Описание: This book provides the vision of a successful biorefinery-the lignocelluloic biomass needs to be efficiently converted to its constituent monomers, comprising mainly of sugars such as glucose, xylose, mannose and arabinose. Accordingly, the first part of the book deals with aspects crucial for the pretreatment and hydrolysis of biomass to give sugars in high yield, as well as the general aspects of bioprocessing technologies which will enable the development of biorefineries through inputs of metabolic engineering, fermentation, downstream processing and formulation. The second part of the book gives the current status and future directions of the biological processes for production of ethanol (a biofuel as well as an important commodity raw material), solvents (butanol, isobutanol, butanediols, propanediols), organic acids (lactic acid, 3-hydroxy propionic acid, fumaric acid, succinic acid and adipic acid), and amino acid (glutamic acid).
The commercial production of some of these commodity bioproducts in the near future will have a far reaching effect in realizing our goal of sustainable conversion of these renewable resources and realizing the concept of biorefinery. Suitable for researchers, practitioners, graduate students and consultants in biochemical/ bioprocess engineering, industrial microbiology, bioprocess technology, metabolic engineering, environmental science and energy, the book offers: Exemplifies the application of metabolic engineering approaches for development of microbial cell factoriesProvides a unique perspective to the industry about the scientific problems and their possible solutions in making a bioprocess work for commercial production of commodity bioproductsDiscusses the processing of renewable resources, such as plant biomass, for mass production of commodity chemicals and liquid fuels to meet our ever- increasing demandsEncourages sustainable green technologies for the utilization of renewable resourcesOffers timely solutions to help address the energy problem as non-renewable fossil oil will soon be unavailable
Автор: Rathore, Anurag S. Название: Process Validation in Manufacturing of Biopharmaceuticals ISBN: 1439850933 ISBN-13(EAN): 9781439850930 Издательство: Taylor&Francis Рейтинг: Цена: 30624.00 р. Наличие на складе: Нет в наличии.
Автор: Kumar Название: An Introduction to Bioanalysis of Biopharmaceuticals ISBN: 3030971929 ISBN-13(EAN): 9783030971922 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The book provides a comprehensive review of the fundamental and practical aspects of bioanalytical support and the integral role it plays in the development of safe and efficacious biopharmaceutical drugs with speed and cost-effectiveness. The book focuses on a broad range of conventional and emerging biopharmaceutical modalities including monoclonal antibody-based therapeutics, gene therapy, cell therapy, peptides and oligonucleotides. The book starts with an introductory overview of bioanalysis showcasing the integral role it plays in understanding the drug disposition (pharmacokinetics/pharmacodynamics and immunogenicity) and the progression of bioanalytical strategy as the drug progresses through discovery and development stages of the program, taking into consideration the continually evolving regulatory landscape. The book further diversifies into individual biopharmaceutical modalities - monoclonal antibodies, antibody-drug conjugates, bispecifics, Fc-fusion proteins, gene therapies, cell therapies, peptides and oligonucleotides. The individual chapters focus on modality-specific bioanalytical assay strategies, critical reagents, assay formats, analytical platforms, associated bioanalytical challenges and mitigation strategies, industry best practices, and the latest understanding of regulatory guidance as applicable to the fast-growing biopharmaceutical landscape.
Автор: Rosales-Mendoza Название: Algae-Based Biopharmaceuticals ISBN: 3319812297 ISBN-13(EAN): 9783319812298 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Поставка под заказ.
