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Biomarkers for Preclinical Alzheimer`s Disease, Perneczky

Perneczky Biomarkers for Preclinical Alzheimer`s Disease 9781493976737

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Автор: Perneczky
Название: Biomarkers for Preclinical Alzheimer`s Disease
ISBN: 9781493976737
Издательство: Springer
Классификация:

Болезнь Альцгеймера и дименция

Науки о жизни (медико-биологические): общие вопросы

Нейронауки

ISBN-10: 1493976737
Обложка/Формат: Hardcover
Страницы: 272
Вес: 6.88 кг.
Дата издания: 2018
Серия: Neuromethods
Язык: English
Издание: 1st ed. 2018
Иллюстрации: 33 tables, color; 34 illustrations, color; 2 illustrations, black and white; viii, 254 p. 36 illus., 34 illus. in color.
Размер: 186 x 263 x 26
Читательская аудитория: Postgraduate, research & scholarly
Основная тема: Neurosciences
Ссылка на Издательство: Link
Рейтинг:
Поставляется из: Германии
Описание: This volume discusses the importance of imaging, fluid, and genetic biomarkers in detecting the earliest pre-symptomatic stages of Alzheimer`s disease (AD). Parts four and five talk about technological advancements in AD diagnosis and ethical considerations in AD research.

Alzheimer`s Disease

Автор: Rudolph
Название: Alzheimer`s Disease
ISBN: 1439827087 ISBN-13(EAN): 9781439827086
Издательство: Taylor&Francis
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Цена: 17149.00 р. ~~24499.00~~ -30%
Наличие на складе: Есть (1 шт.)
Описание:

In recent years, a tremendous amount of effort has been focused on better understanding the fundamentals of Alzheimer's disease (AD) to facilitate early and accurate diagnosis and appropriately targeted therapeutic treatments. Alzheimer's Disease: Targets for New Clinical, Diagnostic, and Therapeutic Strategies provides a detailed synopsis of the current state of the art of diagnostics and therapeutics and identifies emerging technologies and molecules that show promise in the management and treatment of AD.

With contributions from experts drawn from academia, clinical practice, and the biotechnology and pharmaceutical industries, the book explores:

The basis of AD and the role of Aβ oligomers in development of disease
Existing and emerging in vitro biomarker-based methodologies for the diagnosis of AD, focusing on genetic, biochemical, and conformational strategies
In vivo imaging diagnostic approaches
Evolving diagnostic criteria, health regulatory guidelines, biomarkers in clinical trials, and available and emerging therapies
Recent progress in small-molecule disease-modifier drug discovery efforts for AD, specifically in the areas of Aβ, tau, and emerging neuroprotective/neurorepair approaches
How a case study of AD raises issues regarding clinical and pathologic criteria, risk factors, and the amyloid hypothesis
The molecular conformational factors that govern the pathogenicity of aggregating proteins, and how these factors could represent new targets for disease-modifying therapies
The latest epidemiological, pathological, biochemical, and behavioral studies that may shed some light on the risk of developing AD and similar dementias after traumatic brain injury

Examining current hypotheses and suggesting possible new approaches to therapeutic clinical applications, this volume paves the way for a robust pipeline of therapeutics to combat not only AD, but a whole host of other neurodegenerative diseases.

Cardiac Biomarkers. Case Studies and Clinical Correlations

Автор: Maisel Alan S., Jaffe Allan S.
Название: Cardiac Biomarkers. Case Studies and Clinical Correlations
ISBN: 3319429809 ISBN-13(EAN): 9783319429809
Издательство: Springer
Рейтинг:
Цена: 9782.00 р. ~~13974.00~~ -30%
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: This book covers ACS and Heart Failure, the chapters represent the most current, up to date and knowledgeable content on the topic available. It is written by the worlds most respected leaders in biomarkers, with a majority emphasis on what clinicians need to know.

The Editors and their contributors have provided algorithms, annotated case discussions and caveats. They cover biomarkers to predict risk of heart disease, biomarkers of cardiorenal disease , and conclude with a section on new and emerging biomarkers. It be genuinely helpful and practical to those in the field, including not just people working in the field, but nurses, doctors, etc who practice medicine in the clinic, the emergency department and the hospital.?

The Handbook of biomarkers

Автор: Jain K.K.
Название: The Handbook of biomarkers
ISBN: 160761684X ISBN-13(EAN): 9781607616849
Издательство: Springer
Рейтинг:
Цена: 26122.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: This handbook describes many different types of biomarkers and their discovery. It also presents the background information needed for the evaluation of biomarkers as well as the essential procedures for their validation and use in clinical trials.

