Описание: This book approaches the concept of adjustment to aging and endeavors to build reader understanding of this construct through a critical review and discussion. Once the reader understands the origins and nature of adjustment to aging, a second innovation encompasses the development of a proposed empirical model of adjustment to aging and the analysis of its components and correlates. Measures to assess adjustment to aging, policies, programs and interventions comprising adjustment to aging and its components and correlates will also be addressed. Another innovation includes the multidimensional experience of adjustment to aging from the cultural perspective. Lastly, it addresses areas of future development related to this construct.
Future policies and interventions in older populations need to integrate and debate the role of adjustment to aging, and ultimately consider a variety of different strategies, each with a different set of costs and benefits. Health and social professionals will be at the vanguard of policy making and community and institutional interventions. Hence, resources and tools to adequately prepare these individuals for the future years will be vital. It is the author's hope that this resource can be valuable for professionals and students working within the field of aging, as they develop research and intervention policies encompassing adjustment to aging in the coming years.
Название: Methodological issues and strategies in clinical research ISBN: 1433844087 ISBN-13(EAN): 9781433844089 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 9404.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Now in its fifth edition, this classic text helps readers learn how to design, conduct, analyze, and report high-quality clinical studies. Alan E. Kazdin brings together a wide array of authoritative articles with his own expert insights to illustrate fundamental issues research in an accessible manner, including generating ideas, selecting participants, randomization, selecting assessment measures, analyzing data, and evaluating the implications of and publishing the results. New to this edition are articles emphasizing the importance of diversity in research, not only cultural diversity among study participants but also in methodology (including quantitative, qualitative, and mixed methods) the role of big data using technology such as artificial intelligence and apps and strategies to improve transparency and accessibility, including open science practices, replication, and preregistration. From generating hypotheses for study and selecting appropriate assessments to interpreting data and presenting findings, readers will come to better understand the whole research process as well as the importance of ethics and scientific integrity.
Автор: Rajput Название: Drugs and a Methodological Compendium ISBN: 9811979510 ISBN-13(EAN): 9789811979514 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Поставка под заказ.
Описание: This book provides a meticulous view on methodological drug discovery and development insights from bench to bedside. The current book threads almost each step encompassing drug the discovery and development of a molecule. The chapters focus on computational modus operandi, pharmacological optimization approaches, modern high-throughput screening methods and in-vitro procedures, role of structural biologists in drug discovery and development, medicinal chemistry approaches for drug design, formulation and drug delivery, in-vivo evaluations of candidate molecules, clinical trial procedures and others. The book also covers specific case studies, regulatory approval proceedings, and industrial view point alongside the aforementioned conceptual layout. And at the same time, the volume integrates medical, biological, medicinal, pharmacological and computational streams, and it is suggested as an ideal guideline to a wide audience including molecular biologists, biochemist, pharmacologists, medicinal chemist, toxicologists, drug discovery and development researchers, and all other students interested in these disciplines.
