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Evolutionary Dynamics of Malignancy, Jackson
Jackson Evolutionary Dynamics of Malignancy 9783031325724

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Автор: Jackson
Название:  Evolutionary Dynamics of Malignancy
ISBN: 9783031325724
Издательство: Springer
Классификация:
Онкология

Генетика (немедицинская)

ISBN-10: 3031325729
Обложка/Формат: Hardback
Страницы: 269
Вес: 0.00 кг.
Дата издания: 09.07.2023
Язык: English
Основная тема: Biomedicine
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: Advances in cancer genomics are transforming our understanding of cancer, and have profound implications for its prevention, diagnosis, and treatment. Evolutionary dynamics suggests that as few as two mutations can cause transformation of normal cells into cancer stem cells. A process of Darwinian selection, involving a further three or more mutations, taking place over a period of years, can then result in progression to a life-threatening tumour. In many cases the immune response can recognise and eliminate the mutant cells, but most advanced tumours have mutations that activate immune checkpoints and enable the tumour to hide from the immune system. For the most hard-to-treat tumours, future progress will require molecular diagnostics to detect cancer-causing mutations in healthy subjects, and new drugs or vaccines that prevent the progression process. Chapters of this book deal with the signalling pathways that control cell division, and changes in these pathways in cancer cells. Three cell cycle checkpoints that are often mutated in cancer are analysed in detail. A discussion of chronic myeloid leukaemia illustrates the role of reactive oxygen species in driving progression from a chronic to an acute condition. A single drug that suppresses reactive oxygen can prevent disease progression and turn an otherwise deadly disease into a condition that can be managed to enable many years of normal life. Another chapter discusses chronic myelomonocytic leukaemia, a disease that involves both genetic and epigenetic change. Tumour progression is discussed as a multi-stage process in which cancer stem cells evolve into genetically unstable, invasive, metastatic, drug-resistant growths. Each of these stages can act as targets for drugs or immunomodulators, but the future of cancer treatment lies in understanding tumour dynamics, and arresting malignancy at the earliest possible stage. Evolutionary dynamics is a primarily mathematical technique, but the target readership will be tumour biologists, clinicians, and drug developers. Computational detail is provided in an online supplement, but the main text emphasises the implications of the dynamics for an understanding of tumour biology and does not require mathematical expertise.
Дополнительное описание: Chapter 1: Cancer as a Disease of Cell Proliferation.- Chapter 2: Genetic and Chromosomal Instability.- Chapter 3: Cancer as a Disease of Defective Cell Cycle Checkpoint Function.- Chapter 4: The DNA Damage Checkpoint.- Chapter 5: Dynamics of the Spindle



Angiogenesis in Health, Disease and Malignancy

Автор: Ali Salajegheh
Название: Angiogenesis in Health, Disease and Malignancy
ISBN: 3319281380 ISBN-13(EAN): 9783319281384
Издательство: Springer
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Цена: 23508.00 р.
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Описание:

This book is about "Angiogenesis". A process in which new vasculature is formed from pre-existing capillaries. Angiogenesis process is associated with the proliferation and growth of both physiologically normal and neoplastic tissues, through the formation of vascular supply, essential for delivering growth requirements such as oxygen and nutrients.

The book describes more than 100 genes and their key regulatory functions in the context of normal healthy condition, disease and malignancy, cancer proliferation and progression. New insights into the role of angiogenesis and the therapeutic inhibition of its regulators are investigated, due to the great potential for exploitation in the development of a novel treatment for cancer.

New scientists, junior researchers and biomedical science students will find this book an invaluable introductory reference to their insight about angiogenesis and angiogenic role of more than 100 angiogenes and their role in healthy, disease and malignant conditions.

The Role of Apoptosis in Development, Tissue Homeostasis and Malignancy

Автор: R.M. Dexter; A.H. Wyllie; M.C. Raff
Название: The Role of Apoptosis in Development, Tissue Homeostasis and Malignancy
ISBN: 9401042454 ISBN-13(EAN): 9789401042451
Издательство: Springer
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Цена: 13974.00 р.
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Описание: Moreover, because a distinct set of biological events is involved in this death, these events themselves become reason- able targets for new pharmacological agents in the treatment of cancer. Michael Dexter June 1994 Martin Raff Andrew Wyllie x 1 Death from inside out: an overVIew ANDREW H.