Описание: This book constitutes a key reference on the use of algae in the biopharmaceuticals production field; providing an updated outlook on the achievements accomplished thus far and transmitting a prospective view for this biotechnological application. This book provides a detailed description of the technology as well as an updated outlook of the strides achieved thus far in the field of algae-based biopharmaceuticals. Algae constitute attractive expression hosts for the production of recombinant proteins with medical applications. Among the features that make them attractive candidates are: low cost, fast growth, wide biosynthetic capacity, and absence of human pathogens; which constitute substantial advantages with respect to bacterial and mammalian systems. First, the features of algae as convenient hosts for the production of BFs are analyzed in terms of production costs, biosynthetic capacity, and safety (Chapter 1). Second, the genetic engineering tools for algae-species are described. Nuclear and chloroplast-based expression approaches are analyzed and compared in terms of biosynthetic advantages, gene expression complexity, and DNA transfer approaches (Chapter 2). In the following sections, chapters 3 to 7, the state of the art on producing distinct types of BFs in algae species is presented. Although this book is mainly focused on BFs, considering that the production of compounds with health-promoting properties are achieved using genetically-engineered algae strains, chapter 8 deals with nutraceuticals. In the ninth chapter, the developments reported thus far are placed in perspective and challenges for the field are discussed. Critical future prospects comprise the following: optimizing large-scale production in bioreactors, implementing glycoengineering approaches, optimizing nuclear expression, exploring new approaches for oral delivery, and implementing regulatory frameworks to accomplish technology transfer and regulatory approval of algae-made BFs.
Описание: Addressing a significant need by describing the science and process involved to develop biosimilars of monoclonal antibody (mAb) drugs, this book covers all aspects of biosimilar development: preclinical, clinical, regulatory, manufacturing.
Автор: Jos? das Neves; Bruno Sarmento Название: Mucosal Delivery of Biopharmaceuticals ISBN: 1489978380 ISBN-13(EAN): 9781489978387 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
.-1. Concepts in Mucosal Immunity and Mucosal Vaccines .-Simona Gallorini, Derek T. O'Hagan, Barbara C. Baudner
.-2. Mucoadhesion and Characterization of Mucoadhesive Properties .-Tao Yu, Gavin P. Andrews, David S. Jones
.-3. Mucus as a Barrier for Biopharmaceuticals and Drug Delivery Systems .-Hongbo Zhang, Mohammed-Ali Shahbazi, Patrick Almeida, Hйlder A. Santos
.-4. Epithelial Permeation and Absorption Mechanisms of Biopharmaceuticals .-Hanne M rck Nielsen
.-5. Oral Delivery of Biopharmaceuticals .-Catarina Oliveira Silva, Bruno Sarmento, Catarina Pinto Reis
.-6. Buccal Delivery of Biopharmaceuticals: Vaccines and Allergens .-Sevda Şenel, Merve Cansız, Michael J. Rathbone
.-7. Pulmonary Delivery of Biopharmaceuticals .-Fernanda Andrade, Catarina Moura, Bruno Sarmento
.-8. Nasal Delivery of Biopharmaceuticals .-Eiji Yuba, Kenji Kono
.-9. Ocular Delivery of Biopharmaceuticals .-Holly Lorentz, Heather Sheardown
.-10. Vaginal Delivery of Biopharmaceuticals .-Josй das Neves
.-11. Nanoparticles-in-Microsphere Oral Delivery Systems (NiMOS) for Nucleic Acid Therapy in the Gastrointestinal Tract .-Shardool Jain, Mansoor Amiji
.-12. Bacteria-Based Vectors for Oral Gene Therapy .-Yong Bai, Rachael Burchfield, Sangwei Lu, Fenyong Liu
.-13. Self-Assembled Polysaccharide Nanogels for Nasal Delivery of Biopharmaceuticals .-Tomonori Nochi, Yoshikazu Yuki, Kazunari Akiyoshi, Hiroshi Kiyono
.-14. Pheroid(TM) Vesicles and Microsponges for Nasal Delivery of Biopharmaceuticals .-Lissinda H. du Plessis, Awie F. Kotzй
.-15. Delivery Strategies for Developing siRNA-Based Vaginal Microbicides .-Joseph A Katakowski, Deborah Palliser
.-16. Delivery Strategies for Developing Vaginal DNA Vaccine Combining Cell-Penetrating Peptides and Jet Injection .-Takanori Kanazawa, Hiroaki Okada
.-17. Vaccine Delivery Systems for Veterinary Immunization .-Juan M. Irache, Ana I. Camacho, Carlos Gamazo
.-18. Eligen(R) Technology for Oral Delivery of Proteins and Peptides .-Sunita Prem Victor, Willi Paul, and Chandra P. Sharma
.-19. The RapidMist(TM) System for Buccal Delivery of Insulin .-Meena Bansal, Sanjay Bansal, Rachna Kumria
