Biomarkers for Preclinical Alzheimer`s Disease, Perneczky
Автор: Maisel Alan S., Jaffe Allan S. Название: Cardiac Biomarkers. Case Studies and Clinical Correlations ISBN: 3319429809 ISBN-13(EAN): 9783319429809 Издательство: Springer Рейтинг: Цена: 9782.00 р. 13974.00-30% Наличие на складе: Есть (1 шт.) Описание: This book covers ACS and Heart Failure, the chapters represent the most current, up to date and knowledgeable content on the topic available. It is written by the worlds most respected leaders in biomarkers, with a majority emphasis on what clinicians need to know.
The Editors and their contributors have provided algorithms, annotated case discussions and caveats. They cover biomarkers to predict risk of heart disease, biomarkers of cardiorenal disease , and conclude with a section on new and emerging biomarkers. It be genuinely helpful and practical to those in the field, including not just people working in the field, but nurses, doctors, etc who practice medicine in the clinic, the emergency department and the hospital.?
Автор: Rudolph Название: Alzheimer`s Disease ISBN: 1439827087 ISBN-13(EAN): 9781439827086 Издательство: Taylor&Francis Рейтинг: Цена: 17149.00 р. 24499.00-30% Наличие на складе: Есть (1 шт.) Описание:
In recent years, a tremendous amount of effort has been focused on better understanding the fundamentals of Alzheimer's disease (AD) to facilitate early and accurate diagnosis and appropriately targeted therapeutic treatments. Alzheimer's Disease: Targets for New Clinical, Diagnostic, and Therapeutic Strategies provides a detailed synopsis of the current state of the art of diagnostics and therapeutics and identifies emerging technologies and molecules that show promise in the management and treatment of AD.
With contributions from experts drawn from academia, clinical practice, and the biotechnology and pharmaceutical industries, the book explores:
The basis of AD and the role of Aβ oligomers in development of disease
Existing and emerging in vitro biomarker-based methodologies for the diagnosis of AD, focusing on genetic, biochemical, and conformational strategies
In vivo imaging diagnostic approaches
Evolving diagnostic criteria, health regulatory guidelines, biomarkers in clinical trials, and available and emerging therapies
Recent progress in small-molecule disease-modifier drug discovery efforts for AD, specifically in the areas of Aβ, tau, and emerging neuroprotective/neurorepair approaches
How a case study of AD raises issues regarding clinical and pathologic criteria, risk factors, and the amyloid hypothesis
The molecular conformational factors that govern the pathogenicity of aggregating proteins, and how these factors could represent new targets for disease-modifying therapies
The latest epidemiological, pathological, biochemical, and behavioral studies that may shed some light on the risk of developing AD and similar dementias after traumatic brain injury
Examining current hypotheses and suggesting possible new approaches to therapeutic clinical applications, this volume paves the way for a robust pipeline of therapeutics to combat not only AD, but a whole host of other neurodegenerative diseases.
Название: Handbook of Therapeutic Biomarkers in Cancer ISBN: 9814364657 ISBN-13(EAN): 9789814364652 Издательство: Taylor&Francis Рейтинг: Цена: 21437.00 р. Наличие на складе: Поставка под заказ.
Описание: In this volume, a team of internationally recognized experts provide an in-depth description of therapeutic biomarkers across a broad area of cancer research and oncology. With a wealth of information to specific therapies, each chapter focuses on a class of targeted chemotherapy agents. The book describes established and evolving diagnostic tests for therapeutic biomarkers that predict benefit, response, resistance, or drug side effects from specific therapeutic interventions. This volume is an essential handbook for health professionals and scientists researching current applicable biomarkers in oncology.
Автор: Edited by Andrew K. Trull Название: Biomarkers of Disease ISBN: 0521811023 ISBN-13(EAN): 9780521811026 Издательство: Cambridge Academ Рейтинг: Цена: 39125.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This publication takes a critical, evidence-based look at the efficacy of diagnostic tests which are increasingly being used to evaluate organ damage and dysfunction. Some of these assist in diagnosis, others provide a means of monitoring the state of progression of disease and the effectiveness of therapeutic options.