1. Computational Issues Of Maximum Likelihood Estimation Of The Skew-T Distribution And A Proposal For The Initialization Of Numerical Optimization - by Adelchi Azzalini (University of Padua, Italy) and Mahdi Salehi (University of Neyshabur, Iran).- 2. Modelling Earthquakes: Characterizing Inter-Arrival Times And Magnitude - by Christophe Ley (Ghent University, Belgium) and Rosaria Simone (University of Naples Frederico II, Italy).- 3. Multivariate Order Statistics Induced By Ordering Linear Combinations Of Components Of Multivariate Elliptical Random Vectors - by Ahad Jamalizadeh (Shahid Bahonar University, Iran), Roohollah Roozegar (Yasouj University, Iran), Narayanaswamy Balakrishnan (McMaster University, Canada) and Mehrdad Naderi (University of Pretoria, South Africa).- 4. Spatial Interpolation Of Extreme PM1 Values Using Copulas - by Alfred Stein, Fakhereh Alidoost and Vera van Zoest (University of Twente, The Netherlands).- 5. Distributional Aspects Of The Condition Number From A Unified Complex Wishart Setting - by Johannes Ferreira and Andriлtte Bekker (University of Pretoria, South Africa).- 6. Weighted Bivariate Pуlya-Aeppli Type Ii Distributions - by Claire Geldenhuys and Renй Ehlers (University of Pretoria, South Africa).- 7. On The Distribution Of Linear Combinations Of Chi-Square Random Variables - by Carlos A. Coelho (Universidade Nova de Lisboa, Portugal).- 8. Constructing Multivariate Distributions Using The Dirichlet As A Baseline - by Seite Makgai (University of Pretoria, South Africa), Mohammad Arashi (Shahrood University of Technology, Iran), Daan de Waal (University of the Free State), and Andriлtte Bekker (University of Pretoria, South Africa).- 9. Evaluating Risk Measures Using The Normal Mean-Variance Birnbaum-Saunders Distribution - by Mehrdad Naderi (University of Pretoria, South Africa), Ahad Jamalizadeh (Shahid Bahonar University, Iran), Wan-Lun Wang (Feng Chia University, Taiwan), Tsung-I Lin (National Chung Hsing University, Taiwan).- 10. On High-Dimensional Multivariate Bayesian Geostatistics - by Sudipto Banerjee (University of California, USA).- 11. On Improving The Performance Of Logistic Regression Analysis Via Extreme Ranking - by Hani M. Samawi (Georgia Southern University, USA).- 12. Optimal Sample Size Allocation For Multi-Level Stress Testing With Extreme Value Regression Under Time Censoring - by Ping Shing Chan (The Chinese University of Hong Kong, Hong Kong), Hon Yiu So (University of Waterloo, Canada), Hon Keung Tony Ng (Southern Methodist University, USA) and Wei Gao (Northeast Normal University, China).- 13. Robust Mixtures Of Scale Mixtures In The Exponential Family - by Frans Kanfer and Sollie Millard (University of Pretoria, South Africa).- 14. Variable Selection Of Interval-Censored Failure Time Data - by Tony Sun (University of Missouri, USA).- 15. On The Design Of A Platform Trial For The Treatment Of Recurrent Clostridium Difficile Infection By Fecal Microbiota Transplantation - by Christine H. Lee (Royal Jubilee Hospital, Canada), Dina Kao (University of Alberta, Canada), Theodore Steiner (University of Vancouver, Canada), Augustine Wigle (University of Guelph, Canada) and Peter T. Kim (University of Guelph, Canada).- 16. Recent Advances In Bayesian Adaptive Designs And Applications - by J. Jack Lee (University of Texas, USA).- 17. Generalizability Theory For Clinician-Rated Outcomes - by Joseph C. Cappelleri (Executive Director of Biostatistics, Pfizer Inc).- 18. Simultaneous Variable Selection And Estimation In Generalized Semiparametric Mixed Effect Modeling Of Longitudinal Data - by Mozhgan Taavoni and Mohammad Arashi (Shahrood University of Technology, Iran).- 19. Generalized Rayleigh-Exponential-Weibull Distribution and its Application to Modelling of Progressive Type-I Interval Censored Data - by Ding-Geng Chen (University of Pretoria) and Y. L. Lio (University of South Dakota).- 20. Applications Of Spatial Statistics In Poverty Alleviat
Описание: This book approaches the concept of adjustment to aging and endeavors to build reader understanding of this construct through a critical review and discussion. Once the reader understands the origins and nature of adjustment to aging, a second innovation encompasses the development of a proposed empirical model of adjustment to aging and the analysis of its components and correlates. Measures to assess adjustment to aging, policies, programs and interventions comprising adjustment to aging and its components and correlates will also be addressed. Another innovation includes the multidimensional experience of adjustment to aging from the cultural perspective. Lastly, it addresses areas of future development related to this construct. Future policies and interventions in older populations need to integrate and debate the role of adjustment to aging, and ultimately consider a variety of different strategies, each with a different set of costs and benefits. Health and social professionals will be at the vanguard of policy making and community and institutional interventions. Hence, resources and tools to adequately prepare these individuals for the future years will be vital. It is the author's hope that this resource can be valuable for professionals and students working within the field of aging, as they develop research and intervention policies encompassing adjustment to aging in the coming years.