.-20. The Pharmaceutical Development of rhDNase (Dornase Alpha) for the Treatment of Cystic Fibrosis .-Steven J. Shire, Thomas M. Scherer
.-21. Development of the Exubera(R) Insulin Pulmonary Delivery System .-Cynthia L. Stevenson, David Bennett
.-22. Technosphere(R) An Inhalation System for Pulmonary Delivery of Biopharmaceuticals .-Antуnio J. Almeida, Ana Grenha
.-23. ChiSys(R) as a Chitosan-Based Delivery Platform for Nasal Vaccination .-Peter Watts, Alan Smith, Michael Hinchcliffe
.-24. Development of a Cationic Nanoemulsion Platform (Novasorb(R)) for Ocular Delivery .-Frйdйric Lallemand, Philippe Daull, Jean-Sйbastien Garrigue
.-25. Regulatory Aspects and Approval of Biopharmaceuticals for Mucosal Delivery: Quality, Toxicology and Clinical Aspects .-Karen Brigitta Goetz, Yuansheng Sun, Katrin Fйchir, Evelyne Kretzschmar, Isabel Buettel
Автор: Lundblad, Roger L. Название: Approaches to the Conformational Analysis of Biopharmaceuticals ISBN: 1439807809 ISBN-13(EAN): 9781439807804 Издательство: Taylor&Francis Рейтинг: Цена: 31390.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Kn?¤blein 231.95 Название: Modern Biopharmaceuticals Recent Success Stories ISBN: 3527322833 ISBN-13(EAN): 9783527322831 Издательство: Wiley Рейтинг: Цена: 36741.00 р. Наличие на складе: Поставка под заказ.
Essential information for architects, designers, engineers, equipment suppliers, and other professionals who are working in or entering the biopharmaceutical manufacturing field
Biomanufacturing facilities that are designed and built today are radically different than in the past. The vital information and knowledge needed to design and construct these increasingly sophisticated biopharmaceutical manufacturing facilities is difficult to find in published literature--and it's rarely taught in architecture or design schools. This is the first book for architects and designers that fills this void. Process Architecture in Biomanufacturing Facility Design provides information on design principles of biopharmaceutical manufacturing facilities that support emerging innovative processes and technologies, use state-of-the-art equipment, are energy efficient and sustainable, and meet regulatory requirements.
Relying on their many years of hands-on design and operations experience, the authors emphasize concepts and practical approaches toward design, construction, and operation of biomanufacturing facilities, including product-process-facility relationships, closed systems and single use equipment, aseptic manufacturing considerations, design of biocontainment facility and process based laboratory, and sustainability considerations, as well as an outlook on the facility of the future.
Provides guidelines for meeting licensing and regulatory requirements for biomanufacturing facilities in the U.S.A and WHO--especially in emerging global markets in India, China, Latin America, and the Asia/Pacific regions
Focuses on innovative design and equipment, to speed construction and time to market, increase energy efficiency, and reduce footprint, construction and operational costs, as well as the financial risks associated with construction of a new facility prior to the approval of the manufactured products by regulatory agencies
Includes many diagrams that clarify the design approach
Process Architecture in Biomanufacturing Facility Design is an ideal text for professionals involved in the design of facilities for manufacturing of biopharmaceuticals and vaccines, biotechnology, and life-science industry, including architects and designers of industrial facilities, construction, equipment vendors, and mechanical engineers. It is also recommended for university instructors, advanced undergraduates, and graduate students in architecture, industrial engineering, mechanical engineering, industrial design, and industrial interior design.
Автор: Sergio Rosales-Mendoza Название: Algae-Based Biopharmaceuticals ISBN: 3319322303 ISBN-13(EAN): 9783319322308 Издательство: Springer Рейтинг: Цена: 19591.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book constitutes a key reference on the use of algae in the biopharmaceuticals production field; First, the features of algae as convenient hosts for the production of BFs are analyzed in terms of production costs, biosynthetic capacity, and safety (Chapter 1).
Автор: Cavagnaro, Joy A. Название: Translational Medicine ISBN: 0367644274 ISBN-13(EAN): 9780367644277 Издательство: Taylor&Francis Рейтинг: Цена: 26030.00 р. Наличие на складе: Нет в наличии.
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