Описание: PART I: The need for Alzheimer's Disease Biomarkers
1. Epidemiology of Dementia: The Burden on Society, the Challenges for Research
Frank J. Wolters and M. Arfan Ikram
2. Population-based Approaches to Alzheimer's Disease Prevention
Robert Perneczky
3. Systems Biology Methods for Alzheimer's Disease Research towards Molecular Signatures, Subtypes and Stages and Precision Medicine. Application in Cohort Studies and Trials
Juan I. Castrillo, Simone Lista, Harald Hampel, and Craig W. Ritchie
PART II: Innovative Approaches to Cerebrospinal Fluid Biomarker Discovery
4. CSF Lipidomics Analysis: High-Resolution Mass Spectrometry Analytical Platform
Paul L. Wood and Randall L. Woltjer
5. CSF N-glycomics using MALDI MS Techniques in Alzheimer's Disease
Angelo Palmigiano, Angela Messina, Rosaria Ornella Bua, Rita Barone, Luisa Sturiale, Mario Zappia, and Domenico Garozzo
6. MicroRNA Profiling of Alzheimer's Disease Cerebrospinal Fluid Johannes Denk and Holger Jahn
Part III: Novel Blood-based Biomarkers
7. Validation of a Chemiluminescence Immunoassay for Measuring Amyloid-β in Human Blood Plasma
Jonathan Vogelgsang, Jens Wiltfang, and Hans-W. Klafki
8. Mass Spectrometry-based Metabolomic Multiplatform for Alzheimer's Disease Research
Raъl Gonzбlez-Domнnguez, Бlvaro Gonzбlez-Domнnguez, Ana Sayago, and Бngeles Fernбndez-Recamales
9. Blood-based Biomarker Screening with Agnostic Biological Definitions for an Accurate Diagnosis within the Dimensional Spectrum of Neurodegenerative Diseases
Filippo Baldacci, Simone Lista, Sid E. O'Bryant, Roberto Ceravolo, Nicola Toschi, and Harald Hampel,
Part IV: Magnetic Resonance Imaging Methods
10. Functional Magnetic Resonance Imaging in Alzheimer' Disease Drug Development
Stefan Holiga, Ahmed Abdulkadir, Stefan Klцppel, and Juergen Dukart
11. Neuroimaging Methods for MRI Analysis in CSF Biomarkers Studies
Carles Falcon, Grйgory Operto, Josй Luis Molinuevo, and Juan Domingo Gispert
12. Hybrid PET-MRI in Alzheimer's Disease Research
Ismini C. Mainta, Maria I. Vargas, Sara Trombella, Giovanni B. Frisoni, Paul G. Unschuld, Valentina Garibotto
Part V: Molecular Imaging Approaches
13. Amyloid PET Imaging: Standardization and Integration with Other Alzheimer Disease Biomarkers
Silvia Morbelli and Matteo Bauckneht
14. The use of 18F-FDG PET in the Diagnostic Workup of Alzheimer's Dementia
Marion M. Ortner
15. Quantification of Tau Load in Alzheimer's Disease Clinical Trials Using Positron Emission Tomography
Tessa Timmers, Bart N.M. van Berckel, Adriaan Lammertsma, and Rik Ossenkoppele
16. Imaging Neuroinflammation: Quantification of Astrocytosis in a Multitracer PET Approach Elena Rodriguez-Vieitez and Agneta Nordberg
Part VI: Neuropathology
17. Unbiased Lipidomics and Metabolomics of Human Brain Samples
Giuseppe Astarita, Matteo Stocchero, and Giuseppe Paglia
18. Neuropathological Assessment as an Endpoint in Clinical Trial Design
Steve Gentleman and Alan King Lun Liu
Part VII Genomic Methods
19. Analysis of micro-RNA Expression by qPCR on a Microfluidics Platform for Alzheimer's Disease Biomarker Discovery
Petros Takousis
20. Telomere length shortening in Alzheimer's disease - procedures for a causal investigation using single nucleotide polymorphisms in a Mendelian Randomization study
Yiqiang Zhan,