Автор: Carmen Garc?a-Pe?a; Luis Miguel Guti?rrez-Robledo; Название: Aging Research - Methodological Issues ISBN: 3030070255 ISBN-13(EAN): 9783030070250 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Поставка под заказ.
Описание: This is the second edition of a well received book that reviews classical epidemiological and clinical research designs, with a specific focus on aging. Chapters cover basic topics like the scientific method, ethics, and the consequences of certain exclusion criteria. The work also includes a look at clinical concepts like multimorbidity, frailty and functionality. New material includes chapters such as geroscience, health systems research, big data and data mining, financing and future of aging research. The authors reveal the issues and challenges for researchers of age and aging, and also consider, from basic to clinical, and from clinical to public policies of social and health care.The focus on aging is what gives this book its valuable perspective on research methodology. All authors have considerable experience in aging, geriatrics or gerontology, and each chapter includes both a theoretical framework and practical examples of studies in aging. Readers will discover study designs that are reviewed for basic structure, main flaws and advantages, and are analyzed for specific conditions and variables regarding aging.This text is suited to both health care professionals caring for older adults, and researchers who are new to research in aging. It is relevant across the disciplines, including medicine, psychology, social sciences and dentistry, and it supports learning with graphs and figures.
Описание: Based on a Meeting Held in May 1984 in Linz, Federal Republic of Germany
Автор: David G. Ostrow; Ronald C. Kessler Название: Methodological Issues in AIDS Behavioral Research ISBN: 1475785348 ISBN-13(EAN): 9781475785340 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Researchers working on both biological and behavioral aspects of the disease will find this work a singularly effective tool to improve their study designs.
Автор: Jordi Vallverd?; Angel Puyol; Anna Estany Название: Philosophical and Methodological Debates in Public Health ISBN: 3030286258 ISBN-13(EAN): 9783030286255 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This interdisciplinary volume gathers selected, refereed contributions on various aspects of public health from several disciplines and research fields, including the philosophy of science, epidemiology, statistics and ethics. The contributions were originally presented at the 1st Barcelona conference of “Philosophy of Public Health” (5th – 7th May 2016). This book is intended for researchers interested in public health and the contemporary debates surrounding it.
1. Computational Issues Of Maximum Likelihood Estimation Of The Skew-T Distribution And A Proposal For The Initialization Of Numerical Optimization - by Adelchi Azzalini (University of Padua, Italy) and Mahdi Salehi (University of Neyshabur, Iran).- 2. Modelling Earthquakes: Characterizing Inter-Arrival Times And Magnitude - by Christophe Ley (Ghent University, Belgium) and Rosaria Simone (University of Naples Frederico II, Italy).- 3. Multivariate Order Statistics Induced By Ordering Linear Combinations Of Components Of Multivariate Elliptical Random Vectors - by Ahad Jamalizadeh (Shahid Bahonar University, Iran), Roohollah Roozegar (Yasouj University, Iran), Narayanaswamy Balakrishnan (McMaster University, Canada) and Mehrdad Naderi (University of Pretoria, South Africa).- 4. Spatial Interpolation Of Extreme PM1 Values Using Copulas - by Alfred Stein, Fakhereh Alidoost and Vera van Zoest (University of Twente, The Netherlands).- 5. Distributional Aspects Of The Condition Number From A Unified Complex Wishart Setting - by Johannes Ferreira and Andriлtte Bekker (University of Pretoria, South Africa).