Автор: Bona, Constantin A. Название: Cytokines and Cytokine Receptors ISBN: 9057026341 ISBN-13(EAN): 9789057026348 Издательство: Taylor&Francis Рейтинг: Цена: 35218.00 р. Наличие на складе: Нет в наличии.
Автор: Pere Santamaria; Peter Hackett Название: Cytokines and Chemokines in Autoimmune Disease ISBN: 1461349524 ISBN-13(EAN): 9781461349525 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume is ideal for individuals interested in taking an in-depth look at how cytokines and chemokines participate in autoimmune disorders, and how cytokines and chemokines can be used as targets for therapeutic intervention.
Автор: Amy Fulton Название: Chemokine Receptors in Cancer ISBN: 1617378852 ISBN-13(EAN): 9781617378850 Издательство: Springer Рейтинг: Цена: 26120.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Chemokines are a superfamily of low molecular weight cytokines. In humans, there are approximately 45 chemokines that bind to 19 G-protein-coupled receptors. This book reviews what we do and do not know about the role of chemokine receptors in cancer behavior.
Автор: Oystein Bruserud Название: The Chemokine System in Experimental and Clinical Hematology ISBN: 3642264654 ISBN-13(EAN): 9783642264658 Издательство: Springer Рейтинг: Цена: 26120.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This comprehensive explanation of the importance of the chemokine system in hematology focuses on the development of hematologic malignancies, including the immunobiology of stem cell transplantation. It shows that chemokines can be involved in leukemogenesis.
Автор: Lucas Название: Chemokine-Glycosaminoglycan Interactions ISBN: 1071628372 ISBN-13(EAN): 9781071628379 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Philip M. Murphy; Richard Horuk Название: Chemokine Roles in Immunoregulation and Disease ISBN: 3662054051 ISBN-13(EAN): 9783662054055 Издательство: Springer Рейтинг: Цена: 19591.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Amanda E.I. Proudfoot; Timothy N.C. Wells; Christi Название: Chemokine Protocols ISBN: 1617371513 ISBN-13(EAN): 9781617371516 Издательство: Springer Рейтинг: Цена: 20263.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: What has emerged over the years is that most chemokine receptors bind several distinct ligands, and indeed the majority of chemokines are able to bind to multiple chemokine receptors, explaining to some extent the apparent disparity in the numbers of chemokines and rec- tors.
Автор: Gregory Gregoriadis; Brenda McCormack; Anthony C. Название: Vaccine Design ISBN: 0306458187 ISBN-13(EAN): 9780306458187 Издательство: Springer Рейтинг: Цена: 28734.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of a NATO ASI held in Cape Sounion, Greece, June 24-July 5, 1996
Автор: Gregory Gregoriadis; Brenda McCormack; Anthony C. Название: Vaccine Design ISBN: 1489900640 ISBN-13(EAN): 9781489900647 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of a NATO ASI held in Cape Sounion, Greece, June 24-July 5, 1996
Автор: G.A.W. Rook; S. Lightman Название: Steroid Hormones and the T-Cell Cytokine Profile ISBN: 1447112385 ISBN-13(EAN): 9781447112389 Издательство: Springer Рейтинг: Цена: 15672.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The fact that certain adrenal steroid hormones are immunosuppressive and anti-inflammatory has been known for many years, and is routinely exploited by physicians. These effects are attributable to glucocorticoid steroids such as cortisol. Pharmacological doses of glucocorticoids inhibit most or all T cell types. However we now know that the effect of exposure to raised physiological levels is mainly to drive developing lymphocyte responses towards a Th2 cytokine profile (interleukin-4 secreting) while suppressing the development ofThi (gamma interferon- secreting) lymphocytes. Only recently have two further regulatory mechanisms become appar- ent. First, these effects of cortisol are balanced by pro-inflammatory and ThI-enhancing effects of another adrenal steroid, dehydroepiandro- sterone sulfate (DHEAS). Second, the activity of cortisol is directly modulated by enzymes in the target organs and lymphoid tissues that convert it into inactive cortisone. This new information leads to the possibility that immunoregulatory steroids could be used by physicians in novel ways. We can envisage steroid combinations that exploit the anti-inflammatory effects of corti- sol, while the Thi-suppressing and Th2-promoting properties of these hormones are opposed by derivatives of DHEAS. Such therapies are already proving effective in animal models of infection, and could revol- utionize treatment of Th2-mediated diseases such as asthma, where the anti-inflammatory effects of cortisol are desirable but the effects on T lymphocyte differentiation are not.
Название: Cytokine effector functions in tissues ISBN: 0128042141 ISBN-13(EAN): 9780128042144 Издательство: Elsevier Science Рейтинг: Цена: 18696.00 р. Наличие на складе: Нет в наличии.
Описание:
Cytokine Effector Functions in Tissues discusses the cytokines networks in the context of the specific-tissue environment. It is an up-to-date collection of articles that addresses the specific issue of how the cytokines are able to condition tissue specific homeostasis. The book helps the reader understand how cytokines network inside the tissues and highlights whether tissue-protection or exacerbation will be finally controlled. It describes the cytokines detected and regulated in different tissues, such as the brain, lungs, spleen, liver, pancreas and intestine, also addressing the issue of timing in specific cell types.
Categorizes the cytokines based primarily on tissue and target cells
Emphasizes different roles and outcomes observed during innate and adaptive response
Represents a rapid guide to cytokines in health and disease in tissue and organ context
Presents a different view on how known mediators may work if analyzed in a different perspective, determining the final outcome on tissue-specific target cells
Описание: This book explores the major cytokines, such as IL-1 and IFN-?, with respect to the regulation of their gene expression and protein production in specific immune cell types. It discusses both healthy physiological settings and in pathological situations in which the expression of some cytokines could be dysregulated, resulting in either immunodeficiency or exacerbated inflammatory sequelae in animal models as well as in human patients. Cytokines are important regulators of immune responses that require the highly coordinated participation and communication of multiple cell types. The expression of cytokines by various producer cell types is therefore carefully regulated in response to environmental cues at multiple levels: transcription, translation and posttranslational modification. Presenting cutting-edge advances in our understanding of the regulation of cytokine expression, this book is a valuable resource for anyone involved or interested in immune regulation.
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