Описание: Cancer poses a major threat to human health and is one of the leading causes of death worldwide. Today, we know that metastasis, a multistep process whereby tumour cells spread from the site of origin to distant organs, is responsible for most cancer mortality. In fact, more than 90% of cancer-related deaths are attributed to tumour metastasis. Unfortunately, there are no therapies currently available to specifically target metastasis of any human cancer types, and patients with distant metastases ultimately die from their disease. Current conventional treatment modalities are focused on the removal of tumours by surgical resection and/or the killing of malignant cells using cytotoxic chemotherapeutic drugs or ionizing radiation, with no substantial inhibitory effects on the migratory and invasive abilities of cancer cells. Moreover, emerging evidence has shown that these standard treatment modes can unexpectedly increase the motility and invasiveness of surviving tumour cells, inducing or accelerating metastases formation and aggravating malignant progression. This paradoxical phenomenon can help us to understand why, despite the technological advancements in surgical procedures and drug delivery methods, the overall survival rate of numerous cancer types has barely changed over the past several decades, remaining unacceptably poor. Due to the insufficiency of existing therapies in improving the prognosis of cancer patients, new effective treatment options are urgently needed. To this end, the focus must be moved from a simply cytotoxic approach to s metastasis-preventing strategy, substituting the question of why cancer forms and how to kill it for the question of why tumours spread and how to prevent metastasis. In this book, a conceptually new approach to cancer management is presented, by focusing not on the killing of transformed neoplastic cells, but blocking the spread of tumour cells to distant organs, thereby restricting malignant progression and targeting the main cause of cancer-related mortality. Plant-derived flavonoids might be ideal candidates for novel antimetastatic agents, as they are non-toxic and possess the capacity to inhibit multiple steps of metastatic cascade. These polyphenolic phytochemicals act through regulating a number of metastasis-associated signalling cascades in different tumour cells, and also modulate diverse components of tumour microenvironments and attenuate the formation of tumour-specific angiogenesis. Moreover, the combination of certain flavonoids with surgical resection, chemotherapy or radiotherapy may result in the abolishment of the metastasis-promoting effects of these conventional therapeutic modalities, providing novel treatment options for combating cancer in the future. It is expected that the development of flavonoids for antimetastatic drugs and their inclusion in further cancer treatment strategies can substantially improve the prognosis of patients with various types of malignancies in a time when cancer incidence is predicted to continuously increase throughout the world. This book should be read by anyone who is interested in innovative advances in cancer care. Due to its systemic approach to cellular and molecular processes of metastatic cascade, this book might serve as a useful contemporary textbook for medical colleges and universities for studies of cancer development, progression and dissemination.
Автор: Katrin Sak Название: Dietary Flavonoids Interfere with Cancer Radiotherapy ISBN: 1536167800 ISBN-13(EAN): 9781536167801 Издательство: Nova Science Рейтинг: Цена: 11562.00 р. Наличие на складе: Невозможна поставка.
Описание: In parallel with the continuous rise of cancer incidence, efficient treatment becomes an increasingly important public health concern. Radiotherapy has remained one of the most important anticancer approaches for clinical management of a variety of human tumors, as at least half of all oncological patients receive this therapy at some stages of their disease. With the hope to attain greater anticancer response, the interest in using natural plant-derived products as complementary treatments to conventional radiotherapy has substantially increased in the recent years. However, the interactions between phytochemicals and ionizing radiation are not always known and can be often unpredictable. Therefore, in this book, the current findings about the combined treatments of malignant cells with radiation and flavonoids, the largest group of human dietary plant polyphenols, are described. These data show that under carefully chosen dosage-schedule regimens, certain flavonoids or their natural mixtures can behave as potent radiosensitizers, augmenting radiotherapeutic efficacy in different preclinical cancer models. Such radiosensitizing action of flavonoids can be achieved through modulation of the redox status and suppression of several cellular survival pathways activated by radiotherapy, ultimately leading to the death of malignant cells. As flavonoids can concurrently protect normal healthy cells from irradiation-induced injury and thereby minimize toxic adverse reactions, use of these plant-derived agents as complementary approach to radiotherapy might open new avenues for enhancement of clinical outcome. Therefore, combining conventional anticancer modalities with conscious intake of flavonoid supplements as adjuvant agents might be an important future strategy to boost the therapeutic success in the treatment of various human malignancies.
Автор: Tabrez Shams, Imran Khan Mohammad Название: Polyphenols-Based Nanotherapeutics for Cancer Management ISBN: 9811649340 ISBN-13(EAN): 9789811649349 Издательство: Springer Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book reviews the applications of polyphenols in cancer treatment. The subsequent chapters then explore the diverse role of polyphenols in modulating signal transduction pathways in cancer including, cellular proliferation, differentiation, apoptosis, inflammation, angiogenesis, and metastasis.
Автор: Swanson Hollie Название: Flavonoids, Inflammation and Cancer ISBN: 9814651931 ISBN-13(EAN): 9789814651936 Издательство: World Scientific Publishing Цена: 13464.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book provides an insightful analysis of the chemopreventive actions of flavonoids.
Описание: The book comprehensively introduces readers to various aspects of flavonoids, a category of natural metabolites that exhibits various pharmacological effects. It discusses their chemistry, absorption and metabolism, mechanisms of action and toxicology as well as future perspectives for clinical applications, and also provides detailed insights into their anti-cancer properties, since flavonoids are known to modulate tumor-associated intracellular as well as extracellular signaling pathways. The book also highlights the current research on the health effects of selected flavonoids, and their various roles in cancer prevention and treatment. Lastly, the book elucidates nanotechnology-mediated tools to enhance the bioavailability and solubility of flavonoids to improve their bioactivity and pharmacokinetic parameters.
Автор: B?la Buslig; John Manthey Название: Flavonoids in Cell Function ISBN: 1441933832 ISBN-13(EAN): 9781441933836 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The discovery of biological activity associated with flavonoid contaminants in vitamin C preparations from bell peppers and lemons by Szent-Gyorgyi and his associates opened a floodgate of research into the biological functions of this ubiquitous and diverse group of compounds.
Описание: Despite intensive work on molecular carcinogenic mechanisms and novel drug development, cancer has still remained an incurable disease. With the hope to gain therapeutic advantage or miracle cure, more than 50% of cancer patients consume various kinds of herbal supplements when undergoing chemotherapeutic treatment with antineoplastic agents. However, numerous preclinical studies on combined treatment of various cancer cells with natural dietary flavonoids and chemotherapeutic drugs have revealed both desired (additive to synergistic) as well as undesired (antagonistic) interactions, meaning that coadministration of flavonoids and chemotherapeutic drugs can lead to both augmentation as well as abolishment of therapeutic efficacy. This book is the first one to systematically compile currently available information about the modulation of chemotherapeutic efficacy by flavonoids, hopefully being an assistant for cancer patients to make conscious choices in selecting proper plant products during chemotherapeutic treatment.
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