotransmission to Guide the Development of Novel Treatment Strategies Carly Kiselycznyk, Gerard Sanacora
Автор: Ritsner Название: Anhedonia: A Comprehensive Handbook Volume II ISBN: 9401786097 ISBN-13(EAN): 9789401786096 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Anhedonia: A Comprehensive Handbook Volume II
Автор: Yasui, Dag Название: Neuropsychiatric Disorders and Epigenetics ISBN: 0128002263 ISBN-13(EAN): 9780128002261 Издательство: Elsevier Science Рейтинг: Цена: 13980.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Neuropsychiatric Disorders and Epigenetics is a comprehensive reference for the epigenetic basis of most common neuropsychiatric disorders. The volume is organized into chapters representing individual neuropsychiatric disorders, from addition to obesity contributed by leading experts in their respective fields. The epigenetic aspects of each disorder are discussed, in the context of the full range of epigenetic mechanisms including DNA modification, histone post-translational modification, chromatin organization and non-coding RNA. A particular emphasis is placed on potential epigenetic interventions, when the effects of environmental stimuli on epigenetic states is particularly relevant o disease.
Recent discoveries in epigenetic research enabled by epic advances in genomic technologies have positioned the field for broad translation to therapeutic interventions for previously unmanageable disorders Neuropsychiatric disorders represent a prime target of epigenetic interventions as they are highly debilitating, often chronic diseases with enormous costs to society. Thus, this volume will help define epigenetics as a key player in neuropsychiatric disorders, highlighting the full spectrum of epigenetic mechanisms underlying such disorders and introducing the vast range of epigenetic therapies under development.
Analyzes the effects of environmental stimuli on epigenetic states that correlate with neuropsychiatric disease induction
Reviews the epigenetic basis for common neuropsychiatric disorders, thereby guiding translational therapies for clinicians and mechanistic studies for scientists
Extensive use of diagrams, illustrations, tables, and graphical abstracts for each section providing rapid assessment
Автор: Koho Miyoshi; Yasushi Morimura; Kiyoshi Maeda Название: Neuropsychiatric Disorders ISBN: 4431546529 ISBN-13(EAN): 9784431546528 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Around the world societies are facing growing aging populations with the concomitant increase in neuropsychiatric disorders. Neuropsychiatric disorders are organic brain diseases with psychiatric symptoms, as in Alzheimer’s and Parkinson’s diseases, that cause cognitive impairment, including dementia, amnesic syndrome, and personality–behavioral changes. As a clinical science, neuropsychiatry aims to explore the complex interrelationship between behavior and brain function from a variety of perspectives, including those of psychology, neurology, and psychiatry. This concise and updated monograph comprises the latest findings in the field and includes chapters on delusional symptoms, mood disorders and neurotic symptoms, cognitive impairment, behavioral and personality changes, and recently, cerebral alterations revealed in PTSD patients and in endogenous psychoses through neuroimaging and neuropathology. These findings will certainly widen the realm of neuropsychiatry going forward and will prove of great value to specialists as well as to academics and trainees in neurology, psychiatry, neuropsychology, neuroradiology, neuropathology, neurophysiology, neurochemistry, and clinical genetics. Ultimately, neuropsychiatry aims to prevent and reduce the suffering of individuals with the psychiatric symptoms of cerebral disorders.
Автор: Heinz Reichmann Название: Neuropsychiatric Symptoms of Movement Disorders ISBN: 3319095366 ISBN-13(EAN): 9783319095363 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Neuropsychiatric Symptoms of Movement Disorders
Автор: Tom?s Palomo; Richard M. Kostrzewa; Richard J. Ben Название: Staging Neuropsychiatric Disorders ISBN: 148999646X ISBN-13(EAN): 9781489996466 Издательство: Springer Рейтинг: Цена: 26120.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book features chapters by participants of the International Meeting on Staging Neuropsychiatric Disorders: Implications for Etiopathogenesis and Treatment. It highlights prevention and treatment strategies at different stages of disease progression.
Автор: Tom?s Palomo; Richard M. Kostrzewa; Richard J. Ben Название: Staging Neuropsychiatric Disorders ISBN: 1489986847 ISBN-13(EAN): 9781489986849 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Book chapters are authored by participants in the International Meeting on Staging Neuropsychiatric Disorders: Implications for Etiopathogenesis and Treatment, held in Moj?car (Almer?a) Spain from 14-18 October 2009. Chapters are organized into four sections on themes encompassed by Staging Neuropsychiatric Disorders: Clinical Staging in the Pathophysiology of Psychotic and Affective Disorders, Staging Perspectives in Neurodevelopmental Aspects of Neuropsychiatry, Epigenetics and Biomarkers in the Staging of Neuropsychiatric Disorders, and Staging Neurodegenerative Disorders. This volume should serve as a resource for physicians and neuroscientists alike, highlighting the importance of staging neuropsychiatric disorders and the underlying mechanistic dysfunction, for prevention and treatment strategies at different stages of disease progression. Earlier volumes in the series, published by the Fundaci?n Cerebro y Mente in Madrid, Spain: Depressive, Anxiety and Drug Abuse Disorders Eds: T. Palomo and T. Archer Schizophrenia, Movement Disorders and Age Related Cognitive Disorders Eds.: T. Palomo, T. Archer and R.J. Beninger Dopamine Disease States Eds.: R.J. Beninger, T. Palomo and T. Archer Interactive Monoaminergic Disorders Eds.: T. Palomo, R.J. Beninger and T. Archer Neurodegenerative Brain Disorders Eds.: T. Palomo, R.J. Beninger and T. Archer Neurodevelopmental Liabilities in Brain Disease States Eds.: R.J. Beninger, T. Palomo, R.M. Kostrzewa and T. Archer Gene-Environment Interplay in Brain Disease States Eds.: T. Palomo, R.J. Beninger, R.M. Kostrzewa and T. Archer Implications of CoMorbidity for Etiology and Treatment of Neuropsychiatric Disorders Eds.: T. Palomo, R.J. Beninger, R.M. Kostrzewa and T. Archer Beyond Neuropsychiatric Diagnostics: Symptoms not Disorders Eds.: T. Palomo, R.J. Beninger, R.M. Kostrzewa and T. Archer
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