The Pineal Gland and Cancer

Автор: C. Bartsch; H. Bartsch; D.E. Blask; D.P. Cardinali
Название: The Pineal Gland and Cancer
ISBN: 3642640036 ISBN-13(EAN): 9783642640032
Издательство: Springer
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Цена: 15372.00 р.
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Описание: Three years ago, most authors contributing to this book gathered at the Heinrich Fabri Institute of the University of Tubingen at Blaubeuren near Ulm in Germany for the third conference on "Pineal Gland and Cancer." In 1987, the late Derek Gupta organized the second meeting and published the first book on the topic, 10 years after Vera Lapin, as part of the 25th anniversary celebrations of the Vienna Cancer Research Institute, had held the first meeting. It was in Vienna during the 1930s and 1940s that W. Bergmann and P. Engel demonstrated that pineal extracts possess growth inhibitory properties on experimental rodent tumors and R. Hofstatter reported favorable results when these extracts were given to cancer patients. In the 1970s, Vera Lapin and others reported that surgical removal of the pineal gland (pinealectomy) stimulates experimental tumor growth rendering fundamental support for an involvement of the pineal gland in malignancy. A focal question of past and present research in this field is whether the pineal gland exerts its tumor inhibitory activity primarily or exclusively via melatonin. Currently, it appears that the action of melatonin on experimental tumor growth criti- cally depends on the circadian timing of its administration as weH as on the type and stage of cancer, and that primarily highly differentiated tumor ceHs are controHed. Initial clinical applications of the pineal hormone for incurable cancers raise hopes for a promising future use, particularly when combined with other therapies (e. g.

The Pineal Gland and Cancer

Автор: Bartsch
Название: The Pineal Gland and Cancer
ISBN: 3540640517 ISBN-13(EAN): 9783540640516
Издательство: Springer
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Цена: 19426.00 р.
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Описание: The link between the pineal gland and cancer is a rapidly emerging research field due to promising experimental and clinical trials with melatonin. The pineal gland acts as a transducer of environmental light to regulate rhythmic processes, including reproductive function in seasonally breeding animals and the entrainment of circadian rhythms, such as the sleep-wake cycle, in man. This book elucidates the physiological significance of the pineal gland and surveys phenomena and mechanisms of pineal - tumor interaction at the neuroendocrine, neuroimmune, neural, and molecular levels. Yet unidentified low-molecular-weight pineal substances with tumor-inhibiting capacity, a possible involvement of melatonin in electromagnetic field effects on cancer, and the oncotherapeutic potential of melatonin are also addressed. The encouraging results should incite further research to elucidate the exact nature of the link between the pineal gland and cancer for the benefit of patients.

Practical Guide to Peritoneal Malignancy

Автор: Cecil Tom
Название: Practical Guide to Peritoneal Malignancy
ISBN: 1138495115 ISBN-13(EAN): 9781138495111
Издательство: Taylor&Francis
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Цена: 13779.00 р.
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Описание: Peritoneal malignancy is a rapidly growing field within surgical oncology. A large body of evidence now exists, but the practical implications of this evidence base remain unclear. This manual provides a practice-oriented guide to the successful set up and running of a peritoneal malignancy unit.

Molecular Diagnosis and Targeting for Gynecologic Malignancy

Автор: Isonishi
Название: Molecular Diagnosis and Targeting for Gynecologic Malignancy
ISBN: 9813360151 ISBN-13(EAN): 9789813360150
Издательство: Springer
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Цена: 6986.00 р.
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Описание: This book summarizes the important developments in the field of cancer research, specifically uterine cervical/endometrial cancer and ovarian cancer. It highlights the recent advances in gynecologic cancer, such as next generation models of genetically engineered animal models or cancer cell lines, focusing on their significance for advancing our understanding of gynecologic cancer biology, prevention and treatment, and drug response and resistance. Cancer research in the area of gynecologic tumors has undergone an enormous transformation over the past decade, with a greater understanding of tumor biology, elucidation of novel targets for therapeutic intervention, and better recognition of genetic predisposition syndromes. At the same time, the recent advances in basic cancer research have provided key insights into all aspects of gynecologic cancer biology, including developmental pathways and the impact of lineage plasticity, understanding metastatic progression, uncovering the roles of the tumor microenvironment , exploring tumor evolution, and discovering new therapeutic approaches and mechanisms of drug sensitivity and adaptive response. Molecular Diagnosis and Targeting for Gynecologic Malignancy appeals to investigators, clinicians, residents and postdocs who are curious about new research on gynecologic malignancies. It not only presents basic and translational research, but also explores the generalizability of the evidence covering the interface between basic and clinical science. Furthermore, a number of the topics offer the basis for new ideas that have the potential to advance into the gynecologic malignancies. This book provides readers with state-of-the-art information that will help improve the lives of patients with these challenging diseases.

Exploring Pancreatic Metabolism and Malignancy

Автор: Nagaraju
Название: Exploring Pancreatic Metabolism and Malignancy
ISBN: 9813293926 ISBN-13(EAN): 9789813293922
Издательство: Springer
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Цена: 13974.00 р.
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Описание: This book comprehensively describes the association between metabolic syndrome and pancreatic cancer progression, and the mechanism of action and target definition with a view to drug discovery.

Practical guide to peritoneal malignancy

Название: Practical guide to peritoneal malignancy
ISBN: 1138495050 ISBN-13(EAN): 9781138495050
Издательство: Taylor&Francis
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Цена: 27562.00 р.
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Описание: Peritoneal malignancy is a rapidly growing field within surgical oncology. A large body of evidence now exists, but the practical implications of this evidence base remain unclear. This manual provides a practice-oriented guide to the successful set up and running of a peritoneal malignancy unit.