Название: Biomarkers of disease ISBN: 0521088607 ISBN-13(EAN): 9780521088602 Издательство: Cambridge Academ Рейтинг: Цена: 10138.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This publication takes a critical, evidence-based look at the efficacy of diagnostic tests which are increasingly being used to evaluate organ damage and dysfunction. Some of these assist in diagnosis, others provide a means of monitoring the state of progression of disease and the effectiveness of therapeutic options.
Автор: Edelstein, Charles L. Название: Biomarkers of Kidney Disease ISBN: 0128030143 ISBN-13(EAN): 9780128030141 Издательство: Elsevier Science Рейтинг: Цена: 14654.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Biomarkers of Kidney Disease, Second Edition, focuses on the basic and clinical research of biomarkers in common kidney diseases, detailing the characteristics of an ideal biomarker. The latest techniques for biomarker detection, including metabolomics and proteomics are covered in the book.
This comprehensive book details the latest advances made in the field of biomarker research and development in kidney diseases. The book is an ideal companion for those interested in biomarker research and development, proteomics and metabolomics, kidney diseases, statistical analysis, transplantation, and preeclampsia. New chapters include biomarkers of cardiovascular disease in patients with CKD, biomarkers of Polycystic Kidney Disease, and biomarkers and the role of nanomedicine.
Автор: Lenz H. G. Название: Biomarkers in Oncology ISBN: 1441997547 ISBN-13(EAN): 9781441997548 Издательство: Springer Рейтинг: Цена: 25155.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This integrated book covers the entire spectrum of cancer biomarkers in development and clinical use. Predictive and prognostic markers are explored in the context of colon cancer, breast cancer, lung cancer, prostate cancer, and GIST. International experts provide insight into toxicity markers and surrogate markers. Attention is also given to biomarker assay development, validation, and strategies. A powerful tool for determining decisions on therapy, selecting drug regimens, monitoring the efficacy of treatment, and performing individualized surveillance, biomarkers represent the forefront of cancer research and treatment. As these technologies become increasingly available for clinical use, this book will be an essential resource for oncologists and translational researchers.
Автор: Perneczky Название: Biomarkers for Alzheimer`s Disease Drug Development ISBN: 1493977032 ISBN-13(EAN): 9781493977031 Издательство: Springer Рейтинг: Цена: 11179.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
PART I: The need for Alzheimer's Disease Biomarkers
1. Epidemiology of Dementia: The Burden on Society, the Challenges for Research
Frank J. Wolters and M. Arfan Ikram
2. Population-based Approaches to Alzheimer's Disease Prevention
Robert Perneczky
3. Systems Biology Methods for Alzheimer's Disease Research towards Molecular Signatures, Subtypes and Stages and Precision Medicine. Application in Cohort Studies and Trials
Juan I. Castrillo, Simone Lista, Harald Hampel, and Craig W. Ritchie
PART II: Innovative Approaches to Cerebrospinal Fluid Biomarker Discovery
4. CSF Lipidomics Analysis: High-Resolution Mass Spectrometry Analytical Platform
Paul L. Wood and Randall L. Woltjer
5. CSF N-glycomics using MALDI MS Techniques in Alzheimer's Disease
Angelo Palmigiano, Angela Messina, Rosaria Ornella Bua, Rita Barone, Luisa Sturiale, Mario Zappia, and Domenico Garozzo
6. MicroRNA Profiling of Alzheimer's Disease Cerebrospinal Fluid Johannes Denk and Holger Jahn
Part III: Novel Blood-based Biomarkers
7. Validation of a Chemiluminescence Immunoassay for Measuring Amyloid-β in Human Blood Plasma
Jonathan Vogelgsang, Jens Wiltfang, and Hans-W. Klafki
8. Mass Spectrometry-based Metabolomic Multiplatform for Alzheimer's Disease Research
Raъl Gonzбlez-Domнnguez, Бlvaro Gonzбlez-Domнnguez, Ana Sayago, and Бngeles Fernбndez-Recamales
9. Blood-based Biomarker Screening with Agnostic Biological Definitions for an Accurate Diagnosis within the Dimensional Spectrum of Neurodegenerative Diseases
Filippo Baldacci, Simone Lista, Sid E. O'Bryant, Roberto Ceravolo, Nicola Toschi, and Harald Hampel,
Part IV: Magnetic Resonance Imaging Methods
