High Performance Computing for Drug Discovery and Biomedicine, Heifetz

Автор: Giovanni Melillo
Название: Hypoxia and Cancer
ISBN: 1493953559 ISBN-13(EAN): 9781493953554
Издательство: Springer
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Описание: ГЇВїВЅ ГЇВїВЅ ГЇВїВЅ The imbalance between rapidly proliferating tumor cells and inadequate and inefficient tumor vasculature leads to a decrease in oxygen levels (hypoxia and/or anoxia) in tumor tissues.

Автор: Gabriele Proetzel; Michael V. Wiles
Название: Mouse Models for Drug Discovery
ISBN: 149393659X ISBN-13(EAN): 9781493936595
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Описание: Herein, these models are appliedto a wide field of disease areas, including diabetes, cardiovascular disease,skin disorders, cancer, neurodegenerative and neuromuscular diseases, retinaldisorders, as well as various behavioral models.

Автор: Andrea Bonetti; Roberto Leone; Franco Muggia; Step
Название: Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy
ISBN: 1493957104 ISBN-13(EAN): 9781493957101
Издательство: Springer
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Цена: 30745.00 р.
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Описание: Cisplatin, the first member of the family of platinum-containing chemotherapeutic agents, was discovered by Barnett Rosenberg in 1965 and approved by the FDA for marketing in 1978. After 30 years of use in the clinic, cisplatin remains a central element of many treatment regimens. Cisplatin is still an irreplaceable component of a regimen that produces high cure rates in even advanced nonseminomatous germ-cell cancers, and is widely used in the treatment of ovarian cancers and other gynecologic cancers, head and neck, and numerous other tumor types. The development of carboplatin has reduced some of the adverse events associated with cisplatin treatment, and the introduction of the DACH platinum compound oxaliplatin has broadened the spectrum of activity of the platinums to include gastro-intestinal cancers, especially colorectal cancer. The clinical importance of this family of drugs continues to drive investigation into how these drugs work and how to improve their efficacy and reduce their toxicity. The papers in this volume were presented in Verona, Italy, during the tenth International Symposium on Platinum Coordination Compounds in Cancer Chemotherapy. The symposium was jointly organized by the Department of Oncology of the Mater Salutis Hospital – Azienda Sanitaria Locale 21 of the Veneto Region – and by the Department of Medicine and Public Health, Section of Pharmacology, the University of Verona. They reflect the vitality of this field and the increasing use of new molecular and cell biologic, genetic, and biochemical tools to identify approaches to further improve their use.

Автор: Arpad Szallasi; Tam?s B?r?
Название: TRP Channels in Drug Discovery
ISBN: 1493962817 ISBN-13(EAN): 9781493962815
Издательство: Springer
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Описание: With state-of-the-art reviews of the most interesting TRP channels, from TRPA1 to TRPV4, this volume contains key tips on implementation as well as clear and focused laboratory-ready protocols on TRP channels and disorders of airways and the GU tract.

Автор: Sandhya Kortagere
Название: In Silico Models for Drug Discovery
ISBN: 1493962973 ISBN-13(EAN): 9781493962976
Издательство: Springer
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Цена: 16769.00 р.
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Описание: This Methods in Molecular Biology (TM) book surveys in silico models, offering techniques to derive novel antimicrobial targets and methods for computing binding energies of drugs to their target proteins, plus protocols, materials lists, known pitfalls and more.

Автор: Qing Yan
Название: Systems Biology in Drug Discovery and Development
ISBN: 1493957708 ISBN-13(EAN): 9781493957705
Издательство: Springer
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Описание: Due to the failing “one-drug-fits-all” model, it has become increasingly necessary to develop personalized medicine that treats whole systems and brings the right drug to the right patient with the right dosages. In Systems Biology in Drug Discovery and Development: Methods and Protocols, leading experts provide a practical, state-of-the-art, and holistic view of the translation of systems biology into better drug discovery and personalized medical practice. While the first part of the book describes cutting-edge technologies and methods in the field, the second part illustrates how the technologies can be applied in science for disease understanding and therapeutic discovery. As a volume in the highly successful Methods in Molecular Biology™ series, this collection provides the kind of detailed description and implementation advice that is crucial for getting optimal results. Authoritative and up-to-date, Systems Biology in Drug Discovery and Development: Methods and Protocols covers topics from fundamental concepts to advanced technologies in order to best serve biomedical students and professionals at all levels who are interested in vital integrative studies in molecular biology, genetics, bioinformatics, bioengineering, biochemistry, physiology, pathology, microbiology, immunology, pharmacology, toxicology, drug discovery, and clinical medicine.