Biomarkers for Alzheimer`s Disease Drug Development

Автор: Perneczky
Название: Biomarkers for Alzheimer`s Disease Drug Development
ISBN: 1493977032 ISBN-13(EAN): 9781493977031
Издательство: Springer
Рейтинг:
Цена: 11179.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание:

PART I: The need for Alzheimer's Disease Biomarkers

1. Epidemiology of Dementia: The Burden on Society, the Challenges for Research

Frank J. Wolters and M. Arfan Ikram

2. Population-based Approaches to Alzheimer's Disease Prevention

Robert Perneczky

3. Systems Biology Methods for Alzheimer's Disease Research towards Molecular Signatures, Subtypes and Stages and Precision Medicine. Application in Cohort Studies and Trials

Juan I. Castrillo, Simone Lista, Harald Hampel, and Craig W. Ritchie

PART II: Innovative Approaches to Cerebrospinal Fluid Biomarker Discovery

4. CSF Lipidomics Analysis: High-Resolution Mass Spectrometry Analytical Platform

Paul L. Wood and Randall L. Woltjer

5. CSF N-glycomics using MALDI MS Techniques in Alzheimer's Disease

Angelo Palmigiano, Angela Messina, Rosaria Ornella Bua, Rita Barone, Luisa Sturiale, Mario Zappia, and Domenico Garozzo

6. MicroRNA Profiling of Alzheimer's Disease Cerebrospinal Fluid Johannes Denk and Holger Jahn

Part III: Novel Blood-based Biomarkers

7. Validation of a Chemiluminescence Immunoassay for Measuring Amyloid-β in Human Blood Plasma

Jonathan Vogelgsang, Jens Wiltfang, and Hans-W. Klafki

8. Mass Spectrometry-based Metabolomic Multiplatform for Alzheimer's Disease Research

Raъl Gonzбlez-Domнnguez, Бlvaro Gonzбlez-Domнnguez, Ana Sayago, and Бngeles Fernбndez-Recamales

9. Blood-based Biomarker Screening with Agnostic Biological Definitions for an Accurate Diagnosis within the Dimensional Spectrum of Neurodegenerative Diseases

Filippo Baldacci, Simone Lista, Sid E. O'Bryant, Roberto Ceravolo, Nicola Toschi, and Harald Hampel,

Part IV: Magnetic Resonance Imaging Methods

10. Functional Magnetic Resonance Imaging in Alzheimer' Disease Drug Development

Stefan Holiga, Ahmed Abdulkadir, Stefan Klцppel, and Juergen Dukart

11. Neuroimaging Methods for MRI Analysis in CSF Biomarkers Studies

Carles Falcon, Grйgory Operto, Josй Luis Molinuevo, and Juan Domingo Gispert

12. Hybrid PET-MRI in Alzheimer's Disease Research

Ismini C. Mainta, Maria I. Vargas, Sara Trombella, Giovanni B. Frisoni, Paul G. Unschuld, Valentina Garibotto

Part V: Molecular Imaging Approaches

13. Amyloid PET Imaging: Standardization and Integration with Other Alzheimer Disease Biomarkers

Silvia Morbelli and Matteo Bauckneht

14. The use of ¹⁸F-FDG PET in the Diagnostic Workup of Alzheimer's Dementia

Marion M. Ortner

15. Quantification of Tau Load in Alzheimer's Disease Clinical Trials Using Positron Emission Tomography

Tessa Timmers, Bart N.M. van Berckel, Adriaan Lammertsma, and Rik Ossenkoppele

16. Imaging Neuroinflammation: Quantification of Astrocytosis in a Multitracer PET Approach

Elena Rodriguez-Vieitez and Agneta Nordberg

Part VI: Neuropathology

17. Unbiased Lipidomics and Metabolomics of Human Brain Samples

Giuseppe Astarita, Matteo Stocchero, and Giuseppe Paglia

18. Neuropathological Assessment as an Endpoint in Clinical Trial Design

Steve Gentlemanand Alan King Lun Liu

Part VII Genomic Methods

19. Analysis of micro-RNA Expression by qPCR on a Microfluidics Platform for Alzheimer's Disease Biomarker Discovery

Petros Takousis

20. Telomere length shortening in Alzheimer's disease - procedures for a causal investigation using single nucleotide polymorphisms in a Mendelian Randomization study
Yiqiang Zhan,

Biosimilars of Monoclonal Antibodies: A Practical Guide to Manufacturing, Preclinical, and Clinical Development

Автор: Liu
Название: Biosimilars of Monoclonal Antibodies: A Practical Guide to Manufacturing, Preclinical, and Clinical Development
ISBN: 1118662318 ISBN-13(EAN): 9781118662311
Издательство: Wiley
Рейтинг:
Цена: 25653.00 р.
Наличие на складе: Поставка под заказ.

Описание: Addressing a significant need by describing the science and process involved to develop biosimilars of monoclonal antibody (mAb) drugs, this book covers all aspects of biosimilar development: preclinical, clinical, regulatory, manufacturing.