- 6. Weighted Bivariate Pуlya-Aeppli Type Ii Distributions - by Claire Geldenhuys and Renй Ehlers (University of Pretoria, South Africa).- 7. On The Distribution Of Linear Combinations Of Chi-Square Random Variables - by Carlos A. Coelho (Universidade Nova de Lisboa, Portugal).- 8. Constructing Multivariate Distributions Using The Dirichlet As A Baseline - by Seite Makgai (University of Pretoria, South Africa), Mohammad Arashi (Shahrood University of Technology, Iran), Daan de Waal (University of the Free State), and Andriлtte Bekker (University of Pretoria, South Africa).- 9. Evaluating Risk Measures Using The Normal Mean-Variance Birnbaum-Saunders Distribution - by Mehrdad Naderi (University of Pretoria, South Africa), Ahad Jamalizadeh (Shahid Bahonar University, Iran), Wan-Lun Wang (Feng Chia University, Taiwan), Tsung-I Lin (National Chung Hsing University, Taiwan).- 10. On High-Dimensional Multivariate Bayesian Geostatistics - by Sudipto Banerjee (University of California, USA).- 11. On Improving The Performance Of Logistic Regression Analysis Via Extreme Ranking - by Hani M. Samawi (Georgia Southern University, USA).- 12. Optimal Sample Size Allocation For Multi-Level Stress Testing With Extreme Value Regression Under Time Censoring - by Ping Shing Chan (The Chinese University of Hong Kong, Hong Kong), Hon Yiu So (University of Waterloo, Canada), Hon Keung Tony Ng (Southern Methodist University, USA) and Wei Gao (Northeast Normal University, China).- 13. Robust Mixtures Of Scale Mixtures In The Exponential Family - by Frans Kanfer and Sollie Millard (University of Pretoria, South Africa).- 14. Variable Selection Of Interval-Censored Failure Time Data - by Tony Sun (University of Missouri, USA).- 15. On The Design Of A Platform Trial For The Treatment Of Recurrent Clostridium Difficile Infection By Fecal Microbiota Transplantation - by Christine H. Lee (Royal Jubilee Hospital, Canada), Dina Kao (University of Alberta, Canada), Theodore Steiner (University of Vancouver, Canada), Augustine Wigle (University of Guelph, Canada) and Peter T. Kim (University of Guelph, Canada).- 16. Recent Advances In Bayesian Adaptive Designs And Applications - by J. Jack Lee (University of Texas, USA).- 17. Generalizability Theory For Clinician-Rated Outcomes - by Joseph C. Cappelleri (Executive Director of Biostatistics, Pfizer Inc).- 18. Simultaneous Variable Selection And Estimation In Generalized Semiparametric Mixed Effect Modeling Of Longitudinal Data - by Mozhgan Taavoni and Mohammad Arashi (Shahrood University of Technology, Iran).- 19. Generalized Rayleigh-Exponential-Weibull Distribution and its Application to Modelling of Progressive Type-I Interval Censored Data - by Ding-Geng Chen (University of Pretoria) and Y. L. Lio (University of South Dakota).- 20. Applications Of Spatial Statistics In Poverty Alleviat
Автор: Jere R. Behrman; Robin C. Sickles; Paul Taubman Название: Causes, Correlates and Consequences of Death Among Older Adults ISBN: 9401058873 ISBN-13(EAN): 9789401058872 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: 3 years longer than that of the whole population, but life expectancies for blacks were only about 33 years for men and women. Fifty years later, life expectancies at birth had grown to 66 and 71 years for males and females respectively.
Автор: Francisco Aboitiz; Diego Cosmelli Название: From Attention to Goal-Directed Behavior ISBN: 3642089518 ISBN-13(EAN): 9783642089510 Издательство: Springer Рейтинг: Цена: 28732.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume presents an updated view of neurodynamical approaches to attentional mechanisms and related percetual and consciousness questions with a take on neuropsychiatric illnesses which can shed light on these problems, specifically ADHD and schizophrenia
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