Автор: Hildebert Wagner; Rudolf Bauer; Dieter Melchart; P
Название: Chromatographic Fingerprint Analysis of Herbal Medicines Volume III
ISBN: 3319356208 ISBN-13(EAN): 9783319356204
Издательство: Springer
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Описание: Volume III of this manual provides an overview of the analytical investigation of 23 additional Chinese Herbal Drugs, which are most commonly used in Traditional Chinese Medicine. Together with Volumes I and II this current volume represents the most comprehensive overview to analytical studies of those herbal drugs. The quality proof of the investigation meets the standard of the European Drug Regulatory Authority. The authors refer to the bioactive constituents, pharmacological and biological activities of all single herbal drugs, as well as their therapeutic applications. Analytical methods applied are described in detail.

Автор: Seetharama D. Satyanarayanajois
Название: Drug Design and Discovery
ISBN: 1493958240 ISBN-13(EAN): 9781493958245
Издательство: Springer
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Цена: 16070.00 р.
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Описание: Research in the pharmaceutical sciences and medicinal chemistry has taken an important new direction in the past two decades with a focus on large molecules, especially peptides and proteins, as well as DNA therapeutics. In Drug Design and Discovery: Methods and Protocols, leading experts provide an in-depth view of key protocols that are commonly used in drug discovery laboratories. Covering both classic and cutting-edge techniques, this volume explores computational docking, quantitative structure-activity relationship (QSAR), peptide synthesis, labeling of peptides and proteins with fluorescent labels, DNA-microarray, zebrafish model for drug screening, and other analytical screening and biological assays that are routinely used during the drug discovery process. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and accessible, Drug Design and Discovery: Methods and Protocols serve as a vital laboratory reference for pharmaceutical chemists, medicinal chemists, and pharmacologists as well as for molecular biologists.

Автор: Qing Yan
Название: Membrane Transporters in Drug Discovery and Development
ISBN: 1493957333 ISBN-13(EAN): 9781493957330
Издательство: Springer
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Описание: Studies of membrane transporters have had a great impact on our understanding of human diseases and the design of effective drugs. In Membrane Transporters in Drug Discovery and Development: Methods and Protocols, expert researchers provide practical methodologies of the ongoing research on membrane transporters, considering applications of transporter technologies in drug discovery and development. Chapters include new and useful fields and methodologies, including pharmacogenomics, nutrigenomics, systems biology, bioinformatics, nuclear magnetic resonance (NMR), imaging, and quantitative real-time-PCR. Transporter studies in drug discovery and development for various diseases are discussed, including neuropsychiatric disorders, cardiovascular diseases, ophthalmic diseases, cancer, and diabetes. Composed in the highly successful Methods in Molecular Biology™ series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Wide-ranging and current, Membrane Transporters in Drug Discovery and Development: Methods and Protocols delivers a collection of practical protocols that can be used immediately in the lab, along with critical surveys of key topics by leading researchers in the field.

Автор: Sridar V. Chittur
Название: Microarray Methods for Drug Discovery
ISBN: 1493957392 ISBN-13(EAN): 9781493957392
Издательство: Springer
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Цена: 19564.00 р.
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Описание: Authoritative and cutting-edge, this book provides a single volume reference for all types of microarrays. It supplies new information on microarrays for cytogenetics and drug metabolism, and covers a wide range of microarray platforms.

Автор: Leslie W. Tari
Название: Structure-Based Drug Discovery
ISBN: 1493961373 ISBN-13(EAN): 9781493961375
Издательство: Springer
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Описание: Structure-Based Drug Discovery presents an array of methods used to generate crystal structures of biological macromolecules, how to leverage the structural information to design novel ligands anew, and how to iteratively optimize hits and convert them to leads.

Автор: Steven Kanner
Название: Tumor Metabolome Targeting and Drug Development
ISBN: 1493953435 ISBN-13(EAN): 9781493953431
Издательство: Springer
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Описание: In this volume, the major metabolic alterations identified in cancer and tumor-associated cells are explored, including discussions of former and emerging approaches to drug development in targeting cancer cell metabolism.