Oxidative Stress Biomarkers and Antioxidant Protocols

Автор: Armstrong Donald
Название: Oxidative Stress Biomarkers and Antioxidant Protocols
ISBN: 0896038505 ISBN-13(EAN): 9780896038509
Издательство: Springer
Рейтинг:
Цена: 21661.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Donald Armstrong updates and expands his highly praised Free Radical and Antioxidant Protocols (Humana, 1998) with a collection of new and valuable methods for evaluating the pertubations in cell function resulting from increased oxidative stress. Presented in a user-friendly, step-by-step format, these readily reproducible techniques cover both free radical-derived and antioxidant biomarkers. The methodologies demonstrated include ELISA, HPLC, infrared spectroscopy, gas chromatography-mass spectroscopy, immunoblotting, electroelution fractionation, isoelectric focusing, voltametry, and electron paramagnetic resonance imaging. Special emphasis is given to the separation of complex mixtures of plant antioxidants, soft drug design to protect from toxic oxidative metabolites, in vitro oxidation conditions, and correcting for random measurement error to improve statistical interpretation. A soon-to-be-published companion volume, Oxidants and Antioxidants: Ultrastructural and Molecular Biology Protocols (0-89603-851-3), contains state-of-the-art molecular and ultrastructural methods that expand the total number of protocols to 109 assays.

Histopathology of Preclinical Toxicity Studies,

Автор: Peter Greaves
Название: Histopathology of Preclinical Toxicity Studies,
ISBN: 0444538569 ISBN-13(EAN): 9780444538567
Издательство: Elsevier Science
Рейтинг:
Цена: 25096.00 р.
Наличие на складе: Поставка под заказ.

Описание: Describes the pathology found in drug safety studies in laboratory animals with an evidence-based discussion of the relevance of these findings to the clinical investigation of new drugs for humans. This reference is suitable for those involved in drug safety evaluation, including pathologists, toxicologists, and pharmacologists.

Atlas of Biomarkers for Alzheimer`s Disease

Автор: Manuel Men?ndez Gonz?lez
Название: Atlas of Biomarkers for Alzheimer`s Disease
ISBN: 3319079883 ISBN-13(EAN): 9783319079882
Издательство: Springer
Рейтинг:
Цена: 13974.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: A lot of research on biomarkers for Alzheimer is being done in the last few decades. The aim of these studies is to find some method to ease the diagnosis of Alzheimers as early as possible. Such methods are a range of blood or CSF tests on one hand and several types of neuroimaging scans on the other. Many of the images coming both from laboratory and neuroimaging are very visual and illustrative. These images, accompanied by a short description, can perfectly explain the main results and usefulness of every biomarker. The objective of this book would be to summarize the most important studies made in this field. Few publications have systematically compiled results on this topic and only one as an atlas. Readers would be interested in this publication because it allows reviewing the current status of research by handily visualizing the results.

Biomarkers in Alzheimer`s Disease

Автор: Khan, Tapan
Название: Biomarkers in Alzheimer`s Disease
ISBN: 0128048328 ISBN-13(EAN): 9780128048320
Издательство: Elsevier Science
Рейтинг:
Цена: 11620.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание:

Biomarkers in Alzheimer's Disease provides a comprehensive overview of all modalities of Alzheimer's disease biomarkers, including neuroimaging, cerebrospinal fluid, genomic, and peripheral systems. Each chapter integrates molecular/cellular abnormality due to Alzheimer's disease and technological advancement of biomarkers techniques.

The book is ideal for clinical neuroscience and molecular/cellular neuroscience researchers, psychiatrists, and allied healthcare practitioners involved in the diagnosis and management of patients with cognitive impairment and Alzheimer's disease, and for differential diagnosis of Alzheimer's disease with other non-Alzheimer's dementia.

Handbook of Therapeutic Biomarkers in Cancer

Название: Handbook of Therapeutic Biomarkers in Cancer
ISBN: 9814364657 ISBN-13(EAN): 9789814364652
Издательство: Taylor&Francis
Рейтинг:
Цена: 21437.00 р.
Наличие на складе: Поставка под заказ.

Описание: In this volume, a team of internationally recognized experts provide an in-depth description of therapeutic biomarkers across a broad area of cancer research and oncology. With a wealth of information to specific therapies, each chapter focuses on a class of targeted chemotherapy agents. The book describes established and evolving diagnostic tests for therapeutic biomarkers that predict benefit, response, resistance, or drug side effects from specific therapeutic interventions. This volume is an essential handbook for health professionals and scientists researching current applicable biomarkers in oncology.

Biomarkers of Disease

Автор: Edited by Andrew K. Trull
Название: Biomarkers of Disease
ISBN: 0521811023 ISBN-13(EAN): 9780521811026
Издательство: Cambridge Academ
Рейтинг:
Цена: 39125.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: This publication takes a critical, evidence-based look at the efficacy of diagnostic tests which are increasingly being used to evaluate organ damage and dysfunction. Some of these assist in diagnosis, others provide a means of monitoring the state of progression of disease and the effectiveness of therapeutic options.

Biomarkers of disease

Название: Biomarkers of disease
ISBN: 0521088607 ISBN-13(EAN): 9780521088602
Издательство: Cambridge Academ
Рейтинг:
Цена: 10138.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: This publication takes a critical, evidence-based look at the efficacy of diagnostic tests which are increasingly being used to evaluate organ damage and dysfunction. Some of these assist in diagnosis, others provide a means of monitoring the state of progression of disease and the effectiveness of therapeutic options.

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