Автор: Vedral, Josef Название: Non-destructive Diagnostic of High Voltage Electrical Systems ISBN: 8770228027 ISBN-13(EAN): 9788770228022 Издательство: Taylor&Francis Рейтинг: Цена: 16078.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: H. Richard Leuchtag Название: Voltage-Sensitive Ion Channels ISBN: 9048173841 ISBN-13(EAN): 9789048173846 Издательство: Springer Рейтинг: Цена: 32651.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book examines physically oriented approaches not covered in other ion-channel books, and it develops a new physics-based approach to the problem of molecular excitability.
Автор: Gerald Werner Zamponi Название: Voltage-Gated Calcium Channels ISBN: 1441934111 ISBN-13(EAN): 9781441934116 Издательство: Springer Цена: 28732.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: oltage-gated calcium channels are essential mediators of a range of physiological functions, including the communication between nerve Vcells, the regulation of heart beat, muscle contraction, and secretion of hormones such as insulin. Consequently, these channels are critical phar- macological targets in the treatment of a variety of disorders, such as epi- lepsy, hypertension, and pain. Voltage-gated calcium channels have there- fore been subject to intense study by numerous investigators over the past few decades, and an immense body of work has accumulated. In this book, we provide the first comprehensive overview of our current state of knowl- edge concerning this exciting field of research. Leading off with a general review of calcium signaling and techniques to measure calcium channel ac- tivity, the book delves into a provocative overview of the history of the cal- cium channel field, contributed by one of the key pioneers in the field. Dr. Richard Tsien. This is followed by an in depth review of the biochemical and molecular biological characterization of calcium channel genes by Drs. Catterall and Snutch whose research has resulted in major advances in the calcium channel field. A number of chapters are dedicated towards various aspects of calcium channel structure and function, including channel gat- ing, permeation, modulation and interactions with members of the exo- totic machinery--contributed by both established leaders and rising stars in the field.
Автор: James Pawley; Heide Schatten Название: Biological Low-Voltage Scanning Electron Microscopy ISBN: 1489995846 ISBN-13(EAN): 9781489995841 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This comprehensive volume is dedicated to the theory and practical applications of FESEM in biological samples. It provides a comprehensive explanation of instrumentation, applications, and protocols, to teach the reader how to obtain the best quality images.
Автор: Bernd Nilius; Veit Flockerzi Название: Mammalian Transient Receptor Potential (TRP) Cation Channels ISBN: 3662512238 ISBN-13(EAN): 9783662512234 Издательство: Springer Рейтинг: Цена: 49631.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book offers up-to-date information on the molecular and functional properties and pharmacology of mammalian Transient Receptor Potential channels, from close-up views of single protein/channels to broader principles of function and important pathologies.
Описание: This book provides a timely state-of-the-art overview of voltage-gated sodium channels, their pharmacology and related diseases. Among the topics discussed are the structural basis of Na+ channel function, methodological advances in the study of Na+ channels, their pathophysiology and drugs and toxins interactions with these channels.
Автор: Peter C. Ruben Название: Voltage Gated Sodium Channels ISBN: 3662512025 ISBN-13(EAN): 9783662512029 Издательство: Springer Рейтинг: Цена: 43100.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume of Springer`s Handbook of Experimental Pharmacology explores the wide range of factors relating to sodium channels, from their biophysical behavior, structure, and pathological vulnerabilities to the methodologies employed in studying them.
Автор: Zamponi Название: Voltage-Gated Calcium Channels ISBN: 3031088808 ISBN-13(EAN): 9783031088803 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book covers the tremendous progress in the current understanding of the molecular physiology of voltage-gated calcium channels. This book includes unparalleled insights into structural features of calcium channels due to X-ray crystallography and cryo-EM, which in turn yielded critical information into how these channels function under normal and pathophysiological conditions, and how they interact with calcium channel therapeutics. The chapters investigate how, with the advent of high throughput genome sequencing, numerous mutations in various calcium channel genes have been identified in patients with neurological, cardiovascular, neuropsychiatric and other disorders. This is further complemented through a much larger in vivo toolkit such as knock-out and knock-in mice. The chapters further discuss the increased complexity of calcium channel physiology that arises from mRNA editing and splicing. Finally, the book also provides an overview of the updated research on calcium channel inhibitors that can be used both in vivo and in vitro, and which may serve as a spring board for new calcium channel therapeutics for human disease. Voltage-Gated Calcium Channels is useful for academic researchers at all levels in neuroscience, biophysics, cell biology and drug discovery.
Автор: Peter C. Ruben Название: Voltage Gated Sodium Channels ISBN: 3642415873 ISBN-13(EAN): 9783642415876 Издательство: Springer Рейтинг: Цена: 46118.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.
Автор: Bernd Nilius; Veit Flockerzi Название: Mammalian Transient Receptor Potential (TRP) Cation Channels ISBN: 364254214X ISBN-13(EAN): 9783642542145 Издательство: Springer Рейтинг: Цена: 53106.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In this fast moving field the main goal of this volume is to provide up-to-date information on the molecular and functional properties and pharmacology of mammalian TRP channels. Leading experts in the field will describe properties of a single TRP protein/channel or portray more general principles of TRP function and important pathological situations linked to mutations of TRP genes or their altered expression. Thereby this volume on Transient Receptor Potential (TRP) Channels provides valuable information for readers with different expectations and backgrounds, for those who are approaching this field of research as well as for those wanting to make a trip to TRPs.
Описание: This book provides a timely state-of-the-art overview of voltage-gated sodium channels, their structure-function, their pharmacology and related diseases. Among the topics discussed are the structural basis of Na+ channel function, methodological advances in the study of Na+ channels, their pathophysiology and drugs and toxins interactions with these channels and their associated channelopathies.
Автор: Bernd Nilius; Veit Flockerzi Название: Mammalian Transient Receptor Potential (TRP) Cation Channels ISBN: 3319051601 ISBN-13(EAN): 9783319051604 Издательство: Springer Рейтинг: Цена: 41925.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In this fast moving field the main goal of this volume is to provide up-to-date information on the molecular and functional properties and pharmacology of mammalian TRP channels. Leading experts in the field describe properties of a single TRP protein/channel or portray more general principles of TRP function and important pathological situations linked to mutations of TRP genes or their altered expression. Thereby this volume on Transient Receptor Potential (TRP) Channels provides valuable information for readers with different expectations and backgrounds, for those who are approaching this field of research as well as for those wanting to make a trip to TRPs.
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