Автор: Pere Santamaria; Peter Hackett Название: Cytokines and Chemokines in Autoimmune Disease ISBN: 1461349524 ISBN-13(EAN): 9781461349525 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume is ideal for individuals interested in taking an in-depth look at how cytokines and chemokines participate in autoimmune disorders, and how cytokines and chemokines can be used as targets for therapeutic intervention.
Автор: G.A.W. Rook; S. Lightman Название: Steroid Hormones and the T-Cell Cytokine Profile ISBN: 1447112385 ISBN-13(EAN): 9781447112389 Издательство: Springer Рейтинг: Цена: 15672.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The fact that certain adrenal steroid hormones are immunosuppressive and anti-inflammatory has been known for many years, and is routinely exploited by physicians. These effects are attributable to glucocorticoid steroids such as cortisol. Pharmacological doses of glucocorticoids inhibit most or all T cell types. However we now know that the effect of exposure to raised physiological levels is mainly to drive developing lymphocyte responses towards a Th2 cytokine profile (interleukin-4 secreting) while suppressing the development ofThi (gamma interferon- secreting) lymphocytes. Only recently have two further regulatory mechanisms become appar- ent. First, these effects of cortisol are balanced by pro-inflammatory and ThI-enhancing effects of another adrenal steroid, dehydroepiandro- sterone sulfate (DHEAS). Second, the activity of cortisol is directly modulated by enzymes in the target organs and lymphoid tissues that convert it into inactive cortisone. This new information leads to the possibility that immunoregulatory steroids could be used by physicians in novel ways. We can envisage steroid combinations that exploit the anti-inflammatory effects of corti- sol, while the Thi-suppressing and Th2-promoting properties of these hormones are opposed by derivatives of DHEAS. Such therapies are already proving effective in animal models of infection, and could revol- utionize treatment of Th2-mediated diseases such as asthma, where the anti-inflammatory effects of cortisol are desirable but the effects on T lymphocyte differentiation are not.
Автор: De Ley Название: Cytokine Protocols ISBN: 1617794384 ISBN-13(EAN): 9781617794384 Издательство: Springer Рейтинг: Цена: 16769.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: “Recent studies have discovered new known and characterized cytokines, allowing for advancement in miniaturization of micro-analytical methods as well as the extensive development of bio-informatics and nanotechnology. These advancements have allowed researchers to reduces sample sizes making for more accurate determinations then previously possible. In Cytokine Protocols: Second Edition, expert researchers in the field detail many of the methods which are now commonly used to study cytokines. These methods and techniques for studying cytokines include historical importance and the importance of researchers using bioassay, quantification, and characterization of cytokine related RNAs, posttranscriptional modifications of RNA, either naturally or artificially, and observations at the protein level. Written in the highly successful Methods in Molecular Biology™ series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Authoritative and practical, Cytokine Protocols: Second Edition seeks to aid scientists in furthering the crucially important advancement of cytokine research.”
Автор: Takayuki Yoshimoto; Tomohiro Yoshimoto Название: Cytokine Frontiers ISBN: 4431544410 ISBN-13(EAN): 9784431544418 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book details the roles of cytokines under physiological and pathological conditions. It includes coverage of the most important cytokines that relate to the hot topics recently elucidated in the field of immunology.
Автор: Ivana Vancurova Название: Cytokine Bioassays ISBN: 1493909274 ISBN-13(EAN): 9781493909278 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This group includes quantification of multiple cytokines using cytometric bead arrays, ELISPOT assays, proteomics cytokine evaluation, multiplexed proximity ligation assays for high-throughput cytokine analysis and finally, cytokine gene expression analysis by gene arrays.
Автор: Takayuki Yoshimoto; Tomohiro Yoshimoto Название: Cytokine Frontiers ISBN: 4431561242 ISBN-13(EAN): 9784431561248 Издательство: Springer Рейтинг: Цена: 20896.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book details the roles of cytokines under physiological and pathological conditions. It includes coverage of the most important cytokines that relate to the hot topics recently elucidated in the field of immunology.
Автор: Bona, Constantin A. Название: Cytokines and Cytokine Receptors ISBN: 9057026341 ISBN-13(EAN): 9789057026348 Издательство: Taylor&Francis Рейтинг: Цена: 35218.00 р. Наличие на складе: Нет в наличии.
Автор: Amy Fulton Название: Chemokine Receptors in Cancer ISBN: 1617378852 ISBN-13(EAN): 9781617378850 Издательство: Springer Рейтинг: Цена: 26120.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Chemokines are a superfamily of low molecular weight cytokines. In humans, there are approximately 45 chemokines that bind to 19 G-protein-coupled receptors. This book reviews what we do and do not know about the role of chemokine receptors in cancer behavior.
Автор: Oystein Bruserud Название: The Chemokine System in Experimental and Clinical Hematology ISBN: 3642264654 ISBN-13(EAN): 9783642264658 Издательство: Springer Рейтинг: Цена: 26120.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This comprehensive explanation of the importance of the chemokine system in hematology focuses on the development of hematologic malignancies, including the immunobiology of stem cell transplantation. It shows that chemokines can be involved in leukemogenesis.
Автор: Lucas Название: Chemokine-Glycosaminoglycan Interactions ISBN: 1071628372 ISBN-13(EAN): 9781071628379 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Amanda E.I. Proudfoot; Timothy N.C. Wells; Christi Название: Chemokine Protocols ISBN: 1617371513 ISBN-13(EAN): 9781617371516 Издательство: Springer Рейтинг: Цена: 20263.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: What has emerged over the years is that most chemokine receptors bind several distinct ligands, and indeed the majority of chemokines are able to bind to multiple chemokine receptors, explaining to some extent the apparent disparity in the numbers of chemokines and rec- tors.
Автор: Gregory Gregoriadis; Brenda McCormack; Anthony C. Название: Vaccine Design ISBN: 0306458187 ISBN-13(EAN): 9780306458187 Издательство: Springer Рейтинг: Цена: 28734.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of a NATO ASI held in Cape Sounion, Greece, June 24-July 5, 1996
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