Автор: Squier Susan Merrill Название: Epigenetic Landscapes: Drawings as Metaphor ISBN: 0822368722 ISBN-13(EAN): 9780822368724 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 4383.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Devised in the 1940s by the biologist C. H. Waddington, the epigenetic landscape is a metaphor for how gene regulation modulates cellular development. As a scientific model, it fell out of use in the late 1960s but returned at the beginning of the twenty-first century with the advent of big-data genomic research because of its utility among scientists across the life sciences to think more creatively about and to discuss genetics. In Epigenetic Landscapes Susan Merrill Squier follows the model’s cultural trail, from its first visualization by the artist John Piper to its use beyond science. Squier examines three cases in which the metaphor has been imaginatively deployed to illustrate complex systems that link scientific and cultural practices: graphic medicine, landscape architecture, and bioArt. Challenging reductive understandings of epigenetics, Squier boldly reclaims the broader significance of the epigenetic landscape as a figure at the nexus of art, design, and science.
Автор: Saldanha, Sabita Название: Epigenetic Mechanisms in Cancer ISBN: 0128095520 ISBN-13(EAN): 9780128095522 Издательство: Elsevier Science Рейтинг: Цена: 19875.00 р. Наличие на складе: Поставка под заказ.
Описание: Epigenetic Mechanisms in Cancer provides a comprehensive analysis of epigenetic signatures that govern disease development, progression and metastasis. Epigenetic signatures dictating tumor etiologies present an opportunity for biomarker identification which has broad potential for improving diagnosis, prognosis, prediction, and risk assessment. This volumes offer a unique evaluation of signature differences in of childhood, sex-specific and race-specific cancers, and in doing so broadly illuminates the scope of epigenetic biomarkers in clinical environments. Chapters detail the major epigenetic process in humans consisting of DNA methylation, histone modifications and microRNAs (miRNAs) involved in the initiation, progression and metastasis of tumors. Also delineated are recent technologies such as next generation sequencing that are used to identify epigenetic profiles (primarily methylation analysis) in samples (normal, benign and cancerous) and which are highly important to the analysis of epigenetic outcomes.
Offers broad coverage that is applicable to audiences in various area of cancer research - population studies, diagnostics, prognosis, prediction, therapy, risk, etc.
Provides critical review analysis of the topics that will clarify and delineate the potential roles of epigenetic signatures in cancer management
Covers basic, as well as, clinical areas of epigenetic mechanisms in tumorigenesis
Features contributions by leading experts in the field
Provides comprehensive coverage of current epigenetic signatures involved in the etiology of various cancers and miRNAs
Название: Epigenetic cancer therapy ISBN: 0323913679 ISBN-13(EAN): 9780323913676 Издательство: Elsevier Science Рейтинг: Цена: 23917.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Vincenzo Pirrotta Название: Chromatin And Epigenetics: An Introduction To Epigenetic Mechanisms ISBN: 9811257620 ISBN-13(EAN): 9789811257629 Издательство: World Scientific Publishing Рейтинг: Цена: 22968.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book is an introduction to epigenetics, a controversial term that denotes the mechanisms that instruct the genome on how to express the purely genetic information that encodes proteins. Starting with the discovery of repressor proteins in the 1960s, epigenetics evolved into a kind of user manual for the genetic information, telling the genome if, when, how much and in what cells to read genes. Advances in epigenetics in the past 15 years have revealed how it lies at the heart of virtually every branch of biological and medical sciences and an understanding of its basic principles is therefore essential for every student in this field.The field of chromatin and epigenetics has developed very rapidly in the past 15-20 years. The pace in the field of epigenetics has now slowed down, the basic outlines of the mechanisms and implications have solidified and a consensus has been achieved among the researchers in the field. At the same time, these mechanisms and implications are now an integral part of how we think about the genome. Genes are more than just DNA and more than just protein-coding sequences and this realization has revolutionized our understanding of the genome, gene expression and its regulation in development, health and disease. It is time, therefore, for a textbook to help train a new generation of biologists and health scientists as well as providing a basic competence among practitioners in allied fields. The present book has grown out of a course given for the past 13 years to advanced undergraduates at Rutgers University. In keeping with the experience in that course, the book is abundantly illustrated, presents a wealth of specific examples, and includes a chapter describing a number of methods and techniques that have driven the advances in the field.
