Cell Adhesion and Cytoskeletal Molecules in Metastasis, Anne E. Cress; Raymond B. Nagle

Автор: Beauchemin
Название: Metastasis of Colorectal Cancer
ISBN: 9048188326 ISBN-13(EAN): 9789048188321
Издательство: Springer
Рейтинг:
Цена: 28734.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: This book covers colon cancer metastasis from fundamental aspects to clinical practice. Major topics include physiopathology, genetic and epigenetic controls, cancer initiating cells, epithelial-mesenchymal transition, growth factors and signalling, and more.

Автор: Beauchemin
Название: Metastasis of Colorectal Cancer
ISBN: 9400732937 ISBN-13(EAN): 9789400732933
Издательство: Springer
Цена: 28732.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Introduction; N. Beauchemin, J. Huot 1. The Metastatic Process: an Overview; N.Porquet, S. Guot, J. Huot 1.1 Models of metastasis - 1.1.1 The progression model - 1.1.2 The transient compartment model - 1.1.3 The early oncogenesis model - 1.1.4 The fusion model - 1.1.5 The gene transfer models - 1.1.6 The genetic predisposition model 1.2 Metastatic steps - 1.2.1 Development of the primary colorectal cancer - 1.2.1.1 Initiation of the primary neoplasm - 1.2.1.2 Influence of stromal cells - 1.2.1.3 Influence of the extracellular matrix - 1.2.1.4 Epithelial-Mesenchymal transition - 1.2.1.5 Angiogenesis and lymphangiogenesis - 1.2.2 Intravasation - 1.2.3 Circulation of cancer cells - 1.2.4 Extravasation - 1.2.4.1 The adhesion on endothelial cells and the homing concept of metastasis - 1.2.4.2 The passage across the endothelium 1.2.5 Colonization of the secondary sites 1.3 Concluding Remarks References 2. Physiopathology of Colorectal Metastasis; C. Ferrario, M. Basik 2.1 Mechanisms of metastatic spread - 2.1.1 Circulatory spread - 2.1.1.1 Lymphatic spread - 2.1.1.2 Hematogenous spread - 2.1.2 Local spread - 2.1.3 Tumour dormancy 2.2 Sites of metastasis and consequences of spread - 2.2.1 Liver - 2.2.1.1 Steps in liver invasion - 2.2.1.2 Development of liver failure - 2.2.2 Lungs - 2.2.3 Peritoneum - 2.2.4 Bone and bone marrow - 2.2.5 Brain metastasis 2.3 factors contributing to metastatic spread - 2.3.1 Tumour factors - 2.3.1.1 Tissue Factor - 2.3.1.2 EGFR - 2.3.2 Host factors - 2.3.2.1 Immunity - 2.3.2.2 Diet, exercise and liver disease - 2.3.3 Iatrogenic factors 2.4 Conclusion References 3. The Genetic of Colorectal Cancer; A.M. Kaz, W.M. Grady 3.1 Introduction 3.2 The Adenoma-to-Carcinoma Sequence 3.3 Genomic Instability - 3.3.1 Overview - 3.3.2 Chromosome Instability - 3.3.3 DNA Mismatch Repair Inactivation and Microsatellite Instability - 3.3.4 Base Excision Repair Defects/MYH 3.4 Common Deregulated Signalling Pathways - 3.4.1 Wingless/Wnt Signalling Pathway - 3.4.1.1 APC - 3.4.1.2 B-Catenin (CTNNB1) - 3.4.2 KRAS, BRAF and RAS-RAF-MAPK Signalling Pathway - 3.4.2.1 K-RAS - 3.4.2.2 BRAF - 3.4.3 p53 (TP53) - 3.4.4 The Phosphatidylinositol 3-kinase (PI3K) Pathway - 3.4.4.1 PIK3CA - 3.4.4.2 PTEN - 3.4.5 TGF-B Signalling Pathways - 3.4.5.1 TGFBR2 - 3.4.5.2 The SMAD Family of Genes - 3.4.5.3 TGF-B Superfamily Receptors: ACVR2 and BMPR1A 3.5 Genome-Wide Analyses of Colorectal Cancer Genes 3.6 Metastasis Genes 3.7 Conclusions References 4. Epigenetics of Colorectal Cancer; F.J. Carmona, M. Esteller 4.1 Introduction 4.2 DNA methylation defects in colorectal cancer - 4.2.1 Hypomethylation of DNA 4.3 Inactivation of tumour suppressor genes by CpG island hypermethylation 4.4 Epigenetic regulation of microRNA in cancer 4.5 MicroRNAs as metastasis switches 4.6 Histone modification defects in colon cancer 4.7 Epigenetic contribution to co

Автор: Richard J. Ablin; Malcolm D. Mason
Название: Metastasis of Prostate Cancer
ISBN: 9401781524 ISBN-13(EAN): 9789401781527
Издательство: Springer
Рейтинг:
Цена: 28732.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: This volume brings together the key research issues in clinical and laboratory science relating to metastasis in prostate cancer. Prostate cancer is an area of intense research effort, and this book provides a window on contemporary research in this important area.

Автор: Gurmit Singh; Shafaat A. Rabbani
Название: Bone Metastasis
ISBN: 1617375454 ISBN-13(EAN): 9781617375453
Издательство: Springer
Рейтинг:
Цена: 32004.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: The authors illuminate the role of various autocrine, paracrine, and immunological factors involved in the progression and establishment of bone metastases, highlighting the physiological processes that lead to bone degradation, pain, angiogenesis, and dysregulation of bone turnover.