Immunosuppression and Human Malignancy

Автор: David Naor; Benjamin Y. Klein; Nora Tarcic; Jonath
Название: Immunosuppression and Human Malignancy
ISBN: 0896031497 ISBN-13(EAN): 9780896031494
Издательство: Springer
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Цена: 30606.00 р.
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Описание: Professor Naor and his colleagues have written a book that explores another possible reason: cancer cells are recognized by the immune system-but is it possible that the consequence of recognition is inhibition of the immune system-by suppressor T cells or macrophages?

Angiogenesis in Health, Disease and Malignancy

Автор: Salajegheh Ali
Название: Angiogenesis in Health, Disease and Malignancy
ISBN: 331980281X ISBN-13(EAN): 9783319802817
Издательство: Springer
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Цена: 20962.00 р.
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Описание:

1. Introduction to Angiogenesis in Normal Physiology. Disease and Malignancy

2. Adenosine triphosphate-binding cassette (ABC) lipid transporters

3. Angiogenin

4. Angiopoietins

5. Angiotropin

6. C-KIT: tyrosine kinase receptors with potential to initiate

7. CCND1 and E1

8. Cluster of Differentiation 71 (CD71)

9. Connective Tissue Growth Factor (CTGF)

10. COX10

11. Cysteine-rich 61 (Cyr61)

12. Epidermal growth factor

13. Epidermal growth factor domain-like 7 (EGFL7)

14. Erythropoietin-producing hepatocellular receptors A: Ephrin A1, Ephrin A2 and Ephrin A3

15. Erythropoietin-producing hepatocellular receptors B: Ephrin B2, Ephrin B4

16. Ets-1

17. Fibrin

18. Fibroblast growth factors (Acidic: FGF-1; Basic: FGF-2) and its receptors (FGFR)

19. Fibronectin

20. Granulocyte-Macrophage and Granulocyte Colony Stimulating Factor (GM-CSF and G-CSF)

21. GAX and HOXA5

22. Heparanase

23. Hepatocyte Growth Factor (HGF)

24. HIF-1α

25. Insulin-like growth factor

26. Integrins (αv1β3, αv1β5, β8)

27. Interleukins

28. Insulin receptor substrate (IRS1)

29. Iron-sulfur clusters (ISCU)

30. MDM4

31. Matrix Metalloproteinase 2 (MMP2)

32. Monobutyrin

33. Neutrophil activating protein-2 (NAP-2)

34. p27kip1 and p57Kip2 (CDKN1B and CDKN1C)

35. Platelet-derived endothelial cell growth factor (PDGF)

36. Prolyl hydroxylase domain-2 (PHD-2)

37. Phosphatidylinositol-4, 5-bisphosphate 3-kinase (PIK3Ca)

38. PIK3R2 (p85β) - Phosphatidylinositol 3-kinase β-subunit

39. Platelet-activating factor

40. Placenta growth factor (PlGF)

41. Preproendothelin-1 (PreproET-1)

42. Proliferin

43. Prostaglandins

44. ROS1

45. SIRT1

46. SMAD4 (Mothers against Decapentaplegic Homolog 4)

47. Sprouty-Related, EVH1 Domain-containing protein 1 (SPRED-1)

48. Signal transducer and activator of transcription of 5A and S3 (STAT5 and STATS3)

49. SUFU

50. Tenascins

51. Tissue inhibitor of metalloproteinases 1 and 2 (TIMP-1 and TIMP-2)

52. Tissue factor gene

53. Transforming growth factor α and β (TGF- α and TGF- β)

54. Transforming growth factor beta-receptor type II (TGFβR2)

55. TSP-1

56. Tumour necrosis factor-α (TNF-α)

57. Urokinase plasminogen activator

58. Vascular Endothelial Growth Factor (VEGF)

59. Vascular cell adhesion molecule-1 (VCAM-1)

60. Vascular endothelial (VE)-Cadherin

61. Zinc Finger E-Box Binding Homeobox 1 (ZEB1)

62. Miscellaneous genes involved in Angiogenesis in Normal Physiology, Disease and Malignancy
Radiation Therapy for Pelvic Malignancy and its Consequences

Автор: Eli Daniel Ehrenpreis; R de W Marsh; William Small
Название: Radiation Therapy for Pelvic Malignancy and its Consequences
ISBN: 1493922165 ISBN-13(EAN): 9781493922161
Издательство: Springer
Рейтинг:
Цена: 16769.00 р.
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Описание: This book provides a state-of-the-art review of the role of radiation therapy in various pelvic malignancies as well as the consequences of the radiation in the pelvic tissues.

New Drugs For Malignancy, An Issue Of Hematology/Oncology Clinics Of North America,26-3

Автор: Muggia, Franco
Название: New Drugs For Malignancy, An Issue Of Hematology/Oncology Clinics Of North America,26-3
ISBN: 145573876X ISBN-13(EAN): 9781455738762
Издательство: Elsevier Science
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Цена: 13999.00 р.
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Описание: Includes topics such as: Targeting IGF-1R, Tyrosine Kinase Inhibitors in Lung Cancer, Targeting mTOR, Targeting Hedgehog, Mitotic Inhibitors, Topoisomerase I Inhibitors, and New Strategies and Drugs Inhibiting Folate Pathways.


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