Описание: Cellular-molecular approach to evolution has led to radical changes in our understanding of biologic principles ranging from the Cell, to the Life Cycle, Development, Homeostasis, Senescence/Aging, Heterochrony, Pleiotropy, Phenotype, and perhaps the purpose of life itself. Much of this new way of thinking about biology and medicine emanates from experimental evidence for epigenetic inheritance. This leads one to question whether our unicellular state is the actual primary level of selection. One particular system that is now recognized as being under the auspices of epigenetic inheritance is the endocrine system, which is conventionally thought to regulate physiologic homeostasis. However, because the sex hormones play such a major role in behaviors related to the acquisition of epigenetic data, and the processing of such epigenetic data by the gonads during meiosis, their role in the evolution of the organism become tractable. The composite of the activities of the individual over the course of its lifetime can now be understood causally, resulting from the orchestration of its physiology by hormones, prenatally, postnatally and during the aging process, across the entire life span of the organism. Specific behaviors over the course of the life cycle during childhood, adolescence, puberty, adulthood and aging can now be understood mechanistically rather than merely as milestones in the various stages of life. With the above considerations in mind, this book presents the cellular-evolutionary perspective towards the relationship of the organism with its surroundings, human and non-human alike renders biology and medicine a continuum instead of fragmented, un-related anecdotes.
Автор: Spada,Sheila Название: Epigenetic Regulation Of Cancer - Part A,380 ISBN: 0443221782 ISBN-13(EAN): 9780443221781 Издательство: Elsevier Science Рейтинг: Цена: 27791.00 р. Наличие на складе: Поставка под заказ.
Описание: DNA Replication: Mechanisms, Epigenetics, and Gene Therapy Applications presents the latest trends of DNA replication research by reviewing the fundamentals of molecular mechanisms of initiation and termination, functional cross-talk and/or association to the genome, DNA recombination and repair, analytical methods, recent applications, and future directions in the field. This book brings together and synthesizes contributions from active and prominent researchers in the field whose chapters address such topics as basic molecular biology, cell growth and division, DNA isolation and duplication, DNA damage response, epigenetics, DNA methylation, gene silencing, analytical and computational tools, and much more.
Автор: Basha, Mahin Название: Epigenetic Reprogramming During Mouse Embryogenesis ISBN: 1071609602 ISBN-13(EAN): 9781071609606 Издательство: Springer Рейтинг: Цена: 21661.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book addresses the major periodontal pathogens implicated as causal agents in periodontal disease, including Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Fusobacterium nucleatum, Aggregatibacter actinomycetemcomitans, and Prevotella spp.
Автор: Vorcova Название: Epigenetic Processes and Evolution of Life ISBN: 1138541923 ISBN-13(EAN): 9781138541924 Издательство: Taylor&Francis Рейтинг: Цена: 29093.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book covers the possible story of emergence of life and its subsequent evolution, emphasizing the necessary evolutionary step - negotiation of a common "language set" which kept all inhabitants in biosphere together, ensuring a basic level of understanding among them.
Автор: Torday John, Miller Jr William Название: Cellular-Molecular Mechanisms in Epigenetic Evolutionary Biology ISBN: 3030381323 ISBN-13(EAN): 9783030381325 Издательство: Springer Рейтинг: Цена: 25155.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Chapter 1. Introduction
Chapter 2. Darwin, the Modern Synthesis, and a New Biology
Chapter 3. Cognition and the living condition
Chapter 4. What is consciousness? An Evolutionary Perspective
Chapter 5. Networking from the Cell to Quantum Mechanics as Consciousness
Chapter 6. The Nature of information and its communication
Chapter 7. The information cycle and biological information management
Chapter 8. Communication and the accumulation of genetic information
Chapter 9. Non-genic means of information reception and exchange
Chapter 10. The primacy of the unicellular state
Chapter 11. Phenotype, niche construction and natural cellular engineering
Chapter 12. Holobionts
Chapter 13. Four Domains: Cognition-based evolution
Chapter 14. Reconciling physics and biology
Chapter 15. What does this mean for evolution?
Chapter 16. Conclusion: Cellular-molecular evolution in the 21st century
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