10. Functional Magnetic Resonance Imaging in Alzheimer' Disease Drug Development
Stefan Holiga, Ahmed Abdulkadir, Stefan Klцppel, and Juergen Dukart
11. Neuroimaging Methods for MRI Analysis in CSF Biomarkers Studies
Carles Falcon, Grйgory Operto, Josй Luis Molinuevo, and Juan Domingo Gispert
12. Hybrid PET-MRI in Alzheimer's Disease Research
Ismini C. Mainta, Maria I. Vargas, Sara Trombella, Giovanni B. Frisoni, Paul G. Unschuld, Valentina Garibotto
Part V: Molecular Imaging Approaches
13. Amyloid PET Imaging: Standardization and Integration with Other Alzheimer Disease Biomarkers
Silvia Morbelli and Matteo Bauckneht
14. The use of 18F-FDG PET in the Diagnostic Workup of Alzheimer's Dementia
Marion M. Ortner
15. Quantification of Tau Load in Alzheimer's Disease Clinical Trials Using Positron Emission Tomography
Tessa Timmers, Bart N.M. van Berckel, Adriaan Lammertsma, and Rik Ossenkoppele
16. Imaging Neuroinflammation: Quantification of Astrocytosis in a Multitracer PET Approach
Elena Rodriguez-Vieitez and Agneta Nordberg
Part VI: Neuropathology
17. Unbiased Lipidomics and Metabolomics of Human Brain Samples
Giuseppe Astarita, Matteo Stocchero, and Giuseppe Paglia
18. Neuropathological Assessment as an Endpoint in Clinical Trial Design
Steve Gentlemanand Alan King Lun Liu
Part VII Genomic Methods
19. Analysis of micro-RNA Expression by qPCR on a Microfluidics Platform for Alzheimer's Disease Biomarker Discovery
Petros Takousis
20. Telomere length shortening in Alzheimer's disease - procedures for a causal investigation using single nucleotide polymorphisms in a Mendelian Randomization study Yiqiang Zhan,
Описание: Addressing a significant need by describing the science and process involved to develop biosimilars of monoclonal antibody (mAb) drugs, this book covers all aspects of biosimilar development: preclinical, clinical, regulatory, manufacturing.
Автор: Armstrong Donald Название: Oxidative Stress Biomarkers and Antioxidant Protocols ISBN: 0896038505 ISBN-13(EAN): 9780896038509 Издательство: Springer Рейтинг: Цена: 21661.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Donald Armstrong updates and expands his highly praised Free Radical and Antioxidant Protocols (Humana, 1998) with a collection of new and valuable methods for evaluating the pertubations in cell function resulting from increased oxidative stress. Presented in a user-friendly, step-by-step format, these readily reproducible techniques cover both free radical-derived and antioxidant biomarkers. The methodologies demonstrated include ELISA, HPLC, infrared spectroscopy, gas chromatography-mass spectroscopy, immunoblotting, electroelution fractionation, isoelectric focusing, voltametry, and electron paramagnetic resonance imaging. Special emphasis is given to the separation of complex mixtures of plant antioxidants, soft drug design to protect from toxic oxidative metabolites, in vitro oxidation conditions, and correcting for random measurement error to improve statistical interpretation. A soon-to-be-published companion volume, Oxidants and Antioxidants: Ultrastructural and Molecular Biology Protocols (0-89603-851-3), contains state-of-the-art molecular and ultrastructural methods that expand the total number of protocols to 109 assays.
Автор: Peter Greaves Название: Histopathology of Preclinical Toxicity Studies, ISBN: 0444538569 ISBN-13(EAN): 9780444538567 Издательство: Elsevier Science Рейтинг: Цена: 25096.00 р. Наличие на складе: Поставка под заказ.
Описание: Describes the pathology found in drug safety studies in laboratory animals with an evidence-based discussion of the relevance of these findings to the clinical investigation of new drugs for humans. This reference is suitable for those involved in drug safety evaluation, including pathologists, toxicologists, and pharmacologists.
Автор: Jain K.K. Название: The Handbook of biomarkers ISBN: 160761684X ISBN-13(EAN): 9781607616849 Издательство: Springer Рейтинг: Цена: 26122.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This handbook describes many different types of biomarkers and their discovery. It also presents the background information needed for the evaluation of biomarkers as well as the essential procedures for their validation and use in clinical trials.
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